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Article ; Online: Cephalosporin-Related Neurotoxicity in a Ceftriaxone-Treated Critically Ill Child

Marc Sylva / Alan Abdulla / Birgit C.P. Koch / Jaap Mulder

Case Reports in Acute Medicine, Vol 6, Iss 1, Pp 19-

A Case Report

2023 Volume 24

Abstract: Introduction: We describe a child with meningococcal sepsis who suffered cephalosporin-related neurotoxicity. Case Presentation: A four-year-old girl was treated with intravenous ceftriaxone and supportive therapy. After rapid improvement, inotropic and ... ...

Abstract	Introduction: We describe a child with meningococcal sepsis who suffered cephalosporin-related neurotoxicity. Case Presentation: A four-year-old girl was treated with intravenous ceftriaxone and supportive therapy. After rapid improvement, inotropic and respiratory support was stopped within 2 days. However, she developed renal failure and, on day four, deteriorated neurologically. Research into the cause of her encephalopathy revealed supra-therapeutic ceftriaxone concentrations with greatly increased unbound fractions leading to the diagnosis of cephalosporin-related neurotoxicity. Ceftriaxone treatment was discontinued, and renal replacement therapy was initiated on day six. With both discontinuation of ceftriaxone and renal replacement therapy, the girl’s condition improved rapidly. Conclusion: We postulate that in the described case both renal impairment and hypoalbuminemia played an important role in the development of high unbound ceftriaxone serum levels. We advocate therapeutic drug monitoring for ceftriaxone in critically ill children with renal failure or hypoalbuminemia.
Keywords	ceftriaxone ; encephalopathy ; therapeutic drug monitoring ; child ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Karger Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fano interference in quantum resonances from angle-resolved elastic scattering

Prerna Paliwal / Alexander Blech / Christiane P. Koch / Edvardas Narevicius

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 6

Abstract: Probing resonance features in a scattering process is of fundamental interest. Here the authors discuss the Fano interference due to different angular momentum components in the angle resolved scattering cross section of He*-D2 elastic collisions. ...

Abstract	Probing resonance features in a scattering process is of fundamental interest. Here the authors discuss the Fano interference due to different angular momentum components in the angle resolved scattering cross section of He*-D2 elastic collisions.
Keywords	Science ; Q
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative Cost Analysis of Four Different Computer-Assisted Technologies to Implant a Total Knee Arthroplasty over Conventional Instrumentation

Bernhard Christen / Lars Tanner / Max Ettinger / Michel P. Bonnin / Peter P. Koch / Tilman Calliess

Journal of Personalized Medicine, Vol 12, Iss 184, p

2022 Volume 184

Abstract: Several computer-assisted technologies, such as navigation and robotics, have been introduced to Total Knee Arthroplasty (TKA) in order to increase surgical precision and reduce complications. However, these technologies are often criticized due to the ... ...

Abstract	Several computer-assisted technologies, such as navigation and robotics, have been introduced to Total Knee Arthroplasty (TKA) in order to increase surgical precision and reduce complications. However, these technologies are often criticized due to the increased costs and effort associated with them; however, comparative data are missing. The aim of the present study was to evaluate differences in intraoperative workflows and the related perioperative cost-profiles of four current computer-assisted technologies, used to implant a TKA, in order to gain a comparison to conventional instrumentation. For the cost analysis, additional preoperative imaging and instruments, increased operating room (OR) and planning-time, and expenditures for technical support of the equipment and disposals were calculated, in comparison to conventional TKA, for (1) standard computer-navigation, (2) patient specific instruments (PSI), (3) image-based robotic assistance, and (4) imageless robotic assistance. Workflows at four expert centers which use these technologies were reviewed by an independent observer. The total cost calculation was based on a 125 TKA per year unit in Switzerland. Computer-navigation resulted in 14 min (+23%) increased surgery time and, overall, USD 650 in additional costs. PSI technology saved 5 min (8%) OR time but it created USD 1520 in expenditures for imaging and disposals. The image-based robotic system was the most expensive technology; it created overall additional costs of USD 2600, which predominately resulted from technical support, disposals, the CT-Scan, and 14 min of increased OR time. The imageless robotic assistance resulted in the largest increase in OR-time, as it resulted in an additional 25 min (+42%) on average. Overall, additional costs of USD 1530 were calculated. Every one of the assistive technologies in this study increased the total cost of TKA when compared to a conventional technique, and the most important variables, related to cost, were technical support and additional ...
Keywords	robotics ; navigation ; patient-specific instruments ; cost analysis ; Medicine ; R
Subject code	303
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of the freeze–melt cycle of land-fast ice on the distribution of dissolved organic matter in the Laptev and East Siberian seas (Siberian Arctic)

J. A. Hölemann / B. Juhls / D. Bauch / M. Janout / B. P. Koch / B. Heim

Biogeosciences, Vol 18, Pp 3637-

2021 Volume 3655

Abstract: Permafrost degradation in the catchment of major Siberian rivers, combined with higher precipitation in a warming climate, could increase the flux of terrestrially derived dissolved organic matter (tDOM) into the Arctic Ocean (AO). Each year, ∼ 7.9 Tg of ...

Abstract	Permafrost degradation in the catchment of major Siberian rivers, combined with higher precipitation in a warming climate, could increase the flux of terrestrially derived dissolved organic matter (tDOM) into the Arctic Ocean (AO). Each year, ∼ 7.9 Tg of dissolved organic carbon (DOC) is discharged into the AO via the three largest rivers that flow into the Laptev Sea (LS) and East Siberian Sea (ESS). A significant proportion of this tDOM-rich river water undergoes at least one freeze–melt cycle in the land-fast ice that forms along the coast of the Laptev and East Siberian seas in winter. To better understand how growth and melting of land-fast ice affect dissolved organic matter (DOM) dynamics in the LS and ESS, we determined DOC concentrations and the optical properties of coloured dissolved organic matter (CDOM) in sea ice, river water and seawater. The data set, covering different seasons over a 9-year period (2010–2019), was complemented by oceanographic measurements ( T , S ) and determination of the oxygen isotope composition of the seawater. Although removal of tDOM cannot be ruled out, our study suggests that conservative mixing of high-tDOM river water and sea-ice meltwater with low-tDOM seawater is the major factor controlling the surface distribution of tDOM in the LS and ESS. A case study based on data from winter 2012 and spring 2014 reveals that the mixing of about 273 km 3 of low-tDOM land-fast-ice meltwater (containing ∼ 0.3 Tg DOC) with more than 200 km 3 of high-tDOM Lena River water discharged during the spring freshet ( ∼ 2.8 Tg DOC yr −1 ) plays a dominant role in this respect. The mixing of the two low-salinity surface water masses is possible because the meltwater and the river water of the spring freshet flow into the southeastern LS at the same time every year (May–July). In addition, budget calculations indicate that in the course of the growth of land-fast ice in the southeastern LS, ∼ 1.2 Tg DOC yr −1 ( ± 0.54 Tg) can be expelled from the growing ice in winter, together with brines. These DOC-rich brines can then be transported across the shelves into the Arctic halocline and the Transpolar Drift Current flowing from the Siberian Shelf towards Greenland. The study of dissolved organic matter dynamics in the AO is important not only to decipher the Arctic carbon cycle but also because CDOM regulates physical processes such as radiative forcing in the upper ocean, which has important effects on sea surface temperature, water column stratification, biological productivity and UV penetration.
Keywords	Ecology ; QH540-549.5 ; Life ; QH501-531 ; Geology ; QE1-996.5
Subject code	550
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence

Laura E. J. Peeters / Leonardien K. Tjong / Wim J. R. Rietdijk / Teun van Gelder / Birgit C. P. Koch / Jorie Versmissen

Biomedicines, Vol 10, Iss 137, p

2022 Volume 137

Abstract: We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients. Furthermore, sex differences in adherence for spironolactone and other antihypertensive drugs (AHDs) ... ...

Abstract	We aim to investigate sex differences in blood concentrations of spironolactone and the active metabolite canrenone in resistant hypertension patients. Furthermore, sex differences in adherence for spironolactone and other antihypertensive drugs (AHDs) were studied. The patients in this post hoc study had all participated in a single-blind randomized controlled trial called RHYME-RCT (Dutch Trial Register, NL6736). Concentrations in blood of several AHDs were assessed in RHYME-RCT to investigate adherence to treatment. This allowed for a comparison of drug exposure to spironolactone and canrenone between males and females. In linear regression models, no statistically significant sex differences (N = 35) in spironolactone (B =−10.23, SE = 7.92, p = 0.206) or canrenone (B = 1.24, SE = 10.96, p = 0.911) concentrations after adjustment for dose and time between sampling and intake were found. Furthermore, no statistically significant differences in non-adherence to spironolactone were found between sexes (N = 54, male 15% vs. female 38%, p = 0.100), but non-adherence to spironolactone was associated with non-adherence to other AHDs ( p ≤ 0.001). Spironolactone and canrenone concentrations were not different between males and females with resistant hypertension. Although not statistically significant, females were twice as likely to be non-adherent to spironolactone compared to males, and thereby also more likely to be non-adherent to other AHDs.
Keywords	hypertension ; sex differences ; adherence ; drug monitoring ; spironolactone ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sex-Based Difference in the Effect of Metoprolol on Heart Rate and Bradycardia in a Population-Based Setting

Linda C. Hendriksen / Grace Omes-Smit / Birgit C. P. Koch / M. Arfan Ikram / Bruno H. Stricker / Loes E. Visser

Journal of Personalized Medicine, Vol 12, Iss 870, p

2022 Volume 870

Abstract: Background: Metoprolol, a beta-blocker, is used to reduce the heart rate. Although it has been demonstrated that the metoprolol plasma concentration is higher in women than in men, the same dose is recommended. In this study, we investigated whether the ... ...

Abstract	Background: Metoprolol, a beta-blocker, is used to reduce the heart rate. Although it has been demonstrated that the metoprolol plasma concentration is higher in women than in men, the same dose is recommended. In this study, we investigated whether the metoprolol concentration was associated with a stronger heart-rate reduction and bradycardia in women than in men. Methods: This study is part of the Rotterdam Study (RS), a population-based prospective cohort study. Blood samples from a random subset of 2000 participants were used to assess metoprolol plasma levels. An analysis of heart rate (beats per minute, bpm) and bradycardia (<60 bpm) was performed in metoprolol users with an ECG at the day of blood collection to study sex-specific differences in heart rate and the risk of bradycardia. Results: In total, 40 women and 39 men were included. There was a statistically significant association between metoprolol concentration and heart rate in women ( p -value: 0.014) but not in men ( p -value: 0.639). Furthermore, women in the highest concentration group had a more than 15-times-higher risk of bradycardia than women in the lowest concentration group (OR = 15.6; 95% CI = 1.1, 217.3); however, this was not seen in men (OR = 1.3; 95% CI = 0.1, 12.4). After adjustment for age, BMI, time between blood sample and ECG, hypertension, myocardial infarction, heart failure, atrial fibrillation, digoxin use, and calcium channel blocker use, the association between concentration and bradycardia in women remained statistically significant. Conclusions: Women, but not men, had a statistically significantly lower heart rate at higher metoprolol plasma concentration and a statistically significantly increased risk of bradycardia.
Keywords	sex differences ; pharmacodynamics ; pharmacoepidemiology ; metoprolol ; bradycardia ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dissolved Domoic Acid Does Not Improve Growth Rates and Iron Content in Iron-Stressed Pseudo-Nitzschia subcurvata

Jana K. Geuer / Scarlett Trimborn / Florian Koch / Tina Brenneis / Bernd Krock / Boris P. Koch

Frontiers in Marine Science, Vol

2020 Volume 7

Abstract: Many regions of Antarctica are classified as high nutrient low chlorophyll (HNLC) areas. In these, iron availability is limiting primary productivity and subsequent carbon export. Domoic acid (DA) has previously been detected in the Southern Ocean and ... ...

Abstract	Many regions of Antarctica are classified as high nutrient low chlorophyll (HNLC) areas. In these, iron availability is limiting primary productivity and subsequent carbon export. Domoic acid (DA) has previously been detected in the Southern Ocean and suggested to act as a ligand that facilitates iron assimilation for Pseudo-nitzschia spp., species that contribute to Antarctic diatom blooms. An incubation experiment using the Antarctic species Pseudo-nitzschia subcurvata was performed in Antarctic seawater at low and high iron concentrations. Dissolved DA was added to one set of each of the two treatments. This was done to verify whether DA positively affects the growth of the non-toxic species Pseudo-nitzschia subcurvata and increases its cellular iron content, particularly under low iron conditions. We hypothesize that (i) DA is taken up under low iron conditions (ii) that more iron is taken up if DA is available and (iii) that the growth rate increases in the presence of DA. We showed that P. subcurvata did not take up any added DA, even under low iron conditions. Additionally and contrary to our hypothesis, the cells were not positively influenced by the addition of dissolved DA in terms of growth rate, cellular iron and carbon content. Hence, there was no significant difference in iron content between the different treatments. However, the cellular copper content increased under low iron conditions when DA was added. This study suggests that dissolved DA in naturally occurring concentrations does not increase bioavailability of iron to P. subcurvata and that only species producing DA might benefit from it.
Keywords	Antarctica ; copper ; incubation experiment ; diatoms (Bacillariophyceae) ; phytoplankton ; toxin ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	551
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Implementation of Pharmacogenetics in First-Line Care

Denise van der Drift / Mirjam Simoons / Birgit C. P. Koch / Gemma Brufau / Patrick Bindels / Maja Matic / Ron H. N. van Schaik

Genes, Vol 14, Iss 10, p

Evaluation of Its Use by General Practitioners

2023 Volume 1841

Abstract: Pharmacogenetics (PGx) can explain/predict drug therapy outcomes. There is, however, unclarity about the use and usefulness of PGx in primary care. In this study, we investigated PGx tests ordered by general practitioners (GPs) in 2021 at Dept. Clinical ... ...

Abstract	Pharmacogenetics (PGx) can explain/predict drug therapy outcomes. There is, however, unclarity about the use and usefulness of PGx in primary care. In this study, we investigated PGx tests ordered by general practitioners (GPs) in 2021 at Dept. Clinical Chemistry, Erasmus MC, and analyzed the gene tests ordered, drugs/drug groups, reasons for testing and single-gene versus panel testing. Additionally, a survey was sent to 90 GPs asking about their experiences and barriers to implementing PGx. In total, 1206 patients and 6300 PGx tests were requested by GPs. CYP2C19 was requested most frequently (17%), and clopidogrel was the most commonly indicated drug (23%). Regarding drug groups, antidepressants (51%) were the main driver for requesting PGx, followed by antihypertensives (26%). Side effects (79%) and non-response (27%) were the main indicators. Panel testing was preferred over single-gene testing. The survey revealed knowledge on when and how to use PGx as one of the main barriers. In conclusion, PGx is currently used by GPs in clinical practice in the Netherlands. Side effects are the main reason for testing, which mostly involves antidepressants. Lack of knowledge is indicated as a major barrier, indicating the need for more education on PGx for GPs.
Keywords	pharmacogenetics ; pharmacogenomics ; GP ; clinical implementation ; CYP450 ; personalized medicine ; Genetics ; QH426-470
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Modeling and Simulations in Time Domain of a Stimulation Set-up for Cortical Applications

Michael Schweigmann / Frank Kirchhoff / Klaus P. Koch

European Journal of Translational Myology, Vol 26, Iss

2016 Volume 2

Abstract: Electrical stimulation is used for example to treat neuronal disorders and depression with deep brain stimulation or transcranial electrical stimulation. Depending on the application, different electrodes are used and thus different electrical ... ...

Abstract	Electrical stimulation is used for example to treat neuronal disorders and depression with deep brain stimulation or transcranial electrical stimulation. Depending on the application, different electrodes are used and thus different electrical characteristics exist, which have to be handled by the stimulator. Without a measuring device the user would have to rely on the stimulator being able to deliver the needed stimulation signal. Therefore, the objective of this paper is to present a method to increase the level of confidence with characterization and modelling of the electrical behavior by using the example of one channel of our stimulation device for experimental use. In several simulation studies with an electrode model with values in a typical range for cortical applications the influence of the load onto the stimulator and the possibility to pre-estimate measuring signals in complex networks are shown.
Keywords	Cortical electrical stimulation ; Stimulator characterization ; Stimulator model ; Electrode model ; Output impedance ; Medicine ; R ; Human anatomy ; QM1-695
Subject code	620
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Life cycle inventory assessment of carrot crops in France

Grasselly, D / P. Koch / V. Colomb

Acta horticulturae. 2017 Mar. 15, , no. 1153

2017

Abstract: The program AGRIBALYSEÂ® was launched in 2010 by the French environment and energy management Agency (ADEME) to develop a public life cycle inventory database for French agricultural products. Carrot crop was studied at farm gate according to the main ... ...

Abstract	The program AGRIBALYSEÂ® was launched in 2010 by the French environment and energy management Agency (ADEME) to develop a public life cycle inventory database for French agricultural products. Carrot crop was studied at farm gate according to the main growing systems used in the two major production areas (Aquitaine and Lower Normandy). The results obtained for carrot crops are presented and discussed, with a focus on four impact indicators: energy demand, greenhouse gas emissions, acidification and eutrophication. The most impacting practices are the use of N fertilizers, soil fumigation and mechanization. These results represent a step forward to help growers to improve their production systems.
Keywords	acidification ; carrots ; crops ; databases ; energy ; eutrophication ; farms ; greenhouse gas emissions ; growers ; life cycle inventory ; mechanization ; nitrogen fertilizers ; production technology ; soil fumigation ; France
Language	English
Dates of publication	2017-0315
Size	p. 9-14.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the International Symposium on Carrot and Other Apiaceae held Sept 17-19, 2014, Angers, France
ISSN	0567-7572
DOI	10.17660/ActaHortic.2017.1153.2
Database	NAL-Catalogue (AGRICOLA)

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