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Article: Anti-Biofilm Effect of Bacteriophages and Antibiotics against Uropathogenic

Mukane, Laima / Racenis, Karlis / Rezevska, Dace / Petersons, Aivars / Kroica, Juta

2022 Volume 11, Issue 12

Abstract: Escherichia ... ...

Abstract	Escherichia coli
Language	English
Publishing date	2022-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11121706
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Article ; Online: eGFR

Avotins, Lauris / Kroica, Juta / Petersons, Aivars / Zentina, Dace / Kravale, Zaiga / Saulite, Anna / Racenis, Karlis

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 269

Abstract: Background: Shrunken Pore Syndrome (SPS), defined as a reduced ratio between two estimated filtration rates (based on cystatin C and creatinine) is an increasingly recognized risk factor for long-term mortality. Although some patients with other ... ...

Abstract	Background: Shrunken Pore Syndrome (SPS), defined as a reduced ratio between two estimated filtration rates (based on cystatin C and creatinine) is an increasingly recognized risk factor for long-term mortality. Although some patients with other conditions might be erroneously identified as SPS. Our aim was to bring the focus on possible pathophysiologic mechanisms influencing the ratio in the setting of SARS-CoV-2 pneumonia and acute kidney injury. Methods: A single-centered prospective cohort study was conducted to investigate biomarkers in symptomatic COVID-19 pneumonia patients admitted to a hospital in Latvia. Nineteen biomarkers were measured in blood and three in urine samples. Associations were sought between these biomarkers, chronic diseases and the estimated GFR Results: We included 59 patients (average age 65.5 years, 45.8% female) admitted with COVID-19. Acute kidney injury occurred in 27.1%, and 25.4% died. Ratio < 0.6 was seen in 38.6%, associated with female sex, diabetes, hypothyroidism, and higher age. Ratio < 0.6 group had mortality notably higher - 40.9% vs. 16.2% and more cases of acute kidney injury (40.9% vs. 18.9%). Cystatin C showed strong associations with the ratio < 0.6 compared to creatinine. Urea levels and urea/creatinine ratio were higher in the ratio < 0.6 group. After excluding acute kidney injury patients, ratio < 0.6 remained associated with higher cystatin C and urea levels. Other biomarkers linked to a kidney injury as NGAL, and proteinuria did not differ. Conclusion: We prove that reduced ratio is common in hospitalized patients with SARS-CoV-2 pneumonia and is associated with increased mortality during hospitalization. Factors that influence this ratio are complex and, in addition to the possible shrinkage of pores, other conditions such as thickening of glomerular basal membrane, comorbidities, prerenal kidney failure and others may play an important role and should be addressed when diagnosing SPS. We highlight the need for additional diagnostic criteria for SPS and larger studies to better understand its implications in acute COVID-19 settings.
MeSH term(s)	Humans ; Female ; Aged ; Male ; SARS-CoV-2 ; COVID-19 ; Creatinine ; Cystatin C ; Prospective Studies ; Pneumonia ; Acute Kidney Injury/diagnosis ; Urea
Chemical Substances	Creatinine (AYI8EX34EU) ; Cystatin C ; Urea (8W8T17847W)
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03315-x
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Article ; Online: Performance of Fluid Balance as A Marker of Acute Kidney Injury in Children after Open Heart Surgery

Krastiņš Jēkabs / Pētersons Aigars / Pētersons Aivars

Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 73, Iss 2, Pp 125-

2019 Volume 131

Abstract: Acute kidney injury (AKI) is a serious complication in the perioperative period and is consistently associated with increased morbidity and case fatality rate. This has been best studied in the cardiac surgery setting where it has been shown that up to ... ...

Abstract	Acute kidney injury (AKI) is a serious complication in the perioperative period and is consistently associated with increased morbidity and case fatality rate. This has been best studied in the cardiac surgery setting where it has been shown that up to 11.5–86.0% of patients exposed to cardiopulmonary bypass (CPB) will develop AKI, with 2.0–18.9% requiring renal replacement therapy (RRT). A prospective uncontrolled cohort study was conducted between 2011 and 2015, in which 93 children with various congenital heart lesions undergoing CPB were enrolled. Serum creatinine (SCr) level was determined by Jaffé’s method (Cobas 6000 analyser, Roche). Postoperative fluid balance was estimated as the difference between fluid intake and output. Data for further processing were retrieved from anaesthesia and intensive care data management system flowsheets (IntelliView, Philips). AKI developed in 42 patients (45.6%) by meeting at least KDIGO (Kidney Disease: Improving Global Outcomes) stage I criteria (with SCr rise by more than 50% from the baseline). Thirty eight patients complied with the 1st stage of AKI, three with 2nd stage and two with 3rd stage, according the KDIGO classification and staging system. One patient having severity stage II and two patients having severity stage III of AKI required initiation of RRT using peritoneal dialysis. Two patients from the RRT group survived, one died. The median intraoperative urine output was 2.32 ml/kg/h, (range from 0.42–5.87 ml/kg/h). Median CPB time was 163 min., median aortic cross-clamping time was 97.9 min., cooling during CPB to 29.5 °C. The diagnosis of AKI using SCr was delayed by 48 hours after CPB. Median fluid balance (FB) on the first postoperative day in non-AKI patients was 13.58 ml/kg (IQR 0–37.02) vs 49.38 ml/kg (IQR 13.20–69.32) in AKI patients, p < 0.001. AKI is a frequent complication after open heart surgery in children with congenital heart lesions. From 93 patients included in the study, 42 (45.2%) met at least KDIGO Stage I criteria for AKI. FB is a ...
Keywords	acute kidney injury ; fluid balance ; paediatric open-heart surgery ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epidemiological, Clinical and Morphological Characteristics of Immunoglobulin a Nephropathy in Latvia

Kučāne Linda / Popova Anna / Kuzema Viktorija / Lejnieks Aivars / Pētersons Aivars

Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 74, Iss 4, Pp 227-

2020 Volume 231

Abstract: Immunoglobulin A nephropathy (IgAN) is the most common chronic glomerulopathy with variable clinical manifestations. IgAN diagnostics became possible in Latvia in 2013. The study aim was to describe IgAN manifestations in the Latvian population by ... ...

Abstract	Immunoglobulin A nephropathy (IgAN) is the most common chronic glomerulopathy with variable clinical manifestations. IgAN diagnostics became possible in Latvia in 2013. The study aim was to describe IgAN manifestations in the Latvian population by analysing epidemiological, clinical, histological data, and reveal factors that might determine the course of the disease. The retrospective, one-centre study included biopsy-proven IgAN patients over a five-year period in the Nephrology Centre at Pauls Stradiņš Clinical University Hospital. Data from inpatient and outpatient medical records were collected. The study included 69 patients with histologically confirmed IgAN (23% of all renal biopsies): 52% men with mean age of 37. More than a half of them had hypertension, changes in urinalysis and kidney structure, and GFR < ml/min before the biopsy. Pathology data stratified by MEST-C score were: M1 (93%), E1 (5%), S1 (81%), T1 and T2 (24%), C1 (18%). 20% started renal replacement therapy (RRT). Proteinuria, obesity, hyperuricemia, high total MEST-C score, and low serum C3 were associated with a worse prognosis. As a significant part of patients start RRT in the five-year period after the biopsy, the disease course is not benign. IgAN in the study population was diagnosed with clinical and histological signs of advanced disease.
Keywords	glomerulonephritis ; immunoglobulin a ; kidney biopsy ; nephrology ; kidney disease ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article: Use of Phage Cocktail BFC 1.10 in Combination With Ceftazidime-Avibactam in the Treatment of Multidrug-Resistant

Racenis, Karlis / Rezevska, Dace / Madelane, Monta / Lavrinovics, Ervins / Djebara, Sarah / Petersons, Aivars / Kroica, Juta

Frontiers in medicine

2022 Volume 9, Page(s) 851310

Abstract: High-energy trauma with severe bone fractures can be complicated by infection, leading to the development of osteomyelitis. ...

Abstract	High-energy trauma with severe bone fractures can be complicated by infection, leading to the development of osteomyelitis.
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.851310
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Article: Performance of Fluid Balance as A Marker of Acute Kidney Injury in Children after Open Heart Surgery

Krastiņš, Jēkabs / Pētersons, Aigars / Pētersons, Aivars

Proceedings of the Latvian Academy of Sciences. 2019 May 01, v. 73, no. 2

2019

Abstract	Acute kidney injury (AKI) is a serious complication in the perioperative period and is consistently associated with increased morbidity and case fatality rate. This has been best studied in the cardiac surgery setting where it has been shown that up to 11.5–86.0% of patients exposed to cardiopulmonary bypass (CPB) will develop AKI, with 2.0–18.9% requiring renal replacement therapy (RRT). A prospective uncontrolled cohort study was conducted between 2011 and 2015, in which 93 children with various congenital heart lesions undergoing CPB were enrolled. Serum creatinine (SCr) level was determined by Jaffé’s method (Cobas 6000 analyser, Roche). Postoperative fluid balance was estimated as the difference between fluid intake and output. Data for further processing were retrieved from anaesthesia and intensive care data management system flowsheets (IntelliView, Philips). AKI developed in 42 patients (45.6%) by meeting at least KDIGO (Kidney Disease: Improving Global Outcomes) stage I criteria (with SCr rise by more than 50% from the baseline). Thirty eight patients complied with the 1st stage of AKI, three with 2nd stage and two with 3rd stage, according the KDIGO classification and staging system. One patient having severity stage II and two patients having severity stage III of AKI required initiation of RRT using peritoneal dialysis. Two patients from the RRT group survived, one died. The median intraoperative urine output was 2.32 ml/kg/h, (range from 0.42–5.87 ml/kg/h). Median CPB time was 163 min., median aortic cross-clamping time was 97.9 min., cooling during CPB to 29.5 °C. The diagnosis of AKI using SCr was delayed by 48 hours after CPB. Median fluid balance (FB) on the first postoperative day in non-AKI patients was 13.58 ml/kg (IQR 0–37.02) vs 49.38 ml/kg (IQR 13.20–69.32) in AKI patients, p < 0.001. AKI is a frequent complication after open heart surgery in children with congenital heart lesions. From 93 patients included in the study, 42 (45.2%) met at least KDIGO Stage I criteria for AKI. FB is a sensitive marker of kidney dysfunction. Median FB in the 1st postoperative day significantly differed between AKI patients: 49.38 ml/kg (13.20–69.32) versus 13.58 ml/kg in patients with intact kidney function (AUC = 0.84; p = 0.001). Thus it can be used as a marker of AKI.
Keywords	anesthesia ; blood serum ; children ; cohort studies ; creatinine ; dialysis ; heart ; information management ; kidney diseases ; kidneys ; morbidity ; mortality ; patients ; renal function ; surgery ; urine
Language	English
Dates of publication	2019-0501
Size	p. 125-131.
Publishing place	Sciendo
Document type	Article
ZDB-ID	2487550-8
ISSN	2199-5966 ; 1407-009X
ISSN (online)	2199-5966
ISSN	1407-009X
DOI	10.2478/prolas-2019-0020
Database	NAL-Catalogue (AGRICOLA)

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Article: Epidemiological, Clinical and Morphological Characteristics of Immunoglobulin a Nephropathy in Latvia

Kučāne, Linda / Popova, Anna / Kuzema, Viktorija / Lejnieks, Aivars / Pētersons, Aivars

Proceedings of the Latvian Academy of Sciences. 2020 Aug. 01, v. 74, no. 4

2020

Abstract	Immunoglobulin A nephropathy (IgAN) is the most common chronic glomerulopathy with variable clinical manifestations. IgAN diagnostics became possible in Latvia in 2013. The study aim was to describe IgAN manifestations in the Latvian population by analysing epidemiological, clinical, histological data, and reveal factors that might determine the course of the disease. The retrospective, one-centre study included biopsy-proven IgAN patients over a five-year period in the Nephrology Centre at Pauls Stradiņš Clinical University Hospital. Data from inpatient and outpatient medical records were collected. The study included 69 patients with histologically confirmed IgAN (23% of all renal biopsies): 52% men with mean age of 37. More than a half of them had hypertension, changes in urinalysis and kidney structure, and GFR < ml/min before the biopsy. Pathology data stratified by MEST-C score were: M1 (93%), E1 (5%), S1 (81%), T1 and T2 (24%), C1 (18%). 20% started renal replacement therapy (RRT). Proteinuria, obesity, hyperuricemia, high total MEST-C score, and low serum C3 were associated with a worse prognosis. As a significant part of patients start RRT in the five-year period after the biopsy, the disease course is not benign. IgAN in the study population was diagnosed with clinical and histological signs of advanced disease.
Keywords	biopsy ; blood serum ; disease course ; glomerulopathy ; hemodialysis ; histology ; hospitals ; hypertension ; hyperuricemia ; immunoglobulin A ; kidneys ; obesity ; prognosis ; proteinuria ; urinalysis ; Latvia
Language	English
Dates of publication	2020-0801
Size	p. 227-231.
Publishing place	Sciendo
Document type	Article
Note	NAL-AP-2-clean
ISSN	2255-890X
DOI	10.2478/prolas-2020-0036
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early Correction of Post-Kidney Transplant Hyperglycaemia is Associated with Reduction of the Prevalence of Post-Transplant Diabetes Mellitus

Suhecka Klinta / Lejnieks Aivars / Jušinskis Jānis / Maļcevs Aleksandrs / Suhorukovs Vadims / Amerika-Ļebedjkova Diāna / Straupmane Dagnija / Pētersons Aivars / Ziediņa Ieva

Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences, Vol 75, Iss 2, Pp 99-

2021 Volume 105

Abstract: Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus (PTDM) and its associated complications. In a single centre, the prospective study included ... ...

Abstract	Our study was focused on identification and correction of early hyperglycaemia, with the aim to reduce the risk of developing post-transplant diabetes mellitus (PTDM) and its associated complications. In a single centre, the prospective study included adult kidney transplant recipients without diabetes mellitus whose pre-transplant glucometabolic data did not show signs of diabetes mellitus. Starting from the first day after kidney transplantation, patients were closely monitored for hyperglycaemia; glucose level measurements were started to obtain pre-prandial levels. If the blood glucose level exceeded 11.1 mmol/l, hyperglycaemia was corrected with short-acting insulin. A total of 14 patients completed a three-month follow-up. During the first post-transplant week, the blood glucose level exceeded 11.1 mmol/l in nine patients (63.9%). From those patients five (55.5%) did not develop PTDM. None of the patients who did not need insulin treatment developed PTDM. Higher pre-lunch glucose levels increased the risk of developing PTDM (p = 0.006). Patients with diabetes required a two times higher insulin dosage than other patients during the first post-transplantation week. We found that hyperglycaemia is a common problem in the early post-transplant period. Early recognition and correction of inpatient hyperglycaemia was associated with reduction of the prevalence of PTDM in more than a half of the patients in the studied group at three months post transplant.
Keywords	kidney transplantation ; hyperglycaemia – glucose level measurements post-transplant diabetes ; early post-transplant hyperglycaemia ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Predictors of Hyperuricemia after Kidney Transplantation: Association with Graft Function.

Folkmane, Inese / Tzivian, Lilian / Folkmane, Elizabete / Valdmane, Elina / Kuzema, Viktorija / Petersons, Aivars

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 3

Abstract: Background: In kidney transplant recipients (KTR), hyperuricemia (HU) is a commonly-observed phenomenon, due to calcineurin inhibitors and reduced kidney graft function. Factors predicting HU, and its association with graft function, remains equivocal.!# ...

Abstract	Background: In kidney transplant recipients (KTR), hyperuricemia (HU) is a commonly-observed phenomenon, due to calcineurin inhibitors and reduced kidney graft function. Factors predicting HU, and its association with graft function, remains equivocal. Methods: We conducted a retrospective longitudinal study to assess factors associated with HU in KTR, and to determine risk factors associated with graft function, measured as glomerular filtration rate (GFR). Moreover, GFR > 60 mL/min/1.73 m Results: There were 144 patients (mean age 46.6 ± 13.9), with 42.4% of them having HU. Predictors of HU in KTR were the presence of cystic diseases (OR = 9.68 (3.13; 29.9)), the use of diuretics (OR = 4.23 (1.51; 11.9)), and the male gender (OR = 2.45 (1.07; 5.56)). Being a younger age, of female gender, with a normal BMI, and the absence of diuretic medications increased the possibility of normal GFR. HU was the effect modifier of the association between demographic, clinical, and biochemical factors and a normal GFR. Conclusions: Factors associated with HU in KTR: Presence of cystic diseases, diuretic use, and male gender. HU was the effect modifier of the association of demographic, clinical, and biochemical factors to GFR.
MeSH term(s)	Adult ; Calcineurin Inhibitors/therapeutic use ; Diuretics/adverse effects ; Female ; Glomerular Filtration Rate ; Graft Survival ; Humans ; Hyperuricemia/etiology ; Kidney/physiopathology ; Kidney Diseases, Cystic/complications ; Kidney Transplantation/adverse effects ; Logistic Models ; Longitudinal Studies ; Male ; Middle Aged ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Factors ; Sex Factors ; Transplants/physiopathology ; Uric Acid/blood ; Xanthine Oxidase/antagonists & inhibitors
Chemical Substances	Calcineurin Inhibitors ; Diuretics ; Uric Acid (268B43MJ25) ; Xanthine Oxidase (EC 1.17.3.2)
Language	English
Publishing date	2020-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56030095
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Article ; Online: Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant

Racenis, Karlis / Lacis, Janis / Rezevska, Dace / Mukane, Laima / Vilde, Aija / Putnins, Ints / Djebara, Sarah / Merabishvili, Maya / Pirnay, Jean-Paul / Kalnina, Marika / Petersons, Aivars / Stradins, Peteris / Maurins, Sandis / Kroica, Juta

Viruses

2023 Volume 15, Issue 5

Abstract: There is considerable interest in the use of bacteriophages (phages) to ... ...

Abstract	There is considerable interest in the use of bacteriophages (phages) to treat
MeSH term(s)	Male ; Humans ; Middle Aged ; Pseudomonas aeruginosa ; Heart-Assist Devices ; Bacteriophages ; Phage Therapy/methods ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas Infections/therapy ; Pseudomonas Infections/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-05-20
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15051210
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