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  1. Article: Combination of Anti-Angiogenics and Immunotherapies in Renal Cell Carcinoma Show Their Limits: Targeting Fibrosis to Break through the Glass Ceiling?

    Teisseire, Manon / Giuliano, Sandy / Pagès, Gilles

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: This review explores treating metastatic clear cell renal cell carcinoma (ccRCC) through current therapeutic modalities-anti-angiogenic therapies and immunotherapies. While these approaches represent the forefront, their limitations and variable patient ... ...

    Abstract This review explores treating metastatic clear cell renal cell carcinoma (ccRCC) through current therapeutic modalities-anti-angiogenic therapies and immunotherapies. While these approaches represent the forefront, their limitations and variable patient responses highlight the need to comprehend underlying resistance mechanisms. We specifically investigate the role of fibrosis, prevalent in chronic kidney disease, influencing tumour growth and treatment resistance. Our focus extends to unravelling the intricate interplay between fibrosis, immunotherapy resistance, and the tumour microenvironment for effective therapy development. The analysis centres on connective tissue growth factor (CTGF), revealing its multifaceted role in ccRCC-promoting fibrosis, angiogenesis, and cancer progression. We discuss the potential of targeting CTGF to address the problem of fibrosis in ccRCC. Emphasising the crucial relationship between fibrosis and the immune system in ccRCC, we propose that targeting CTGF holds promise for overcoming obstacles to cancer treatment. However, we recognise that an in-depth understanding of the mechanisms and potential limitations is imperative and, therefore, advocate for further research. This is an essential prerequisite for the successful integration of CTGF-targeted therapies into the clinical landscape.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: The path to « the Golden Age » for the treatment of metastatic renal cell carcinoma.

    Pagès, Gilles

    Oncotarget

    2018  Volume 9, Issue 87, Page(s) 35796

    Abstract: This corrects the article DOI: 10.18632/oncotarget.25832.]. ...

    Abstract [This corrects the article DOI: 10.18632/oncotarget.25832.].
    Language English
    Publishing date 2018-11-06
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The path to « the Golden Age » for the treatment of metastatic renal cell carcinoma.

    Pagès, Gilles

    Oncotarget

    2018  Volume 9, Issue 60, Page(s) 31564–31565

    Language English
    Publishing date 2018-08-03
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.25832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Angiogenesis and Lymphangiogenesis in Medulloblastoma Development.

    Penco-Campillo, Manon / Pages, Gilles / Martial, Sonia

    Biology

    2023  Volume 12, Issue 7

    Abstract: Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients' quality ... ...

    Abstract Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients' quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways.
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12071028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

    Penco-Campillo, Manon / Pagès, Gilles / Martial, Sonia

    Biology (Basel). 2023 July 21, v. 12, no. 7

    2023  

    Abstract: Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality ... ...

    Abstract Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways.
    Keywords angiogenesis ; brain neoplasms ; drug therapy ; quality of life ; relapse
    Language English
    Dates of publication 2023-0721
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12071028
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Checkpoint inhibitors and anti-angiogenic agents: a winning combination.

    Brest, Patrick / Mograbi, Baharia / Pagès, Gilles / Hofman, Paul / Milano, Gerard

    British journal of cancer

    2023  Volume 129, Issue 9, Page(s) 1367–1372

    Abstract: The combination of immune checkpoint inhibitors and anti-angiogenic agents is a promising new approach in cancer treatment. Immune checkpoint inhibitors block the signals that help cancer cells evade the immune system, while anti-angiogenic agents target ...

    Abstract The combination of immune checkpoint inhibitors and anti-angiogenic agents is a promising new approach in cancer treatment. Immune checkpoint inhibitors block the signals that help cancer cells evade the immune system, while anti-angiogenic agents target the blood vessels that supply the tumour with nutrients and oxygen, limiting its growth. Importantly, this combination triggers synergistic effects based on molecular and cellular mechanisms, leading to better response rates and longer progression-free survival than treatment alone. However, these combinations can also lead to increased side effects and require close monitoring.
    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Neovascularization, Pathologic/drug therapy ; Angiogenesis Inhibitors/pharmacology ; Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors ; Angiogenesis Inhibitors
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-023-02437-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.142: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Inhibiting ALK2/ALK3 Signaling to Differentiate and Chemo-Sensitize Medulloblastoma.

    Filipponi, Doria / Pagnuzzi-Boncompagni, Marina / Pagès, Gilles

    Cancers

    2022  Volume 14, Issue 9

    Abstract: Background: Medulloblastoma (MB) is a malignant pediatric brain tumor, and it represents the leading cause of death related to cancer in childhood. New perspectives for therapeutic development have emerged with the identification of cancer stem cells ( ... ...

    Abstract Background: Medulloblastoma (MB) is a malignant pediatric brain tumor, and it represents the leading cause of death related to cancer in childhood. New perspectives for therapeutic development have emerged with the identification of cancer stem cells (CSCs) displaying tumor initiating capability and chemoresistance. However, the mechanisms responsible for CSCs maintenance are poorly understood. The lack of a universal marker signature represents the main constraints to identify and isolate CSCs within the tumor.
    Methods: To identify signaling pathways promoting CSC maintenance in MB, we combined tumorsphere assays with targeted neurogenesis PCR pathway arrays.
    Results: We showed a consistent induction of signaling pathways regulating pluripotency of CSCs in all the screened MB cells. BMP4 signaling was consistently enriched in all tumorsphere(s) independently of their specific stem-cell marker profile. The octamer-binding transcription factor 4 (OCT4), an important regulator of embryonic pluripotency, enhanced CSC maintenance in MBs by inducing the BMP4 signaling pathway. Consistently, inhibition of BMP4 signaling with LDN-193189 reduced stem-cell traits and promoted cell differentiation.
    Conclusions: Our work suggests that interfering with the BMP4 signaling pathway impaired the maintenance of the CSC pool by promoting cell differentiation. Hence, differentiation therapy might represent an innovative therapeutic to improve the current standard of care in MB patients.
    Language English
    Publishing date 2022-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14092095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opposing Roles of Vascular Endothelial Growth Factor C in Metastatic Dissemination and Resistance to Radio/Chemotherapy: Discussion of Mechanisms and Therapeutic Strategies.

    Montemagno, Christopher / Luciano, Frédéric / Pagès, Gilles

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2475, Page(s) 1–23

    Abstract: Many cancers can be cured by combining surgery with healthy margins, radiation therapy and chemotherapies. However, when the pathology becomes metastatic, cancers can be incurable. The best situation involves "chronicization" of the pathology even for ... ...

    Abstract Many cancers can be cured by combining surgery with healthy margins, radiation therapy and chemotherapies. However, when the pathology becomes metastatic, cancers can be incurable. The best situation involves "chronicization" of the pathology even for several years. However, most of the time, patients die within a few months. To disseminate throughout the body, cancer cells must enter the vascular network and seed in another organ. However, during the initiation of cancer processes, the tumor is avascular. Later, the production of angiogenic factors causes tumor neovascularization and subsequent growth and spread, and the presence of blood and/or lymphatic vessels is associated with high grade tumors. Moreover, during tumor development, cancer cells enter lymphatic vessels and disseminate via the lymphatic network. Hence, blood and lymphatic vessels are considered as main routes of metastatic dissemination and cancer aggressiveness. Therefore, anti-angiogenic drugs entered in the therapeutic arsenal from 2004. Despite undeniable effects however, they are far from curative and only prolong survival by a few months.Recently, the concepts of angio/lymphangiogenesis were revisited by analyzing the role of blood and lymphatic vessels at the initiation steps of tumor development. During this period, cancer cells enter lymphatic vessels and activate immune cells within lymph nodes to initiate an antitumor immune response. Moreover, the presence of blood vessels at the proximity of the initial nodule allows immune cells to reach the tumor and eliminate cancer cells. Therefore, blood and lymphatic networks have a beneficial role during a defined time window. Considering only their detrimental effects is a concern. Hence, administration of anti-angio/lymphangiogenic therapies should be revisited to avoid the destruction of networks involved in antitumor immune response. This review mainly focuses on one of the main drivers of lymphangiogenesis, the VEGFC and its beneficial and pejorative roles according to the grade of aggressive tumors.
    MeSH term(s) Humans ; Lymph Nodes/metabolism ; Lymphangiogenesis ; Lymphatic Metastasis/pathology ; Lymphatic Vessels/metabolism ; Vascular Endothelial Growth Factor C/metabolism
    Chemical Substances Vascular Endothelial Growth Factor C
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2217-9_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Langevin algorithms for Markovian Neural Networks and Deep Stochastic control

    Bras, Pierre / Pagès, Gilles

    2022  

    Abstract: Stochastic Gradient Descent Langevin Dynamics (SGLD) algorithms, which add noise to the classic gradient descent, are known to improve the training of neural networks in some cases where the neural network is very deep. In this paper we study the ... ...

    Abstract Stochastic Gradient Descent Langevin Dynamics (SGLD) algorithms, which add noise to the classic gradient descent, are known to improve the training of neural networks in some cases where the neural network is very deep. In this paper we study the possibilities of training acceleration for the numerical resolution of stochastic control problems through gradient descent, where the control is parametrized by a neural network. If the control is applied at many discretization times then solving the stochastic control problem reduces to minimizing the loss of a very deep neural network. We numerically show that Langevin algorithms improve the training on various stochastic control problems like hedging and resource management, and for different choices of gradient descent methods.

    Comment: 12 pages
    Keywords Quantitative Finance - Computational Finance ; Computer Science - Machine Learning ; Mathematics - Optimization and Control ; Statistics - Machine Learning
    Subject code 510
    Publishing date 2022-12-22
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Metastatic Heterogeneity of Breast Cancer: Companion and Theranostic Approach in Nuclear Medicine.

    Montemagno, Christopher / Pagès, Gilles

    Cancers

    2020  Volume 12, Issue 4

    Abstract: Breast cancer is the most common malignancy in women throughout the world. Metastatic dissemination to vital organs is the leading cause of breast cancer-related deaths. The treatment of metastases is mainly based on the primary tumor characteristics. ... ...

    Abstract Breast cancer is the most common malignancy in women throughout the world. Metastatic dissemination to vital organs is the leading cause of breast cancer-related deaths. The treatment of metastases is mainly based on the primary tumor characteristics. However, breast cancer metastases exhibit high heterogeneity leading to different prognosis and therapeutic responses. Getting access to phenotype of metastases would allow better management of patients. The advent of theranostics in nuclear medicine has opened new opportunities for the diagnosis and treatment of cancer patients. The aim of this review is to provide an overview of current knowledge and future directions in nuclear medicine for therapeutic management of metastatic breast cancer patients.
    Language English
    Publishing date 2020-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12040821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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