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  1. AU="Pabon, Jonathan"
  2. AU="Samalantin, K M"
  3. AU="Babin, Patrick J"
  4. AU="Sesti, Giorgio"

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  1. Article: Engineered bacteria launch and control an oncolytic virus.

    Singer, Zakary S / Pabón, Jonathan / Huang, Hsinyen / Rice, Charles M / Danino, Tal

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby : One-sentence summary: Bacteria are engineered to act as a synthetic " ... ...

    Abstract The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic engineering of new microbial therapies. Here we design a cooperative strategy whereby
    One-sentence summary: Bacteria are engineered to act as a synthetic "capsid" delivering Senecavirus A genome and controlling its spread.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.28.559873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Drebrin Regulation of Calcium Signaling in Immune Cells.

    Pabon, Jonathan / Law, Man Kit / August, Avery

    Advances in experimental medicine and biology

    2017  Volume 1006, Page(s) 281–290

    Abstract: Store-operated ... ...

    Abstract Store-operated Ca
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-4-431-56550-5_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP).

    Li, Melody M H / Aguilar, Eduardo G / Michailidis, Eleftherios / Pabon, Jonathan / Park, Paul / Wu, Xianfang / de Jong, Ype P / Schneider, William M / Molina, Henrik / Rice, Charles M / MacDonald, Margaret R

    Journal of virology

    2019  Volume 93, Issue 18

    Abstract: Given the unprecedented scale of the recent Ebola and Zika viral epidemics, it is crucial to understand the biology of host factors with broad antiviral action in order to develop novel therapeutic approaches. Here, we look into one such factor: zinc ... ...

    Abstract Given the unprecedented scale of the recent Ebola and Zika viral epidemics, it is crucial to understand the biology of host factors with broad antiviral action in order to develop novel therapeutic approaches. Here, we look into one such factor: zinc finger antiviral protein (ZAP) inhibits a variety of RNA and DNA viruses. Alternative splicing results in two isoforms that differ at their C termini: ZAPL (long) encodes a poly(ADP-ribose) polymerase (PARP)-like domain that is missing in ZAPS (short). Previously, it has been shown that ZAPL is more antiviral than ZAPS, while the latter is more induced by interferon (IFN). In this study, we discovered and confirmed the expression of two additional splice variants of human ZAP: ZAPXL (extralong) and ZAPM (medium). We also found two haplotypes of human ZAP. Since ZAPL and ZAPS have differential activities, we hypothesize that all four ZAP isoforms have evolved to mediate distinct antiviral and/or cellular functions. By taking a gene-knockout-and-reconstitution approach, we have characterized the antiviral, translational inhibition, and IFN activation activities of individual ZAP isoforms. Our work demonstrates that ZAPL and ZAPXL are more active against alphaviruses and hepatitis B virus (HBV) than ZAPS and ZAPM and elucidates the effects of splice variants on the action of a broad-spectrum antiviral factor.
    MeSH term(s) A549 Cells ; Alphavirus/genetics ; Alternative Splicing ; Cell Line ; HEK293 Cells ; Haplotypes ; HeLa Cells ; Hepatitis B virus/genetics ; Humans ; Protein Isoforms ; RNA Splicing/genetics ; RNA, Viral/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Virus Replication/drug effects ; Zinc Fingers
    Chemical Substances Protein Isoforms ; RNA, Viral ; RNA-Binding Proteins ; ZC3HAV1 protein, human
    Language English
    Publishing date 2019-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00715-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A robust cell culture system supporting the complete life cycle of hepatitis B virus.

    Michailidis, Eleftherios / Pabon, Jonathan / Xiang, Kuanhui / Park, Paul / Ramanan, Vyas / Hoffmann, Hans-Heinrich / Schneider, William M / Bhatia, Sangeeta N / de Jong, Ype P / Shlomai, Amir / Rice, Charles M

    Scientific reports

    2017  Volume 7, Issue 1, Page(s) 16616

    Abstract: The discovery of sodium taurocholate cotransporting polypeptide (NTCP) as the hepatitis B virus (HBV) receptor enabled researchers to create hepatoma cell lines susceptible to HBV infection. Infection in current systems, however, is inefficient and virus ...

    Abstract The discovery of sodium taurocholate cotransporting polypeptide (NTCP) as the hepatitis B virus (HBV) receptor enabled researchers to create hepatoma cell lines susceptible to HBV infection. Infection in current systems, however, is inefficient and virus fails to spread. Infection efficiency is enhanced by treating cells with polyethylene glycol 8000 (PEG) during infection. However, this alone does not promote virus spread. Here we show that maintaining PEG in culture medium increases the rate of infection by at least one order of magnitude, and, most importantly, promotes virus spread. To demonstrate the utility of this system, we show that two interferon-stimulated genes (ISGs), ISG20 and tetherin, restrict HBV spread in NTCP-expressing hepatoma cells. Thus, this protocol can be easily applied to existing cell culture systems to study the complete HBV life cycle, including virus spread.
    MeSH term(s) Analysis of Variance ; Cell Culture Techniques ; Cell Line ; Coculture Techniques ; Fluorescent Antibody Technique ; Hep G2 Cells ; Hepatitis B/virology ; Hepatitis B virus/metabolism ; Hepatitis B virus/physiology ; Humans ; In Vitro Techniques ; Virus Replication
    Language English
    Publishing date 2017-11-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-017-16882-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.

    Law, Mankit / Lee, YongChan / Morales, J Luis / Ning, Gang / Huang, Weishan / Pabon, Jonathan / Kannan, Arun K / Jeong, Ah-Reum / Wood, Amie / Carter, Chavez / Mohinta, Sonia / Song, Jihong / August, Avery

    Journal of immunology (Baltimore, Md. : 1950)

    2015  Volume 195, Issue 2, Page(s) 426–430

    Abstract: Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein ... ...

    Abstract Mast cells play critical roles in allergic responses. Calcium signaling controls the function of these cells, and a role for actin in regulating calcium influx into cells has been suggested. We have previously identified the actin reorganizing protein Drebrin as a target of the immunosuppressant 3,5-bistrifluoromethyl pyrazole, which inhibits calcium influx into cells. In this study, we show that Drebrin(-/-) mice exhibit reduced IgE-mediated histamine release and passive systemic anaphylaxis, and Drebrin(-/-) mast cells also exhibit defects in FcεRI-mediated degranulation. Drebrin(-/-) mast cells exhibit defects in actin cytoskeleton organization and calcium responses downstream of the FcεRI, and agents that relieve actin reorganization rescue mast cell FcεRI-induced degranulation. Our results indicate that Drebrin regulates the actin cytoskeleton and calcium responses in mast cells, thus regulating mast cell function in vivo.
    MeSH term(s) Actin Cytoskeleton/chemistry ; Actin Cytoskeleton/immunology ; Actin Cytoskeleton/pathology ; Actins/genetics ; Actins/immunology ; Anaphylaxis/chemically induced ; Anaphylaxis/genetics ; Anaphylaxis/immunology ; Anaphylaxis/pathology ; Animals ; Calcium/metabolism ; Calcium Signaling ; Cell Degranulation/immunology ; Gene Expression Regulation ; Immunoglobulin E/administration & dosage ; Immunoglobulin E/chemistry ; Immunosuppressive Agents/pharmacology ; Mast Cells/immunology ; Mast Cells/pathology ; Mice ; Mice, Knockout ; Neuropeptides/genetics ; Neuropeptides/immunology ; Pyrazoles/pharmacology ; Receptors, IgG/genetics ; Receptors, IgG/immunology ; Serum Albumin/chemistry ; Serum Albumin/immunology
    Chemical Substances Actins ; Fcgr1 protein, mouse ; Immunosuppressive Agents ; Neuropeptides ; Pyrazoles ; Receptors, IgG ; Serum Albumin ; drebrins ; Immunoglobulin E (37341-29-0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2015-07-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1401442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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