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  1. Article ; Online: Correction: COVID-19 and flu: conserved or specific immune signature?

    Paget, Christophe / Trottein, François

    Cellular & molecular immunology

    2022  Volume 19, Issue 12, Page(s) 1439

    Language English
    Publishing date 2022-08-30
    Publishing country China
    Document type Published Erratum
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-022-00914-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6681: Show issues Location:
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  2. Article ; Online: STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer.

    Richter, Fabian / Paget, Christophe / Apetoh, Lionel

    Cell stress

    2023  Volume 7, Issue 11, Page(s) 95–104

    Abstract: Adoptive cell therapy (ACT) can successfully treat hematopoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the ... ...

    Abstract Adoptive cell therapy (ACT) can successfully treat hematopoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the immunosuppressive tumor microenvironment (TME). Alternative methods to boost the anticancer efficacy of adoptively transferred cells are actively pursued. Among adjuvants that are utilized to stimulate anticancer immune responses, ligands of the stimulator of interferon genes (STING) pathway have received increasing attention. STING activation can trigger dendritic cell (DC) activation and endogenous immune responses, thereby preventing tumor escape. Activation of the STING pathway in the context of ACT was accordingly associated with improved T cell trafficking and persistence in the TME combined with the reduced presence of immunosuppressive cells. Recent findings also suggest cell-intrinsic effects of STING ligands on T cells. Activation of the STING signaling pathway was in this regard shown to enhance effector functions of CD4
    Language English
    Publishing date 2023-11-14
    Publishing country Austria
    Document type Journal Article ; Review
    ISSN 2523-0204
    ISSN (online) 2523-0204
    DOI 10.15698/cst2023.11.291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COVID-19 and flu: conserved or specific immune signature?

    Paget, Christophe / Trottein, François

    Cellular & molecular immunology

    2021  Volume 18, Issue 2, Page(s) 245–246

    MeSH term(s) COVID-19 ; Humans ; Immunity ; Influenza, Human ; Leukocyte Count ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-020-00595-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS.

    Guillon, Antoine / Jouan, Youenn / Kassa-Sombo, Arthur / Paget, Christophe / Dequin, Pierre-François

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 101

    MeSH term(s) Humans ; COVID-19/complications ; Interleukin-6 ; Hydrocortisone/therapeutic use ; Lung ; Respiratory Distress Syndrome/drug therapy
    Chemical Substances Interleukin-6 ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04887-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  5. Article ; Online: Mechanisms of Bacterial Superinfection Post-influenza: A Role for Unconventional T Cells.

    Paget, Christophe / Trottein, François

    Frontiers in immunology

    2019  Volume 10, Page(s) 336

    Abstract: Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens. Indeed, influenza results in significant seasonal and pandemic morbidity and mortality. ... ...

    Abstract Despite the widespread application of vaccination programs and antiviral drug treatments, influenza viruses are still among the most harmful human pathogens. Indeed, influenza results in significant seasonal and pandemic morbidity and mortality. Furthermore, severe bacterial infections can occur in the aftermath of influenza virus infection, and contribute substantially to the excess morbidity and mortality associated with influenza. Here, we review the main features of influenza viruses and current knowledge about the mechanical and immune mechanisms that underlie post-influenza secondary bacterial infections. We present the emerging literature describing the role of "innate-like" unconventional T cells in post-influenza bacterial superinfection. Unconventional T cell populations span the border between the innate and adaptive arms of the immune system, and are prevalent in mucosal tissues (including the airways). They mainly comprise Natural Killer T cells, mucosal-associated invariant T cells and γδ T cells. We provide an overview of the principal functions that these cells play in pulmonary barrier functions and immunity, highlighting their unique ability to sense environmental factors and promote protection against respiratory bacterial infections. We focus on two major opportunistic pathogens involved in superinfections, namely
    MeSH term(s) Animals ; Bacterial Infections/immunology ; Bacterial Infections/therapy ; Humans ; Influenza, Human/immunology ; Influenza, Human/therapy ; Superinfection/immunology ; Superinfection/therapy ; T-Lymphocytes/immunology
    Language English
    Publishing date 2019-03-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases.

    Paget, Christophe / Doz-Deblauwe, Emilie / Winter, Nathalie / Briard, Benoit

    Cells

    2022  Volume 11, Issue 7

    Abstract: The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and ... ...

    Abstract The NLRP3 inflammasome is a cytosolic multimeric protein platform that leads to the activation of the protease zymogen, caspase-1 (CASP1). Inflammasome activation mediates the proteolytic activation of pro-inflammatory cytokines (IL-1β and IL-18) and program cell death called pyroptosis. The pyroptosis is mediated by the protein executioner Gasdermin D (GSDMD), which forms pores at the plasma membrane to facilitate IL-1β/IL-18 secretion and causes pyroptosis. The NLRP3 inflammasome is activated in response to a large number of pathogenic and sterile insults. However, an uncontrolled inflammasome activation may drive inflammation-associated diseases. Initially, inflammasome-competent cells were believed to be limited to macrophages, dendritic cells (DC), and monocytes. However, emerging evidence indicates that neutrophils can assemble inflammasomes in response to various stimuli with functional relevance. Interestingly, the regulation of inflammasome in neutrophils appears to be unconventional. This review provides a broad overview of the role and regulation of inflammasomes-and more specifically NLRP3-in neutrophils.
    MeSH term(s) Communicable Diseases ; Humans ; Inflammasomes/metabolism ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neutrophils/metabolism
    Chemical Substances Inflammasomes ; Interleukin-18 ; NLR Family, Pyrin Domain-Containing 3 Protein
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11071188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CD1 and MR1: An update after a long-awaited reunion.

    Gherardin, Nicholas A / Legoux, Francois / Consonni, Michela / Paget, Christophe

    Immunity

    2022  Volume 55, Issue 12, Page(s) 2211–2216

    Abstract: CD1 molecules and the MHC-related protein 1 (MR1) present lipid and small molecule antigens, respectively, for T cell surveillance. The biology of these molecules, the antigens they present, and the T cells that respond to them were recently discussed ... ...

    Abstract CD1 molecules and the MHC-related protein 1 (MR1) present lipid and small molecule antigens, respectively, for T cell surveillance. The biology of these molecules, the antigens they present, and the T cells that respond to them were recently discussed during the 12
    MeSH term(s) Histocompatibility Antigens Class I ; Minor Histocompatibility Antigens ; Antigens, CD1/metabolism ; T-Lymphocytes ; Antigens ; Antigen Presentation
    Chemical Substances Histocompatibility Antigens Class I ; Minor Histocompatibility Antigens ; Antigens, CD1 ; Antigens
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Clinical Conference ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  8. Article ; Online: Deconstructing iNKT cell development at single-cell resolution.

    Baranek, Thomas / de Amat Herbozo, Carolina / Mallevaey, Thierry / Paget, Christophe

    Trends in immunology

    2022  Volume 43, Issue 7, Page(s) 503–512

    Abstract: Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/ ... ...

    Abstract Invariant natural killer T (iNKT) cells are increasingly regarded as disease biomarkers and immunotherapeutic targets. However, a greater understanding of their biology is necessary to effectively target these cells in the clinic. The discovery of iNKT1/2/17 cell effector subsets was a milestone in our understanding of iNKT cell development and function. Recent transcriptomic studies have uncovered an even greater heterogeneity and challenge our understanding of iNKT cell ontogeny and effector differentiation. We propose a refined model whereby iNKT cells differentiate through a dynamic and continuous instructive process that requires the accumulation and integration of various signals within the thymus or peripheral tissues. Within this framework, we question the existence of true iNKT2 cells and discuss the parallels between mouse and human iNKT cells.
    MeSH term(s) Animals ; Cell Differentiation ; Humans ; Mice ; Natural Killer T-Cells
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1601: Show issues Location:
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    Zs.MG 2: Show issues

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  9. Article ; Online: Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections.

    Trottein, François / Paget, Christophe

    Frontiers in immunology

    2018  Volume 9, Page(s) 1750

    Abstract: The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult. Conversely, the adaptive ... ...

    Abstract The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult. Conversely, the adaptive immune response emerges after several days and relies on the innate immune response for its initiation and subsequent outcome. However, the recent discovery of immune cells displaying merged properties indicates that this distinction is not mutually exclusive. These populations that span the innate-adaptive border of immunity comprise, among others, CD1d-restricted natural killer T cells and MR1-restricted mucosal-associated invariant T cells. These cells have the unique ability to swiftly activate in response to non-peptidic antigens through their T cell receptor and/or to activating cytokines in order to modulate many aspects of the immune response. Despite they recirculate all through the body
    MeSH term(s) Adaptive Immunity ; Animals ; Antigens, CD1d/analysis ; Histocompatibility Antigens Class I/analysis ; Humans ; Immunity, Innate ; Immunotherapy, Adoptive ; Minor Histocompatibility Antigens/analysis ; Mucosal-Associated Invariant T Cells/immunology ; Natural Killer T-Cells/immunology ; Pneumonia, Bacterial/immunology ; Pneumonia, Viral/immunology ; Tuberculosis, Pulmonary/immunology ; Vaccines/therapeutic use
    Chemical Substances Antigens, CD1d ; CD1D protein, human ; Histocompatibility Antigens Class I ; MR1 protein, human ; Minor Histocompatibility Antigens ; Vaccines
    Language English
    Publishing date 2018-08-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pneumocystis

    Chesnay, Adélaïde / Paget, Christophe / Heuzé-Vourc'h, Nathalie / Baranek, Thomas / Desoubeaux, Guillaume

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 2

    Abstract: ... ...

    Abstract Pneumocystis
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8020129
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