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  1. Article ; Online: High throughput computational evaluation of how scaffold architecture, material selection, and loading modality influence the cellular micromechanical environment in tissue engineering strategies.

    Page, Mitchell I / Linde, Peter E / Puttlitz, Christian M

    JOR spine

    2021  Volume 4, Issue 3, Page(s) e1152

    Abstract: Background: In tissue engineering (TE) strategies, cell processes are regulated by mechanical stimuli. Although TE scaffolds have been developed to replicate tissue-level mechanical properties, it is intractable to experimentally measure and prescribe ... ...

    Abstract Background: In tissue engineering (TE) strategies, cell processes are regulated by mechanical stimuli. Although TE scaffolds have been developed to replicate tissue-level mechanical properties, it is intractable to experimentally measure and prescribe the cellular micromechanical environment (CME) generated within these constructs. Accordingly, this study aimed to fill this lack of understanding by modeling the CME in TE scaffolds using the finite element method.
    Methods: A repeating unit of composite fiber scaffold for annulus fibrosus (AF) repair with a fibrin hydrogel matrix was prescribed a series of loading, material, and architectural parameters. The distribution of CME in the scaffold was predicted and compared to proposed target mechanics based on anabolic responses of AF cells.
    Results: The multi-axial loading modality predicted the greatest percentage of cell volumes falling within the CME target envelope (%PTE) in the study (65 %PTE for 5.0% equibiaxial tensile strain with 50 kPa radial-direction compression; 7.6 %PTE without radial pressure). Additionally, the architectural scale had a moderate influence on the CME (maximum of 17 %PTE), with minimal change in the tissue-level properties of the scaffold. Scaffold materials and architectures had secondary influences on the predicted regeneration by modifying the tissue-level scaffold mechanics.
    Conclusions: Scaffold loading modality was identified as the critical factor for TE the AF. Scaffold materials and architecture were also predicted to modulate the scaffold loading and, therefore, control the CME indirectly. This study facilitated an improved understanding of the relationship between tissue-level and cell-level mechanics to drive anabolic cell responses for tissue regeneration.
    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improved Electrical Impedance Tomography Reconstruction via a Bayesian Approach With an Anatomical Statistical Shape Model.

    Page, Mitchell I / Nicholson, Ruanui / Tawhai, Merryn H / Clark, Alys R / Kumar, Haribalan

    IEEE transactions on bio-medical engineering

    2023  Volume 70, Issue 8, Page(s) 2486–2495

    Abstract: Objective: electrical impedance tomography (EIT) is a promising technique for rapid and continuous bedside monitoring of lung function. Accurate and reliable EIT reconstruction of ventilation requires patient-specific shape information. However, this ... ...

    Abstract Objective: electrical impedance tomography (EIT) is a promising technique for rapid and continuous bedside monitoring of lung function. Accurate and reliable EIT reconstruction of ventilation requires patient-specific shape information. However, this shape information is often not available and current EIT reconstruction methods typically have limited spatial fidelity. This study sought to develop a statistical shape model (SSM) of the torso and lungs and evaluate whether patient-specific predictions of torso and lung shape could enhance EIT reconstructions in a Bayesian framework.
    Methods: torso and lung finite element surface meshes were fitted to computed tomography data from 81 participants, and a SSM was generated using principal component analysis and regression analyses. Predicted shapes were implemented in a Bayesian EIT framework and were quantitatively compared to generic reconstruction methods.
    Results: Five principal shape modes explained 38% of the cohort variance in lung and torso geometry, and regression analysis yielded nine total anthropometrics and pulmonary function metrics that significantly predicted these shape modes. Incorporation of SSM-derived structural information enhanced the accuracy and reliability of the EIT reconstruction as compared to generic reconstructions, demonstrated by reduced relative error, total variation, and Mahalanobis distance.
    Conclusion: As compared to deterministic approaches, Bayesian EIT afforded more reliable quantitative and visual interpretation of the reconstructed ventilation distribution. However, no conclusive improvement of reconstruction performance using patient specific structural information was observed as compared to the mean shape of the SSM.
    Significance: The presented Bayesian framework builds towards a more accurate and reliable method for ventilation monitoring via EIT.
    MeSH term(s) Humans ; Tomography/methods ; Bayes Theorem ; Electric Impedance ; Reproducibility of Results ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 160429-6
    ISSN 1558-2531 ; 0018-9294
    ISSN (online) 1558-2531
    ISSN 0018-9294
    DOI 10.1109/TBME.2023.3250650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Computational modeling to predict the micromechanical environment in tissue engineering scaffolds.

    Page, Mitchell I / Linde, Peter E / Puttlitz, Christian M

    Journal of biomechanics

    2021  Volume 120, Page(s) 110355

    Abstract: Cell fate in tissue engineering (TE) strategies is paramount to regenerate healthy, functional organs. The mechanical loads experienced by cells play an important role in cell fate. However, in TE scaffolds with a cell-laden hydrogel matrix, it is ... ...

    Abstract Cell fate in tissue engineering (TE) strategies is paramount to regenerate healthy, functional organs. The mechanical loads experienced by cells play an important role in cell fate. However, in TE scaffolds with a cell-laden hydrogel matrix, it is prohibitively complex to prescribe and measure this cellular micromechanical environment (CME). Accordingly, this study aimed to develop a finite element (FE) model of a TE scaffold unit cell that can be subsequently implemented to predict the CME and cell fates under prescribed loading. The compressible hyperelastic mechanics of a fibrin hydrogel were characterized by fitting unconfined compression and confined compression experimental data. This material model was implemented in a unit cell FE model of a TE scaffold. The FE mesh and boundary conditions were evaluated with respect to the mechanical response of a region of interest (ROI). A compressible second-order reduced polynomial hyperelastic model gave the best fit to the experimental data (C
    MeSH term(s) Finite Element Analysis ; Hydrogels ; Stress, Mechanical ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Hydrogels
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2021.110355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 700: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Biomechanical evaluation of a novel repair strategy for intervertebral disc herniation in an ovine lumbar spine model.

    Page, Mitchell I / Easley, Jeremiah T / Bonilla, Andres F / Patel, Vikas V / Puttlitz, Christian M

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 1018257

    Abstract: Following herniation of the intervertebral disc, there is a need for advanced surgical strategies to protect the diseased tissue from further herniation and to minimize further degeneration. Accordingly, a novel tissue engineered implant for annulus ... ...

    Abstract Following herniation of the intervertebral disc, there is a need for advanced surgical strategies to protect the diseased tissue from further herniation and to minimize further degeneration. Accordingly, a novel tissue engineered implant for annulus fibrosus (AF) repair was fabricated
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1018257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intubation Biomechanics: Clinical Implications of Computational Modeling of Intervertebral Motion and Spinal Cord Strain during Tracheal Intubation in an Intact Cervical Spine.

    Gadomski, Benjamin C / Hindman, Bradley J / Page, Mitchell I / Dexter, Franklin / Puttlitz, Christian M

    Anesthesiology

    2021  Volume 135, Issue 6, Page(s) 1055–1065

    MeSH term(s) Biomechanical Phenomena/physiology ; Cervical Vertebrae/injuries ; Cervical Vertebrae/physiology ; Computer Simulation ; Humans ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Laryngoscopy/adverse effects ; Laryngoscopy/methods ; Range of Motion, Articular/physiology ; Spinal Cord/physiology ; Spinal Cord Injuries/etiology ; Spinal Cord Injuries/physiopathology ; Spinal Cord Injuries/prevention & control ; Sprains and Strains/etiology ; Sprains and Strains/physiopathology ; Sprains and Strains/prevention & control
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

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  6. Article ; Online: Intubation biomechanics: Computational modeling to identify methods to minimize cervical spine motion and spinal cord strain during laryngoscopy and tracheal intubation in an intact cervical spine.

    Gadomski, Benjamin C / Hindman, Bradley J / Poland, Michael J / Page, Mitchell I / Dexter, Franklin / Puttlitz, Christian M

    Journal of clinical anesthesia

    2022  Volume 81, Page(s) 110909

    Abstract: Study objective: To minimize the risk of cervical spinal cord injury in patients who have cervical spine pathology, minimizing cervical spine motion during laryngoscopy and tracheal intubation is commonly recommended. However, clinicians may better aim ... ...

    Abstract Study objective: To minimize the risk of cervical spinal cord injury in patients who have cervical spine pathology, minimizing cervical spine motion during laryngoscopy and tracheal intubation is commonly recommended. However, clinicians may better aim to reduce cervical spinal cord strain during airway management of their patients. The aim of this study was to predict laryngoscope force characteristics (location, magnitude, and direction) that would minimize cervical spine motions and cord strains.
    Design: We utilized a computational model of the adult human cervical spine and spinal cord to predict intervertebral motions (rotation [flexion/extension] and translation [subluxation]) and cord strains (stretch and compression) during laryngoscopy.
    Interventions: Routine direct (Macintosh) laryngoscopy conditions were defined by a specific force application location (mid-C3 vertebral body), magnitude (48.8 N), and direction (70 degrees). Sixty laryngoscope force conditions were simulated using 4 force locations (cephalad and caudad of routine), 5 magnitudes (25-200% of routine), and 3 directions (50, 70, 90 degrees).
    Main results: Under all conditions, extension at Oc-C1 and C1-C2 were greater than in all other cervical segments. Decreasing force magnitude to values reported for indirect laryngoscopes (8-17 N) decreased cervical extension to ~50% of routine values. The cervical cord was most likely to experience potentially injurious compressive strain at C3, but force magnitudes ≤50% of routine (≤24.4 N) decreased strain in C3 and all other cord regions to non-injurious values. Changing laryngoscope force locations and directions had minor effects on motion and strain.
    Conclusions: The model predicts clinicians can most effectively minimize cervical spine motion and cord strain during laryngoscopy by decreasing laryngoscope force magnitude. Very low force magnitudes (<5 N, ~10% of routine) are necessary to decrease overall cervical extension to <50% of routine values. Force magnitudes ≤24.4 N (≤50% of routine) are predicted to help prevent potentially injurious compressive cord strain.
    MeSH term(s) Adult ; Biomechanical Phenomena ; Cervical Vertebrae ; Computer Simulation ; Humans ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods ; Laryngoscopes/adverse effects ; Laryngoscopy/adverse effects ; Laryngoscopy/methods ; Spinal Cord
    Language English
    Publishing date 2022-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2022.110909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2622: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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