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  1. Article ; Online: The use of biological membranes for correction of congenital malformations.

    Marchetto, C / Sgrò, A / Gamba, P / Trojan, D / Pagliara, C / Midrio, P

    Cell and tissue banking

    2022  Volume 23, Issue 3, Page(s) 607–614

    Abstract: Many congenital malformations often require a multidisciplinary and multistep surgical treatment, including the use of biological membranes. Aims of the study were to describe the use of these membranes for the correction of malformations, their clinical ...

    Abstract Many congenital malformations often require a multidisciplinary and multistep surgical treatment, including the use of biological membranes. Aims of the study were to describe the use of these membranes for the correction of malformations, their clinical performance at follow-up, and patient's tolerance to them. The study included patients treated between 2009 and November 2020 in two referral centers. They were affected by abdominal wall defects (AWD), esophageal atresia/tracheo-esophageal fistula (EA/TEF), diaphragmatic hernia (CDH), spinal defects (SD), and anorectal malformations (ARM). The human origin membranes used during surgery were amniotic membrane, fascia lata, and pericardium provided by the local tissue bank and the porcine-derived membrane available on the market. Thirty-one patients were retrieved. The sample included 10 AWD, 7 EA/TEF, 5 CDH, 4 SD, 2 ARM, and 3 miscellaneous defects. The median age at repair was 139 days (range: 10,5-1494). The median follow-up was 1021 days (range: 485,5-1535). Two patients were lost at follow-up. The defects were successfully repaired and the membranes perfectly tolerated in 28/29 cases. In 1 case of CDH the fascia lata was replaced with a Goretex patch due to recurrence of the defect. This is the largest series on the use of biological membranes in congenital malformations. The variety of tissues allows to choose the best material for each malformation. The excellent tolerance and performance of this first series of patients encourage the use of these membranes to correct different type of malformations at any age.
    MeSH term(s) Animals ; Esophageal Atresia/surgery ; Hernias, Diaphragmatic, Congenital/surgery ; Humans ; Retrospective Studies ; Swine ; Tracheoesophageal Fistula/surgery
    Language English
    Publishing date 2022-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-022-10003-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5972: Show issues Location:
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  2. Article: Eosinophilic Esophagitis in Esophageal Atresia: Is It Really a New Disease?

    Pagliara, Camilla / Zambaiti, Elisa / Antoniello, Luca M / Gamba, Piergiorgio

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 7

    Abstract: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease. Symptoms are related to mucosal eosinophilic-predominant inflammation that leads to esophageal dysfunction. Recent data suggest that esophageal atresia (EA) patients may ... ...

    Abstract Eosinophilic esophagitis (EoE) is a chronic, immune-mediated esophageal disease. Symptoms are related to mucosal eosinophilic-predominant inflammation that leads to esophageal dysfunction. Recent data suggest that esophageal atresia (EA) patients may have an increased incidence of EoE compared to the general population. As EoE symptoms may be confused with EA-related symptoms, they may significantly worsen morbidity in this specific group of patients. We investigated specific characteristics of patients with AE and EoE compared to those with EoE only. We conducted an observational retrospective monocentric study including all patients diagnosed with EoE from 1 January 2010 to 31 December 2021. For each patient, demographic, clinical and histopathological data were collected and then compared between the two cohorts (EA-EoE vs. EoE only). During the study period, 62 patients were included: 17 children were in the follow-up because of EA (18.1% of 94 EA patients screened in that period), while the other 45 presented EoE only. The demographic and clinical features of EA-EoE patients demonstrate a lower prevalence of allergic subjects (23.5% vs. 80%, p < 0.05), a lower age of presentation (3.1 vs. 12.2 years, p < 0.05), non-specific symptoms and a higher resolution rate with PPI therapy (64.7% vs. 17.8%, p < 0.05) compared to EoE-only patients. Our data confirm that EA patients are at high risk for developing EoE. As symptoms may overlap with the EA spectrum, early recognition of EoE may prevent patients from receiving unnecessary invasive therapeutic interventions and from developing complications from untreated EoE.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9071032
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  3. Article ; Online: Comparison of outcomes following radiological reduction of intussusception with or without sedation.

    Pagliara, Camilla / Zambaiti, Elisa / Fati, Federica / Guanà, Riccardo / Scottoni, Federico / Gennari, Fabrizio / Gamba, Piergiorgio

    Minerva pediatrics

    2023  

    Abstract: Background: Non-operative radiological reduction (NORR) is usually the first line treatment in pediatric ileo-colic intussusception. The aim of our study was to compare outcomes of NORR with or without sedation.: Methods: All patients undergoing to ... ...

    Abstract Background: Non-operative radiological reduction (NORR) is usually the first line treatment in pediatric ileo-colic intussusception. The aim of our study was to compare outcomes of NORR with or without sedation.
    Methods: All patients undergoing to contrast enema NORR for intussusception between 01.01.2015 to 31.12.2020 in two hospitals were included: in one centre patients were sedated (A) while in the other patients were awake (B). Primary outcome was the rate of radiological reduction. Secondary outcomes were length-of-stay, complications and recurrence rate.
    Results: Seventy-seven and 49 patients were included in group A and B respectively. Successful reduction rate was 72.7% in group A and 61.2% in group B (P>0.05). There were no complications related to the procedure among the 2 groups. Adverse events to sedation were observed in 3 patients.
    Conclusions: NORR has similar success rate when performed under sedation or awake, despite the former being graved by additional anesthesiologic risks and thus warrant careful indications.
    Language English
    Publishing date 2023-06-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062664-X
    ISSN 2724-5780
    ISSN (online) 2724-5780
    DOI 10.23736/S2724-5276.23.07149-5
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  4. Article: Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series.

    Pagliara, Camilla / Zambaiti, Elisa / Brooks, Giulia / Bonadies, Luca / Tognon, Costanza / Salvadori, Sabrina / Sgrò, Alberto / Leon, Francesco Fascetti

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10020315
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  5. Article: Oxygen-enriched oleic matrix (NovoX) for wound healing in pediatric patients undergoing open surgical treatment for pilonidal disease: Preliminary experience.

    Bisol, Marta / Tykhomyrova, Sophia / Pagliara, Camilla / Scarpa, Maria-Grazia / Guida, Edoardo / Olenik, Damiana / Codrich, Daniela / Schleef, Jürgen / Boscarelli, Alessandro

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 1068280

    Abstract: Introduction: Pilonidal disease (PD) is a common infectious and inflammatory condition affecting the gluteal cleft and sacrococcygeal region. The optimal treatment for PD remains controversial. While the open technique reduces the number of relapses ... ...

    Abstract Introduction: Pilonidal disease (PD) is a common infectious and inflammatory condition affecting the gluteal cleft and sacrococcygeal region. The optimal treatment for PD remains controversial. While the open technique reduces the number of relapses compared to minimally invasive approaches, it is associated with a longer healing time. Reactive oxygen species are a key part of the normal wound-healing process. Herein, we reported our preliminary experience using a new oxygen-enriched oil-based product called NovoX for wound healing after open surgery for PD.
    Materials and methods: We used a new oxygen-enriched product for wound healing in three pediatric patients undergoing open surgical repair for PD between December 2021 and April 2022. During postoperative follow-up, healing time and the aesthetic result were evaluated.
    Results: Our preliminary study included three patients with chronic PD. The average follow-up time was 5 weeks, corresponding to the end of the healing process and the resumption of normal daily activities. Only one mild complication occurred during the study period. No short-term side effects were reported. The cosmetic result was reported as satisfactory.
    Conclusion: NovoX is easy to apply, safe, and effective for treating pediatric patients undergoing open surgical treatment for PD, leading to slightly faster wound healing with good aesthetic outcomes.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1068280
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  6. Article ; Online: Incidental Ultrasound Diagnosis of Neonatal Intussusception Secondary to Meckel's Diverticulum in a Neurologically Impaired Child.

    Guanà, Riccardo / Pagliara, Camilla / Zambaiti, Elisa / Scottoni, Federico / Pane, Alessandro / Garofalo, Salvatore / Pizzol, Antonio / Giuliani, Francesca / Carpino, Andrea / Gennari, Fabrizio

    The American journal of case reports

    2021  Volume 22, Page(s) e932280

    Abstract: BACKGROUND Intussusception is the most common cause of intestinal obstruction in children, with a peak incidence usually before the second year of age, while in neonates it is a rare entity. We describe a delayed and incidental diagnosis of neonatal ... ...

    Abstract BACKGROUND Intussusception is the most common cause of intestinal obstruction in children, with a peak incidence usually before the second year of age, while in neonates it is a rare entity. We describe a delayed and incidental diagnosis of neonatal intussusception secondary to Meckel's diverticulum in a neonate with shaken baby syndrome (SBS). This is, to the best of our knowledge, the first reported case of a neonatal intussusception with a Meckel's diverticulum as a lead point in a neurologically impaired child. CASE REPORT A term baby presented at 22 days of age at our Emergency Department in severe conditions due to a suspected SBS. Eight days following hospitalization in the Intensive Care Unit, an isolated episode of rectal bleeding occurred, without any worsening of general conditions or abdominal distension. The ultrasonography showed a "doughnut sign" with high suspicion of ileocecal intussusception. A rectal barium contrast enema was performed but was not resolutive. At exploratory laparotomy an ileocecal intussusception with Meckel's diverticulum acting as a lead point was identified and an intestinal resection was needed due to the ischemic condition of the ileum. The post-operative course was uneventful and the baby recovered well; the residual neurological impairment needed long-term follow-up. CONCLUSIONS Intussusception is a rare entity in neonates and, when severe neurological impairment is present, the diagnosis can be missed because of the compromised condition of the baby and the paucity of gastrointestinal manifestations. In addition, due to the high incidence of lead point in neonatal cases, we recommend reserving non-operative treatment only for selected cases.
    MeSH term(s) Child ; Humans ; Ileum ; Infant ; Infant, Newborn ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Meckel Diverticulum/complications ; Meckel Diverticulum/diagnostic imaging ; Ultrasonography
    Language English
    Publishing date 2021-09-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.932280
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  7. Article ; Online: Multisystem inflammatory syndrome in SARS-CoV-2 infection mimicking acute appendicitis in children.

    Guanà, Riccardo / Pagliara, Camilla / Delmonaco, Angelo Giovanni / Scottoni, Federico / Bordese, Roberto / Pruccoli, Giulia / Gennari, Fabrizio

    Pediatrics and neonatology

    2020  Volume 62, Issue 1, Page(s) 122–124

    Keywords covid19
    Language English
    Publishing date 2020-09-23
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2020.09.007
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  8. Article ; Online: Testicular torsion during the COVID-19 pandemic: Results of a multicenter study in northern Italy.

    Zambaiti, Elisa / Cerchia, Elisa / Guanà, Riccardo / Scottoni, Federico / Giannotti, Giulia / Dalla Rosa, Davide / Pagliara, Camilla / Gobbi, Dalia / Trovalusci, Emanuele / Bucci, Valeria / Carretto, Elena / Bulotta, Anna Lavinia / Chiarenza, Salvatore Fabio / Midrio, Paola / Gamba, Piergiorgio / Cheli, Maurizio / Alberti, Daniele / Gennari, Fabrizio / Gerocarni Nappo, Simona

    Journal of pediatric urology

    2022  Volume 18, Issue 4, Page(s) 530.e1–530.e6

    Abstract: Introduction: The literature reported an increased avoidance of the Emergency Department (ED) during COrona VIrus Disease 19 (COVID-19) pandemic, causing a subsequent increase of morbidity and mortality for acute conditions. Testicular torsion is a ... ...

    Abstract Introduction: The literature reported an increased avoidance of the Emergency Department (ED) during COrona VIrus Disease 19 (COVID-19) pandemic, causing a subsequent increase of morbidity and mortality for acute conditions. Testicular torsion is a surgical emergency, which can lead to the loss of the affected testicle if a delayed treatment occurs. As testicular loss is time-related, outcome was hypothesized to be negatively affected by the pandemic.
    Objective: The aim is to investigate whether presentation, treatment and outcomes of children with testicular torsion were delayed during COVID-19.
    Study design: Medical records of pediatric patients operated for testicular torsion of six Paediatric Surgical Units in Northern Italy between January 2019 and December 2020 were retrospectively reviewed. Patients were divided as for ones treated during (dC) or before the pandemic (pC). To reflect possible seasonality, related to lockdown restrictions, winter and summer calendar blocks were also analysed. For all cohorts, demographic data, pre-operative evaluation, operative notes and post-operative outcomes were reviewed. Primary outcomes were referral time, time from diagnosis to surgery and ischemic time, while secondary outcomes were orchiectomy and atrophy rates. Statistic was conducted as appropriate.
    Results: A total of 188 patients with acute testicular torsion were included in the study period, 89 in the pre-COVID-19 (pC) period and 99 during COVID-19 (dC). Time from symptom onset to the access to the Emergency Department (T1) was not different among the two populations (pC: 5,5 h, dC: 6 h, p 0.374), and similarly time from diagnosis to surgery (pC: 2,5 h, dC: 2,5 h, p 0.970) and ischemic time (pC: 8,2 h, dC: 10 h, p 0.655). T1 was <6 h in 46/99 patients (46%) pC and 45/89 patients (51%) dC (p = 0.88, Fisher's exact test). Subgroup analysis accounting for different lockdown measures, confirm the absence of any difference. Orchiectomies rate was 23% (23/99) dC and 21% (19/89) pC (p = 0.861, Fisher's exact test) and rate of post-operative atrophy was 9% dC (7/76) and 14% pC (10/70), p = 0,44, Fisher's exact test.
    Discussion: Despite worldwide pediatric ED accesses reduction, we reported that neither ischemic time nor the long-term outcomes in children with testicular torsion increased during the COVID-19 pandemic. In the available literature, few studies investigated the topic and are controversial on the results. Similarly to our findings, some studies found that timing and orchiectomy rates were not significantly different during the pandemic, while others reported a correlation to pandemic seasonality. Furthermore, in the recent pediatric literature it has been reported a delayed testicular torsion diagnosis due to shame in informing parents. Strengths of this study are the large numerosity, its multicentric design and a long study period. Its main limitation is being retrospective.
    Conclusions: We reported our large cohort from one of the most heavily COVID-19-affected regions, finding that referral, intra-hospital protocols and ischemic time in testicular torsion were not increased during to the pandemic, as well as orchiectomy rate and atrophy.
    MeSH term(s) Male ; Child ; Humans ; Spermatic Cord Torsion/epidemiology ; Spermatic Cord Torsion/surgery ; Spermatic Cord Torsion/diagnosis ; Retrospective Studies ; Pandemics ; COVID-19/epidemiology ; Communicable Disease Control ; Orchiectomy/methods ; Atrophy
    Language English
    Publishing date 2022-06-12
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2022.06.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6387: Show issues Location:
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  9. Article: Multisystem inflammatory syndrome in SARS-CoV-2 infection mimicking acute appendicitis in children

    Guanà, Riccardo / Pagliara, Camilla / Delmonaco, Angelo Giovanni / Scottoni, Federico / Bordese, Roberto / Pruccoli, Giulia / Gennari, Fabrizio

    Pediatr. neonatol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #786191
    Database COVID19

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  10. Article ; Online: Multisystem inflammatory syndrome in SARS-CoV-2 infection mimicking acute appendicitis in children

    Guanà, Riccardo / Pagliara, Camilla / Delmonaco, Angelo Giovanni / Scottoni, Federico / Bordese, Roberto / Pruccoli, Giulia / Gennari, Fabrizio

    Pediatrics & Neonatology ; ISSN 1875-9572

    2020  

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.pedneo.2020.09.007
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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