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  1. Article ; Online: Photodynamic therapy for treatment of bacterial keratitis.

    de Paiva, Alexandre de Carvalho Mendes / Ferreira, Michelle da Costa / da Fonseca, Adenilson de Souza

    Photodiagnosis and photodynamic therapy

    2022  Volume 37, Page(s) 102717

    Abstract: Microbial keratitis is the main cause of corneal opacification and the fourth leading cause of blindness worldwide, with bacteria the major infectious agent. Recently, bacterial keratitis has become a serious threat due to routine use of antibiotics ... ...

    Abstract Microbial keratitis is the main cause of corneal opacification and the fourth leading cause of blindness worldwide, with bacteria the major infectious agent. Recently, bacterial keratitis has become a serious threat due to routine use of antibiotics leading to selection of resistant and multidrug-resistant bacteria strains. New approaches for treatment of bacterial keratitis are necessary to outcome the increasing antibiotic resistance. Antimicrobial photodynamic therapy is based on three agents: photosensitizer, oxygen, and light radiation. This therapy has been successful for treatment of infections in different tissues and organs as well as against different type of infectious agents and no resistance development. Also, new photosensitizers are being developed that has increased the spectrum of therapeutic protocols for treatment of a number of infectious diseases. Thus, antimicrobial photodynamic therapy has an extraordinary potential for treatment of those bacterial keratitis cases that actually are not solved by traditional antibiotic therapy.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/microbiology ; Humans ; Keratitis/drug therapy ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Photosensitizing Agents
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2022.102717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Presumed endogenous fungal endophthalmitis in a patient with lymphopenia and confirmed SARS-CoV-2 infection.

    Carvalho, Erika Moreira / Santos, Nathalia Silva / Paiva, Alexandre de Carvalho Mendes / Teixeira, Fernando Henrique Flores / Biancardi, Ana Luiza / Curi, André Luiz Land

    Arquivos brasileiros de oftalmologia

    2023  Volume 86, Issue 2, Page(s) 190–191

    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Antifungal Agents/therapeutic use ; Endophthalmitis/microbiology ; Lymphopenia/complications ; Lymphopenia/drug therapy ; Eye Infections, Fungal/drug therapy
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-05-01
    Publishing country Brazil
    Document type Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.2022-0203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Different clinical manifestations of ocular sporotrichosis in the same patient: an alert to ophthalmologists in nonendemic areas.

    Paiva, Alexandre de Carvalho Mendes / Biancardi, Ana Luiza / Curi, André Luiz Land

    Arquivos brasileiros de oftalmologia

    2020  Volume 83, Issue 5, Page(s) 457–458

    MeSH term(s) Antifungal Agents/therapeutic use ; Humans ; Ophthalmologists ; Sporotrichosis/diagnosis ; Sporotrichosis/drug therapy
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2020-10-20
    Publishing country Brazil
    Document type Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.20200107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An atypical early-onset X-linked retinoschisis mimicking uveitis masquerade syndrome.

    Paiva, Alexandre de Carvalho Mendes / Teixeira, Fernando Henrique Flores / Carvalho, Erika Moreira / Santos, Nathalia Silva / Biancardi, Ana Luiza / Curi, André Luiz Land

    Arquivos brasileiros de oftalmologia

    2022  Volume 85, Issue 3, Page(s) 322–323

    MeSH term(s) Eye Neoplasms ; Humans ; Retinoschisis/diagnostic imaging ; Retinoschisis/genetics ; Uveitis ; Vision Disorders
    Language English
    Publishing date 2022-06-22
    Publishing country Brazil
    Document type Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.202200103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An unusual case of presumed cytomegalovirus: retinitis in a non-HIV patient treated for IgG 4-related disease.

    Teixeira, Fernando Henrique Flores / Paiva, Alexandre de Carvalho Mendes / Carvalho, Erika Moreira / Santos, Nathalia Silva / Biancardi, Ana Luiza / Curi, André Luiz Land

    Arquivos brasileiros de oftalmologia

    2022  Volume 85, Issue 5, Page(s) 543–544

    MeSH term(s) Antiviral Agents/therapeutic use ; Cytomegalovirus ; Humans ; Immunoglobulin G/therapeutic use ; Retinitis
    Chemical Substances Antiviral Agents ; Immunoglobulin G
    Language English
    Publishing date 2022-09-10
    Publishing country Brazil
    Document type Case Reports ; Letter
    ZDB-ID 603915-7
    ISSN 1678-2925 ; 0004-2749
    ISSN (online) 1678-2925
    ISSN 0004-2749
    DOI 10.5935/0004-2749.2022-0230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Could adverse effects and complications of selective laser trabeculoplasty be decreased by low-power laser therapy?

    Paiva, Alexandre de Carvalho Mendes / da Fonseca, Adenilson de Souza

    International ophthalmology

    2017  Volume 39, Issue 1, Page(s) 243–257

    Abstract: Selective laser trabeculoplasty (SLT) has been used for treatment of primary open-angle glaucoma, ocular hypertension, pigmenter and pseudoexfoliative glaucoma being considered a low-risk procedure. Therefore, transitory and permanent adverse effects ... ...

    Abstract Selective laser trabeculoplasty (SLT) has been used for treatment of primary open-angle glaucoma, ocular hypertension, pigmenter and pseudoexfoliative glaucoma being considered a low-risk procedure. Therefore, transitory and permanent adverse effects have been reported, including corneal changes, subclinical edema, and reduction in endothelial cells and in central corneal thickness. Despite rarer, serious corneal complications after SLT can be permanent and lead to visual impairment, central corneal haze, opacity and narrowing. The mechanism involves increase of vasoactive and chemotactic cytokines causing inflammatory infiltrate, destruction of stromal collagen by fibroblasts and increase of matrix metalloproteinases type 2, which impair reepithelization. SLT also increases free radical production and reduces antioxidant enzymes, resulting in endothelium damages. Low-power laser therapy (LPLT) has been used in regenerative medicine based on its biostimulatory and anti-inflammatory effects. Biostimulation occurs through the interaction of laser photons with cytochrome C oxidase enzyme, which activates intracellular biochemical cascades causing synthesis of a number of molecules related to anti-inflammatory, regenerative effects, pain relief and reduction in edema. It has been showed that LPLT reduces gene expression related to pro-inflammatory cytokines and matrix metalloproteinases, and it increases expression of growth factors related to its proliferative and healing actions. Although radiations emitted by low-power lasers are considered safe and able to induce therapeutic effects, researches based on experimental models for glaucoma could bring important data if LPLT could be an alternative approach to improve acceptation for patients undergoing SLT.
    MeSH term(s) Glaucoma/physiopathology ; Glaucoma/rehabilitation ; Glaucoma/surgery ; Humans ; Intraocular Pressure ; Laser Therapy/adverse effects ; Lasers, Solid-State/adverse effects ; Lasers, Solid-State/therapeutic use ; Low-Level Light Therapy/methods ; Postoperative Complications/prevention & control ; Trabeculectomy/adverse effects ; Trabeculectomy/methods
    Language English
    Publishing date 2017-11-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-017-0775-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A case of Bartonella neuroretinitis with macular star diagnosed by clinical, epidemiological, serological, and molecular data: resolution after initiation of antimicrobial therapy.

    Eyer-Silva, Walter de Araujo / Wutke, Letícia Stéfanie Curvello / Paiva, Alexandre de Carvalho Mendes / Silva, Guilherme Almeida Rosa da / Ferry, Fernando Raphael de Almeida / Signorini, Dario José Hart Pontes / Oliveira, Jonathan Gonçalves de / Lemos, Elba Regina Sampaio

    Revista da Sociedade Brasileira de Medicina Tropical

    2020  Volume 53, Page(s) e20190516

    Abstract: The differential diagnosis of optic neuritis is broad and varied. We report the case of a 24-year-old Brazilian man who presented with five-week history of fever, malaise, myalgia, severe fatigue, tender right preauricular lymphadenopathy, and acute ... ...

    Abstract The differential diagnosis of optic neuritis is broad and varied. We report the case of a 24-year-old Brazilian man who presented with five-week history of fever, malaise, myalgia, severe fatigue, tender right preauricular lymphadenopathy, and acute vision blurring associated with right optic disc swelling and exudates in a macular star pattern. His illness developed soon after an infestation of fleas broke out among his cats. Diagnosis of ocular bartonellosis was confirmed by serological and molecular analyses targeting amplification of Bartonella spp. htrA gene. Signs and symptoms only improved after initiation of antimicrobial therapy.
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Bartonella henselae/isolation & purification ; Cats ; Doxycycline/therapeutic use ; Humans ; Male ; Retinitis/diagnosis ; Retinitis/drug therapy ; Retinitis/microbiology ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2020-06-22
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0516-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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