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  1. Article: Exploring the bioaccessibility and intestinal absorption of major classes of pure phenolic compounds using

    Pais, Adriana C S / Coscueta, Ezequiel R / Pintado, Maria Manuela / Silvestre, Armando J D / Santos, Sónia A O

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28894

    Abstract: The bioaccessibility and bioavailability of phenolic compounds (PC) influence directly their role in disease prevention/control. Studies have evaluated this ability through complex plant and food matrices, which may reflect more a synergistic effect of ... ...

    Abstract The bioaccessibility and bioavailability of phenolic compounds (PC) influence directly their role in disease prevention/control. Studies have evaluated this ability through complex plant and food matrices, which may reflect more a synergistic effect of the matrix than the ability of the PCs, hindering their individual exploitation in nutraceutical or pharmaceutical applications. In the present study ten pure PCs representing major classes were evaluated for their bioaccessibility and intestinal absorption in an
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies.

    Santos, Sónia A O / Félix, Rafael / Pais, Adriana C S / Rocha, Sílvia M / Silvestre, Armando J D

    Biomolecules

    2019  Volume 9, Issue 12

    Abstract: The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly ... ...

    Abstract The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussed.
    MeSH term(s) Antioxidants/analysis ; Antioxidants/chemistry ; Chemical Fractionation/methods ; Chromatography, High Pressure Liquid/methods ; Hypoglycemic Agents/analysis ; Hypoglycemic Agents/chemistry ; Liquid-Liquid Extraction/methods ; Mass Spectrometry/methods ; Phenols/analysis ; Phenols/chemistry ; Phenols/isolation & purification ; Polysaccharides/analysis ; Polysaccharides/chemistry ; Seaweed/chemistry ; Solid Phase Extraction/methods ; Solvents ; Tannins/analysis ; Tannins/chemistry ; Tannins/isolation & purification
    Chemical Substances Antioxidants ; Hypoglycemic Agents ; Phenols ; Polysaccharides ; Solvents ; Tannins
    Language English
    Publishing date 2019-12-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom9120847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Current Research on the Bioprospection of Linear Diterpenes from

    Pais, Adriana C S / Saraiva, Jorge A / Rocha, Sílvia M / Silvestre, Armando J D / Santos, Sónia A O

    Marine drugs

    2019  Volume 17, Issue 10

    Abstract: Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown ... ...

    Abstract Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga
    MeSH term(s) Anti-Infective Agents/isolation & purification ; Antioxidants/isolation & purification ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Green Chemistry Technology/methods ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Structure ; Phaeophyceae/chemistry ; Plant Extracts/isolation & purification ; Seaweed/chemistry
    Chemical Substances Anti-Infective Agents ; Antioxidants ; Diterpenes ; Plant Extracts
    Language English
    Publishing date 2019-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17100556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Current Research on the Bioprospection of Linear Diterpenes from <i>Bifurcaria bifurcata</i>: From Extraction Methodologies to Possible Applications

    Pais, Adriana C.S / Saraiva, Jorge A / Rocha, Sílvia M / Silvestre, Armando J.D / Santos, Sónia A.O

    Marine drugs. 2019 Sept. 28, v. 17, no. 10

    2019  

    Abstract: Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga ... ...

    Abstract Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.
    Keywords Bifurcaria bifurcata ; bioactive compounds ; bioactive properties ; diterpenoids ; fractionation ; macroalgae ; marine resources
    Language English
    Dates of publication 2019-0928
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17100556
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Polar Lipids of Commercial

    Moreira, Ana S P / da Costa, Elisabete / Melo, Tânia / Lopes, Diana / Pais, Adriana C S / Santos, Sónia A O / Pitarma, Bárbara / Mendes, Madalena / Abreu, Maria H / Collén, Pi Nyvall / Domingues, Pedro / Domingues, M Rosário

    Foods (Basel, Switzerland)

    2021  Volume 10, Issue 5

    Abstract: Macroalgae of the ... ...

    Abstract Macroalgae of the genus
    Language English
    Publishing date 2021-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods10050914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High pressure extraction of bioactive diterpenes from the macroalgae

    Pais, Adriana C S / Pinto, Carlos A / Ramos, Patrícia A B / Pinto, Ricardo J B / Rosa, Daniela / Duarte, Maria F / Abreu, M Helena / Rocha, Silvia M / Saraiva, Jorge A / Silvestre, Armando J D / Santos, Sónia A O

    RSC advances

    2019  Volume 9, Issue 68, Page(s) 39893–39903

    Abstract: The brown ... ...

    Abstract The brown macroalgae
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/c9ra06547d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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