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  1. Article ; Online: ASO Author Reflections: Adjuvant Therapy for Resectable Pancreatic Cancer in the Real World-Not as Common as One Might Think.

    Paiella, Salvatore / Malleo, Giuseppe / Casciani, Fabio / Salvia, Roberto

    Annals of surgical oncology

    2024  Volume 31, Issue 5, Page(s) 2959–2960

    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery ; Combined Modality Therapy
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15014-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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  2. Article ; Online: The Italian registry of families at risk for pancreatic cancer (IRFARPC): implementation and evolution of a national program for pancreatic cancer surveillance in high-risk individuals.

    Archibugi, Livia / Casciani, Fabio / Carrara, Silvia / Secchettin, Erica / Falconi, Massimo / Capurso, Gabriele / Paiella, Salvatore

    Familial cancer

    2024  

    Abstract: Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to reduce disease-specific lethality. Given the relatively low prevalence of the disease, the ideal target of ... ...

    Abstract Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to reduce disease-specific lethality. Given the relatively low prevalence of the disease, the ideal target of such approaches is an enriched cohort of individuals harboring a lifetime risk of developing PC significantly higher compared to the general population, given either a substantial aggregation of PC cases in their family (i.e. familial pancreatic cancer) or a genomic landscape enriched with pathogenic variants associated with pancreatic carcinogenesis (i.e. mutation carriers). In Italy, a national registry for the census and surveillance of high-risk individuals for PC was launched in 2015, enrolling some 1200 subjects as of today. In this perspective, the scientific background, multi-level structure, and evolution of IRFARPC are outlined, as well as its long-term results, future developments, and areas for improvement.
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-024-00366-3
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  3. Article: Screening for pancreatic cancer-a compelling challenge.

    Capurso, Gabriele / Paiella, Salvatore / Falconi, Massimo

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 2, Page(s) 264–266

    Language English
    Publishing date 2021-04-09
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-20-861
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  4. Article ; Online: Adjuvant Therapy After Upfront Resection of Resectable Pancreatic Cancer: Patterns of Omission and Use-A Prospective Real-Life Study.

    Paiella, Salvatore / Malleo, Giuseppe / Lionetto, Gabriella / Cattelani, Alice / Casciani, Fabio / Secchettin, Erica / De Pastena, Matteo / Bassi, Claudio / Salvia, Roberto

    Annals of surgical oncology

    2024  Volume 31, Issue 5, Page(s) 2892–2901

    Abstract: Background: Little is known about adjuvant therapy (AT) omission and use outside of randomized trials. We aimed to assess the patterns of AT omission and use in a cohort of upfront resected pancreatic cancer patients in a real-life scenario.: Methods!# ...

    Abstract Background: Little is known about adjuvant therapy (AT) omission and use outside of randomized trials. We aimed to assess the patterns of AT omission and use in a cohort of upfront resected pancreatic cancer patients in a real-life scenario.
    Methods: From January 2019 to July 2022, 317 patients with resected pancreatic cancer and operated upfront were prospectively enrolled in this prospective observational trial according to the previously calculated sample size. The association between perioperative variables and the risk of AT omission and AT delay was analyzed using multivariable logistic regression.
    Results: Eighty patients (25.2%) did not receive AT. The main reasons for AT omission were postoperative complications (38.8%), oncologist's choice (21.2%), baseline comorbidities (20%), patient's choice (10%), and early recurrence (10%). At the multivariable analysis, the odds of not receiving AT increased significantly for older patients (odds ratio [OR] 1.1, p < 0.001), those having an American Society of Anesthesiologists score ≥II (OR 2.03, p = 0.015), or developing postoperative pancreatic fistula (OR 2.5, p = 0.019). The likelihood of not receiving FOLFIRINOX as AT increased for older patients (OR 1.1, p < 0.001), in the presence of early-stage disease (stage I-IIa vs. IIb-III, OR 2.82, p =0.031; N0 vs. N+, OR 3, p = 0.03), and for patients who experienced postoperative major complications (OR 4.7, p = 0.009). A twofold increased likelihood of delay in AT was found in patients experiencing postoperative complications (OR 3.86, p = 0.011).
    Conclusions: AT is not delivered in about one-quarter of upfront resected pancreatic cancer patients. Age, comorbidities, and postoperative complications are the main drivers of AT omission and mFOLFIRINOX non-use.
    Clinicaltrials registration: NCT03788382.
    MeSH term(s) Humans ; Pancreatic Neoplasms/therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prospective Studies ; Neoadjuvant Therapy ; Postoperative Complications ; Chemotherapy, Adjuvant
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-14951-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: ASO Author Reflections: Preoperative Nutritional Care: The 'Cinderella' of Surgical Management in Patients with Pancreatic Cancer.

    Paiella, Salvatore / Trestini, Ilaria / Milella, Michele / Salvia, Roberto

    Annals of surgical oncology

    2020  Volume 27, Issue 13, Page(s) 5335–5336

    MeSH term(s) Humans ; Nutritional Support ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/therapy ; Preoperative Care
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08547-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Le terapie ablative delle neoplasie pancreatiche.

    Crinò, Stefano Francesco / Conti Bellocchi, Maria Cristina / Paiella, Salvatore / Gabbrielli, Armando

    Recenti progressi in medicina

    2021  Volume 112, Issue 1, Page(s) 75–80

    Abstract: The interest for pancreatic neoplasm ablation under endoscopic ultrasound (EUS) guidance has increased during the last decade because of technology advancement and availability of dedicated devices for thermal ablation. The most commonly used technique ... ...

    Title translation Ablative therapies of pancreatic neoplasms.
    Abstract The interest for pancreatic neoplasm ablation under endoscopic ultrasound (EUS) guidance has increased during the last decade because of technology advancement and availability of dedicated devices for thermal ablation. The most commonly used technique is radiofrequency ablation (RFA). Currently, three needle-electrodes and one "through-the-needle" probe are available. Published studies mainly demonstrated the feasibility and safety of the procedure. However, the role of EUS-RFA for the treatment of pancreatic ductal adenocarcinoma is not yet well defined. Randomized studies are needed to assess any advantage in terms of survival and quality of life when RFA is included in a multimodal treatment strategy compared with chemo(radio)therapy alone. In the setting of pancreatic neuroendocrine tumors (pNETs), published studies are consistent in demonstrating the efficacy of EUS-RFA in relieving symptoms related to hormone secretion by functioning pNETs. Moreover, EUS-RFA could find a role even in selected patients with small non-functioning pNETs when treatment is indicated but surgical resection would like to be avoided. Finally, EUS-RFA can be applied also for the treatment of pancreatic cystic neoplasm. However, patients should be carefully selected taking into account the low incidence of progression of cystic neoplasms towards malignancy and factors related to the patient, such as age, symptoms, comorbidity, and life expectancy.
    MeSH term(s) Carcinoma, Pancreatic Ductal/surgery ; Endosonography ; Humans ; Neuroectodermal Tumors, Primitive ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Quality of Life
    Language Italian
    Publishing date 2021-02-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3525.35127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 193: Show issues Location:
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  7. Article ; Online: The effect of early oral postoperative feeding on the recovery of intestinal motility after gastrointestinal surgery: Protocol for a systematic review and meta-analysis.

    Canzan, Federica / Caliaro, Arianna / Cavada, Maria Luisa / Mezzalira, Elisabetta / Paiella, Salvatore / Ambrosi, Elisa

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0273085

    Abstract: Background: Given the ever-shorter length of hospital stay after surgical procedures, nowadays it is more important than ever to study interventions that may have an impact on surgical patients' wellbeing. According to the ERAS (Enhanced Recovery After ... ...

    Abstract Background: Given the ever-shorter length of hospital stay after surgical procedures, nowadays it is more important than ever to study interventions that may have an impact on surgical patients' wellbeing. According to the ERAS (Enhanced Recovery After Surgery protocols) program, early feeding must be considered one of the key components to facilitate early recovery while improving outcomes and patients' overall experiences. To date, the international literature has reported that early postoperative feeding compared with traditional (or late) timing is safe; nevertheless, small clinical outcomes effects has been reported, also for recovery of gastrointestinal function. Therefore, the effectiveness of early postoperative feeding to reduce postoperative ileus duration remains still debated.
    Objective: To analyse the effects of early versus delayed oral feeding (liquids and food) on the recovery of intestinal motility after gastrointestinal surgery.
    Search methods: Pubmed, Embase, Cinahl, Cochrane Central Register of Controlled Trials (CENTRAL), and the ClincalTrials.gov register will be searched to identify the RCTs of interest.
    Study inclusion: Randomized clinical trials (RCTs) comparing the effect of early postoperative versus late oral feeding on major postoperative outcomes after gastrointestinal surgery will be included.
    Data collection and analysis: Two review authors will independently screen titles and abstracts to determine the initially selected studies' inclusion. Any disagreements will be resolved through discussion and consulting a third review author. The research team members will then proceed with the methodological evaluation of the studies and their eligibility for inclusion in the systematic review.
    MeSH term(s) Digestive System Surgical Procedures/adverse effects ; Gastrointestinal Motility ; Humans ; Ileus/etiology ; Ileus/prevention & control ; Meta-Analysis as Topic ; Postoperative Complications/prevention & control ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273085
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  8. Article: ERAS with or without supplemental artificial nutrition in open pancreatoduodenectomy for cancer. A multicenter, randomized, open labeled trial (RASTA study protocol).

    Gianotti, Luca / Paiella, Salvatore / Frigerio, Isabella / Pecorelli, Nicolò / Capretti, Giovanni / Sandini, Marta / Bernasconi, Davide Paolo

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1113723

    Abstract: Purpose: The role of supplemental artificial nutrition in patients perioperatively treated according to enhanced recovery programs (ERAS) on surgery-related morbidity is not known. Therefore, there is a need of a clinical trials specifically designed to ...

    Abstract Purpose: The role of supplemental artificial nutrition in patients perioperatively treated according to enhanced recovery programs (ERAS) on surgery-related morbidity is not known. Therefore, there is a need of a clinical trials specifically designed to explore whether given a full nutritional requirement by parenteral feeding after surgery coupled with oral food "at will" compared to oral food "at will" alone, within an established ERAS program, could achieve a reduction of the morbidity burden.
    Materials and analysis: RASTA will be a multicenter, randomized, parallel-arm, open labeled, superiority trial. The trial will be conducted in five Italian Institutions with proven experience in pancreatic surgery and already applying an established ERAS program. Adult patients (age ≥ 18 and < 90 years of age) candidate to elective open pancreatoduodenectomy (PD) for any periampullary or pancreatic cancer will be randomized to receive a full ERAS protocol that establishes oral food "at will" plus parenteral nutrition (PN) from postoperative day 1 to day 5 (treatment arm), or to ERAS protocol without PN (control arm). The primary endpoint of the trial is the complication burden within 90 days after the day of surgery. The complication burden will be assessed by the Comprehensive Complication Index, that incorporates all complications and their severity as defined by the Clavien-Dindo classification, and summarizes postoperative morbidity with a numerical scale ranging from 0 to 100. The H0 hypothesis tested is that he administration of a parenteral nutrition added to the ERAS protocol will not affect the CCI as compared to standard of care (ERAS). The H1 hypothesis is that the administration of a parenteral nutrition added to the ERAS protocol will positively affect the CCI as compared to standard of care (ERAS). The trial has been registered at ClinicalTrials.gov (number: NCT04438447; date: 18/05/2020).
    Conclusion: This upcoming trial will permit to establish if early postoperative artificial nutritional support after PD may improve postoperative outcomes compared to oral nutrition alone within an established ERAS program.
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1113723
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  9. Article: Unmet needs in preoperative biliary stenting for patient candidates for pancreaticoduodenectomy: a viewpoint.

    Paiella, Salvatore / De Pastena, Matteo / Salvia, Roberto

    Hepatobiliary surgery and nutrition

    2019  Volume 8, Issue 4, Page(s) 426–427

    Language English
    Publishing date 2019-08-22
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2019.02.07
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  10. Article ; Online: Reply to: Central pancreatectomy for benign or low-grade malignant pancreatic lesions - A single-center retrospective analysis of 116 cases.

    Paiella, Salvatore / De Pastena, Matteo / Salvia, Roberto

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2019  Volume 45, Issue 6, Page(s) 1125

    MeSH term(s) Humans ; Pancreas ; Pancreatectomy ; Pancreatic Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2019-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2019.02.004
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    Zs.MO 549: Show issues

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