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  1. Article ; Online: Artificial Intelligence and Disease Modeling: Focus on Neurological Disorders.

    Ribba, Benjamin / Pagano, Gennaro / Korsbo, Niklas / Ivaturi, Vijay / Soubret, Antoine

    Clinical pharmacology and therapeutics

    2024  Volume 115, Issue 6, Page(s) 1208–1211

    MeSH term(s) Humans ; Artificial Intelligence ; Nervous System Diseases/physiopathology ; Models, Biological
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article ; Editorial
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3253
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 20: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Sweet as Parkinson's disease: Rethinking the impact of diabetes mellitus.

    Cerasa, Antonio / Pagano, Gennaro

    Parkinsonism & related disorders

    2021  Volume 93, Page(s) 107–108

    MeSH term(s) Diabetes Mellitus, Type 2 ; Humans ; Parkinson Disease/complications ; Risk Factors
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2021.10.018
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    Zs.MO 420: Show issues

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  3. Article ; Online: This is NOT the End for Immunotherapy in Parkinson's Disease - A Perspective from Early Drug Development Scientists.

    Brundin, Patrik / Svoboda, Hanno / Bonni, Azad / Pagano, Gennaro

    Journal of Parkinson's disease

    2022  

    Language English
    Publishing date 2022-11-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-229008
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    Zs.A 6964: Show issues Location:
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  4. Article: Identifying prodromal symptoms at high specificity for Parkinson's disease.

    Jackson, Holly / Anzures-Cabrera, Judith / Simuni, Tanya / Postuma, Ronald B / Marek, Kenneth / Pagano, Gennaro

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1232387

    Abstract: Introduction: To test drugs with the potential to prevent the onset of Parkinson's disease (PD), it is key to identify individuals in the general population at high risk of developing PD. This is often difficult because most of the clinical markers are ... ...

    Abstract Introduction: To test drugs with the potential to prevent the onset of Parkinson's disease (PD), it is key to identify individuals in the general population at high risk of developing PD. This is often difficult because most of the clinical markers are non-specific, common in PD but also common in older adults (e.g., sleep problems).
    Objective: We aimed to identify the clinical markers at high specificity for developing PD by comparing individuals with PD or prodromal PD to healthy controls.
    Methods: We investigated motor and non-motor symptoms (Movement Disorder Society Unified Parkinson's Disease Rating Scale Part 1 and 2 items) in 64 prodromal PD and 422 PD individuals calculating the odds ratios, adjusting for age and gender, for PD and prodromal PD versus 195 healthy controls. Symptoms at high specificity were defined as having an adjusted odds ratio ≥ 6.
    Results: Constipation had an adjusted odds ratio, 6.14 [95% CI: 2.94-12.80] showing high specificity for prodromal PD, and speech difficulties had an adjusted odds ratio, 9.61 [95% CI: 7.88-48.81] showing high specificity for PD. The proportion of participants showing these specific markers was moderate (e.g., prevalence of constipation was 43.75% in prodromal PD, and speech difficulties was 33.89% in PD), suggesting these symptoms may make robust predictors of prodromal PD and PD, respectively.
    Discussion: Clinical markers at high specificity for developing PD could be used as tools in the screening of general populations to identify individuals at higher risk of developing PD.
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1232387
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  5. Article: Pathophysiology and Symptomatology of Drooling in Parkinson's Disease.

    Polychronis, Sotirios / Nasios, Grigorios / Dardiotis, Efthimios / Messinis, Lambros / Pagano, Gennaro

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 3

    Abstract: Drooling can present in patients with Parkinson's disease (PD), and it is manifested as an excessive pooling of saliva inside the oral cavity. Currently, the exact pathophysiological mechanism of drooling in PD is not yet fully explicated. Thus, it ... ...

    Abstract Drooling can present in patients with Parkinson's disease (PD), and it is manifested as an excessive pooling of saliva inside the oral cavity. Currently, the exact pathophysiological mechanism of drooling in PD is not yet fully explicated. Thus, it becomes crucial to understand if some clinical characteristics may emphasize drooling or if they are just concomitant. In PD, excessive drooling has been associated with a higher burden of non-motor symptoms, such as cognitive impairment, sleep problems, autonomic dysfunction, constipation and orthostatic hypotension, and of worse severity of motor fluctuations and bradykinesia. PD patients with excessive drooling also showed a reduction of striatal DAT availability at DaTSCAN imaging. Excessive drooling in patients with Parkinson's cannot be attributed to a single factor but to a mixture of factors, including but not limited to impaired nigrostriatal pathways.
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10030516
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  6. Article: Pediatric non-Hodgkin lymphoma as a rare cause of spinal cord injury: When lymphoma hides in the canal.

    Zama, Daniele / Candela, Egidio / Pagano, Gennaro / Venturelli, Francesco / Melchionda, Fraia / Toni, Francesco / Zucchelli, Mino / Pession, Andrea

    Clinical case reports

    2024  Volume 12, Issue 3, Page(s) e7789

    Abstract: Key clinical message: Spinal cord compression from non-Hodgkin lymphoma (NHL) should be considered as a potential diagnosis in cases of acute signs of myelopathy in pediatric patients.: Abstract: Spinal cord compression in pediatric non-Hodgkin ... ...

    Abstract Key clinical message: Spinal cord compression from non-Hodgkin lymphoma (NHL) should be considered as a potential diagnosis in cases of acute signs of myelopathy in pediatric patients.
    Abstract: Spinal cord compression in pediatric non-Hodgkin lymphoma (NHL) is a rare presentation with potential diagnostic challenges. We report on two pediatric patients with NHL who exhibited myelopathy signs as initial presentation. Considering NHL as a differential diagnosis in pediatric patients presenting with spinal cord compression is crucial for optimizing the outcome of these patients.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7789
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  7. Article ; Online: Molecular Imaging of the Serotonergic System in Parkinson's Disease.

    Pagano, Gennaro / Politis, Marios

    International review of neurobiology

    2018  Volume 141, Page(s) 173–210

    Abstract: In the last decades, the main focus of molecular imaging of Parkinson's disease has been on non-dopaminergic systems involved in the disease alongside the pathognomonic dopaminergic changes. Molecular imaging can detect, in vivo, both presynaptic and ... ...

    Abstract In the last decades, the main focus of molecular imaging of Parkinson's disease has been on non-dopaminergic systems involved in the disease alongside the pathognomonic dopaminergic changes. Molecular imaging can detect, in vivo, both presynaptic and postsynaptic serotonergic changes in the brain and has played a key role in elucidating the pathophysiology of the serotonergic system in Parkinson's disease. Alterations in the serotonergic system may happen very early in the course of the disease and have shown a leading role in the development of tremor and dyskinesias, and in several non-motor symptoms, including sleep, cognitive and neuropsychiatric disturbances. These studies increasingly recognize that the regional topography of serotonergic brain areas associates with specific dysfunctions. In parallel with this trend, more recent molecular serotonergic imaging approaches are investigating serotonergic modulatory treatment and their contributions to the improvement of cognitive functions. In this review, we discussed post-mortem, preclinical and imaging evidence of serotonergic system changes in Parkinson's disease, and described how disease-specific serotonergic changes are relevant for motor and non-motor symptoms and complications. Future directions of serotonergic imaging have been also described alongside with the novel findings on the role of serotonergic system in asymptomatic LRRK2 carriers.
    MeSH term(s) Aniline Compounds ; Animals ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/etiology ; Cognition Disorders/metabolism ; Depression/diagnostic imaging ; Depression/etiology ; Depression/metabolism ; Humans ; Molecular Imaging/methods ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Positron-Emission Tomography/methods ; Receptors, Serotonin/metabolism ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Sleep Wake Disorders/diagnostic imaging ; Sleep Wake Disorders/etiology ; Sleep Wake Disorders/metabolism ; Sulfides ; Tremor/diagnostic imaging ; Tremor/etiology ; Tremor/metabolism
    Chemical Substances 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile ; Aniline Compounds ; Receptors, Serotonin ; Serotonin Plasma Membrane Transport Proteins ; Sulfides
    Language English
    Publishing date 2018-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2018.08.002
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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.180: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Is the Hitman in Cardiac Death Hidden in the Sympathetic Nervous System Remodeling?

    Pagano, Gennaro / Cannavo, Alessandro / Rengo, Giuseppe

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 1, Page(s) 14–16

    MeSH term(s) Cardiomyopathies ; Death, Sudden, Cardiac ; Humans ; Sympathetic Nervous System ; Ventricular Premature Complexes
    Language English
    Publishing date 2020-01-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.11.018
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    Zs.MO 196: Show issues

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  9. Article: Editorial: Molecular Mechanisms Involved in Heart Failure, Parkinson's, and Alzheimer's Diseases.

    Femminella, Grazia Daniela / Pagano, Gennaro / Liccardo, Daniela / Cannavo, Alessandro

    Frontiers in molecular biosciences

    2021  Volume 8, Page(s) 754987

    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2021.754987
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  10. Article: Hoehn and Yahr Stage and Striatal Dat-SPECT Uptake Are Predictors of Parkinson's Disease Motor Progression.

    Jackson, Holly / Anzures-Cabrera, Judith / Taylor, Kirsten I / Pagano, Gennaro

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 765765

    Abstract: Currently, no treatments available for Parkinson's disease (PD) can slow PD progression. At the early stage of the disease, only a subset of individuals with PD progress quickly, while the majority have a slowly progressive form of the disease. In ... ...

    Abstract Currently, no treatments available for Parkinson's disease (PD) can slow PD progression. At the early stage of the disease, only a subset of individuals with PD progress quickly, while the majority have a slowly progressive form of the disease. In developing treatments that aim to slow PD progression, clinical trials aim to include individuals who are likely to progress faster, such that a treatment effect, if one exists, can be identified easier and earlier. The aim of the present study was to identify baseline predictors of clinical progression in early PD. We analyzed 12-month data acquired from the PASADENA trial Part 1 (NCT03100149,
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.765765
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