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Article: The Protective Effect of Abortion on Preeclampsia: An Analysis of Current Research.

Norman, Sarah J / Fontus, Gena / Forestier, Chancée / Hiba, Tasneem / Colon Pagan, Stephanie / Osondu, Michael / Shylovich, Volha

Cureus

2024 Volume 16, Issue 2, Page(s) e54131

Abstract: A review of the current literature on preeclampsia (PE) confirms that this pregnancy complication remains a common cause of maternal mortality. Within the last several decades, obstetric and gynecological researchers worldwide have indicated an ... ...

Abstract	A review of the current literature on preeclampsia (PE) confirms that this pregnancy complication remains a common cause of maternal mortality. Within the last several decades, obstetric and gynecological researchers worldwide have indicated an association between prior abortions and the development of PE. Different studies have debated whether abortion is a protective or risk factor for PE. However, the most current literature demonstrates a stronger likelihood that a positive history of abortions will offer a protective effect against PE. This association has been supported by advancements in the reproductive immunology literature, which states complex fetal and paternal pathological mechanisms help to build maternal immunological tolerance, thus protecting expectant mothers from pregnancy complications. This literature review will compare studies supporting prior abortions offering a protective effect against PE with those stating prior abortions are a risk factor for the development of PE. Additionally, this critical review will discuss the advancements and current understanding of reproductive immunology and how it pertains to this association between positive abortion history and PE.
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54131
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Book ; Online: Using Machine Learning to Select High-Quality Measurements

Edmonds, Andrew / Brown, David / Vinas, Luciano / Pagan, Samantha

2021

Abstract: We describe the use of machine learning algorithms to select high-quality measurements for the Mu2e experiment. This technique is important for experiments with backgrounds that arise due to measurement errors. The algorithms use multiple pieces of ... ...

Abstract	We describe the use of machine learning algorithms to select high-quality measurements for the Mu2e experiment. This technique is important for experiments with backgrounds that arise due to measurement errors. The algorithms use multiple pieces of ancillary information that are sensitive to measurement quality to separate high-quality and low-quality measurements. Comment: 8 pages, 3 figures
Keywords	Physics - Data Analysis ; Statistics and Probability ; Computer Science - Machine Learning ; High Energy Physics - Experiment
Publishing date	2021-05-28
Publishing country	us
Document type	Book ; Online
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Article ; Online: Individual monitoring in nuclear medicine therapeutic procedures using extremity dosemeters LiF(Mg, Cu, P).

Sarti, G / Del Dottore, F / Fabbri, C / Tassinari, L / Pagan, S / Rustignoli, M / Motta, P

Radiation protection dosimetry

2011 Volume 144, Issue 1-4, Page(s) 521–524

Abstract: Unsealed beta-gamma-emitting sources are used (15 GBq (90)Y each session) in nuclear medicine therapeutic procedures. Inside the manipulation cell and while giving the injection to the patient, the skin exposure is very high; electron radiation field is ... ...

Abstract	Unsealed beta-gamma-emitting sources are used (15 GBq (90)Y each session) in nuclear medicine therapeutic procedures. Inside the manipulation cell and while giving the injection to the patient, the skin exposure is very high; electron radiation field is not homogeneous and thus the exposure of the extremities is not uniform. Particular individual monitoring is adopted: single thermoluminescence dosemeter, wrapped in polyethylene film and placed on an adhesive tape, is positioned on the tip of the fingers; 6-10 dosemeters are assigned to each operator per session. The energy and angle response is studied for X-ray spectra, (90)Sr/Y and (204)Tl--a unique mean calibration factor is calculated in order to estimate H(p)(0.07). Performance of dosemeter is analysed according to ISO 62387-1(2007) and the combined uncertainty (calculated using the Monte Carlo method) results lie in the order of 11 %. This method reveals the critical step of manipulation and administration and ensures that dose limits are not exceeded.
MeSH term(s)	Calibration ; Copper/analysis ; Fluorides/analysis ; Humans ; Lithium Compounds/analysis ; Magnesium/analysis ; Monte Carlo Method ; Nuclear Medicine/manpower ; Nuclear Medicine/methods ; Occupational Exposure/prevention & control ; Phosphorus/analysis ; Photons ; Radiation Monitoring/instrumentation ; Radiation Monitoring/methods ; Radiometry/instrumentation ; Radiometry/methods ; Radiotherapy/methods ; Thermoluminescent Dosimetry/instrumentation ; Thermoluminescent Dosimetry/methods ; Uncertainty ; Yttrium Radioisotopes/analysis
Chemical Substances	Lithium Compounds ; Yttrium Radioisotopes ; lithium fluoride (1485XST65B) ; Phosphorus (27YLU75U4W) ; Copper (789U1901C5) ; Magnesium (I38ZP9992A) ; Fluorides (Q80VPU408O)
Language	English
Publishing date	2011-03
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncq331
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Article ; Online: Donor monocyte-derived macrophages promote human acute graft-versus-host disease.

Jardine, Laura / Cytlak, Urszula / Gunawan, Merry / Reynolds, Gary / Green, Kile / Wang, Xiao-Nong / Pagan, Sarah / Paramitha, Maharani / Lamb, Christopher A / Long, Anna K / Hurst, Erin / Nair, Smeera / Jackson, Graham H / Publicover, Amy / Bigley, Venetia / Haniffa, Muzlifah / Simpson, A J / Collin, Matthew

The Journal of clinical investigation

2020 Volume 130, Issue 9, Page(s) 4574–4586

Abstract: Myelopoiesis is invariably present and contributes to pathology in animal models of graft-versus-host disease (GVHD). In humans, a rich inflammatory infiltrate bearing macrophage markers has also been described in histological studies. In order to ... ...

Abstract	Myelopoiesis is invariably present and contributes to pathology in animal models of graft-versus-host disease (GVHD). In humans, a rich inflammatory infiltrate bearing macrophage markers has also been described in histological studies. In order to determine the origin, functional properties, and role in pathogenesis of these cells, we isolated single-cell suspensions from acute cutaneous GVHD and subjected them to genotype, transcriptome, and in vitro functional analysis. A donor-derived population of CD11c+CD14+ cells was the dominant population of all leukocytes in GVHD. Surface phenotype and NanoString gene expression profiling indicated the closest steady-state counterpart of these cells to be monocyte-derived macrophages. In GVHD, however, there was upregulation of monocyte antigens SIRPα and S100A8/9 transcripts associated with leukocyte trafficking, pattern recognition, antigen presentation, and costimulation. Isolated GVHD macrophages stimulated greater proliferation and activation of allogeneic T cells and secreted higher levels of inflammatory cytokines than their steady-state counterparts. In HLA-matched mixed leukocyte reactions, we also observed differentiation of activated macrophages with a similar phenotype. These exhibited cytopathicity to a keratinocyte cell line and mediated pathological damage to skin explants independently of T cells. Together, these results define the origin, functional properties, and potential pathogenic roles of human GVHD macrophages.
MeSH term(s)	Gene Expression Regulation/immunology ; Graft vs Host Disease/immunology ; Graft vs Host Disease/pathology ; Humans ; Macrophages/immunology ; Macrophages/pathology ; Monocytes/immunology ; Monocytes/pathology ; Skin Diseases/immunology ; Skin Diseases/pathology ; Tissue Donors
Language	English
Publishing date	2020-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI133909
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Article ; Online: Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans.

Cytlak, Urszula / Resteu, Anastasia / Pagan, Sarah / Green, Kile / Milne, Paul / Maisuria, Sheetal / McDonald, David / Hulme, Gillian / Filby, Andrew / Carpenter, Benjamin / Queen, Rachel / Hambleton, Sophie / Hague, Rosie / Lango Allen, Hana / Thaventhiran, James E D / Doody, Gina / Collin, Matthew / Bigley, Venetia

Immunity

2020 Volume 53, Issue 2, Page(s) 353–370.e8

Abstract: The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 ... ...

Abstract	The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have been described including AXL
MeSH term(s)	Animals ; Antigens, CD1/metabolism ; Antigens, CD34/metabolism ; Cell Line ; Cell Lineage/immunology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Glycoproteins/metabolism ; Hematopoiesis/physiology ; Hematopoietic Stem Cells/cytology ; Humans ; Interferon Regulatory Factors/metabolism ; Interleukin-3 Receptor alpha Subunit/metabolism ; Lipopolysaccharide Receptors/metabolism ; Mice ; Receptors, Immunologic/metabolism
Chemical Substances	Antigens, CD1 ; Antigens, CD34 ; BTLA protein, human ; CD14 protein, human ; CD1C protein, human ; Glycoproteins ; IL3RA protein, human ; Interferon Regulatory Factors ; Interleukin-3 Receptor alpha Subunit ; Lipopolysaccharide Receptors ; Receptors, Immunologic ; interferon regulatory factor-8
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2020.07.003
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Play, Playfulness, and Self-Efficacy: Parental Experiences with Children on the Autism Spectrum.

Román-Oyola, Rosa / Figueroa-Feliciano, Verónica / Torres-Martínez, Yoliannie / Torres-Vélez, Jorge / Encarnación-Pizarro, Keyshla / Fragoso-Pagán, Samariz / Torres-Colón, Luis

Occupational therapy international

2018 Volume 2018, Page(s) 4636780

Abstract: Background: Play serves as an essential medium for parent-child interaction; however, engaging children with ASD through play can be a challenge for parents.: Purpose: The purpose of this phenomenological study was to explore the perspectives of ... ...

Abstract	Background: Play serves as an essential medium for parent-child interaction; however, engaging children with ASD through play can be a challenge for parents. Purpose: The purpose of this phenomenological study was to explore the perspectives of parents with children on the autism spectrum regarding play experiences and self-efficacy during play encounters. Method: Semistructured interviews were administered to 8 parents of children 3-7 years of age with ASD. The analysis was guided by the constant comparison method. Findings: Parental narratives denoted playful experiences reflecting components of Skard and Bundy's model of playfulness. The facilitation of framing and suspension of reality were generally more challenging than facilitating intrinsic motivation and internal control. Participants associated self-efficacy during play with their perceived ability to interact with their child and with positive emotions experienced during play. Fathers generally derived a greater sense of self-efficacy from play encounters than mothers, and this was explained by differences in fathers' and mothers' motivations for playing. Mothers were motivated to play for outcome-oriented reasons (e.g., promote the child's progress) whereas fathers' motivations depicted greater emotional emphasis, reflecting a better match between motivation and perceived indicators of efficacy during play. Conclusion: The results suggest that a good match between motivation for playing and perceived indicators of efficacy during play is important for a parental sense of self-efficacy. Occupational therapists should utilize coaching strategies to increase parents' understanding of play and playfulness and how they can affect a sense of parental self-efficacy.
MeSH term(s)	Adult ; Autism Spectrum Disorder/therapy ; Child ; Child, Preschool ; Emotions ; Fathers/psychology ; Female ; Humans ; Male ; Middle Aged ; Mothers/psychology ; Motivation ; Occupational Therapy ; Parent-Child Relations ; Play and Playthings ; Self Efficacy
Language	English
Publishing date	2018-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2095334-3
ISSN	1557-0703 ; 0966-7903
ISSN (online)	1557-0703
ISSN	0966-7903
DOI	10.1155/2018/4636780
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Article ; Online: Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis.

Milne, Paul / Bomken, Simon / Slater, Olga / Kumar, Ashish / Nelson, Adam / Roy, Somak / Velazquez, Jessica / Mankad, Kshitij / Nicholson, James / Yeomanson, Dan / Grundy, Richard / Kamal, Ahmed / Penn, Anthony / Pears, Jane / Millen, Gerard / Morland, Bruce / Hayden, James / Lam, Jason / Madkhali, Maymoon /

MacDonald, Jamie / Singh, Preeti / Pagan, Sarah / Rodriguez-Galindo, Carlos / Minkov, Milen / Donadieu, Jean / Picarsic, Jennifer / Allen, Carl / Bigley, Venetia / Collin, Matthew

Blood advances

2022 Volume 7, Issue 10, Page(s) 2171–2176

Abstract: Most children with high-risk Langerhans cell histiocytosis (LCH) have BRAFV600E mutation. BRAFV600E alleles are detectable in myeloid mononuclear cells at diagnosis but it is not known if the cellular distribution of mutation evolves over time. Here, the ...

Abstract	Most children with high-risk Langerhans cell histiocytosis (LCH) have BRAFV600E mutation. BRAFV600E alleles are detectable in myeloid mononuclear cells at diagnosis but it is not known if the cellular distribution of mutation evolves over time. Here, the profiles of 16 patients with high-risk disease were analyzed. Two received conventional salvage chemotherapy, 4 patients on inhibitors were tracked at intervals of 3 to 6 years, and 10 patients, also given inhibitors, were analyzed more than 2 years after diagnosis. In contrast to the patients responding to salvage chemotherapy who completely cleared BRAFV600E within 6 months, children who received inhibitors maintained high BRAFV600E alleles in their blood. At diagnosis, mutation was detected predominantly in monocytes and myeloid dendritic cells. With time, mutation switched to the T-cell compartment, which accounted for most of the mutational burden in peripheral blood mononuclear cells, more than 2 years from diagnosis (median, 85.4%; range, 44.5%-100%). The highest level of mutation occurred in naïve CD4+ T cells (median, 51.2%; range, 3.8%-93.5%). This study reveals an unexpected lineage switch of BRAFV600E mutation in high-risk LCH, which may influence monitoring strategies for the potential withdrawal of inhibitor treatment and has new implications for the pathogenesis of neurodegeneration, which occurred in 4 patients.
MeSH term(s)	Humans ; Dendritic Cells/pathology ; Histiocytosis, Langerhans-Cell/genetics ; Histiocytosis, Langerhans-Cell/pathology ; Leukocytes, Mononuclear ; Monocytes/pathology ; Mutation ; Male ; Female ; Infant ; Child, Preschool ; T-Lymphocytes/pathology ; Cell Lineage/genetics
Chemical Substances	BRAF protein, human (EC 2.7.11.1)
Language	English
Publishing date	2022-10-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2021006732
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Article ; Online: Erratum: Measurement of the 2νββ Decay Half-Life of ^{130}Te with CUORE [Phys. Rev. Lett. 126, 171801 (2021)].

Adams, D Q / Alduino, C / Alfonso, K / Avignone, F T / Azzolini, O / Bari, G / Bellini, F / Benato, G / Biassoni, M / Branca, A / Brofferio, C / Bucci, C / Camilleri, J / Caminata, A / Campani, A / Canonica, L / Cao, X G / Capelli, S / Cappelli, L /

Cardani, L / Carniti, P / Casali, N / Chiesa, D / Clemenza, M / Copello, S / Cosmelli, C / Cremonesi, O / Creswick, R J / D'Addabbo, A / Dafinei, I / Davis, C J / Dell'Oro, S / Di Domizio, S / Dompè, V / Fang, D Q / Fantini, G / Faverzani, M / Ferri, E / Ferroni, F / Fiorini, E / Franceschi, M A / Freedman, S J / Fu, S H / Fujikawa, B K / Giachero, A / Gironi, L / Giuliani, A / Gorla, P / Gotti, C / Gutierrez, T D / Han, K / Heeger, K M / Huang, R G / Huang, H Z / Johnston, J / Keppel, G / Kolomensky, Yu G / Ligi, C / Ma, L / Ma, Y G / Marini, L / Maruyama, R H / Mayer, D / Mei, Y / Moggi, N / Morganti, S / Napolitano, T / Nastasi, M / Nikkel, J / Nones, C / Norman, E B / Nucciotti, A / Nutini, I / O'Donnell, T / Ouellet, J L / Pagan, S / Pagliarone, C E / Pagnanini, L / Pallavicini, M / Pattavina, L / Pavan, M / Pessina, G / Pettinacci, V / Pira, C / Pirro, S / Pozzi, S / Previtali, E / Puiu, A / Rosenfeld, C / Rusconi, C / Sakai, M / Sangiorgio, S / Schmidt, B / Scielzo, N D / Sharma, V / Singh, V / Sisti, M / Speller, D / Surukuchi, P T / Taffarello, L / Terranova, F / Tomei, C / Vetter, K J / Vignati, M / Wagaarachchi, S L / Wang, B S / Welliver, B / Wilson, J / Wilson, K / Winslow, L A / Zimmermann, S / Zucchelli, S

Physical review letters

2024 Volume 131, Issue 24, Page(s) 249902

Abstract: This corrects the article DOI: 10.1103/PhysRevLett.126.171801. ...

Abstract	This corrects the article DOI: 10.1103/PhysRevLett.126.171801.
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.249902
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Article ; Online: Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands.

Jardine, Laura / Hambleton, Sophie / Bigley, Venetia / Pagan, Sarah / Wang, Xiao-Nong / Collin, Matthew

Leukemia & lymphoma

2012 Volume 54, Issue 1, Page(s) 167–173

Abstract: Natural killer (NK) cell immunosurveillance may be impaired by malignant disease, resulting in tumor escape and disease progression. Therapies that enhance NK cytotoxicity may therefore prove valuable in remission-induction and maintenance treatment ... ...

Abstract	Natural killer (NK) cell immunosurveillance may be impaired by malignant disease, resulting in tumor escape and disease progression. Therapies that enhance NK cytotoxicity may therefore prove valuable in remission-induction and maintenance treatment regimens. Acute lymphoblastic leukemia (ALL) has previously been considered resistant to NK cell lysis and not tractable to this approach. Our study demonstrates that bortezomib, valproate and troglitazone can up-regulate NK activating ligands on a B-ALL cell line and on a proportion but not all adult primary B-ALL samples. Drug-treated ALL cells trigger higher levels of NK degranulation, as measured by CD107a expression, and this effect is dependent on signaling through the NK activating receptor NKG2D. These results suggest that bortezomib, valproate and troglitazone may have clinical utility in sensitizing ALL to NK mediated lysis in vivo.
MeSH term(s)	Boronic Acids/pharmacology ; Bortezomib ; Cell Degranulation/drug effects ; Cell Line, Tumor ; Chromans/pharmacology ; Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Pyrazines/pharmacology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Thiazolidinediones/pharmacology ; Troglitazone ; Up-Regulation/drug effects ; Valproic Acid/pharmacology
Chemical Substances	Boronic Acids ; Chromans ; KLRK1 protein, human ; Ligands ; NK Cell Lectin-Like Receptor Subfamily K ; Pyrazines ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; Thiazolidinediones ; Valproic Acid (614OI1Z5WI) ; Bortezomib (69G8BD63PP) ; Troglitazone (I66ZZ0ZN0E)
Language	English
Publishing date	2012-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2012.708026
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Article ; Online: Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia.

Milne, Paul / Wilhelm-Benartzi, Charlotte / Grunwald, Michael R / Bigley, Venetia / Dillon, Richard / Freeman, Sylvie D / Gallagher, Kathleen / Publicover, Amy / Pagan, Sarah / Marr, Helen / Jones, Gail L / Dickinson, Anne M / Grech, Angela / Burnett, Alan K / Russell, Nigel H / Levis, Mark / Knapper, Steven / Collin, Matthew

Blood advances

2019 Volume 3, Issue 20, Page(s) 3052–3061

Abstract: Fms-like tyrosine kinase 3 (Flt3) is expressed on progenitor cells and acute myeloid leukemia (AML) blasts. Fms-like tyrosine kinase 3 ligand (Flt3L) is detectable during homeostasis and increases in hypoplasia due to genetic defects or treatment with ... ...

Abstract	Fms-like tyrosine kinase 3 (Flt3) is expressed on progenitor cells and acute myeloid leukemia (AML) blasts. Fms-like tyrosine kinase 3 ligand (Flt3L) is detectable during homeostasis and increases in hypoplasia due to genetic defects or treatment with cytoreductive agents. Conversely, Flt3+ AML is associated with depletion of Flt3L to undetectable levels. After induction chemotherapy, Flt3L is restored in patients entering complete remission (CR) but remains depressed in those with refractory disease. Weekly sampling reveals marked differences in the kinetics of Flt3L response during the first 6 weeks of treatment, proportionate to the clearance of blasts and cellularity of the bone marrow. In the UK NCRI AML17 trial, Flt3L was measured at day 26 in a subgroup of 140 patients with Flt3 mutation randomized to the tyrosine kinase inhibitor lestaurtinib or placebo. In these patients, attainment of CR was associated with higher Flt3L at day 26 (Mann-Whitney UP < .0001). Day 26 Flt3L was also associated with survival; Flt3L ≤291 pg/mL was associated with inferior event-free survival (EFS), and Flt3L >1185 pg/mL was associated with higher overall survival (OS; P = .0119). The separation of EFS and OS curves increased when minimal residual disease (MRD) status was combined with Flt3L measurement, and Flt3L retained a near-significant association with survival after adjusting for MRD in a proportional hazards model. Serial measurement of Flt3L in patients who had received a hematopoietic stem cell transplant for AML illustrates the potential value of monitoring Flt3L to identify relapse. Measurement of Flt3L is a noninvasive test with the potential to inform clinical decisions in patients with AML.
MeSH term(s)	Biomarkers ; Gene Expression ; Hematopoietic Stem Cell Transplantation ; Humans ; Immunophenotyping ; Induction Chemotherapy ; Leukemia, Myeloid, Acute/blood ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/mortality ; Membrane Proteins/blood ; Neoplastic Stem Cells/metabolism ; Prognosis ; Proportional Hazards Models ; Treatment Outcome
Chemical Substances	Biomarkers ; Membrane Proteins ; flt3 ligand protein
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2019000197
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