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  1. Article: Complete Pathological Response After Neoadjuvant Chemo-Immunotherapy in Malignant Pleural Mesothelioma.

    Tostes, Francinne T / Zugman, Miguel / Paes, Vitor R / Schvartsman, Gustavo

    Frontiers in oncology

    2022  Volume 12, Page(s) 836751

    Language English
    Publishing date 2022-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.836751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Basic Life Support: an accessible tool in layperson training.

    Bonizzio, Carolina Reis / Nagao, Christopher K / Polho, Gabriel B / Paes, Vitor R

    Revista da Associacao Medica Brasileira (1992)

    2019  Volume 65, Issue 10, Page(s) 1300–1307

    Abstract: Objectives: 1) To evaluate the efficiency of a new method of training laypeople on cardiopulmonary resuscitation (CPR). 2) To assess previous knowledge of the participants.: Methods: Instructors were trained according to the 2015 American Heart ... ...

    Abstract Objectives: 1) To evaluate the efficiency of a new method of training laypeople on cardiopulmonary resuscitation (CPR). 2) To assess previous knowledge of the participants.
    Methods: Instructors were trained according to the 2015 American Heart Association Guidelines, with emphasis on CPR. Dummies made with PET bottles were used, and a questionnaire was applied to the participants before and after training. Statistical analysis was performed in the R commander program. Participants with incomplete documents were excluded from the study.
    Results: Out of 101 participants, 96 were included: 69 lay people, 17 health professionals, and ten health students. There was an improvement in the overall performance after training (mean pre: 62.7%, mean post: 75.8%, p <0.01), also present in the following main concepts: "mouth-to-mouth breathing is not necessary" (p <0.01), "risk of contamination" (p <0.01), "compression technique" (p <0.01). The concepts "recognition of severity" and "what is chest compression" did not improve, but had good pre-test means, 96.8% and 81.2%. There was no statistical difference in the knowledge between the groups (laypeople vs. health professionals and students, pre=0,06 e post=0,33).
    Conclusion: The tools used in training were efficient. However, further studies are necessary to assess the long-term impact of this intervention.
    MeSH term(s) Adolescent ; Adult ; Brazil ; Cardiopulmonary Resuscitation/education ; Cardiopulmonary Resuscitation/methods ; Educational Status ; Female ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Health Personnel/education ; Humans ; Male ; Middle Aged ; Students ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2019-11-07
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.65.10.1300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The wake and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimer's disease.

    Satpati, Abhijit / Soloviev, Alexander V / Pereira, Felipe L / Mladinov, Mihovil / Larsen, Eva / Leite, Renata E P / Suemoto, Claudia K / Rodriguez, Roberta D / Paes, Vitor R / Walsh, Christine / Spina, Salvatore / Seeley, William W / Pasqualucci, Carlos A / Filho, Wilson Jacob / Neylan, Thomas C / Grinberg, Lea T

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Background: Sleep-wake dysfunction is an early and common event in Alzheimer's disease (AD). The lateral hypothalamic area (LHA) regulates the sleep and wake cycle through wake-promoting orexinergic and sleep-promoting melanin-concentrating hormone (MCH) ...

    Abstract Background: Sleep-wake dysfunction is an early and common event in Alzheimer's disease (AD). The lateral hypothalamic area (LHA) regulates the sleep and wake cycle through wake-promoting orexinergic and sleep-promoting melanin-concentrating hormone (MCH) neurons. These neurons share close anatomical proximity with functional reciprocity. This study investigated the pattern of neuronal loss (ORX and MCH) in the LHA in AD. Understanding the degeneration pattern of these neurons will be instrumental in designing potential therapeutics to slow down the disease progression and remediate the sleep-wake dysfunction in AD.
    Methods: Postmortem human brain tissue of subjects with AD (across progressive stages) and controls were examined using unbiased stereology. Neuronal counting was done using double immunohistochemistry with ORX, pTau (CP13), and MCH, pTau (CP13) labeled neurons on formalin-fixed, celloidin-embedded tissue.
    Results: We observed a progressive decline in orexinergic (ORX) neurons and a relative preservation of the melanin-concentrating hormone (MCH) neurons. The decline in ORX neurons was seen from BB 2 (56%, p=0.0634). By the late stage of the disease (BB 5-6), the decline in ORX neurons was 76% (p=0.0043). In contrast, the MCH neurons demonstrated an insignificant decline by BB 6 (25%, p=0.1313).
    Conclusions: Our data demonstrated very early substantial ORX neuronal loss in the LHA, while MCH neurons were resilient to AD pTau accumulation. Interventions capable of preventing ORX neuronal loss and inhibiting pTau accumulation in the LHA can reinstate sleep-wake dysfunction in AD and possibly prevent the progression of the disease.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.06.583765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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