Article ; Online: Epidemiology of VITT.
2022 Volume 59, Issue 2, Page(s) 72–75
Abstract: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening syndrome of aggressive thrombosis, often profound thrombocytopenia, and frequently overt disseminated intravascular coagulation. It has been associated with 2 adenovirus ... ...
Abstract | Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening syndrome of aggressive thrombosis, often profound thrombocytopenia, and frequently overt disseminated intravascular coagulation. It has been associated with 2 adenovirus vector COVID-19 vaccines: ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Janssen). Unlike the myriad of other conditions that cause thrombosis and thrombocytopenia, VITT has an important distinguishing feature: affected individuals have platelet activating anti-PF4 antibodies that appear in a predictable time frame following vaccination. The reported incidence of VITT differs between jurisdictions; it is dependent on accurate ascertainment of cases and accurate estimates of the size of the vaccinated population. The incidence ranges from 1 case per 26,500 to 127,3000 first doses of ChAdOx1 nCoV-19 administered. It is estimated at 1 case per 518,181 second doses of ChAdOx1 nCoV-19 administered, and 1 case per 263,000 Ad26.COV2.S doses administered. There are no clear risk factors for VITT, including sex, age, or comorbidities. VITT is a rare event, but its considerable morbidity and mortality merit ongoing pharmacovigilance, and accurate case ascertainment. |
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MeSH term(s) | Ad26COVS1/adverse effects ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19/adverse effects ; Humans ; Purpura, Thrombocytopenic, Idiopathic/chemically induced ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Thrombosis/chemically induced ; Thrombosis/epidemiology |
Chemical Substances | Ad26COVS1 (JT2NS6183B) ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) |
Language | English |
Publishing date | 2022-02-08 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 206923-4 |
ISSN | 1532-8686 ; 0037-1963 |
ISSN (online) | 1532-8686 |
ISSN | 0037-1963 |
DOI | 10.1053/j.seminhematol.2022.02.002 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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