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Article ; Online: Aneurysm Treatment with Woven EndoBridge-17: Angiographic and Clinical Results at 12 Months from a Retrospective, 2-Center Series.

Pagano, P / Cortese, J / Soize, S / Caroff, J / Manceau, P F / Moret, J / Spelle, L / Pierot, L

AJNR. American journal of neuroradiology

2023 Volume 44, Issue 4, Page(s) 467–473

Abstract: Background and purpose: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial aneurysms using the latest generation of the Woven ... ...

Abstract	Background and purpose: This retrospective, 2-center study investigated the feasibility, safety, and efficacy at 12-month follow-up of the treatment of ruptured, unruptured, and recurrent intracranial aneurysms using the latest generation of the Woven EndoBridge (WEB) device, the WEB-17 system. Materials and methods: Aneurysms treated with WEB-17 were extracted from the databases of 2 neurovascular centers. Patients, aneurysm characteristics, complications, and clinical and anatomic results were analyzed. Results: From February 2017 to May 2021, two hundred twelve patients with 233 aneurysms (181/233, 77.7%, unruptured-recurrent, and 52/233, 22.3%, ruptured) were included. High treatment feasibility (95.3%) was reported and was similar in ruptured aneurysms (94.2%) and unruptured-recurrent aneurysms (95.6%) ( Conclusions: The WEB-17 system showed high feasibility for ruptured and unruptured aneurysms, typical and atypical locations, and some aneurysms with an angle of ≥45°. As the most recent generation device, the WEB-17 also demonstrates high safety and good efficacy.
MeSH term(s)	Humans ; Treatment Outcome ; Retrospective Studies ; Embolization, Therapeutic/methods ; Endovascular Procedures/methods ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/therapy ; Aneurysm, Ruptured/diagnostic imaging ; Aneurysm, Ruptured/therapy
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7830
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Article ; Online: Integrative Transcriptomics Data Mining to Explore the Functions of

Pagano, Paola / Pagano, Andrea / Paternolli, Stefano / Balestrazzi, Alma / Macovei, Anca

Genes

2023 Volume 14, Issue 4

Abstract: The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3'-phosphate of DNA in the DNA-topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A ... ...

Abstract	The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3'-phosphate of DNA in the DNA-topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small
MeSH term(s)	Arabidopsis/metabolism ; Transcriptome/genetics ; DNA Damage ; DNA/metabolism ; Data Mining
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-04-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14040884
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Book ; Online: C-Ports

Pagano, P. / Antonelli, S. / Tardo, A.

a proposal for a comprehensive standardization and implementation plan of digital services offered by the "Port of the Future"

2021

Abstract: In this paper we address the topic of a possible path to standardize the ICT services expected to be delivered by the so-called "Port of the Future". How the most relevant technologies and Information Systems are used by the Port Communities for their ... ...

Abstract	In this paper we address the topic of a possible path to standardize the ICT services expected to be delivered by the so-called "Port of the Future". How the most relevant technologies and Information Systems are used by the Port Communities for their businesses is discussed together with a detailed analysis of the on-going actions carried on by Standard Setting Organizations. Considering the examples given by the C-ITS Platform and the C-Roads programme at EU level, a proposal of contents to be considered in a comprehensive standardization action is given. The innovation services are therefore grouped into four bundles: (i) Vessel \& Marine Navigation, (ii) e-Freight \& (Intermodal) Logistics, (iii) Passenger Transport, (iv) Environmental sustainability. The standardized version of these applications will be finally labeled as C-Port services. Alongside the standardization plan, a proposal for ranking the ports on the basis of a specially-defined C-Port vector is discussed with the purpose of addressing the well-known lack of consensus around the mathematical definition of the Smart Port Index. Considering the good practice and the background offered by the Port of Livorno in terms of innovation actions, the prospected final user applications are then labeled as Day 1, Day 1.5, and Day 2 services in consideration of the technical and commercial gaps to be filled. As a case study about the evolution in the C-Port vector experienced by the Port of Livorno in the last years will also be discussed. Comment: 27 pages, 3 equations, 12 figures, 3 tables
Keywords	Computer Science - Computers and Society
Subject code	028
Publishing date	2021-04-27
Publishing country	us
Document type	Book ; Online
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Article ; Online: Integrative Transcriptomics Data Mining to Explore the Functions of TDP1α and TDP1β Genes in the Arabidopsis thaliana Model Plant

Pagano, Paola / Pagano, Andrea / Paternolli, Stefano / Balestrazzi, Alma / Macovei, Anca

Genes (Basel). 2023 Apr. 09, v. 14, no. 4

2023

Abstract: The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA in the DNA–topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small TDP1 gene ... ...

Abstract	The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA in the DNA–topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small TDP1 gene subfamily is present in plants, where TDP1α has been linked to genome stability maintenance, while TDP1β has unknown functions. This work aimed to comparatively investigate the function of the TDP1 genes by taking advantage of the rich transcriptomics databases available for the Arabidopsis thaliana model plant. A data mining approach was carried out to collect information regarding gene expression in different tissues, genetic backgrounds, and stress conditions, using platforms where RNA-seq and microarray data are deposited. The gathered data allowed us to distinguish between common and divergent functions of the two genes. Namely, TDP1β seems to be involved in root development and associated with gibberellin and brassinosteroid phytohormones, whereas TDP1α is more responsive to light and abscisic acid. During stress conditions, both genes are highly responsive to biotic and abiotic treatments in a time- and stress-dependent manner. Data validation using gamma-ray treatments applied to Arabidopsis seedlings indicated the accumulation of DNA damage and extensive cell death associated with the observed changes in the TDP1 genes expression profiles.
Keywords	Arabidopsis thaliana ; DNA ; DNA damage ; DNA repair ; DNA topoisomerase ; abscisic acid ; brassinosteroids ; cell death ; gene expression ; genes ; gibberellins ; microarray technology ; sequence analysis ; transcriptomics ; tyrosine
Language	English
Dates of publication	2023-0409
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14040884
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Intracranial aneurysm treatment with intrasaccular flow disruption: comparison of WEB-21 and WEB-17 systems.

Pagano, Paolo / Paiusan, Laurentiu / Soize, Sebastien / Pierot, Laurent

Journal of neurointerventional surgery

2021 Volume 14, Issue 9, Page(s) 904–909

Abstract: Background: New generations of Woven EndoBridge (WEB) devices (WEB-21 and WEB-17) are available to treat aneurysms with a width <6.5 mm. Limited comparisons between both systems exist in the literature, but mid-term efficacy has not been compared. Our ... ...

Abstract	Background: New generations of Woven EndoBridge (WEB) devices (WEB-21 and WEB-17) are available to treat aneurysms with a width <6.5 mm. Limited comparisons between both systems exist in the literature, but mid-term efficacy has not been compared. Our study aimed to compare the indications, feasibility, and safety of both systems and to evaluate their efficacy at mid-term follow-up (12 months). Methods: Aneurysms treated with WEB-21 and WEB-17 were extracted from a prospective database. Patient and aneurysm characteristics, complications, and anatomical results were analyzed by an interventional neuroradiologist, independent of the procedures. Results: From June 2015 to November 2019, 87 patients with 92 aneurysms were treated with WEB-21 (38/92, 41.3%) and WEB-17 (54/92, 58.7%). WEB-21 and WEB-17 had high treatment feasibility (97.4% and 94.4%, respectively). A higher percentage of ruptured aneurysms were treated with WEB-17 (9.3%) than with WEB-21 (2.6%; p=0.03). Morbidity and mortality at 1 month were similar in both groups (no morbidity in either group, and mortality 2.7% in the WEB-21 group and 2.0% in the WEB-17 group). The rate of complete and adequate aneurysm occlusion was not significantly higher with the WEB-17 system (59.2% and 95.9%, respectively) compared with the WEB-21 (52.9% and 85.3%, respectively). Conclusions: This study showed the high feasibility of aneurysm treatment with both the WEB-21 and WEB-17 systems. Indications were relatively similar with both devices except for ruptured aneurysms, which were more frequently treated with the WEB-17 device. Efficacy at 12 months (complete and adequate occlusions) was slightly, but not significantly, better with the WEB-17 device.
MeSH term(s)	Aneurysm, Ruptured/therapy ; Embolization, Therapeutic ; Endovascular Procedures/methods ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2021-017876
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Zs.A 6845: Show issues

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Book ; Online: A New Space Weather Tool for Identifying Eruptive Active Regions

Pagano, P. / Mackay, D. H. / Yardley, S. L.

2019

Abstract: One of the main goals of solar physics is the timely identification of eruptive active regions. Space missions such as Solar Orbiter or future Space Weather forecasting missions would largely benefit from this achievement. Our aim is to produce a ... ...

Abstract	One of the main goals of solar physics is the timely identification of eruptive active regions. Space missions such as Solar Orbiter or future Space Weather forecasting missions would largely benefit from this achievement. Our aim is to produce a relatively simple technique that can provide real time indications or predictions that an active region will produce an eruption. We expand on the theoretical work of \citet{Pagano2019fp} that was able to distinguish eruptive from non-eruptive active regions. From this we introduce a new operational metric that uses a combination of observed line-of-sight magnetograms, 3D data-driven simulations and the projection of the 3D simulations forward in time. Results show that the new metric correctly distinguishes active regions as eruptive when observable signatures of eruption have been identified and as non-eruptive when there are no observable signatures of eruption. After successfully distinguishing eruptive from non-eruptive active regions we illustrate how this metric may be used in a "real-time" operational sense were three levels of warning are categorised. These categories are: high risk (red), medium risk (amber) and low risk (green) of eruption. Through considering individual cases we find that the separation into eruptive and non-eruptive active regions is more robust the longer the time series of observed magnetograms used to simulate the build up of magnetic stress and free magnetic energy within the active region. Finally, we conclude that this proof of concept study delivers promising results where the ability to categorise the risk of an eruption is a major achievement.
Keywords	Astrophysics - Solar and Stellar Astrophysics
Subject code	621
Publishing date	2019-10-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: In vitro activity of omadacycline and levofloxacin against Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus in human urine supplemented with calcium and magnesium.

Pagano, Paul / Marra, Andrea / Shinabarger, Dean / Pillar, Chris

The Journal of antimicrobial chemotherapy

2020 Volume 75, Issue 8, Page(s) 2160–2163

Abstract: Background: Omadacycline, an aminomethylcycline, was approved in 2018 for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. In a Phase Ib study, around 34% of the absorbed dose of ... ...

Abstract	Background: Omadacycline, an aminomethylcycline, was approved in 2018 for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. In a Phase Ib study, around 34% of the absorbed dose of omadacycline was shown to be excreted in urine-an important property for urinary tract infection (UTI) treatment. Therefore, omadacycline has been studied in two Phase II trials for the treatment of uncomplicated UTIs and acute pyelonephritis. The activity of omadacycline against UTI pathogens in human urine is important to understand in this context. Objectives: To study the in vitro activity of omadacycline against UTI pathogens in human urine supplemented with calcium and magnesium. Methods: Omadacycline activity was compared with that of levofloxacin against the urinary pathogens Escherichia coli, Klebsiella pneumoniae and Staphylococcus saprophyticus in standard medium, pooled normal human urine and neutral pH-adjusted pooled normal human urine spiked with calcium or magnesium at concentrations consistent with hypercalcaemia and hypermagnesaemia. Results: The activities of omadacycline and levofloxacin against these urinary pathogens were lower in urine relative to standard medium; addition of Mg2+ to broth and urine had a further negative impact on omadacycline activity, whereas the addition of Ca2+ had less of an impact. Levofloxacin activity was not substantially reduced in either broth or urine by the addition of divalent cations. Conclusions: The activity of omadacycline against UTI organisms was lower in urine relative to standard medium and was negatively impacted by magnesium. Omadacycline displayed slightly reduced activity when excess calcium was present, but, overall, the differences were ≤2-fold. These observations should be considered along with the pharmacokinetics of the agent for clinical context.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Calcium ; Escherichia coli ; Humans ; Klebsiella pneumoniae ; Levofloxacin ; Magnesium ; Microbial Sensitivity Tests ; Staphylococcus saprophyticus ; Tetracyclines ; Urinary Tract Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Tetracyclines ; omadacycline (090IP5RV8F) ; Levofloxacin (6GNT3Y5LMF) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkaa138
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Scalable OneM2M IoT Open-Source Platform Evaluated in an SDN Optical Network Controller Scenario.

Troscia, Martina / Sgambelluri, Andrea / Paolucci, Francesco / Castoldi, Piero / Pagano, Paolo / Cugini, Filippo

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 2

Abstract: Software Defined Networking represents a mature technology for the control of optical networks, though all open controller implementations present in the literature still lack the adequate level of maturity and completeness to be considered for (pre)- ... ...

Abstract	Software Defined Networking represents a mature technology for the control of optical networks, though all open controller implementations present in the literature still lack the adequate level of maturity and completeness to be considered for (pre)-production network deployments. This work aims at experimenting on, assessing and discussing the use of the OneM2M open-source platform in the context of optical networks. Network elements and devices are implemented as IoT devices, and the control application is built on top of an OneM2M-compliant server. The work concretely addresses the scalability and flexibility performances of the proposed solution, accounting for the expected growth of optical networks. The two experiment scenarios show promising results and confirm that the OneM2M platform can be adopted in such a context, paving the way to other researches and studies.
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22020431
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Article ; Online: Stealth Luminescent Organic Nanoparticles Made from Quadrupolar Dyes for Two-Photon Bioimaging: Effect of End-Groups and Core.

Rosendale, Morgane / Daniel, Jonathan / Castet, Frédéric / Pagano, Paolo / Verlhac, Jean-Baptiste / Blanchard-Desce, Mireille

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 7

Abstract: Molecular-based Fluorescent Organic Nanoparticles (FONs) are versatile light-emitting nano-tools whose properties can be rationally addressed by bottom-up molecular engineering. A challenging property to gain control over is the interaction of the FONs' ... ...

Abstract	Molecular-based Fluorescent Organic Nanoparticles (FONs) are versatile light-emitting nano-tools whose properties can be rationally addressed by bottom-up molecular engineering. A challenging property to gain control over is the interaction of the FONs' surface with biological systems. Indeed, most types of nanoparticles tend to interact with biological membranes. To address this limitation, we recently reported on two-photon (2P) absorbing, red to near infrared (NIR) emitting quadrupolar extended dyes built from a benzothiadiazole core and diphenylamino endgroups that yield spontaneously stealth FONs. In this paper, we expand our understanding of the structure-property relationship between the dye structure and the FONs 2P absorption response, fluorescence and stealthiness by characterizing a dye-related series of FONs. We observe that increasing the strength of the donor end-groups or of the core acceptor in the quadrupolar (D-π-A-π-D) dye structure allows for the tuning of optical properties, notably red-shifting both the emission (from red to NIR) and 2P absorption spectra while inducing a decrease in their fluorescence quantum yield. Thanks to their strong 1P and 2P absorption, all FONs whose median size varies between 11 and 28 nm exhibit giant 1P (10
MeSH term(s)	Fluorescent Dyes/chemistry ; Hydrophobic and Hydrophilic Interactions ; Nanoparticles/chemistry ; Photons ; Spectrometry, Fluorescence
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27072230
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Article ; Online: Deployment of low-profile flow-diverter through a double lumen balloon catheter (remo-diversion technique) to treat recurrent middle cerebral artery bifurcation aneurysm: A technical note.

Pagano, Paolo / Calvão Pires, Pedro / Paiusan, Laurentiu / Soize, Sebastien / Manceau, Pierre François / Pierot, Laurent

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2022 Volume 30, Issue 1, Page(s) 120–124

Abstract: Wide neck intracranial aneurysms are often difficult to treat with coiling alone, and sophisticated techniques such as balloon-assisted coiling, stent-assisted coiling, flow-diversion, or intrasaccular flow-disruption are sometimes required.This ... ...

Abstract	Wide neck intracranial aneurysms are often difficult to treat with coiling alone, and sophisticated techniques such as balloon-assisted coiling, stent-assisted coiling, flow-diversion, or intrasaccular flow-disruption are sometimes required.This technical note reports the endovascular treatment of a recurrent middle cerebral bifurcation aneurysm by remodeling technique followed by flow-diverter (Silk Vista Baby) deployment through a remodeling balloon (double lumen balloon Eclipse 2L).
MeSH term(s)	Humans ; Intracranial Aneurysm/therapy ; Intracranial Aneurysm/surgery ; Embolization, Therapeutic/methods ; Middle Cerebral Artery/diagnostic imaging ; Treatment Outcome ; Stents ; Catheters ; Endovascular Procedures/methods ; Cerebral Angiography/methods ; Retrospective Studies
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199221091647
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