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  1. Article: Lassa virus NP DEDDh 3'-5' exoribonuclease activity is required for optimal viral RNA replication and mutation control.

    Huang, Cheng / Mantlo, Emily / Paessler, Slobodan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Lassa virus (LASV), a mammarenavirus ... ...

    Abstract Lassa virus (LASV), a mammarenavirus from
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.12.536665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Novel neurodigital interface reduces motion sickness in virtual reality.

    Dopsaj, Milivoj / Tan, Wilhelmina / Perovic, Vladimir / Stajic, Zoran / Milosavljevic, Nemanja / Paessler, Slobodan / Makishima, Tomoko

    Neuroscience letters

    2024  Volume 825, Page(s) 137692

    Abstract: Virtual reality (VR) is a computer-created 3D environment with a focus on realistic scenes and pictures created for entertainment, medical and/or educational and training purposes. One of the major side effects of VR immersion reported in the scientific ... ...

    Abstract Virtual reality (VR) is a computer-created 3D environment with a focus on realistic scenes and pictures created for entertainment, medical and/or educational and training purposes. One of the major side effects of VR immersion reported in the scientific literature, media and social media is Visually Induced Motion Sickness (VIMS), with clinical symptoms such as disorientation, nausea, and oculomotor discomfort. VIMS is mostly caused by the discrepancy between the visual and vestibular systems and can lead to dizziness, nausea, and disorientation. In this study, we present one potential novel solution to combat motion sickness in VR, showcasing a significant reduction of nausea in VR users employing the META Quest 2 headsets in conjunction with a whole-body controller. Using a neurodigital approach, we facilitate a more immersive and comfortable VR experience. Our findings indicate a marked reduction in VR-induced nausea, paving the way to promote VR technology for broader applications across various fields.
    MeSH term(s) Humans ; Virtual Reality ; Motion Sickness/diagnosis ; Dizziness ; Nausea ; Confusion/complications ; User-Computer Interface
    Language English
    Publishing date 2024-02-19
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2024.137692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The Importance of Lassa Fever and Its Disease Management in West Africa.

    Reyna, Rachel A / Littlefield, Kirsten E / Shehu, Nathan / Makishima, Tomoko / Maruyama, Junki / Paessler, Slobodan

    Viruses

    2024  Volume 16, Issue 2

    Abstract: Lassa virus (LASV) is a zoonotic pathogen endemic throughout western Africa and is responsible for a human disease known as Lassa fever (LF). Historically, LASV has been emphasized as one of the greatest public health threats in West Africa, with up to ... ...

    Abstract Lassa virus (LASV) is a zoonotic pathogen endemic throughout western Africa and is responsible for a human disease known as Lassa fever (LF). Historically, LASV has been emphasized as one of the greatest public health threats in West Africa, with up to 300,000 cases and 5000 associated deaths per year. This, and the fact that the disease has been reported in travelers, has driven a rapid production of various vaccine candidates. Several of these vaccines are currently in clinical development, despite limitations in understanding the immune response to infection. Alarmingly, the host immune response has been implicated in the induction of sensorineural hearing loss in LF survivors, legitimately raising safety questions about any future vaccines as well as efficacy in preventing potential hearing loss. The objective of this article is to revisit the importance and prevalence of LF in West Africa, with focus on Nigeria, and discuss current therapeutic approaches and ongoing vaccine development. In addition, we aim to emphasize the need for more scientific studies relating to LF-associated hearing loss, and to promote critical discussion about potential risks and benefits of vaccinating the population in endemic regions of West Africa.
    MeSH term(s) Humans ; Lassa Fever/epidemiology ; Lassa Fever/prevention & control ; Lassa virus ; Africa, Western/epidemiology ; Hearing Loss, Sensorineural ; Viral Vaccines ; Disease Management
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16020266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel Entropy-Based Phylogenetic Algorithm: A New Approach for Classifying SARS-CoV-2 Variants.

    Perovic, Vladimir / Glisic, Sanja / Veljkovic, Milena / Paessler, Slobodan / Veljkovic, Veljko

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 10

    Abstract: The SARS-CoV-2 virus, the causative agent of COVID-19, is known for its genetic diversity. Virus variants of concern (VOCs) as well as variants of interest (VOIs) are classified by the World Health Organization (WHO) according to their potential risk to ... ...

    Abstract The SARS-CoV-2 virus, the causative agent of COVID-19, is known for its genetic diversity. Virus variants of concern (VOCs) as well as variants of interest (VOIs) are classified by the World Health Organization (WHO) according to their potential risk to global health. This study seeks to enhance the identification and classification of such variants by developing a novel bioinformatics criterion centered on the virus's spike protein (SP1), a key player in host cell entry, immune response, and a mutational hotspot. To achieve this, we pioneered a unique phylogenetic algorithm which calculates EIIP-entropy as a distance measure based on the distribution of the electron-ion interaction potential (EIIP) of amino acids in SP1. This method offers a comprehensive, scalable, and rapid approach to analyze large genomic data sets and predict the impact of specific mutations. This innovative approach provides a robust tool for classifying emergent SARS-CoV-2 variants into potential VOCs or VOIs. It could significantly augment surveillance efforts and understanding of variant characteristics, while also offering potential applicability to the analysis and classification of other emerging viral pathogens and enhancing global readiness against emerging and re-emerging viral pathogens.
    Language English
    Publishing date 2023-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25101463
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  5. Article ; Online: Simple Theoretical Criterion for Selection of Natural Compounds with Anti-COVID-19 Activity.

    Veljkovic, Veljko / Glisic, Sanja / Perovic, Vladimir / Veljkovic, Milena / Paessler, Slobodan

    Frontiers in bioscience (Landmark edition)

    2022  Volume 27, Issue 5, Page(s) 152

    Abstract: Background: A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical ... ...

    Abstract Background: A novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the leading threat to global health. An effective antiviral could not only help those still vulnerable to the virus but could be a critical treatment if a virus emerges toward evading coronavirus disease 2019 (COVID-19) vaccines. Despite the significant efforts to test already-approved drugs for their potential to kill the virus, researchers found very few actually worked.
    Methods: The present report uses the electronic molecular descriptors, the quasi-valence number (AQVN), and the electron-ion interaction potential (EIIP), for the analysis of natural compounds with proven therapeutic activity against the COVID-19.
    Results: Based on the analysis of the electronic properties of natural compounds which are effective against SARS-CoV-2 virus the simple theoretical criterion for the selection of candidate compounds for the treatment of COVID-19 is proposed.
    Conclusions: The proposed theoretical criterion can be used for the identification and optimization of new lead compounds for the treatment of the COVID-19 disease and for the selection of the food and food supplements which could have a beneficial effect on COVID-19 patients.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19 Vaccines ; Humans ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines
    Language English
    Publishing date 2022-05-30
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2705152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Vaccine Candidates against Arenavirus Infections.

    Saito, Takeshi / Reyna, Rachel A / Taniguchi, Satoshi / Littlefield, Kirsten / Paessler, Slobodan / Maruyama, Junki

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: The viral ... ...

    Abstract The viral family
    Language English
    Publishing date 2023-03-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of reverse genetics system for Guanarito virus: substitution of E1497K in the L protein of Guanarito virus S-26764 strain changes plaque phenotype and growth kinetics.

    Taniguchi, Satoshi / Maruyama, Junki / Saito, Takeshi / Littlefield, Kirsten / Reyna, Rachel A / Manning, John T / Huang, Cheng / Saijo, Masayuki / Paessler, Slobodan

    Journal of virology

    2024  Volume 98, Issue 2, Page(s) e0196423

    Abstract: Guanarito virus (GTOV) is the causative agent of Venezuelan hemorrhagic fever. GTOV belongs to the ... ...

    Abstract Guanarito virus (GTOV) is the causative agent of Venezuelan hemorrhagic fever. GTOV belongs to the genus
    MeSH term(s) Animals ; Female ; Humans ; Arenaviridae/genetics ; Arenaviridae Infections/virology ; Arenaviruses, New World/genetics ; Chlorocebus aethiops ; Hemorrhagic Fevers, Viral/virology ; Phenotype ; Reverse Genetics/methods ; Vaccines ; Vero Cells
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01964-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Evolution of SARS-CoV-2 virus and assessment of the effectiveness of COVID-19 vaccine.

    Veljkovic, Veljko / Perovic, Vladimir / Chambers, Isabelle / Paessler, Slobodan

    F1000Research

    2021  Volume 10, Page(s) 28

    Abstract: A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARS-CoV-2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV ... ...

    Abstract A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARS-CoV-2 represents the principal target for most vaccines currently under development. Despite the presence of a CoV proof-reading function in viral replication, SP protein from SARS-CoV still extensively mutates, which might have an impact on current and future vaccine development. Here, we present analysis of more than 1600 SP unique variants suggesting that vaccine candidates based on the Wuhan-Hu-1 reference strain would be effective against most of currently circulated SARS-CoV-2 viruses, but that further monitoring of the evolution of this virus is important for identification of other mutations, which could affect the effectiveness of vaccines.
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.28215.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Audio / Video: Untersuchungen zum Nachweis von Antikörpern gegen die Equinen Enzephalitis-Viren in humanem und tierischem Serum bzw. Plasma

    Pfeffer, M. / Pässler, Slobodan

    Forschungsvorhaben 0499-V-4302 ; Abschlussbericht = Detection of antibodies against the equine encephalitis viruses in sera of human and animal origin

    (Forschungsbericht aus der Wehrmedizin ; [20]04,6)

    2004  

    Title variant Detection of antibodies against the equine encephalitis viruses in sera of human and animal origin
    Author's details von M. Pfeffer. Bearb.: S. Pässler und M. Pfeffer. [Auftraggeber Bundesministerium der Verteidigung, Referat InSan I 1]
    Series title Forschungsbericht aus der Wehrmedizin ; [20]04,6
    Collection
    Language German
    Size 37 S., Ill., graph. Darst., 30 cm
    Edition Als Ms. gedr.
    Publisher Streitkräfteamt, Abt. 3, FIZBw
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Audio / Video
    HBZ-ID HT014146035
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 432 -2004,6- verfügbar in Königswinter Königswinter

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  10. Article: Using electronic biology based platform to predict flu vaccine efficacy for 2018/2019.

    Paessler, Slobodan / Veljkovic, Veljko

    F1000Research

    2018  Volume 7, Page(s) 298

    Abstract: Flu epidemics and potential pandemics pose great challenges to public health institutions, scientists and vaccine producers. Creating right vaccine composition for different parts of the world is not trivial and has been historically very problematic. ... ...

    Abstract Flu epidemics and potential pandemics pose great challenges to public health institutions, scientists and vaccine producers. Creating right vaccine composition for different parts of the world is not trivial and has been historically very problematic. This often resulted in decrease in vaccinations and reduced trust in public health officials. To improve future protection of population against flu we urgently need new methods for vaccine efficacy prediction and vaccine virus selection.
    Language English
    Publishing date 2018-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.14140.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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