Article ; Online: Paclitaxel as HIPEC-Drug after Surgical Cytoreduction for Ovarian Peritoneal Metastases: A Randomized Phase III Clinical Trial (HIPECOVA).
Current oncology (Toronto, Ont.)
2024 Volume 31, Issue 2, Page(s) 660–671
Abstract: Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal ... ...
Abstract | Multidisciplinary strategies have transformed the management of advanced ovarian cancer. We aimed to evaluate the effectiveness of paclitaxel in hyperthermic intraperitoneal chemotherapy (HIPEC) following surgical cytoreduction for ovarian peritoneal metastases in a randomized phase III trial conducted between August 2012 and December 2019. Seventy-six patients were randomized to either the HIPEC or no HIPEC group. Although median values for the primary endpoints (recurrence-free survival (RFS) and overall survival (OS)) revealed superior outcomes for the HIPEC (RFS: 23 months, OS: 48 months) over the control group (RFS: 19 months, OS: 46 months), these differences were not statistically significant ( |
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MeSH term(s) | Female ; Humans ; Paclitaxel/therapeutic use ; Hyperthermic Intraperitoneal Chemotherapy ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/surgery ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Follow-Up Studies ; Hyperthermia, Induced ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery |
Chemical Substances | Paclitaxel (P88XT4IS4D) |
Language | English |
Publishing date | 2024-01-24 |
Publishing country | Switzerland |
Document type | Randomized Controlled Trial ; Clinical Trial, Phase III ; Journal Article |
ZDB-ID | 1236972-x |
ISSN | 1718-7729 ; 1198-0052 |
ISSN (online) | 1718-7729 |
ISSN | 1198-0052 |
DOI | 10.3390/curroncol31020048 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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