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Article ; Online: Intracranial aneurysm treatment with intrasaccular flow disruption: comparison of WEB-21 and WEB-17 systems.

Pagano, Paolo / Paiusan, Laurentiu / Soize, Sebastien / Pierot, Laurent

2021 Volume 14, Issue 9, Page(s) 904–909

Abstract: Background: New generations of Woven EndoBridge (WEB) devices (WEB-21 and WEB-17) are available to treat aneurysms with a width <6.5 mm. Limited comparisons between both systems exist in the literature, but mid-term efficacy has not been compared. Our ... ...

Abstract	Background: New generations of Woven EndoBridge (WEB) devices (WEB-21 and WEB-17) are available to treat aneurysms with a width <6.5 mm. Limited comparisons between both systems exist in the literature, but mid-term efficacy has not been compared. Our study aimed to compare the indications, feasibility, and safety of both systems and to evaluate their efficacy at mid-term follow-up (12 months). Methods: Aneurysms treated with WEB-21 and WEB-17 were extracted from a prospective database. Patient and aneurysm characteristics, complications, and anatomical results were analyzed by an interventional neuroradiologist, independent of the procedures. Results: From June 2015 to November 2019, 87 patients with 92 aneurysms were treated with WEB-21 (38/92, 41.3%) and WEB-17 (54/92, 58.7%). WEB-21 and WEB-17 had high treatment feasibility (97.4% and 94.4%, respectively). A higher percentage of ruptured aneurysms were treated with WEB-17 (9.3%) than with WEB-21 (2.6%; p=0.03). Morbidity and mortality at 1 month were similar in both groups (no morbidity in either group, and mortality 2.7% in the WEB-21 group and 2.0% in the WEB-17 group). The rate of complete and adequate aneurysm occlusion was not significantly higher with the WEB-17 system (59.2% and 95.9%, respectively) compared with the WEB-21 (52.9% and 85.3%, respectively). Conclusions: This study showed the high feasibility of aneurysm treatment with both the WEB-21 and WEB-17 systems. Indications were relatively similar with both devices except for ruptured aneurysms, which were more frequently treated with the WEB-17 device. Efficacy at 12 months (complete and adequate occlusions) was slightly, but not significantly, better with the WEB-17 device.
MeSH term(s)	Aneurysm, Ruptured/therapy ; Embolization, Therapeutic ; Endovascular Procedures/methods ; Humans ; Intracranial Aneurysm/diagnostic imaging ; Intracranial Aneurysm/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2021-017876
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Article ; Online: Scalable OneM2M IoT Open-Source Platform Evaluated in an SDN Optical Network Controller Scenario.

Troscia, Martina / Sgambelluri, Andrea / Paolucci, Francesco / Castoldi, Piero / Pagano, Paolo / Cugini, Filippo

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 2

Abstract: Software Defined Networking represents a mature technology for the control of optical networks, though all open controller implementations present in the literature still lack the adequate level of maturity and completeness to be considered for (pre)- ... ...

Abstract	Software Defined Networking represents a mature technology for the control of optical networks, though all open controller implementations present in the literature still lack the adequate level of maturity and completeness to be considered for (pre)-production network deployments. This work aims at experimenting on, assessing and discussing the use of the OneM2M open-source platform in the context of optical networks. Network elements and devices are implemented as IoT devices, and the control application is built on top of an OneM2M-compliant server. The work concretely addresses the scalability and flexibility performances of the proposed solution, accounting for the expected growth of optical networks. The two experiment scenarios show promising results and confirm that the OneM2M platform can be adopted in such a context, paving the way to other researches and studies.
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22020431
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Article ; Online: Stealth Luminescent Organic Nanoparticles Made from Quadrupolar Dyes for Two-Photon Bioimaging: Effect of End-Groups and Core.

Rosendale, Morgane / Daniel, Jonathan / Castet, Frédéric / Pagano, Paolo / Verlhac, Jean-Baptiste / Blanchard-Desce, Mireille

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 7

Abstract: Molecular-based Fluorescent Organic Nanoparticles (FONs) are versatile light-emitting nano-tools whose properties can be rationally addressed by bottom-up molecular engineering. A challenging property to gain control over is the interaction of the FONs' ... ...

Abstract	Molecular-based Fluorescent Organic Nanoparticles (FONs) are versatile light-emitting nano-tools whose properties can be rationally addressed by bottom-up molecular engineering. A challenging property to gain control over is the interaction of the FONs' surface with biological systems. Indeed, most types of nanoparticles tend to interact with biological membranes. To address this limitation, we recently reported on two-photon (2P) absorbing, red to near infrared (NIR) emitting quadrupolar extended dyes built from a benzothiadiazole core and diphenylamino endgroups that yield spontaneously stealth FONs. In this paper, we expand our understanding of the structure-property relationship between the dye structure and the FONs 2P absorption response, fluorescence and stealthiness by characterizing a dye-related series of FONs. We observe that increasing the strength of the donor end-groups or of the core acceptor in the quadrupolar (D-π-A-π-D) dye structure allows for the tuning of optical properties, notably red-shifting both the emission (from red to NIR) and 2P absorption spectra while inducing a decrease in their fluorescence quantum yield. Thanks to their strong 1P and 2P absorption, all FONs whose median size varies between 11 and 28 nm exhibit giant 1P (10
MeSH term(s)	Fluorescent Dyes/chemistry ; Hydrophobic and Hydrophilic Interactions ; Nanoparticles/chemistry ; Photons ; Spectrometry, Fluorescence
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2022-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27072230
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Article ; Online: Deployment of low-profile flow-diverter through a double lumen balloon catheter (remo-diversion technique) to treat recurrent middle cerebral artery bifurcation aneurysm: A technical note.

Pagano, Paolo / Calvão Pires, Pedro / Paiusan, Laurentiu / Soize, Sebastien / Manceau, Pierre François / Pierot, Laurent

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2022 Volume 30, Issue 1, Page(s) 120–124

Abstract: Wide neck intracranial aneurysms are often difficult to treat with coiling alone, and sophisticated techniques such as balloon-assisted coiling, stent-assisted coiling, flow-diversion, or intrasaccular flow-disruption are sometimes required.This ... ...

Abstract	Wide neck intracranial aneurysms are often difficult to treat with coiling alone, and sophisticated techniques such as balloon-assisted coiling, stent-assisted coiling, flow-diversion, or intrasaccular flow-disruption are sometimes required.This technical note reports the endovascular treatment of a recurrent middle cerebral bifurcation aneurysm by remodeling technique followed by flow-diverter (Silk Vista Baby) deployment through a remodeling balloon (double lumen balloon Eclipse 2L).
MeSH term(s)	Humans ; Intracranial Aneurysm/therapy ; Intracranial Aneurysm/surgery ; Embolization, Therapeutic/methods ; Middle Cerebral Artery/diagnostic imaging ; Treatment Outcome ; Stents ; Catheters ; Endovascular Procedures/methods ; Cerebral Angiography/methods ; Retrospective Studies
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199221091647
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Article: Ultrabright Red to NIR Emitting Fluorescent Organic Nanoparticles Made from Quadrupolar Dyes with Giant Two-Photon Absorption (2PA) in the NIR Region. Confinement Effect on Fluorescence and 2PA and Tuning of Surface Properties

Pagano, Paolo / Rosendale, Morgane / Daniel, Jonathan / Verlhac, Jean-Baptiste / Blanchard-Desce, Mireille

Journal of physical chemistry. 2021 Nov. 11, v. 125, no. 46

2021

Abstract: Fluorescent Organic Nanoparticles (FONs) are light-emitting, molecular-based nanoparticles that can be obtained from the nanoprecipitation of dedicated hydrophobic organic dyes in water. They represent a versatile family of water-soluble fluorescent ... ...

Abstract	Fluorescent Organic Nanoparticles (FONs) are light-emitting, molecular-based nanoparticles that can be obtained from the nanoprecipitation of dedicated hydrophobic organic dyes in water. They represent a versatile family of water-soluble fluorescent nanotools whose luminescent properties can be tuned by bottom-up molecular engineering of their composing dyes. We recently reported on a quadrupolar red-emitting dye that yields spontaneously stealthy bare FONs which do not require coating to hinder interactions with cell membranes. Its quadrupolar design also hints to the possibility that it may be a strong two-photon absorber for bioimaging purposes. In this paper, we further investigate the two-photon absorption (2PA) of this dye and resulting FONs and report on a structure-related series of extended dyes engineered to yield NIR-emitting FONs. All dyes lead to stable, small (12–20 nm in diameter), and bright FONs. The experimental study reveals that molecular confinement strongly influences the fluorescence and 2PA properties of these dyes depending on the nature of the π-extended system. As expected, extension of the π-conjugated system induces a red-shift of the absorption and emission bands as well as an increase and spectral broadening of the 2PA responses in solution. Upon aggregation of the dyes within nanoparticles, a reduction of the fluorescence quantum yield is observed whose amplitude depends strongly on the nature of the π-conjugated systems. Interestingly, the peak 2PA cross sections increase upon confinement of the shortest dye, while a spectral broadening and slight red shift of the 2PA bands of the most extended dyes is observed. Taken together, these properties allow the most extended dye to yield very bright NIR-emitting FONs (εᵐᵃˣΦ = 7 × 10⁶ M–¹ cm–¹, σ₂ᵐᵃˣΦ = 4 × 10⁵ GM). Interestingly, the nature of the π-conjugated system was also found to modulate the stealthiness of the resulting nanoparticles toward biological membranes. As a result, by fine-tuning the molecular design of the quadrupolar FON-composing dyes, we achieved NIR-absorbing, NIR-emitting, spontaneously stealthy small nanoparticles having record one- and two-photon brightness. Finally, we demonstrate that these FONs can be noncovalently surface-coated with a polycationic polymer, thanks to their highly negative surface potentials. This induces a reversal of their surface potential which in turn triggers their internalization within cells.
Keywords	absorption ; bioimaging ; dyes ; fluorescence ; hydrophobicity ; polymers ; water solubility
Language	English
Dates of publication	2021-1111
Size	p. 25695-25705.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.1c07831
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: An ICT Prototyping Framework for the "Port of the Future".

Barasti, Davide / Troscia, Martina / Lattuca, Domenico / Tardo, Alexandr / Barsanti, Igor / Pagano, Paolo

Sensors (Basel, Switzerland)

2021 Volume 22, Issue 1

Abstract: Seaports are genuine, intermodal hubs connecting seaways to inland transport links, such as roads and railways. Seaports are located at the focal point of institutional, industrial, and control activities in a jungle of interconnected information systems. ...

Abstract	Seaports are genuine, intermodal hubs connecting seaways to inland transport links, such as roads and railways. Seaports are located at the focal point of institutional, industrial, and control activities in a jungle of interconnected information systems. System integration is setting considerable challenges when a group of independent providers are asked to implement complementary software functionalities. For this reason, seaports are the ideal playground where software is highly composite and tailored to a large variety of final users (from the so-called port communities). Although the target would be that of shaping the Port Authorities to be providers of (digital) innovation services, the state-of-the-art is still that of considering them as final users, or proxies of them. For this reason, we show how a canonical cloud, virtualizing a distributed architecture, can be structured to host different, possibly overlapped, tenants, slicing the information system at the infrastructure, platform, and software layers. Resources at the infrastructure and platform layers are shared so that a variety of independent applications can make use of the local calculus and access the data stored in a Data Lake. Such a cloud is adopted by the Port of Livorno as a rapid prototyping framework for the development and deployment of ICT innovation services. In order to demonstrate the versatility of this framework, three case studies relating to as many prototype ICT services (Navigation Safety, e-Freight, and Logistics) released within three industrial tenants are here presented and discussed.
MeSH term(s)	Industry ; Lakes ; Software
Language	English
Publishing date	2021-12-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22010246
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Article ; Online: Celiac Trunk Mycotic Aneurysm: Diagnosis and Treatment of a Post-infective Endocarditis Complication.

Gabrielli, Daniela / Pagano, Paolo / Boni, Mariavirginia / Di Giosia, Paolo / Procaccini, Luca / Mincuzzi, Erica / Marinucci, Carlo / Rossi, Brunella / D' Emidio, Fabio

Vascular and endovascular surgery

2022 Volume 56, Issue 8, Page(s) 793–796

Abstract: Pseudoaneurysms could be the dynamic evolution of an infectious break in the arterial wall; in the post-antibiotic era they are uncommon complication following infective endocarditis (IE) and are associated with high rates of morbidity and mortality ... ...

Abstract	Pseudoaneurysms could be the dynamic evolution of an infectious break in the arterial wall; in the post-antibiotic era they are uncommon complication following infective endocarditis (IE) and are associated with high rates of morbidity and mortality especially for patients in whom a prompt diagnosis and therapeutic strategy are not performed. In this report, we describe a case of pseudoaneurysm of the celiac trunk developed as a complication of IE. Endovascular treatment is our first-line approach.
MeSH term(s)	Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/surgery ; Aneurysm, Infected/diagnostic imaging ; Aneurysm, Infected/etiology ; Aneurysm, Infected/surgery ; Anti-Bacterial Agents/therapeutic use ; Endocarditis/diagnosis ; Endocarditis/diagnostic imaging ; Humans ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/15385744221114528
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Article ; Online: Images in Vascular Medicine: Rare vascular infection in spondylodiscitis.

Gabrielli, Daniela / Pagano, Paolo / Boni, Maria Virginia / Marinucci, Carlo / Rossi, Brunella / Santi, Ivan / D'Emidio, Fabio

Vascular medicine (London, England)

2021 Volume 26, Issue 3, Page(s) 348–349

MeSH term(s)	Cardiology ; Discitis/diagnostic imaging ; Discitis/drug therapy ; Humans
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X20988349
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Book ; Online: Acoustic wave properties in footpoints of coronal loops in 3D MHD simulations

Riedl, Julia M. / Van Doorsselaere, Tom / Reale, Fabio / Goossens, Marcel / Petralia, Antonino / Pagano, Paolo

2021

Abstract: Acoustic waves excited in the photosphere and below might play an integral part in the heating of the solar chromosphere and corona. However, it is yet not fully clear how much of the initially acoustic wave flux reaches the corona and in what form. We ... ...

Abstract	Acoustic waves excited in the photosphere and below might play an integral part in the heating of the solar chromosphere and corona. However, it is yet not fully clear how much of the initially acoustic wave flux reaches the corona and in what form. We investigate the wave propagation, damping, transmission, and conversion in the lower layers of the solar atmosphere using 3D numerical MHD simulations. A model of a gravitationally stratified expanding straight coronal loop, stretching from photosphere to photosphere, is perturbed at one footpoint by an acoustic driver with a period of 370 seconds. For this period acoustic cutoff regions are present below the transition region (TR). About 2% of the initial energy from the driver reach the corona. The shape of the cutoff regions and the height of the TR show a highly dynamic behavior. Taking only the driven waves into account, the waves have a propagating nature below and above the cutoff region, but are standing and evanescent within the cutoff region. Studying the driven waves together with the background motions in the model reveals standing waves between the cutoff region and the TR. These standing waves cause an oscillation of the TR height. In addition, fast or leaky sausage body-like waves might have been excited close to the base of the loop. These waves then possibly convert to fast or leaky sausage surface-like waves at the top of the main cutoff region, followed by a conversion to slow sausage body-like waves around the TR. Comment: 23 pages, 12 figures, accepted in ApJ
Keywords	Astrophysics - Solar and Stellar Astrophysics
Subject code	551
Publishing date	2021-09-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intestinal duplications: incidentally ileum duplication cyst in young female.

Martini, Chiara / Pagano, Paolo / Perrone, Gennaro / Bresciani, Paolo / Dell'Abate, Paolo

BJR case reports

2019 Volume 5, Issue 3, Page(s) 20180077

Abstract: Gastrointestinal tract duplication is a rare congenital malformation in young patients and in adults, that occur anywhere from the mouth to the anus and their macroscopic structure may be cystic or tubular. Intestinal duplication does not show specific ... ...

Abstract	Gastrointestinal tract duplication is a rare congenital malformation in young patients and in adults, that occur anywhere from the mouth to the anus and their macroscopic structure may be cystic or tubular. Intestinal duplication does not show specific symptoms, indeed they can present with a variety of symptoms including abdominal distension and pain, sickness, hemorrhage, chronic respiratory disorders, as well as non-painful abdominal mass. Nonetheless, intestinal duplication can remain completely asymptomatic and be diagnosed as an incidental finding. Presentation with acute complications such as intestinal invagination or mechanical occlusion is quite rare. We present a case of asymptomatic ileum duplication cyst in young female who referred to the emergency department for trauma and was screened by eco-Focus Assessment Sonography for Trauma (eco-FAST), followed by MR and CT. The patient underwent ileal resection and prophylactic appendicectomy with ileo-cecal termino-lateral anastomosis. In this case, the intestinal duplication cyst was an asymptomatic incidental finding.
Language	English
Publishing date	2019-04-03
Publishing country	England
Document type	Journal Article
ISSN	2055-7159
ISSN (online)	2055-7159
DOI	10.1259/bjrcr.20180077
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