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Article ; Online: Social inequalities and COVID-19 mortality between neighborhoods of Bariloche city, Argentina.

Perner, Mónica Serena / Trotta, Andrés / Bilal, Usama / Acharya, Binod / Quick, Harrison / Pacífico, Natalia / Berazategui, Romina / Alazraqui, Marcio / Diez Roux, Ana V

International journal for equity in health

2023 Volume 22, Issue 1, Page(s) 198

Abstract: Background: The COVID-19 pandemic has shown how intraurban inequalities are likely to reinforce health and social inequalities. Studies at small area level help to visualize social inequialities hidden in large areas as cities or regions.: Aim: To ... ...

Abstract	Background: The COVID-19 pandemic has shown how intraurban inequalities are likely to reinforce health and social inequalities. Studies at small area level help to visualize social inequialities hidden in large areas as cities or regions. Aim: To describe the spatial patterning of COVID-19 death rates in neighborhoods of the medium-sized city of Bariloche, Argentina, and to explore its relationship with the socioeconomic characteristics of neighborhoods. Methods: We conducted an ecological study in Bariloche, Argentina. The outcome was counts of COVID-19 deaths between June 2020 and May 2022 obtained from the surveillance system and georeferenced to neighborhoods. We estimated crude- and age-adjusted death rates by neighborhood using a Bayesian approach through a Poisson regression that accounts for spatial-autocorrelation via Conditional Autoregressive (CAR) structure. We also analyzed associations of age-adjusted death rates with area-level socioeconomic indicators. Results: Median COVID-19 death rate across neighborhoods was 17.9 (10th/90th percentile of 6.3/35.2) per 10,000 inhabitants. We found lower age-adjusted rates in the city core and western part of the city. The age-adjusted death rate in the most deprived areas was almost double than in the least deprived areas, with an education-related relative index of inequality (RII) of 2.14 (95% CI 1.55 to 2.96). Conclusion: We found spatial heterogeneity and intraurban variability in age-adjusted COVID-19 death rates, with a clear social gradient, and a higher burden in already deprived areas. This highlights the importance of studying inequalities in health outcomes across small areas to inform placed-based interventions.
MeSH term(s)	Humans ; Cities ; Argentina/epidemiology ; Bayes Theorem ; Pandemics ; COVID-19 ; Socioeconomic Factors ; Mortality
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2092056-8
ISSN	1475-9276 ; 1475-9276
ISSN (online)	1475-9276
ISSN	1475-9276
DOI	10.1186/s12939-023-02019-w
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Article ; Online: Association Between Household Deprivation and Living in Informal Settlements and Incidence of Diarrhea in Children Under 5 in Eleven Latin American Cities.

Alpaugh, Victoria / Ortigoza, Ana / Braverman Bronstein, Ariela / Pérez-Ferrer, Carolina / Wagner-Gutierrez, Nicolle / Pacifico, Natalia / Ezeh, Alex / Caiaffa, Waleska Teixeira / Lovasi, Gina / Bilal, Usama

Journal of urban health : bulletin of the New York Academy of Medicine

2024

Abstract: Diarrhea is a leading cause of death in children globally, mostly due to inadequate sanitary conditions and overcrowding. Poor housing quality and lack of tenure security that characterize informal settlements are key underlying contributors to these ... ...

Abstract	Diarrhea is a leading cause of death in children globally, mostly due to inadequate sanitary conditions and overcrowding. Poor housing quality and lack of tenure security that characterize informal settlements are key underlying contributors to these risk factors for childhood diarrhea deaths. The objective of this study is to better understand the physical attributes of informal settlement households in Latin American cities that are associated with childhood diarrhea. We used data from a household survey (Encuesta CAF) conducted by the Corporación Andina de Fomento (CAF), using responses from sampled individuals in eleven cities. We created a household deprivation score based on household water and sewage infrastructure, overcrowding, flooring and wall material, and security of tenure. We fitted a multivariable logistic regression model to estimate odds ratios (OR) and 95% confidence intervals (95% CI) to test the association between the deprivation score and its individual components and childhood diarrhea during the prior 2 weeks. We included a total of 4732 households with children, out of which 12.2% had diarrhea in the 2-week period prior to completing the survey. After adjusting for respondent age, gender, and city, we found a higher risk of diarrhea associated with higher household deprivation scores. Specifically, we found that the odds of diarrhea for children living in a mild and severe deprived household were 1.04 (95% CI 0.84-1.28) and 3.19 times (95% CI 1.80-5.63) higher, respectively, in comparison to households with no deprivation. These results highlight the connections between childhood health and deprived living conditions common in informal settlements.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1435288-6
ISSN	1468-2869 ; 1099-3460
ISSN (online)	1468-2869
ISSN	1099-3460
DOI	10.1007/s11524-024-00854-y
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Article ; Online: Multi-strip silicon sensors for beam array monitoring in micro-beam radiation therapy.

Alagoz, E / Brauer-Krisch, E / Bravin, A / Cornelius, I / Fournier, P / Hansen, T E / Kok, A / Lerch, M / Monakhov, E / Morse, J / Pacifico, N / Petasecca, M / Povoli, M / Requard, H / Rozenfeld, A D / Salome, M / Sandaker, H / Stugu, B

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

2016 Volume 32, Issue 12, Page(s) 1795–1800

Abstract: We present here the latest results from tests performed at the ESRF ID17 and ID21 beamlines for the characterization of novel beam monitors for Microbeam Radiation Therapy (MRT), which is currently being implemented at ID17. MRT aims at treating solid ... ...

Abstract	We present here the latest results from tests performed at the ESRF ID17 and ID21 beamlines for the characterization of novel beam monitors for Microbeam Radiation Therapy (MRT), which is currently being implemented at ID17. MRT aims at treating solid tumors by exploiting an array of evenly spaced microbeams, having an energy spectrum distributed between 27 and 600keV and peaking at 100keV. Given the high instantaneous dose delivered (up to 20kGy/s), the position and the intensity of the microbeams has to be precisely and instantly monitored. For this purpose, we developed dedicated silicon microstrip beam monitors. We have successfully characterized them, both with a microbeam array at ID17, and a submicron scanning beam at ID21. We present here the latest results obtained in recent tests along with an outlook on future developments.
MeSH term(s)	Equipment Design ; Microtechnology/instrumentation ; Radiotherapy/instrumentation ; Radiotherapy Dosage ; Silicon
Chemical Substances	Silicon (Z4152N8IUI)
Language	English
Publishing date	2016-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1122650-x
ISSN	1724-191X ; 1120-1797
ISSN (online)	1724-191X
ISSN	1120-1797
DOI	10.1016/j.ejmp.2016.11.005
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Article ; Online: Full recovery after cardiac arrest secondary to accidental iatrogenic venous air embolism in a cat.

Pacifico, Nicole / Weishaar, Kristen M / Boozer, Lindsay B / Nakamura, Reid K

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

2010 Volume 20, Issue 2, Page(s) 264–267

Abstract: Objective: To describe the successful management of cardiac arrest following accidental venous air embolism (VAE) in a cat.: Case summary: A 3-year-old spayed female domestic shorthair cat, weighing 4 kg, was presented for continuation of its ... ...

Abstract	Objective: To describe the successful management of cardiac arrest following accidental venous air embolism (VAE) in a cat. Case summary: A 3-year-old spayed female domestic shorthair cat, weighing 4 kg, was presented for continuation of its chemotherapy protocol. The cat was inadvertently administered approximately 5.5 mL of air IV during initiation of fluid therapy. Immediate cardiac arrest resulted and CPR successfully achieved return of spontaneous circulation. The cat was discharged 5 days later and is reportedly clinically normal 7 months post-discharge. New or unique information provided: VAE has been rarely reported in the veterinary literature. This is the first report of a cat surviving cardiac arrest secondary to VAE.
MeSH term(s)	Animals ; Cardiopulmonary Resuscitation/veterinary ; Cat Diseases/etiology ; Cat Diseases/therapy ; Cats ; Embolism, Air/etiology ; Embolism, Air/therapy ; Embolism, Air/veterinary ; Female ; Fluid Therapy/adverse effects ; Fluid Therapy/veterinary ; Heart Arrest/etiology ; Heart Arrest/therapy ; Heart Arrest/veterinary ; Iatrogenic Disease/veterinary ; Lymphoma, Non-Hodgkin/therapy ; Lymphoma, Non-Hodgkin/veterinary ; Oxygen Inhalation Therapy/methods ; Oxygen Inhalation Therapy/veterinary ; Treatment Outcome ; Veins
Language	English
Publishing date	2010-04-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2077212-9
ISSN	1476-4431 ; 1479-3261
ISSN (online)	1476-4431
ISSN	1479-3261
DOI	10.1111/j.1476-4431.2009.00476.x
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Article: Full recovery after cardiac arrest secondary to accidental iatrogenic venous air embolism in a cat

Pacifico, Nicole / Weishaar, Kristen M / Boozer, Lindsay B / Nakamura, Reid K

Journal of veterinary emergency and critical care. 2010 Apr., v. 20, no. 2

2010

Abstract: To describe the successful management of cardiac arrest following accidental venous air embolism (VAE) in a cat. A 3-year-old spayed female domestic shorthair cat, weighing 4 kg, was presented for continuation of its chemotherapy protocol. The cat was ... ...

Abstract	To describe the successful management of cardiac arrest following accidental venous air embolism (VAE) in a cat. A 3-year-old spayed female domestic shorthair cat, weighing 4 kg, was presented for continuation of its chemotherapy protocol. The cat was inadvertently administered approximately 5.5 mL of air IV during initiation of fluid therapy. Immediate cardiac arrest resulted and CPR successfully achieved return of spontaneous circulation. The cat was discharged 5 days later and is reportedly clinically normal 7 months post-discharge. VAE has been rarely reported in the veterinary literature. This is the first report of a cat surviving cardiac arrest secondary to VAE.
Keywords	air ; cardiac arrest ; cats ; embolism ; fluid therapy
Language	English
Dates of publication	2010-04
Size	p. 264-267.
Publisher	Blackwell Publishing Inc
Publishing place	Malden, USA
Document type	Article
ZDB-ID	2077212-9
ISSN	1476-4431 ; 1479-3261
ISSN (online)	1476-4431
ISSN	1479-3261
DOI	10.1111/j.1476-4431.2009.00476.x
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Article ; Online: Severe hypocholesterolaemia is often neglected in haematological malignancies.

Pugliese, Luca / Bernardini, Ilaria / Pacifico, Nazareno / Peverini, Manola / Damaskopoulou, Eleni / Cataldi, Samuela / Albi, Elisabetta

European journal of cancer (Oxford, England : 1990)

2010 Volume 46, Issue 9, Page(s) 1735–1743

Abstract: Aim of the study: It is generally believed that high levels of cholesterol (hypercholesterolaemia) are life-threatening, while low levels seem to be positive. Unfortunately this assumption is far from true, and can be indicative of an underlying serious ...

Abstract	Aim of the study: It is generally believed that high levels of cholesterol (hypercholesterolaemia) are life-threatening, while low levels seem to be positive. Unfortunately this assumption is far from true, and can be indicative of an underlying serious medical condition in most of the cases (i.e. cancer). However, the biological role of severe hypocholesterolaemia is poorly understood. Here, the possible biological process is being investigated. Cholesterol plays a key role in cell proliferation, hence it has been suggested that low cholesterol levels are probably linked to the high cellular cholesterol demands from neoplastic cells. Summary of the methods: We used serum and isolated T-lymphocytes from patients with acute lymphoblast leukaemia and human lymphoblast cell line to test this hypothesis. Results: We found that patients with low serum cholesterol levels have instead high levels of cholesterol in lymphocytes. These data were supported with in vitro studies. In fact we have demonstrated that low cholesterol level in the culture medium was related to the neoplastic cellular growth, suggesting a greater use by lymphoma cells for their proliferation. Therefore by inhibiting cholesterol synthesis by mevastatin, in vitro, we showed that cholesterol levels did not change significantly in culture medium and the cellular growth was inhibited. Concluding statement: Following these preliminary results, blood cholesterol levels could be potentially considered a good biological marker to follow up the neoplastic process.
MeSH term(s)	Adult ; Anticholesteremic Agents/pharmacology ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cholesterol/blood ; Female ; Humans ; Lovastatin/analogs & derivatives ; Lovastatin/pharmacology ; Male ; Middle Aged ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood ; T-Lymphocytes/metabolism ; Young Adult
Chemical Substances	Anticholesteremic Agents ; mevastatin (1UQM1K0W9X) ; Cholesterol (97C5T2UQ7J) ; Lovastatin (9LHU78OQFD)
Language	English
Publishing date	2010-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2010.03.041
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Article ; Online: Clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 infection in a Latin American country: Results from the ECCOVID multicenter prospective study.

Cordova, Ezequiel / Mykietiuk, Analia / Sued, Omar / De Vedia, Lautaro / Pacifico, Natalia / Garcia Hernandez, Matias H / Baeza, Natalia M / Garibaldi, Franco / Alzogaray, Maria Fernanda / Contreras, Rosa / Soler Puy, Lucrecia / Scapellato, Pablo G / Barcelona, Laura / Golikow, Mariana L / Piñeiro, Maria Florencia / Miño, Hugo J / Consalvo, Maria Fernanda / Nemirovsky, Corina / Sanchez, Marisa /

Cabral, Myrna / Lamponi Tappata, Lucia / Blasco, Mariano / Ballivian, Jamile / Lopardo, Gustavo / Stryjewski, Martin E

PloS one

2021 Volume 16, Issue 10, Page(s) e0258260

Abstract: Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina.: Methods! ...

Abstract	Background: Clinical features and outcomes of SARS-CoV-2 infections diverge in different countries. The aim of this study was to describe clinical characteristics and outcomes in a cohort of patients hospitalized with SARS-CoV-2 in Argentina. Methods: Multicenter prospective cohort study of ≥18 years-old patients with confirmed SARS-CoV-2 infection consecutively admitted to 19 hospitals in Argentina. Multivariable logistic regression models were used to identify variables associated with 30-day mortality and admission to intensive care unit (ICU). Results: A total of 809 patients were analyzed. Median age was 53 years, 56% were males and 71% had at least one comorbidity. The most common comorbidities were hypertension (32%), obesity (23%) and diabetes (17%). Disease severity at admission was classified as mild 25%, moderate 51%, severe 17%, and critical 7%. Almost half of patients (49%) required supplemental oxygen, 18% ICU, and 12% invasive ventilation. Overall, 30-day mortality was 11%. Factors independently associated with ICU admission were male gender (OR 1.81; 95%CI 1.16-2.81), hypertension (OR 3.21; 95%CI 2.08-4.95), obesity (OR 2.38; 95%CI 1.51-3.7), oxygen saturation ≤93% (OR 6.45; 95%CI 4.20-9.92) and lymphopenia (OR 3.21; 95%CI 2.08-4.95). Factors independently associated with 30-day mortality included age ≥60 years-old (OR 2.68; 95% CI 1.63-4.43), oxygen saturation ≤93% (OR 3.19; 95%CI 1.97-5.16) and lymphopenia (OR 2.65; 95%CI 1.64-4.27). Conclusions: This cohort validates crucial clinical data on patients hospitalized with SARS-CoV-2 in Argentina.
MeSH term(s)	Adult ; Age Factors ; Aged ; Argentina/epidemiology ; COVID-19/mortality ; COVID-19/therapy ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; SARS-CoV-2 ; Sex Factors
Language	English
Publishing date	2021-10-08
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Validation Study
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0258260
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Article ; Online: AEgIS at ELENA: outlook for physics with a pulsed cold antihydrogen beam.

Doser, M / Aghion, S / Amsler, C / Bonomi, G / Brusa, R S / Caccia, M / Caravita, R / Castelli, F / Cerchiari, G / Comparat, D / Consolati, G / Demetrio, A / Di Noto, L / Evans, C / Fanì, M / Ferragut, R / Fesel, J / Fontana, A / Gerber, S /

Giammarchi, M / Gligorova, A / Guatieri, F / Haider, S / Hinterberger, A / Holmestad, H / Kellerbauer, A / Khalidova, O / Krasnický, D / Lagomarsino, V / Lansonneur, P / Lebrun, P / Malbrunot, C / Mariazzi, S / Marton, J / Matveev, V / Mazzotta, Z / Müller, S R / Nebbia, G / Nedelec, P / Oberthaler, M / Pacifico, N / Pagano, D / Penasa, L / Petracek, V / Prelz, F / Prevedelli, M / Rienaecker, B / Robert, J / Røhne, O M / Rotondi, A / Sandaker, H / Santoro, R / Smestad, L / Sorrentino, F / Testera, G / Tietje, I C / Widmann, E / Yzombard, P / Zimmer, C / Zmeskal, J / Zurlo, N

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

2018 Volume 376, Issue 2116

Abstract: The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the ... ...

Abstract	The efficient production of cold antihydrogen atoms in particle traps at CERN's Antiproton Decelerator has opened up the possibility of performing direct measurements of the Earth's gravitational acceleration on purely antimatter bodies. The goal of the AEgIS collaboration is to measure the value of
Language	English
Publishing date	2018-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	208381-4
ISSN	1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
ISSN (online)	1471-2962
ISSN	0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
DOI	10.1098/rsta.2017.0274
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Article ; Online: A moiré deflectometer for antimatter.

Aghion, S / Ahlén, O / Amsler, C / Ariga, A / Ariga, T / Belov, A S / Berggren, K / Bonomi, G / Bräunig, P / Bremer, J / Brusa, R S / Cabaret, L / Canali, C / Caravita, R / Castelli, F / Cerchiari, G / Cialdi, S / Comparat, D / Consolati, G /

Derking, H / Di Domizio, S / Di Noto, L / Doser, M / Dudarev, A / Ereditato, A / Ferragut, R / Fontana, A / Genova, P / Giammarchi, M / Gligorova, A / Gninenko, S N / Haider, S / Huse, T / Jordan, E / Jørgensen, L V / Kaltenbacher, T / Kawada, J / Kellerbauer, A / Kimura, M / Knecht, A / Krasnický, D / Lagomarsino, V / Lehner, S / Magnani, A / Malbrunot, C / Mariazzi, S / Matveev, V A / Moia, F / Nebbia, G / Nédélec, P / Oberthaler, M K / Pacifico, N / Petràček, V / Pistillo, C / Prelz, F / Prevedelli, M / Regenfus, C / Riccardi, C / Røhne, O / Rotondi, A / Sandaker, H / Scampoli, P / Storey, J / Vasquez, M A Subieta / Špaček, M / Testera, G / Vaccarone, R / Widmann, E / Zavatarelli, S / Zmeskal, J

Nature communications

2014 Volume 5, Page(s) 4538

Abstract: The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that ... ...

Abstract	The precise measurement of forces is one way to obtain deep insight into the fundamental interactions present in nature. In the context of neutral antimatter, the gravitational interaction is of high interest, potentially revealing new forces that violate the weak equivalence principle. Here we report on a successful extension of a tool from atom optics--the moiré deflectometer--for a measurement of the acceleration of slow antiprotons. The setup consists of two identical transmission gratings and a spatially resolving emulsion detector for antiproton annihilations. Absolute referencing of the observed antimatter pattern with a photon pattern experiencing no deflection allows the direct inference of forces present. The concept is also straightforwardly applicable to antihydrogen measurements as pursued by the AEgIS collaboration. The combination of these very different techniques from high energy and atomic physics opens a very promising route to the direct detection of the gravitational acceleration of neutral antimatter.
Language	English
Publishing date	2014-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms5538
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Article ; Online: Experiments with low-energy antimatter

Consolati G. / Aghion S. / Amsler C. / Ariga A. / Ariga T. / Belov A. / Bonomi G. / Bräunig P. / Bremer J. / Brusa R.S. / Cabaret L. / Caccia M. / Caravita R. / Castelli F. / Cerchiari G. / Chlouba K. / Cialdi S. / Comparat D. / Demetrio A. /

Derking H. / Di Noto L. / Doser M. / Dudarev A. / Ereditato A. / Ferragut R. / Fontana A. / Gerber S. / Giammarchi M. / Gligorova A. / Gninenko S. / Haider S. / Hogan S. / Holmestad H. / Huse T. / Jordan E. J. / Kawada J. / Kellerbauer A. / Kimura M. / Krasnicky D. / Lagomarsino V. / Lehner S. / Malbrunot C. / Mariazzi S. / Matveev V. / Mazzotta Z. / Nebbia G. / Nedelec P. / Oberthaler M. / Pacifico N. / Penasa L. / Petracek V. / Pistillo C. / Prelz F. / Prevedelli M. / Ravelli L. / Riccardi C. / Røhne O.M. / Rosenberger S. / Rotondi A. / Sacerdoti M. / Sandaker H. / Santoro R. / Scampoli P. / Simon M. / Spacek M. / Storey J. / Strojek I. M. / Subieta M. / Testera G. / Widmann E. / Yzombard P. / Zavatarelli S. / Zmeskal J.

EPJ Web of Conferences, Vol 96, p

2015 Volume 01007

Abstract: Investigations on antimatter allow us to shed light on fundamental issues of contemporary physics. The only antiatom presently available, antihydrogen, is produced making use of the Antiproton Decelerator (AD) facility at CERN. International ... ...

Abstract	Investigations on antimatter allow us to shed light on fundamental issues of contemporary physics. The only antiatom presently available, antihydrogen, is produced making use of the Antiproton Decelerator (AD) facility at CERN. International collaborations currently on the floor (ALPHA, ASACUSA and ATRAP) have succeeded in producing antihydrogen and are now involved in its confinement and manipulation. The AEGIS experiment is currently completing the commissioning of the apparatus which will generate and manipulate antiatoms. The present paper, after a report on the main results achieved with antihydrogen physics, gives an overview of the AEGIS experiment, describes its current status and discusses its first target.
Keywords	Science ; Q ; Physics ; QC1-999
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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