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Article ; Online: Methane Emission, Carbon Footprint and Productivity of Specialized Dairy Cows Supplemented with Bitter Cassava ( Manihot esculenta Crantz)

Isabel Cristina Molina-Botero / Xiomara Gaviria-Uribe / Juan Pablo Rios-Betancur / Manuela Medina-Campuzano / Mercedes Toro-Trujillo / Ricardo González-Quintero / Bernardo Ospina / Jacobo Arango

Animals, Vol 14, Iss 1, p

2023 Volume 19

Abstract: The objective of this research was to determine the effect of cassava ( Manihot esculenta Crantz) supplementation on enteric methane (CH 4 ) emissions, carbon footprint, and production parameters in dairy cows. Daily concentrate supply for Jersey and ... ...

Abstract	The objective of this research was to determine the effect of cassava ( Manihot esculenta Crantz) supplementation on enteric methane (CH 4 ) emissions, carbon footprint, and production parameters in dairy cows. Daily concentrate supply for Jersey and Jersey * Holstein breeds was evaluated in four treatments (T): T1: 100% commercial concentrate; T2: 70% concentrate + 30% cassava leaves; T3: 70% concentrate + 30% cassava roots; and T4: 70% concentrate + 15% cassava leaves + 15% cassava root chips. Measurements of CH 4 emissions were performed using the polytunnel technique. Average daily dry matter intake ranged from 7.8 to 8.5 kg dry matter (DM). Cassava leaves were characterized by a high crude protein (CP) content (171 g CP/kg DM), with 5 times more neutral detergent fiber (NDF) content than cassava root (587 vs. 108 g NDF/kg DM). Average enteric CH 4 emissions per animal ranged from 194 to 234 g/d ( p > 0.05 ). The carbon footprint was reduced by replacing 30% of the concentrate with cassava leaves and/or roots. Energy-corrected milk production was 1.15 times higher in Jersey * Holstein animals than Jersey cows (47 vs. 55 kg). Therefore, supplementation with cassava leaves and/or roots is a nutritionally and environmentally sustainable strategy.
Keywords	greenhouse gases ; milk production ; ruminants ; supplementation ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efectos fiscales de los asentamientos hidroeléctricos

Juan Pablo Ríos Ocampo / Luis Diego Vélez Gómez

Semestre Económico, Vol 18, Iss 38, Pp 137-

el caso de la cuenca de los ríos Negro y Nare en Colombia

2016 Volume 160

Abstract: Con la presencia de asentamientos hidroeléctricos en su territorio, los municipios del oriente y nordeste antioqueño han visto afectada su estructura tributaria y territorial, a pesar de la reglamentación compensatoria del sector eléctrico. Este ... ...

Abstract	Con la presencia de asentamientos hidroeléctricos en su territorio, los municipios del oriente y nordeste antioqueño han visto afectada su estructura tributaria y territorial, a pesar de la reglamentación compensatoria del sector eléctrico. Este artículo, analiza los efectos tributarios generados por la compensación del impuesto predial. Para lograrlo se revisan los montos recibidos por los municipios de las empresas generadoras y se realiza una indagación empírica del impuesto bajo los escenarios con y sin asentamientos hidroeléctricos. De esta forma se determina el diferencial tributario. Se concluye que, además de la insuficiencia de las transferencias para compensar la pérdida del capital natural de las cuencas hidroeléctricas, la expansión del sector eléctrico genera regresividad tributaria, por causa de privilegios y exenciones concebidos por las Leyes. With the presence of hydroelectric settlements in their territory, the municipalities of the eastern and northeastern regions of Antioquia have seen their fiscal and territorial structure affected despite the regulatory compensation established for the electric sector. This article analyses the taxation effects generated by the compensation of property taxes. To do so, different sums received by different municipalities from generating companies are analyzed and an empiric tax analysis is done for both types of territories (with and without hydroelectric settlements). This is how the taxation differential is determined. It is also concluded that, besides the influence of transfers for compensating the loss of the natural capital of the hydroelectric basins, the expansion of the electric sector generates taxation digressivety due to the privileges and exemptions conceived by the law
Keywords	Impuestos locales ; impuestos y subsidios ; impuestos ambientales y subsidios ; externalidades de los impuestos ; Colombia ; Local taxes ; Taxes and subsidies ; Environmental taxes and subsides ; tax externalities ; Economic theory. Demography ; HB1-3840 ; Economics as a science ; HB71-74
Language	English
Publishing date	2016-03-01T00:00:00Z
Publisher	Universidad de Medellín, Sello Editorial
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ¿A qué se dedica la nefrología?

Ricardo Silvariño / José Boggia / Fiorella Cavalleri / Liliana Gadola / Juan Fernández-Ceán / Francisco González / Pablo Ríos / Laura Solá / Alejandro Ferreiro / Gabriela Otatti / Marcelo Nin / Raúl Lombardi / Oscar Noboa

Revista Médica del Uruguay, Vol 38, Iss

2022 Volume 1

Abstract: La principal habilidad de una especialidad médica es su capacidad de diagnosticar y tomar decisiones clínicas oportunas, en circunstancias difíciles, complejas e inciertas. El desarrollo de esta habilidad requiere aprendizaje, tiempo y experiencia, y es ... ...

Abstract	La principal habilidad de una especialidad médica es su capacidad de diagnosticar y tomar decisiones clínicas oportunas, en circunstancias difíciles, complejas e inciertas. El desarrollo de esta habilidad requiere aprendizaje, tiempo y experiencia, y es más que una colección de competencias(1). La Sociedad Uruguaya de Nefrología (SUN) se ha embarcado recientemente en dos importantes desafíos: iniciar el camino de la recertificación médica y buscar herramientas que, con rigurosidad técnica, permitan estimar el número de especialistas necesarios para el sistema de salud uruguayo en la próxima década. Estos desafíos tienen como punto de inicio común la necesidad de establecer de manera detallada a qué se dedica la especialidad.
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	Spanish
Publishing date	2022-03-01T00:00:00Z
Publisher	Sindicato Médico del Uruguay
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Orthophosphate and Sulfate Utilization for C–E (E = P, S) Bond Formation via Trichlorosilyl Phosphide and Sulfide Anions

Geeson, Michael B / Pablo Ríos / Wesley J. Transue / Christopher C. Cummins

Journal of the American Chemical Society. 2019 Mar. 22, v. 141, no. 15

2019

Abstract: Reduction of phosphoric acid (H₃PO₄) or tetra-n-butylammonium bisulfate ([TBA][HSO₄]) with trichlorosilane leads to the formation of the bis(trichlorosilyl)phosphide ([P(SiCl₃)₂]⁻, 1) and trichlorosilylsulfide ([Cl₃SiS]⁻, 2) anions, respectively. ... ...

Abstract	Reduction of phosphoric acid (H₃PO₄) or tetra-n-butylammonium bisulfate ([TBA][HSO₄]) with trichlorosilane leads to the formation of the bis(trichlorosilyl)phosphide ([P(SiCl₃)₂]⁻, 1) and trichlorosilylsulfide ([Cl₃SiS]⁻, 2) anions, respectively. Balanced equations for the formation of the TBA salts of anions 1 and 2 were formulated based on the identification of hexachlorodisiloxane and hydrogen gas as byproducts arising from these reductive processes: i) [H₂PO₄]⁻ + 10HSiCl₃ → 1 + 4O(SiCl₃)₂ + 6H₂ for P and ii) [HSO₄]⁻ + 9HSiCl₃ → 2 + 4O(SiCl₃)₂ + 5H₂ for S. Hydrogen gas was identified by its subsequent use to hydrogenate an alkene ((−)-terpinen-4-ol) using Crabtree’s catalyst ([(COD)Ir(py)(PCy₃)][PF₆], COD = 1,5-cyclooctadiene, py = pyridine, Cy = cyclohexyl). Phosphide 1 was generated in situ by the reaction of phosphoric acid and trichlorosilane and used to convert an alkyl chloride (1-chlorooctane) to the corresponding primary phosphine, which was isolated in 41% yield. Anion 1 was also prepared from [TBA][H₂PO₄] and isolated in 62% yield on a gram scale. Treatment of [TBA]1 with an excess of benzyl chloride leads to the formation of tetrabenzylphosphonium chloride, which was isolated in 61% yield. Sulfide 2 was used as a thionation reagent, converting benzophenone to thiobenzophenone in 62% yield. It also converted benzyl bromide to benzyl mercaptan in 55% yield. The TBA salt of trimetaphosphate ([TBA]₃[P₃O₉]·2H₂O), also a precursor to anion 1, was found to react with either trichlorosilane or silicon(IV) chloride to provide bis(trimetaphosphate)silicate, [TBA]₂[Si(P₃O₉)₂], characterized by NMR spectroscopy, X-ray crystallography, and elemental analysis. Trichlorosilane reduction of [TBA]₂[Si(P₃O₉)₂] also provided anion 1. The electronic structures of 1 and 2 were investigated using a suite of theoretical methods; the computational studies suggest that the trichlorosilyl ligand is a good π-acceptor and forms σ-bonds with a high degree of s character.
Keywords	X-ray diffraction ; anions ; benzophenones ; byproducts ; catalysts ; chemical oxygen demand ; equations ; hydrogen ; ligands ; nuclear magnetic resonance spectroscopy ; organobromine compounds ; organochlorine compounds ; orthophosphates ; phosphides ; phosphine ; phosphoric acid ; pyridines ; quaternary ammonium compounds ; silicates ; silicon ; sulfates
Language	English
Dates of publication	2019-0322
Size	p. 6375-6384.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.9b01475
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The receptor PTPRU is a redox sensitive pseudophosphatase

Iain M. Hay / Gareth W. Fearnley / Pablo Rios / Maja Köhn / Hayley J. Sharpe / Janet E. Deane

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 13

Abstract: Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may ... ...

Abstract	Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy receptor for substrate sequestration.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The receptor PTPRU is a redox sensitive pseudophosphatase

Iain M. Hay / Gareth W. Fearnley / Pablo Rios / Maja Köhn / Hayley J. Sharpe / Janet E. Deane

Nature Communications, Vol 11, Iss 1, Pp 1-

2020 Volume 13

Abstract	Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy receptor for substrate sequestration.
Keywords	Science ; Q
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The HCV genome domains 5BSL3.1 and 5BSL3.3 act as managers of translation

Cristina Romero-López / Pablo Ríos-Marco / Beatriz Berzal-Herranz / Alfredo Berzal-Herranz

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 12

Abstract: Abstract The RNA genome of the hepatitis C virus (HCV) encodes a single open reading frame (ORF) containing numerous functional elements. Among these, the cis-acting replication element (CRE) at the 3′ end of the viral ORF, has become of increasing ... ...

Abstract	Abstract The RNA genome of the hepatitis C virus (HCV) encodes a single open reading frame (ORF) containing numerous functional elements. Among these, the cis-acting replication element (CRE) at the 3′ end of the viral ORF, has become of increasing interest given its dual role as a viral translation repressor and replication enhancer. Long-range RNA-RNA contacts mediated by the CRE build the structural scaffold required for its proper functioning. The recruitment of different cellular factors, many related to the functioning of the translation machinery, might aid in the CRE-exerted downregulation of viral translation. The present data show that the CRE promotes a defect in polysome production, and hinders the assembly of the 80S complex, likely through the direct, high affinity recruitment of the 40S ribosomal subunit. This interaction involves the highly conserved 5BSL3.1 and 5BSL3.3 domains of the CRE, and is strictly dependent on RNA-protein contacts, particularly with the ribosomal proteins RPSA and RPS29. These observations support a model in which the CRE-mediated inhibition of viral translation is a multifactorial process defined by the establishment of long-range RNA-RNA interactions between the 5′ and 3′ ends of the viral genome, the sequestration of the 40S subunit by the CRE, and the subsequent stalling of polysome elongation at the 3′ end of the ORF, all governed by the highly stable hairpin domains 5BSL3.1 and 5BSL3.3. The present data thus suggest a new managerial role in HCV translation for these 5BSL3.1 and 5BSL3.3 domains.
Keywords	Medicine ; R ; Science ; Q
Subject code	410
Language	English
Publishing date	2018-10-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver.

Sven Stadlbauer / Pablo Rios / Ken Ohmori / Keisuke Suzuki / Maja Köhn

PLoS ONE, Vol 10, Iss 7, p e

2015 Volume 0134336

Abstract: Natural polyphenols like oligomeric catechins (procyanidins) derived from green tea and herbal medicines are interesting compounds for pharmaceutical research due to their ability to protect against carcinogenesis in animal models. It is nevertheless ... ...

Abstract	Natural polyphenols like oligomeric catechins (procyanidins) derived from green tea and herbal medicines are interesting compounds for pharmaceutical research due to their ability to protect against carcinogenesis in animal models. It is nevertheless still unclear how intracellular pathways are modulated by polyphenols. Monomeric polyphenols were shown to affect the activity of some protein phosphatases (PPs). The three phosphatases of regenerating liver (PRLs) are close relatives and promising therapeutic targets in cancer. In the present study we show that several procyanidins inhibit the activity of all three members of the PRL family in the low micromolar range, whereas monomeric epicatechins show weak inhibitory activity. Increasing the number of catechin units in procyanidins to more than three does not further enhance the potency. Remarkably, the tested procyanidins showed selectivity in vitro when compared to other PPs, and over 10-fold selectivity toward PRL-1 over PRL-2 and PRL-3. As PRL overexpression induces cell migration compared to control cells, the effect of procyanidins on this phenotype was studied. Treatment with procyanidin C2 led to a decrease in cell migration of PRL-1- and PRL-3-overexpressing cells, suggesting the compound-dependent inhibition of PRL-promoted cell migration. Treatment with procyanidin B3 led to selective suppression of PRL-1 overexpressing cells, thereby corroborating the selectivity toward PRL-1- over PRL-3 in vitro. Together, our results show that procyanidins negatively affect PRL activity, suggesting that PRLs could be targets in the polypharmacology of natural polyphenols. Furthermore, they are interesting candidates for the development of PRL-1 inhibitors due to their low cellular toxicity and the selectivity within the PRL family.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells

Alberto Sola-Leyva / Luisa C. López-Cara / Pablo Ríos-Marco / Antonio Ríos / Carmen Marco / María P. Carrasco-Jiménez

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract A full understanding of the molecular mechanism of action of choline kinase α (ChoKα) inhibitors at the cell level is essential for developing therapeutic and preventive approaches for cancer. The aim of the present study was to evaluate the ... ...

Abstract	Abstract A full understanding of the molecular mechanism of action of choline kinase α (ChoKα) inhibitors at the cell level is essential for developing therapeutic and preventive approaches for cancer. The aim of the present study was to evaluate the effects of the ChoKα inhibitors EB-3D and EB-3P on lipid metabolism in HepG2 cells. We used [methyl-14C]choline, [1,2-1 4C]acetic acid and [2-3H]glycerol as exogenous precursors of the corresponding phospholipids and neutral lipids. [Methyl-14C]choline was also used to determine choline uptake. Protein levels were determined by Western blot. Ultrastructural alterations were investigated by transmission electron microscopy. In this work, we demonstrate that EB-3D and EB-3P interfere with phosphatidylcholine biosynthesis via both CDP-choline pathway and choline uptake by the cell. Moreover, the synthesis of both diacylglycerols and triacylglycerols was affected by cell exposure to both inhibitors. These effects were accompanied by a substantial decrease in cholesterol biosynthesis, as well as alterations in the expression of proteins related to cholesterol homeostasis. We also found that EB-3D and EB-3P lowered ChoKα protein levels. All these effects could be explained by the modulation of the AMP-activated protein kinase signalling pathway. We show that both inhibitors cause mitochondrial alteration and an endoplasmic reticulum stress response. EB-3D and EB-3P exert effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. Taken together, results show that EB-3D and EB-3P have potential anti-cancer activity through the deregulation of lipid metabolism.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL‑3

Birgit Hoeger / Pablo Rios / Anna Berteotti / Bernhard Hoermann / Guangyou Duan / Maja Köhn

ACS Omega, Vol 2, Iss 12, Pp 9171-

2017 Volume 9180

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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