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  1. Article ; Online: Looking for lights in the fog of long-term neurological COVID.

    Padovani, Alessandro / Pilotto, Andrea

    Nature reviews. Neurology

    2023  Volume 19, Issue 1, Page(s) 7–8

    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00750-6
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  2. Article ; Online: Unravelling the mysteries: a reflection on rare neurological diseases.

    Filosto, Massimiliano / Mancuso, Michelangelo / Federico, Antonio / Padovani, Alessandro

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  Volume 45, Issue 3, Page(s) 833–835

    MeSH term(s) Humans ; Nervous System Diseases/diagnosis ; Nervous System Diseases/therapy ; Rare Diseases
    Language English
    Publishing date 2024-02-01
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07374-2
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  3. Article ; Online: The WHO-Intersectoral Global Action Plan (IGAP) on epilepsy and other neurologic disorders in sub-Saharan Africa: an Italian Society of Neurology intervention model.

    Leone, Massimo / Berardelli, Alfredo / Somse, Pierre / Padovani, Alessandro / Guidotti, Giovanni

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  

    Language English
    Publishing date 2024-01-29
    Publishing country Italy
    Document type Letter
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-024-07338-6
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  4. Article ; Online: Extemporaneous combination of donepezil and memantine to treat dementia in Alzheimer disease: evidence from Italian real-world data.

    Padovani, Alessandro / Falato, Serena / Pegoraro, Valeria

    Current medical research and opinion

    2023  Volume 39, Issue 4, Page(s) 567–577

    Abstract: Objective: Providing evidence on donepezil and memantine administration as extemporaneous combination (DM-EXT) to treat Alzheimer Disease (AD) in Italy, and describing demographic and clinical features of AD patients prescribed DM-EXT.: Methods: ... ...

    Abstract Objective: Providing evidence on donepezil and memantine administration as extemporaneous combination (DM-EXT) to treat Alzheimer Disease (AD) in Italy, and describing demographic and clinical features of AD patients prescribed DM-EXT.
    Methods: Retrospective observational study using IQVIA Italian LifeLink Treatment Dynamics (LRx) and Longitudinal Patient Database (LPD). Prevalent users of DM-EXT were identified on the databases (cohorts DMp
    Results: Cohorts DMp
    Conclusions: Prescription of DM-EXT is a common practice in Italy. Because the administration of fixed-dose (FDCs) instead of extemporaneous combinations improves treatment adherence, the introduction of an FDC containing donepezil and memantine might enhance AD patients' management and reduce caregiver burden.
    MeSH term(s) Humans ; Female ; Male ; Donepezil/therapeutic use ; Alzheimer Disease ; Memantine/therapeutic use ; Retrospective Studies ; Italy
    Chemical Substances Donepezil (8SSC91326P) ; Memantine (W8O17SJF3T)
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80296-7
    ISSN 1473-4877 ; 0300-7995
    ISSN (online) 1473-4877
    ISSN 0300-7995
    DOI 10.1080/03007995.2023.2182530
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  5. Article ; Online: Neuropsychiatric Symptoms in Frontotemporal Dementia: More Than Just Noise?

    Altomare, Daniele / Rivolta, Jasmine / Libri, Ilenia / Mattioli, Irene / Cantoni, Valentina / Padovani, Alessandro / Borroni, Barbara

    Journal of Alzheimer's disease : JAD

    2024  Volume 98, Issue 1, Page(s) 133–144

    Abstract: Background: Neuropsychiatric symptoms cause significant suffering and poor quality of life for patients and their caregivers. They are not considered specific to frontotemporal dementia (FTD); therefore, their clinical role and impact might be ... ...

    Abstract Background: Neuropsychiatric symptoms cause significant suffering and poor quality of life for patients and their caregivers. They are not considered specific to frontotemporal dementia (FTD); therefore, their clinical role and impact might be underestimated.
    Objective: The aims of the present study are to: 1) describe the prevalence of neuropsychiatric symptoms in FTD starting from the prodromal stage, 2) define their association with disease severity, 3) identify symptoms which are unrelated to FTD-specific symptoms, and 4) assess their association with clinical features and outcomes.
    Results: In this retrospective study, we analyzed data of 461 FTD patients, including behavioral variant of FTD (bvFTD, n = 318) and primary progressive aphasia (PPA, n = 143). Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory, and patients' staging and global disease severity were estimated using the Clinical Dementia Rating plus NACC FTLD.
    Results: The most common neuropsychiatric symptoms in prodromal FTD were irritability (48%), depression (35%), and anxiety (34%); delusions were reported in 6%of prodromal bvFTD cases. The severity of most neuropsychiatric symptoms increased with global disease severity. Psychosis (delusions and hallucinations) and mood symptoms (depression and anxiety) were mostly independent from FTD-specific symptoms. Psychosis was associated with older age, higher disease severity, shorter survival rate, and was higher in bvFTD than in PPA.
    Conclusions: Neuropsychiatric symptoms are common in patients with FTD, also in the prodromal phase. Psychosis might be unrelated to FTD pathology, and be associated with worse clinical outcomes. The prompt detection and treatment of these symptoms might improve patient's management and quality of life.
    MeSH term(s) Humans ; Frontotemporal Dementia/psychology ; Retrospective Studies ; Quality of Life ; Neuropsychological Tests ; Psychotic Disorders
    Language English
    Publishing date 2024-02-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231256
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  6. Article: The Early Diagnosis of Alzheimer's Disease: A Patient-Centred Conversation with the Care Team.

    Nasreddine, Ziad / Garibotto, Valentina / Kyaga, Simon / Padovani, Alessandro

    Neurology and therapy

    2022  Volume 12, Issue 1, Page(s) 11–23

    Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60-80% of dementia cases, affecting approximately 10 million people in Europe. Neuroimaging techniques and cerebrospinal fluid biomarkers used in combination with cognitive ... ...

    Abstract Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60-80% of dementia cases, affecting approximately 10 million people in Europe. Neuroimaging techniques and cerebrospinal fluid biomarkers used in combination with cognitive assessment tools open the door to early diagnosis of AD. However, these tools present some challenges that need to be overcome, such as low sensitivity or specificity, high cost, limited availability or invasiveness. Thus, low-cost and non-invasive alternatives, such as plasma biomarkers, have the potential to drive changes in AD screening and diagnosis. In addition to the technical aspects, organisational challenges as well as ethical concerns need to be addressed. In many countries, there is an insufficient number of specialists to recognise, evaluate and diagnose dementia and the waiting times to see a specialist are long. Given that there is currently no cure for AD, it is important to consider the potential psychological impact of an early diagnosis. In addition, counselling before biomarker sampling and during diagnosis disclosure is vital to guarantee that the patients have all the information necessary and their queries are addressed in a sensitive manner. Here, we illustrate (using a clinical vignette) current challenges of diagnosis and discuss some of the benefits and challenges of early diagnosis in AD including the value of biomarkers in combination with clinical evaluation. Lastly, some guidelines for disclosing early diagnosis of AD are provided based on our experiences.
    Language English
    Publishing date 2022-12-18
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-022-00428-7
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  7. Article ; Online: Large Collaborative Registries and Real-world Data to Manage Amyloid-Related Imaging Abnormalities.

    Piazza, Fabrizio / Frölich, Lutz / Padovani, Alessandro

    JAMA neurology

    2022  Volume 79, Issue 6, Page(s) 633–634

    MeSH term(s) Amyloidogenic Proteins ; Amyloidosis ; Humans ; Registries
    Chemical Substances Amyloidogenic Proteins
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2022.0731
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  8. Article ; Online: Emergency management of intracerebral hemorrhage.

    Mazzoleni, Valentina / Padovani, Alessandro / Morotti, Andrea

    Journal of critical care

    2022  Volume 74, Page(s) 154232

    Abstract: Acute intracerebral hemorrhage is a medical emergency with high mortality and morbidity. Neuroimaging has a fundamental role in the etiological diagnosis, patients monitoring and in the risk stratification of hematoma expansion and poor outcome. The ... ...

    Abstract Acute intracerebral hemorrhage is a medical emergency with high mortality and morbidity. Neuroimaging has a fundamental role in the etiological diagnosis, patients monitoring and in the risk stratification of hematoma expansion and poor outcome. The cornerstones of medical treatment in the acute phase are blood pressure lowering and coagulopathy reversal. Prevention of hematoma expansion is the main goal of these therapies and their efficacy is strongly time-dependent with a narrow time window. This review provides an update on the etiological diagnostic workup, acute treatment and prognosis of intracerebral hemorrhage.
    MeSH term(s) Humans ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/therapy ; Prognosis ; Blood Pressure/physiology ; Hematoma/diagnosis ; Hematoma/therapy ; Vital Signs
    Language English
    Publishing date 2022-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.154232
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    Zs.A 2152: Show issues Location:
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  9. Article ; Online: Looking at the burden of neurological disorders in Europe.

    Padovani, Alessandro / Pilotto, Andrea

    The Lancet. Public health

    2020  Volume 5, Issue 10, Page(s) e523

    MeSH term(s) Europe/epidemiology ; Global Burden of Disease ; Humans ; Mental Disorders ; Nervous System Diseases/epidemiology
    Language English
    Publishing date 2020-10-02
    Publishing country England
    Document type Letter ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(20)30205-X
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  10. Article ; Online: Lifting the mask on neurological manifestations of COVID-19.

    Pezzini, Alessandro / Padovani, Alessandro

    Nature reviews. Neurology

    2020  Volume 16, Issue 11, Page(s) 636–644

    Abstract: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In ... ...

    Abstract As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic spreads, it is becoming increasingly evident that coronavirus disease 2019 (COVID-19) is not limited to the respiratory system, and that other organs can be affected. In particular, virus-related neurological manifestations are being reported more and more frequently in the scientific literature. In this article, we review the literature on the association between COVID-19 and neurological manifestations, present evidence from preclinical research suggesting that SARS-CoV-2 could be responsible for many of these manifestations, and summarize the biological pathways that could underlie each neurological symptom. Understanding the mechanisms that lead to neurological manifestations in patients with COVID-19 and how these manifestations correlate with clinical outcomes will be instrumental in guiding the optimal use of targeted therapeutic strategies.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Nervous System Diseases/diagnosis ; Nervous System Diseases/epidemiology ; Nervous System Diseases/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-020-0398-3
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