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Article ; Online: Importance of Genetic Testing in the Diagnosis of Clear Cell Sarcoma.

Alberca Páramo, A / Padilla Valverde, D / Villarejo Campos, P / García Rojo, M

2021 Volume 113, Issue 3, Page(s) 336–338

Title translation	Relevancia del estudio genético en el diagnóstico del sarcoma de células claras.
MeSH term(s)	Genetic Testing ; Humans ; Sarcoma, Clear Cell/diagnosis ; Sarcoma, Clear Cell/genetics ; Soft Tissue Neoplasms
Language	Spanish
Publishing date	2021-11-10
Publishing country	Spain
Document type	Case Reports
ZDB-ID	390255-9
ISSN	1578-2190 ; 0001-7310 ; 1138-8196
ISSN (online)	1578-2190
ISSN	0001-7310 ; 1138-8196
DOI	10.1016/j.ad.2020.06.009
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Article ; Online: Paclitaxel as HIPEC-Drug after Surgical Cytoreduction for Ovarian Peritoneal Metastases: A Randomized Phase III Clinical Trial (HIPECOVA).

Villarejo Campos, Pedro / Sánchez García, Susana / Amo-Salas, Mariano / García Santos, Esther / López de la Manzanara, Carlos / Alberca, Ana / Padilla-Valverde, David / Redondo Calvo, Francisco Javier / Martín, Jesús

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 2, Page(s) 660–671

Abstract: Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal ... ...

Abstract	Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal metastases in a randomized phase III trial conducted between August 2012 and December 2019. Seventy-six patients were randomized to either the HIPEC or no HIPEC group. Although median values for the primary endpoints (recurrence-free survival (RFS) and overall survival (OS)) revealed superior outcomes for the HIPEC (RFS: 23 months, OS: 48 months) over the control group (RFS: 19 months, OS: 46 months), these differences were not statistically significant (
MeSH term(s)	Female ; Humans ; Paclitaxel/therapeutic use ; Hyperthermic Intraperitoneal Chemotherapy ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/surgery ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Follow-Up Studies ; Hyperthermia, Induced ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31020048
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Article ; Online: The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer.

Bodoque-Villar, Raquel / Padilla-Valverde, David / González-López, Lucía María / Muñoz-Rodríguez, José Ramón / Arias-Pardilla, Javier / Villar-Rodríguez, Clara / Gómez-Romero, Francisco Javier / Verdugo-Moreno, Gema / Redondo-Calvo, Francisco Javier / Serrano-Oviedo, Leticia

World journal of surgical oncology

2023 Volume 21, Issue 1, Page(s) 287

Abstract: Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with different cells and factors. ... ...

Abstract	Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer is that a large part of the tumor volume is composed of a stroma with different cells and factors. Among these, we can highlight the cytokines, which perform their function through binding to their receptors. Given the impact of the CXCR4 receptor in the interactions between tumor cells and their microenvironment and its involvement in important signaling pathways in cancer, it is proposed as a very promising prognostic biomarker and as a goal for new targeted therapies. Numerous studies analyze the expression of CXCR4 but we suggest focusing on the expression of CXCR4 in the stroma. Methods: Expression of CXCR4 in specimens from 33 patients with PDAC was evaluated by immunohistochemistry techniques and matched with clinicopathological parameters, overall and disease-free survival rates. Results: The percentage of stroma was lower in non-tumor tissue (32.4 ± 5.2) than in tumor pancreatic tissue (67.4 ± 4.8), P-value = 0.001. The level of CXCR4 expression in stromal cells was diminished in non-tumor tissue (8.7 ± 4.6) and higher in tumor pancreatic tissue (23.5 ± 6.1), P-value = 0.022. No significant differences were identified in total cell count and inflammatory cells between non-tumor tissue and pancreatic tumor tissue. No association was observed between CXCR4 expression and any of the clinical or pathological data, overall and disease-free survival rates. Analyzing exclusively the stroma of tumor samples, the CXCR4 expression was associated with tumor differentiation, P-value = 0.05. Conclusions: In this study, we reflect the importance of CXCR4 expression in the stroma of patients diagnosed with PDAC. Our results revealed a high CXCR4 expression in the tumor stroma, which is related to a poor tumor differentiation. On the contrary, we could not find an association between CXCR4 expression and survival and the rest of the clinicopathological variables. Focusing the study on the CXCR4 expression in the tumor stroma could generate more robust results. Therefore, we consider it key to develop more studies to enlighten the role of this receptor in PDAC and its implication as a possible biomarker.
MeSH term(s)	Humans ; Carcinoma, Pancreatic Ductal ; Pancreatic Neoplasms ; Receptors, CXCR4 ; Tumor Microenvironment ; Biomarkers, Tumor ; Pancreatic Neoplasms
Chemical Substances	CXCR4 protein, human ; Receptors, CXCR4 ; Biomarkers, Tumor
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-023-03168-6
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Article ; Online: Variante anatómica sintomática de la duplicación de la vía biliar común tipo IV.

Alberca-Páramo, Ana / García-Santos, Esther P / Padilla-Valverde, David / Villarejo-Campos, Pedro / Estaire-Gómez, Mercedes / Martín-Fernández, Jesús

Cirugia y cirujanos

2020 Volume 88, Issue 6, Page(s) 776–781

Abstract: Introduction: Duplicity of the common bile duct is an unusual congenital disorder.: Case report: A 80-year-old woman with duplication of the common bile duct with retrograde endoscopic cholangiopancreatography (ERCP) who did not resolve the symptoms.! ...

Title translation	Anatomy variant symptomatic of the duplication of the common bile duct type IV.
Abstract	Introduction: Duplicity of the common bile duct is an unusual congenital disorder. Case report: A 80-year-old woman with duplication of the common bile duct with retrograde endoscopic cholangiopancreatography (ERCP) who did not resolve the symptoms. Discussion: Our case is a variant of type IV to the classification of duplicity of the common bile duct. The magnetic resonance cholangiography and presurgical ERCP allows assessment of the bile ducts, their caliber, and assessment of abnormalities. The treatment before duplicity of the common bile duct will depend on the clinic and the type of opening of the accessory common bile duct. Conclusions: It is important to perform a pre-surgical study and during surgery with intrasurgical cholangiography.
MeSH term(s)	Aged, 80 and over ; Aluminum Silicates ; Bile Ducts ; Cholangiography ; Cholangiopancreatography, Endoscopic Retrograde ; Cholecystectomy, Laparoscopic ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/surgery ; Female ; Humans
Chemical Substances	Aluminum Silicates ; mica (V8A1AW0880)
Language	English
Publishing date	2020-11-30
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.19001109
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Article ; Online: Anatomy variant symptomatic of the duplication of the common bile duct type IV.

Alberca-Páramo, Ana / García-Santos, Esther Pilar / Padilla-Valverde, David / Villarejo-Campos, Pedro / Estaire-Gómez, Mercedes / Fernández, Jesús Martín

Cirugia y cirujanos

2020 Volume 88, Issue 3, Page(s) 370–375

Abstract: Introduction: Duplicity of the common bile duct (BCBD) is an unusual congenital disorder.: Case report: A 80-year-old woman with duplication of the common bile duct with retrograde endoscopic cholangiopancreatography (ERCP) who did not resolve the ... ...

Title translation	Variante anatómica sintomática de la duplicación de la vía biliar común tipo IV.
Abstract	Introduction: Duplicity of the common bile duct (BCBD) is an unusual congenital disorder. Case report: A 80-year-old woman with duplication of the common bile duct with retrograde endoscopic cholangiopancreatography (ERCP) who did not resolve the symptoms. Discussion: Our case is a variant of type IV to the classification of DCBC. The MR cholangiography and presurgical ERCP allows assessment of the bile ducts, their caliber, and assessment of abnormalities. The treatment before DCBC will depend on the clinic and the type of opening of the CBCA. Conclusions: It is important to perform a pre-surgical study and during surgery with CIO.
MeSH term(s)	Aged, 80 and over ; Balloon Embolectomy ; Cholangiography ; Cholangiopancreatography, Endoscopic Retrograde ; Cholecystitis/drug therapy ; Cholecystitis/surgery ; Chronic Disease ; Combined Modality Therapy ; Common Bile Duct/abnormalities ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/surgery ; Female ; Hepatic Duct, Common/abnormalities ; Humans ; Magnetic Resonance Imaging ; Prostheses and Implants ; Sphincterotomy, Endoscopic ; Tomography, X-Ray Computed ; Ursodeoxycholic Acid/therapeutic use
Chemical Substances	Ursodeoxycholic Acid (724L30Y2QR)
Language	English
Publishing date	2020-06-15
Publishing country	Mexico
Document type	Case Reports ; Journal Article
ZDB-ID	730699-4
ISSN	2444-054X ; 0009-7411
ISSN (online)	2444-054X
ISSN	0009-7411
DOI	10.24875/CIRU.19001109
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Article: Safety of perioperative hyperthermic intraperitoneal chemotherapy with gemcitabine in patients with resected pancreatic adenocarcinoma: a pilot study of the clinical trial EudraCT 2016-004298-41.

Padilla-Valverde, David / García-Santos, Esther / Sanchez, Susana / Manzanares, Carmen / Rodriguez, Marta / González, Lucia / Ambrós, Alfonso / Cano, Juana M / Serrano, Leticia / Bodoque, Raquel / Vergara, Teresa / Martin, Jesus

Journal of gastrointestinal oncology

2021 Volume 12, Issue Suppl 1, Page(s) S80–S90

Abstract: Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) with gemcitabine, after cytoreductive surgery, may reduce the tumor progression of pancreatic cancer through the reduction of the neoplastic volume and the subpopulation of residual ... ...

Abstract	Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) with gemcitabine, after cytoreductive surgery, may reduce the tumor progression of pancreatic cancer through the reduction of the neoplastic volume and the subpopulation of residual pancreatic cancer stem cells, improving the survival of patients with pancreatic cancer and decreasing the recurrence of the disease. Methods: A pilot study is performed with the first ten patients in the experimental group. A randomized study (phase II-III clinical trial) that requires a population of 42 patients, with 21 patients in each group. All patients have a diagnosis of ductal adenocarcinoma of the pancreas, which will be surgically resected with curative intention. (I) Group I: after an R0 resection, patients receive individualized adjuvant treatments. (II) Group II: after an R0 resection, HIPEC is performed with gemcitabine (120 mg/m Results: From 2018 to 2019, 31 patients were recruited for our clinical trial. Fifteen patients were excluded because of intraoperative unresectability or a different intraoperative histologic diagnosis. Ten patients were included in the experimental group (resection plus HIPEC gemcitabine). The mean age was 65±7 years, and six patients were female (60%). We confirmed the histologic diagnosis of ductal pancreatic adenocarcinoma in all patients prior to HIPEC. Total pancreatectomy was performed in five patients. The surgical median time was 360 min, and the hospital stay was 11 days. Four patients showed complications classified as Clavien-Dindo type II and one showing type I. Six patients were classified as having stage III tumors. To date, no hospital mortality, locoregional recurrence, or differences between the two groups in terms of perioperative complications, biochemical and gasometric values, or Clavien-Dindo complication grades were observed. Conclusions: Our clinical pilot study demonstrated a similar perioperative outcome that allows the trial until main objectives are achieved.
Language	English
Publishing date	2021-05-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2594644-4
ISSN	2219-679X ; 2078-6891
ISSN (online)	2219-679X
ISSN	2078-6891
DOI	10.21037/jgo-20-238
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Article ; Online: Laparoscopic cytoreductive surgery and HIPEC is effective regarding peritoneum tissue paclitaxel distribution.

Padilla-Valverde, D / Villarejo, P / Redondo, J / Oyarzabal, J / Estella, A / Palomino, T / Fernandez, E / Sanchez, S / Sánchez, S / Faba, P / Baladron, V / Alberca, A / Montenegro, O / Fernández, J / Marta, P / Martín, J

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2019 Volume 21, Issue 9, Page(s) 1260–1269

Abstract: Background: In some patients with peritoneal carcinomatosis, we could perform the cytoreductive surgery and the HIPEC procedure by a complete laparoscopic approach to avoid morbidity. We consider that using laparoscopic approach for performing ... ...

Abstract	Background: In some patients with peritoneal carcinomatosis, we could perform the cytoreductive surgery and the HIPEC procedure by a complete laparoscopic approach to avoid morbidity. We consider that using laparoscopic approach for performing peritoneal carcinomatosis cytoreductive surgery and HIPEC with closed CO Objective: Monitoring the effectiveness of the drug distribution in a laparoscopic ctoreductive and HIPEC surgery group with CO Results: G1-G2: phrenic right peritoneum, p: 0.46. Phrenic left peritoneum, p: 0.46. Pelvic peritoneum, p: 0.17. Serum paclitaxel: p: 0.01. G1-G3: phrenic right peritoneum, p: 0.34. Phrenic left peritoneum, p: 0.34. Pelvic peritoneum, p: 0.17. Serum paclitaxel G1-G3, p: 0.02. Conclusions: A total laparoscopic approach for ctoreductive surgery and closed HIPEC with CO
MeSH term(s)	Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/pharmacokinetics ; Chemotherapy, Cancer, Regional Perfusion ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/methods ; Female ; Hyperthermia, Induced ; Laparoscopy/methods ; Lymph Node Excision/methods ; Paclitaxel/administration & dosage ; Paclitaxel/pharmacokinetics ; Pelvic Neoplasms/metabolism ; Pelvic Neoplasms/pathology ; Pelvic Neoplasms/therapy ; Peritoneal Neoplasms/metabolism ; Peritoneal Neoplasms/pathology ; Peritoneal Neoplasms/therapy ; Swine ; Tissue Distribution
Chemical Substances	Antineoplastic Agents, Phytogenic ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-02-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-019-02052-8
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Article: Pancreatectomy with duodenal preservation in a intraductal papillary mucinosus neoplasia case.

García-Santos, Esther P / Padilla-Valverde, David / Villarejo-Campos, Pedro / Sánchez-García, Susana / Puerto-Puerto, Alejandro / Martín-Fernández, Jesús

Gastroenterologia y hepatologia

2017 Volume 41, Issue 5, Page(s) 306–307

Title translation	Pancreatectomía con preservación duodenal en un caso de neoplasia mucinosa papilar intraductal.
MeSH term(s)	Duodenum ; Female ; Humans ; Middle Aged ; Organ Sparing Treatments/methods ; Pancreatectomy/methods ; Pancreatic Cyst/diagnostic imaging ; Pancreatic Cyst/etiology ; Pancreatic Cyst/pathology ; Pancreatic Cyst/surgery ; Pancreatic Ducts/surgery ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery
Language	Spanish
Publishing date	2017-06-24
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2017.05.015
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Article ; Online: Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO

Sánchez-García, Susana / Padilla-Valverde, David / Villarejo-Campos, Pedro / García-Santos, Esther P / Martín-Fernández, Jesús

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2017 Volume 33, Issue 6, Page(s) 684–689

Abstract: Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected ...

Abstract	Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection. Objective: Development of an experimental model of HIPEC by laparoscopic approach, with CO Material and methods: We performed CRS in a porcine model of 5 pigs (35-38 kg) by laparoscopic approach. Laparoscopic HIPEC by CO Results: No statistically significant differences was found in blood gases, haemodynamic or temperature in the experimental study. In clinical study, there were no technical complications during laparoscopic-HIPEC approach, and we observed no changes in haemodynamic variables during the procedure. Conclusions: CRS and HIPEC laparoscopic model by CO
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Journal Article
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.1080/02656736.2017.1302100
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Article ; Online: Intraperitoneal chemotherapy hyperthermia (HIPEC) for peritoneal carcinomatosis of ovarian cancer origin by fluid and CO2 recirculation using the closed abdomen technique (PRS-1.0 Combat): A clinical pilot study.

Sánchez-García, Susana / Villarejo-Campos, Pedro / Padilla-Valverde, David / Amo-Salas, Mariano / Martín-Fernández, Jesús

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2016 Volume 32, Issue 5, Page(s) 488–495

Abstract: Background This paper reports a study of 21 patients with peritoneal carcinomatosis from ovarian cancer who underwent cytoreductive surgery and HIPEC by means of PRS-1.0 Combat®, a new model for closed abdomen HIPEC aimed at improving fluid distribution ... ...

Abstract	Background This paper reports a study of 21 patients with peritoneal carcinomatosis from ovarian cancer who underwent cytoreductive surgery and HIPEC by means of PRS-1.0 Combat®, a new model for closed abdomen HIPEC aimed at improving fluid distribution with assistance from a CO2 recirculation system. This new technology has been previously shown to be successful in an experimental study (pig model) performed by our group, and has been approved for use in our hospital. Methods Twenty-one patients with peritoneal carcinomatosis of ovarian cancer origin were included in the study. Cytoreductive surgery and HIPEC were performed by a closed abdomen fluid and CO2 recirculation technique using the PRS-1.0 Combat(®) model. We analysed the intraoperative safety tolerance and post-operative morbidity and mortality during the first 30 days. Results Between November 2011 and March 2014 21 patients with epithelial ovarian cancer, International Federation of Gynecology and Obstetrics stage II-IV, were included in the study. During the procedure there were no significant haemodynamic or analytical disturbances. Complication rates were 38.1% and 57.14% for grade III/IV and minor (grade I/II) complications, respectively. Post-operative mortality was 4.76% (one patient). Complete cytoreductive surgery and intraperitoneal chemotherapy improved overall survival and disease-free survival in women with advanced ovarian cancer. The association of intra-abdominal hyperthermia with chemotherapy (HIPEC) increased the therapeutic benefit. Conclusions This study has shown that closed abdomen intraperitoneal chemohyperthermia by a fluid and CO2 recirculation system (PRS-1.0 Combat(®)) can be a safe and feasible model for the treatment of peritoneal carcinomatosis of ovarian cancer origin.
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.3109/02656736.2016.1152515
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