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  1. Book ; Online: Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease

    Pagliaro, Pasquale / Santillo, Mariarosaria

    2019  

    Keywords Physiology ; Science (General)
    Size 1 electronic resource (258 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020101991
    ISBN 9782889457267 ; 2889457265
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Back and forth from basic science to clinical translation.

    Pagliaro, Pasquale

    Minerva anestesiologica

    2020  Volume 86, Issue 8, Page(s) 890–891

    MeSH term(s) Biomedical Research ; Humans
    Language English
    Publishing date 2020-03-11
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.20.14555-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 516: Show issues Location:
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  3. Article ; Online: Is macrophages heterogeneity important in determining COVID-19 lethality?

    Pagliaro, Pasquale

    Medical hypotheses

    2020  Volume 143, Page(s) 110073

    Abstract: COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and ... ...

    Abstract COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells that sense and respond to infections by producing a plethora of inflammatory molecules and by interacting with other inflammatory cells. Therefore, macrophages may be diriment on eliminating pathogens and promoting organ repair. However, macrophages can be a major player of the so called cytokine storm and may be damaging to the tissues. It is believed that macrophage activation syndrome is induced by SARS-CoV to be lethal. Surprisingly and fortunately few children die from COVID-19. For instance, in Italy, out of more than 30.000 deaths for COVID-19, three are children. Therefore, we must wonder why? Are macrophages different in children compared to adults? In my opinion they are different. It has been demonstrated that macrophages populate the lung in three "developmental waves", and it has been suggested that similar waves may be observed in other important organs, such as the heart and kidney. It is most likely that macrophages heterogeneity is involved in determining the severity. There are no doubts that macrophages are important in determining life or death in these patients. Comparing macrophages of children with those of adults with different degrees of disease severity is, therefore, mandatory.
    MeSH term(s) Adult ; Age Factors ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Cytokine Release Syndrome/etiology ; Host Microbial Interactions/immunology ; Humans ; Lung/immunology ; Macrophage Activation ; Macrophage Activation Syndrome/etiology ; Macrophages/classification ; Macrophages/immunology ; Models, Biological ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects.

    Pagliaro, Pasquale / Penna, Claudia

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 7

    Abstract: Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including the production of reactive oxygen species (ROS), altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ... ...

    Abstract Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including the production of reactive oxygen species (ROS), altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ROS are also involved in these MIRI processes, resulting in the irreversible opening of the mitochondrial permeability transition pore (mPTP). These mechanisms and processes are associated with NLRP3 inflammasome priming and activation, which can also induce cell death by pyroptosis through the up-regulation of the caspase-1 pathway and IL-18 release. In addition, endothelial dysfunction, both in the presence and absence of MIRI, is also accompanied by altered oxygen levels, decreased nitric oxide production, and ROS overproduction, resulting in the expression of adhesion molecules and leukocyte infiltration in which the NLRP3 inflammasome plays a central role, thus contributing, through endothelial dysfunction, to the alteration of coronary flow, typical of ischemic heart disease. Given the intricate interrelationship between ROS and NLRP3, ROS inhibitors can reduce NLRP3 inflammasome activation, while NLRP3 inhibitors can reduce oxidative stress and inflammation. NLRP3 inhibitors have been intensively studied as anti-inflammatory agents in basic cardiovascular sciences. In this review, we analyze the interrelation between ROS and NLRP3 in ischemic heart disease and the effects of some NLRP3 inhibitors as possible therapeutic agents in this disease condition. All compounds considered in this review need larger studies to confirm their appropriate use in clinical scenarios as anti-ischemic drugs.
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inhibitors of NLRP3 Inflammasome in Ischemic Heart Disease: Focus on Functional and Redox Aspects

    Pagliaro, Pasquale / Penna, Claudia

    Antioxidants. 2023 July 07, v. 12, no. 7

    2023  

    Abstract: Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including the production of reactive oxygen species (ROS), altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ... ...

    Abstract Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including the production of reactive oxygen species (ROS), altered cellular osmolarity, and inflammatory response. Calcium overload, altered oxygen levels, and mitochondrial ROS are also involved in these MIRI processes, resulting in the irreversible opening of the mitochondrial permeability transition pore (mPTP). These mechanisms and processes are associated with NLRP3 inflammasome priming and activation, which can also induce cell death by pyroptosis through the up-regulation of the caspase-1 pathway and IL-18 release. In addition, endothelial dysfunction, both in the presence and absence of MIRI, is also accompanied by altered oxygen levels, decreased nitric oxide production, and ROS overproduction, resulting in the expression of adhesion molecules and leukocyte infiltration in which the NLRP3 inflammasome plays a central role, thus contributing, through endothelial dysfunction, to the alteration of coronary flow, typical of ischemic heart disease. Given the intricate interrelationship between ROS and NLRP3, ROS inhibitors can reduce NLRP3 inflammasome activation, while NLRP3 inhibitors can reduce oxidative stress and inflammation. NLRP3 inhibitors have been intensively studied as anti-inflammatory agents in basic cardiovascular sciences. In this review, we analyze the interrelation between ROS and NLRP3 in ischemic heart disease and the effects of some NLRP3 inhibitors as possible therapeutic agents in this disease condition. All compounds considered in this review need larger studies to confirm their appropriate use in clinical scenarios as anti-ischemic drugs.
    Keywords adhesion ; calcium ; caspase-1 ; inflammasomes ; inflammation ; interleukin-18 ; leukocytes ; mitochondria ; myocardial ischemia ; nitric oxide ; osmolarity ; oxidative stress ; oxygen ; permeability ; pyroptosis ; reactive oxygen species ; therapeutics
    Language English
    Dates of publication 2023-0707
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12071396
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Editorial Commentary: Long and narrow road to win over myocardial ischemia-reperfusion injury.

    Samaja, Michele / Pagliaro, Pasquale

    Trends in cardiovascular medicine

    2022  Volume 33, Issue 6, Page(s) 367–368

    MeSH term(s) Humans ; Myocardial Reperfusion Injury/prevention & control ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/therapy ; Myocardial Infarction
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2022.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3419: Show issues Location:
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  7. Article ; Online: Expanding the Frontiers of Guardian Antioxidant Selenoproteins in Cardiovascular Pathophysiology.

    Angelone, Tommaso / Rocca, Carmine / Lionetti, Vincenzo / Penna, Claudia / Pagliaro, Pasquale

    Antioxidants & redox signaling

    2024  Volume 40, Issue 7-9, Page(s) 369–432

    Abstract: Significance: ...

    Abstract Significance:
    MeSH term(s) Humans ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Selenoproteins/metabolism ; Selenium/metabolism ; Cardiovascular Diseases ; Inflammation
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; Selenoproteins ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1483836-9
    ISSN 1557-7716 ; 1523-0864
    ISSN (online) 1557-7716
    ISSN 1523-0864
    DOI 10.1089/ars.2023.0285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5488: Show issues Location:
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  8. Article: Is macrophages heterogeneity important in determining COVID-19 lethality?

    Pagliaro, Pasquale

    Med Hypotheses

    Abstract: COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and ... ...

    Abstract COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells that sense and respond to infections by producing a plethora of inflammatory molecules and by interacting with other inflammatory cells. Therefore, macrophages may be diriment on eliminating pathogens and promoting organ repair. However, macrophages can be a major player of the so called cytokine storm and may be damaging to the tissues. It is believed that macrophage activation syndrome is induced by SARS-CoV to be lethal. Surprisingly and fortunately few children die from COVID-19. For instance, in Italy, out of more than 30.000 deaths for COVID-19, three are children. Therefore, we must wonder why? Are macrophages different in children compared to adults? In my opinion they are different. It has been demonstrated that macrophages populate the lung in three "developmental waves", and it has been suggested that similar waves may be observed in other important organs, such as the heart and kidney. It is most likely that macrophages heterogeneity is involved in determining the severity. There are no doubts that macrophages are important in determining life or death in these patients. Comparing macrophages of children with those of adults with different degrees of disease severity is, therefore, mandatory.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #625601
    Database COVID19

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  9. Article ; Online: Is macrophages heterogeneity important in determining COVID-19 lethality?

    Pagliaro, Pasquale

    reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano

    2020  

    Abstract: COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and ... ...

    Abstract COVID-19 (coronavirus disease 2019) pandemic due to infection with SARS-CoV-2 has led to the death of thousands of adults worldwide. It is now clear that the hyper-inflammatory response triggered by SARS-CoV-2 plays a major role in disease severity and lethality of the infection. Macrophages are innate immune cells that sense and respond to infections by producing a plethora of inflammatory molecules and by interacting with other inflammatory cells. Therefore, macrophages may be diriment on eliminating pathogens and promoting organ repair. However, macrophages can be a major player of the so called cytokine storm and may be damaging to the tissues. It is believed that macrophage activation syndrome is induced by SARS-CoV to be lethal. Surprisingly and fortunately few children die from COVID-19. For instance, in Italy, out of more than 30.000 deaths for COVID-19, three are children. Therefore, we must wonder why? Are macrophages different in children compared to adults? In my opinion they are different. It has been demonstrated that macrophages populate the lung in three “developmental waves”, and it has been suggested that similar waves may be observed in other important organs, such as the heart and kidney. It is most likely that macrophages heterogeneity is involved in determining the severity. There are no doubts that macrophages are important in determining life or death in these patients. Comparing macrophages of children with those of adults with different degrees of disease severity is, therefore, mandatory.
    Keywords heterogeneidad de macrófagos ; Síndrome respiratorio agudo grave ; COVID-19 ; SARS-CoV-2 ; Coronavirus ; Macrophages heterogeneity ; covid19
    Publisher Science Direct
    Publishing country co
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Is macrophages heterogeneity important in determining COVID-19 lethality?

    Pagliaro, Pasquale

    Medical Hypotheses

    2020  Volume 143, Page(s) 110073

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110073
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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