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Article ; Online: Should we screen for sarcopenia in Romanian patients with osteoporosis? An overview of the current knowledge on osteosarcopenia

Mihai Gabriela / Pascanu Ionela Maria

Acta Marisiensis - Seria Medica, Vol 69, Iss 2, Pp 93-

2023 Volume 97

Abstract: The combination of osteoporosis and sarcopenia is wider known as “osteosarcopenia”, and it is considered to be a “hazardous duet” for the patient. The clinical consequences of this geriatric syndrome include a higher risk of fractures and mortality ... ...

Abstract	The combination of osteoporosis and sarcopenia is wider known as “osteosarcopenia”, and it is considered to be a “hazardous duet” for the patient. The clinical consequences of this geriatric syndrome include a higher risk of fractures and mortality compared to osteoporosis or sarcopenia alone. Fractures are considered to be a burden for the patient but also for the health care system from an economic point of view, therefore it is important to prevent them. Emerging evidence shows that osteosarcopenia is an increasingly prevalent disease. The Fracture Risk Assessment Tool (FRAX) is of major importance for the management of a patient, however, muscle weakness is not part of this instrument. It has been suggested to go “beyond the FRAX” and to evaluate muscle mass/strength besides bone mineral density when it comes to the management of a patient with a sustained fragility fracture. In this review we try to answer whether this is feasible or not when it comes to Romanian patients.
Keywords	osteoporosis ; sarcopenia ; osteosarcopenia ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article: The Role of Genetic Polymorphisms in Differentiated Thyroid Cancer: A 2023 Update.

Tiucă, Robert Aurelian / Tiucă, Oana Mirela / Pașcanu, Ionela Maria

Biomedicines

2023 Volume 11, Issue 4

Abstract: Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the ...

Abstract	Thyroid cancer is the most common endocrine malignancy, with an increasing trend in the past decades. It has a variety of different histological subtypes, the most frequent one being differentiated thyroid cancer, which refers to papillary carcinoma, the most common histological type, followed by follicular carcinoma. Associations between genetic polymorphisms and thyroid cancer have been investigated over the years and are an intriguing topic for the scientific world. To date, the results of associations of single nucleotide polymorphisms, the most common genetic variations in the genome, with thyroid cancer have been inconsistent, but many promising results could potentially influence future research toward developing new targeted therapies and new prognostic biomarkers, thus consolidating a more personalized management for these patients. This review focuses on emphasizing the existing literature data regarding genetic polymorphisms investigated for their potential association with differentiated thyroid cancer and highlights the opportunity of using genetic variations as biomarkers of diagnosis and prognosis for thyroid cancer patients.
Language	English
Publishing date	2023-04-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11041075
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Article ; Online: Recurrent submandibular fistula after Sunitinib treatment in a patient with renal cell carcinoma: a case report.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Cosarca, Adina / Bereczki, Despina Temistocle / Ormenisan, Alina

Medicine and pharmacy reports

2023 Volume 96, Issue 3, Page(s) 323–327

Abstract: Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was ... ...

Abstract	Sunitinib is commonly used in the treatment of patients with renal cell carcinoma and is associated with serious side-effects. We present the first report of a recurrent submandibular fistula in a patient treated with sunitinib. A 68-year-old man was referred to our clinic for a cutaneous fistula situated on the right side of his lower jaw. The patient had been diagnosed with bone metastases from a renal carcinoma 2 years ago and had received a single 4 mg dose of zoledronic acid and subsequent treatment with sunitinib 37.5 mg once daily for the past 4 weeks. The patient was treated surgically by a perilesional incision and primary closure with sutures, advised on meticulous oral hygiene and was kept on an antimicrobial agent in the form of clindamycin. After reinitiating his oncological treatment with sunitinib the cutaneous fistula re-appeared and bone abnormalities were also detected on his X-ray. After 18 months a contralateral cutaneous fistula was observed along with a spontaneous avulsion of the patient's left molar. Repeat surgical treatment and sequestrectomy was performed with the subsequent histopathological examination revealing a suspicion of osteonecrosis of the jaw and an associated Actinomyces infection.
Language	English
Publishing date	2023-07-27
Publishing country	Romania
Document type	Case Reports
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2502
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Article ; Online: False positive cases in thyroid cytopathology - the experience of a single laboratory and a systematic review.

Mezei, Tibor / Kolcsár, Melinda / Pașcanu, Ionela / Vielh, Philippe

Cytopathology : official journal of the British Society for Clinical Cytology

2021 Volume 32, Issue 4, Page(s) 493–504

Abstract: Introduction: Fine needle aspiration (FNA) is fundamental in the pre-operative assessment of thyroid nodules. However, the shining success of thyroid FNA is occasionally eclipsed by false positive (FP) cytological diagnoses. We describe our experience ... ...

Abstract	Introduction: Fine needle aspiration (FNA) is fundamental in the pre-operative assessment of thyroid nodules. However, the shining success of thyroid FNA is occasionally eclipsed by false positive (FP) cytological diagnoses. We describe our experience regarding FP cytological diagnoses and present a literature review concerning FP rates. Materials and methods: We retrospectively analyzed 2031 consecutive cytology reports. FP was defined as a case with "suspicious for malignancy" or "malignant" cytology, whose surgical follow-up failed to confirm the initial diagnosis of malignancy. We used the PubMed database for the literature review using specific search terms ("thyroid", "cytology", "false positive"). Results: Out of 2031 FNA reports, 93 cases with "suspicious for malignancy" or "malignant" cytology underwent surgical excision. Histopathology did not confirm malignancy in 10 cases (0.6% FP rate). Nodules with FP cytology were significantly larger (P = 0.0024) than those with with TP (true positive) cytology. A review of 25 publications shows comparable results to ours with some slight differences. The majority of studies achieve a FP rate below 3%. Most FP cytological diagnoses turn out to be non-neoplastic lesions (nodular hyperplasia, adenomatous nodule, lymphocytic thyroiditis), which combined account for 80.5% of all histological diagnoses. Conclusions: Thyroid nodules with FP cytology were larger than nodules with TP cytology. Most studies manage to adhere to the recommended FP rates, or values close to them, with some outliers. Nevertheless, the mean FP rate values are very close to the value recommended by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The FP rate value depends on how one defines true negative cases, which can be either histologically proven benign cases, via a benign clinical course, or by assuming that cytologically benign cases remain as such.
MeSH term(s)	Biopsy, Fine-Needle ; False Positive Reactions ; Female ; Humans ; Male ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.12984
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Article ; Online: Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.

Golu, Mihai Vlad / Paşcanu, Ionela / Petrovan, Cecilia / Mocan, Simona / Cosarcă, Adina / Temistocle, Despina Bereczki / Ormenişan, Alina

Medicine and pharmacy reports

2024 Volume 97, Issue 1, Page(s) 76–83

Abstract: Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency ... ...

Abstract	Aim: The aim of this retrospective study was to identify the clinical, radiological, and histological characteristics of patients diagnosed with osteonecrosis of the jaw (ONJ) and treated at the Oral and Maxillo-Facial Surgery Clinic of the Emergency Clinical County Hospital of Targu Mures between 2017 and 2022. The study aimed to analyze correlations between patient characteristics, particularly their history of bone modifying agent use or local radiotherapy during cancer treatment, in order to identify specific patient profiles that could aid in evaluating treatment response and guide individualized treatment strategies. Methods: Fifty-two patients diagnosed with ONJ were included in the study. The patients were divided into two groups based on their medical history: the bone modifying agent use group and the radiotherapy group. Clinical, radiological, and histological data were collected and analyzed. Statistical analysis, including p-values, was performed to compare patient characteristics between the two groups. Results: Patients in the radiotherapy group were significantly older than those in the bone modifying agent use group (66 years vs. 56.9 years, p=0.001). There was a higher proportion of males in the radiotherapy group compared to the bone modifying agent use group (90% vs. 22%, p<0.001). Jaw involvement was more prevalent in the radiotherapy group compared to the bone modifying agent use group (95% vs. 66%, p=0.018). Histological analysis showed a similar frequency of Actinomyces species in both groups (50% vs. 34%, p=0.264). Conclusions: The findings of this study suggest the existence of two distinct patient profiles based on their treatment history (bone modifying agent use vs. radiotherapy) in ONJ. Patients in the radiotherapy group were older, predominantly male, and exhibited a higher prevalence of jaw involvement. Histological analysis revealed no significant differences in Actinomyces species frequency between the two groups. These distinct patient profiles may indicate different responses to treatment, emphasizing the need for individualized treatment strategies tailored to specific patient characteristics. Further research is warranted to validate these findings and develop personalized approaches for managing ONJ.
Language	English
Publishing date	2024-01-29
Publishing country	Romania
Document type	Journal Article
ZDB-ID	2974425-8
ISSN	2668-0572 ; 2602-0807
ISSN (online)	2668-0572
ISSN	2602-0807
DOI	10.15386/mpr-2610
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Article ; Online: Use of the continuous glucose monitoring system in the management of hypoglicemia in insulin autoimmune syndrome

Pop Andrada Raluca / Ruscanu Claudia Emanuela / Roman Gabriela / Pascanu Ionela Maria

Acta Marisiensis - Seria Medica, Vol 68, Iss 2, Pp 89-

2022 Volume 92

Abstract: Background: Insulin autoimune syndrome (IAS), also known as Hirata’s disease, is a rare cause of spontaneous hyperinsulinemic hypoglicemia characterised by the presence of autoantibodies directed against human insulin (IAA). ...

Abstract	Background: Insulin autoimune syndrome (IAS), also known as Hirata’s disease, is a rare cause of spontaneous hyperinsulinemic hypoglicemia characterised by the presence of autoantibodies directed against human insulin (IAA).
Keywords	insulin autoimune syndrome ; hirata’s disease ; continuous monitoring system ; insulin autoantibodies ; Medicine ; R
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Predictors of mortality for patients with hip fracture: a study of the nationwide 1-year records of 24,950 fractures in Romania.

Gasparik, Andrea I / Lorenzovici, László / Pașcanu, Ionela M / Csata, Zsombor / Poiană, Cătălina / Dobre, Ramona / Bartelick, Miruna M

Archives of osteoporosis

2023 Volume 18, Issue 1, Page(s) 69

Abstract: We conducted a study evaluating incidence rates and influencing factors in Romanian hip fracture patients. Our results showed that the type of fracture and its respective surgical procedure as well as hospital characteristics correlate with mortality. ... ...

Abstract	We conducted a study evaluating incidence rates and influencing factors in Romanian hip fracture patients. Our results showed that the type of fracture and its respective surgical procedure as well as hospital characteristics correlate with mortality. Updated incidences can result in updated treatment guidelines. Purpose: The aim of our study was to assess incidence rates for a revision-calibration of the Romanian FRAX tool and to evaluate particularities of hip fracture cases to determine patient- and hospital-related variables affecting mortality. Methods: We conducted a retrospective study using hospital reports of hip fracture codes to the National School of Statistics (NSS) from January 1, 2019, until December 31, 2019. The study population included 24,950 patients presenting to Romanian public hospitals in all 41 counties: ≥ the age of 40 with diagnostic ICD 10 codes: S72.0 femoral neck fracture, S72.1 pertrochanteric femoral fracture, and S72.2 subtrochanteric femoral fracture and procedure codes: O11104 (trochanteric/sub capital internal fixation), O12101 (hemiarthroplasty), O11808 (closed femoral reduction with internal fixation), O12103 (partial arthroplasty), O12104 (total arthroplasty). Hospital length of stay (LoS) was classified as follows: < 6, 6-9, 10-14, and ≥ 15 days. Results: Incidence of hip fractures was 248/100,000 among those aged 50 + and 184/100,000 within the 40 + age category. Average age of the patients was 77 years (80 for females, 71 for males); 83.7% of the patients were 65 + with equivalent urban-rural distributions. Males had a 1.7 times higher mortality risk. Each year increase in age added a mortality risk of 6.9%. In-hospital mortality was 1.34 times higher among patients living in urban areas. Hemiarthroplasty and partial/total unilateral/bilateral arthroplasty had a lower risk of mortality than trochanteric/sub capital internal fixation (p < 0.02, p < 0.033). Conclusion: Gender, age, residence, and procedure type had significant impact on mortality. Updated incidence rates will allow the revision of Romania's FRAX model.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Romania/epidemiology ; Retrospective Studies ; Hip Fractures/epidemiology ; Hip Fractures/surgery ; Femoral Neck Fractures/epidemiology ; Femoral Neck Fractures/surgery ; Femoral Fractures ; Fracture Fixation, Internal
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-023-01253-7
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Article ; Online: Evaluation of Plasma AA/DHA+EPA Ratio in Obese Romanian Children

Huțanu Adina / Zaharia Mihaela / Farczadi Lenard / Pașcanu Ionela Maria / Pop Raluca Monica / Dobreanu Minodora

Romanian Journal of Laboratory Medicine, Vol 29, Iss 2, Pp 165-

2021 Volume 178

Abstract: The aim of the study was to evaluate the plasma profile of arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), as well to analyze the relationship of Omega 6/Omega 3 ratio with anthropo-metric parameters and insulin ... ...

Abstract	The aim of the study was to evaluate the plasma profile of arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), as well to analyze the relationship of Omega 6/Omega 3 ratio with anthropo-metric parameters and insulin resistance markers.
Keywords	omega fatty acids ; polyunsaturated fatty acids ; obesity ; homa-ir ; insulin resistance ; Medicine ; R
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: New Insights in Growth Hormone Stimulation Tests Protocols

Armean Iulia / Pop Raluca / Gherlan Iuliana / Pașcanu Ionela

Acta Medica Marisiensis, Vol 64, Iss 4, Pp 151-

2018 Volume 156

Abstract: Objective: The objective of this study was to analyze the performance of 2 stimulation tests used in the diagnosis of growth hormone deficiency. ...

Abstract	Objective: The objective of this study was to analyze the performance of 2 stimulation tests used in the diagnosis of growth hormone deficiency.
Keywords	stimulation tests ; growth hormone deficiency ; auxology ; Medicine ; R
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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Article ; Online: Acute Drug-Induced Cholestatic Syndrome in Basedow Graves’ Disease

Tiucă Robert Aurelian / Boeriu Alina Mioara / Georgescu Rareș Adrian / Pașcanu Ionela Maria

Journal of Interdisciplinary Medicine, Vol 5, Iss 2, Pp 81-

2020 Volume 85

Abstract: Introduction: Graves’ disease (GD), an autoimmune disorder caused by high levels of auto-antibodies against the thyroid-stimulating hormone receptor, is considered the most common cause of thyrotoxicosis, characterized by features such as goiter, ... ...

Abstract	Introduction: Graves’ disease (GD), an autoimmune disorder caused by high levels of auto-antibodies against the thyroid-stimulating hormone receptor, is considered the most common cause of thyrotoxicosis, characterized by features such as goiter, ophthalmopathy and dermopathy. In our country, the administration of antithyroid drugs (ATD) is the first line of treatment in this disease. Side effects are rare but some of them, such as agranulocytosis or liver damage, may become serious.
Keywords	graves’ disease ; methimazole ; hepatitis ; cytolysis ; cholestatic syndrome ; Medicine ; R
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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