Article ; Online: Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients.
Molecules (Basel, Switzerland)
2022 Volume 27, Issue 19
Abstract: Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF ... ...
| Abstract | Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF and P-pg serum levels in SR in SLE. Methods: Case−control study including 188 SLE patients who were divided into two groups (90 in the steroid-resistant group and 98 in the steroid-sensitive (SS) group) and 35 healthy controls. MIF and P-gp serum levels were determined by ELISA. Multivariable logistic regression and chi-squared automatic interaction detection (CHAID) were used to explore risk factors for SR. Results: The steroid-resistant group presented higher MIF and P-gp serum levels in comparison with the SS (p < 0.001) and reference (p < 0.001) groups. MIF correlated positively with P-gp (rho = 0.41, p < 0.001). MIF (≥15.75 ng/mL) and P-gp (≥15.22 ng/mL) were a risk factor for SR (OR = 2.29, OR = 5.27). CHAID identified high P-gp as the main risk factor for SR and high MIF as the second risk factor in those patients with low P-gp. Conclusions: An association between MIF and P-gp serum levels was observed in SR. CHAID identified P-gp ≥ 15.22 ng/mL as the main risk factor for SR. More studies are needed to validate these results. |
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| MeSH term(s) | ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Case-Control Studies ; Humans ; Intramolecular Oxidoreductases ; Lupus Erythematosus, Systemic/drug therapy ; Macrophage Migration-Inhibitory Factors/metabolism ; Steroids | |||||
| Chemical Substances | ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Macrophage Migration-Inhibitory Factors ; Steroids ; Intramolecular Oxidoreductases (EC 5.3.-) ; MIF protein, human (EC 5.3.2.1) | |||||
| Language | English | |||||
| Publishing date | 2022-10-10 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1413402-0 | |||||
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 | |||||
| ISSN (online) | 1420-3049 | |||||
| ISSN | 1431-5165 ; 1420-3049 | |||||
| DOI | 10.3390/molecules27196741 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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