LIVIVO - Search results -

Search results

Result 1 - 10 of total 15

Search options

Article ; Online: c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis.

Pal, Aditya Kumar / Ghosh, Anirban

2022 Volume 12, Issue 1, Page(s) 13127

Abstract: In this study, we probe the role of secondary messenger c-di-AMP in drug tolerance, which includes both persister and resistant mutant characterization of Mycobacterium smegmatis. Specifically, with the use of c-di-AMP null and overproducing mutants, we ... ...

Abstract	In this study, we probe the role of secondary messenger c-di-AMP in drug tolerance, which includes both persister and resistant mutant characterization of Mycobacterium smegmatis. Specifically, with the use of c-di-AMP null and overproducing mutants, we showed how c-di-AMP plays a significant role in resistance mutagenesis against antibiotics with different mechanisms of action. We elucidated the specific molecular mechanism linking the elevated intracellular c-di-AMP level and high mutant generation and highlighted the significance of non-homology-based DNA repair. Further investigation enabled us to identify the unique mutational landscape of target and non-target mutation categories linked to intracellular c-di-AMP levels. Overall fitness cost of unique target mutations was estimated in different strain backgrounds, and then we showed the critical role of c-di-AMP in driving epistatic interactions between resistance genes, resulting in the evolution of multi-drug tolerance. Finally, we identified the role of c-di-AMP in persister cells regrowth and mutant enrichment upon cessation of antibiotic treatment.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Dinucleoside Phosphates ; Drug Tolerance ; Mycobacterium smegmatis/genetics ; Phenotype
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Dinucleoside Phosphates ; cyclic diadenosine phosphate
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-17051-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Author Correction: c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis.

Pal, Aditya Kumar / Ghosh, Anirban

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16216

Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20905-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Elucidating the role of c-di-AMP in

Chaudhary, Vikas / Pal, Aditya Kumar / Singla, Mamta / Ghosh, Anirban

Heliyon

2023 Volume 9, Issue 5, Page(s) e15686

Abstract: Cyclic-di-AMP (c-di-AMP) is an important secondary messenger molecule that plays a critical role in monitoring several important cellular processes, especially in several Gram-positive bacteria. In this study, we seek to unravel the physiological ... ...

Abstract	Cyclic-di-AMP (c-di-AMP) is an important secondary messenger molecule that plays a critical role in monitoring several important cellular processes, especially in several Gram-positive bacteria. In this study, we seek to unravel the physiological significance of the molecule c-di-AMP in
Language	English
Publishing date	2023-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15686
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Intra-protein interactions of SARS-CoV-2 and SARS: a bioinformatic analysis for plausible explanation regarding stability, divergency, and severity.

Mitra, Debanjan / Pal, Aditya K / Das Mohapatra, Pradeep Kr

Systems microbiology and biomanufacturing

2022 Volume 2, Issue 4, Page(s) 653–664

Abstract: The current nightmare for the whole world is COVID-19. The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province of China, was first reported on December 30, 2019. SARS-CoV first disclosed in 2002 but had not outspread worldwide. After ...

Abstract	The current nightmare for the whole world is COVID-19. The occurrence of concentrated pneumonia cases in Wuhan city, Hubei province of China, was first reported on December 30, 2019. SARS-CoV first disclosed in 2002 but had not outspread worldwide. After 18 years, in 2020, it reemerged and outspread worldwide as SARS-CoV-2 (COVID-19), as the most dangerous virus-creating disease in the world. Is it possible to create a favorable evolution within the short time (18 years)? If possible, then what are those properties or factors that are changed in SARS-CoV-2 to make it undefeated? What are the fundamental differences between SARS-CoV-2 and SARS? The study is one of the initiatives to find out all those queries. Here, four types of protein sequences from SARS-CoV-2 and SARS were retrieved from the database to study their physicochemical and structural properties. Results showed that charged residues are playing a pivotal role in SARS-CoV-2 evolution and contribute to the helix stabilization. The formation of the cyclic salt bridge and other intra-protein interactions specially network aromatic-aromatic interaction also play the crucial role in SAS-CoV-2. This comparative study will help to understand the evolution from SARS to SARS-CoV-2 and helpful in protein engineering.
Language	English
Publishing date	2022-03-21
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	3033857-8
ISSN	2662-7663 ; 2662-7655
ISSN (online)	2662-7663
ISSN	2662-7655
DOI	10.1007/s43393-022-00091-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Elucidating the role of c-di-AMP in Mycobacterium smegmatis: Phenotypic characterization and functional analysis

Chaudhary, Vikas / Pal, Aditya Kumar / Singla, Mamta / Ghosh, Anirban

Heliyon. 2023 May, v. 9, no. 5 p.e15686-

2023

Abstract	Cyclic-di-AMP (c-di-AMP) is an important secondary messenger molecule that plays a critical role in monitoring several important cellular processes, especially in several Gram-positive bacteria. In this study, we seek to unravel the physiological significance of the molecule c-di-AMP in Mycobacterium smegmatis under different conditions, using strains with altered c-di-AMP levels: c-di-AMP null mutant (ΔdisA) and a c-di-AMP over-expression mutant (Δpde). Our thorough analysis of the mutants revealed that the intracellular concentration of c-di-AMP could determine many basic phenotypes such as colony architecture, cell shape, cell size, membrane permeability etc. Additionally, it was shown to play a significant role in multiple stress adaptation pathways in the case of different DNA and membrane stresses. Our study also revealed how the biofilm phenotypes of M. smegmatis cells are altered with high intracellular c-di-AMP concentration. Next, we checked how c-di-AMP contributes to antibiotic resistance or susceptibility characteristics of M. smegmatis, which was followed by a detailed transcriptome profile analysis to reveal key genes and pathways such as translation, arginine biosynthesis, cell wall and plasma membrane are regulated by c-di-AMP in mycobacteria.
Keywords	DNA ; Mycobacterium smegmatis ; antibiotic resistance ; arginine ; biofilm ; biosynthesis ; cell walls ; membrane permeability ; mutants ; phenotype ; plasma membrane ; second messengers ; transcriptome ; Second messenger ; c-di-AMP ; Stress response ; Antibiotics ; Phenotypic microarray ; RNA-Seq ; DisA ; Pde ; CFU ; WT ; MIC ; PM ; RNA-seq
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15686
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Sub-operon promoter arrangement of

Singla, Mamta / Pal, Aditya Kumar / Chaudhary, Vikas / Behra, Phani Rama Krishna / Ghosh, Anirban

Journal of biosciences

2023 Volume 48

Abstract: Bacterial second messenger signaling often plays an important role in cellular physiology. In this study, we have attempted to understand how c-di-AMP synthesis and degradation are transcriptionally regulated ... ...

Abstract	Bacterial second messenger signaling often plays an important role in cellular physiology. In this study, we have attempted to understand how c-di-AMP synthesis and degradation are transcriptionally regulated in
MeSH term(s)	Mycobacterium smegmatis/genetics ; Mycobacterium smegmatis/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Homeostasis/genetics ; Operon/genetics ; Gene Expression Regulation, Bacterial
Chemical Substances	cyclic diadenosine phosphate ; Bacterial Proteins
Language	English
Publishing date	2023-07-13
Publishing country	India
Document type	Journal Article
ZDB-ID	756157-x
ISSN	0973-7138 ; 0250-5991
ISSN (online)	0973-7138
ISSN	0250-5991
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Anubhuti -- An annotated dataset for emotional analysis of Bengali short stories

Pal, Aditya / Karn, Bhaskar

2020

Abstract: Thousands of short stories and articles are being written in many different languages all around the world today. Bengali, or Bangla, is the second highest spoken language in India after Hindi and is the national language of the country of Bangladesh. ... ...

Abstract	Thousands of short stories and articles are being written in many different languages all around the world today. Bengali, or Bangla, is the second highest spoken language in India after Hindi and is the national language of the country of Bangladesh. This work reports in detail the creation of Anubhuti -- the first and largest text corpus for analyzing emotions expressed by writers of Bengali short stories. We explain the data collection methods, the manual annotation process and the resulting high inter-annotator agreement of the dataset due to the linguistic expertise of the annotators and the clear methodology of labelling followed. We also address some of the challenges faced in the collection of raw data and annotation process of a low resource language like Bengali. We have verified the performance of our dataset with baseline Machine Learning as well as a Deep Learning model for emotion classification and have found that these standard models have a high accuracy and relevant feature selection on Anubhuti. In addition, we also explain how this dataset can be of interest to linguists and data analysts to study the flow of emotions as expressed by writers of Bengali literature. Comment: 4 pages, 6 figures
Keywords	Computer Science - Computation and Language
Subject code	410
Publishing date	2020-10-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Vartani Spellcheck -- Automatic Context-Sensitive Spelling Correction of OCR-generated Hindi Text Using BERT and Levenshtein Distance

Pal, Aditya / Mustafi, Abhijit

2020

Abstract: Traditional Optical Character Recognition (OCR) systems that generate text of highly inflectional Indic languages like Hindi tend to suffer from poor accuracy due to a wide alphabet set, compound characters and difficulty in segmenting characters in a ... ...

Abstract	Traditional Optical Character Recognition (OCR) systems that generate text of highly inflectional Indic languages like Hindi tend to suffer from poor accuracy due to a wide alphabet set, compound characters and difficulty in segmenting characters in a word. Automatic spelling error detection and context-sensitive error correction can be used to improve accuracy by post-processing the text generated by these OCR systems. A majority of previously developed language models for error correction of Hindi spelling have been context-free. In this paper, we present Vartani Spellcheck - a context-sensitive approach for spelling correction of Hindi text using a state-of-the-art transformer - BERT in conjunction with the Levenshtein distance algorithm, popularly known as Edit Distance. We use a lookup dictionary and context-based named entity recognition (NER) for detection of possible spelling errors in the text. Our proposed technique has been tested on a large corpus of text generated by the widely used Tesseract OCR on the Hindi epic Ramayana. With an accuracy of 81%, the results show a significant improvement over some of the previously established context-sensitive error correction mechanisms for Hindi. We also explain how Vartani Spellcheck may be used for on-the-fly autocorrect suggestion during continuous typing in a text editor environment. Comment: 5 pages, 3 figures
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
Subject code	006
Publishing date	2020-12-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: C

Bag, Kingshuk / Pal, Aditya Kumar / Basu, Subhadip / Singla, Mamta / Sarkar, Biplab / Chatterji, Dipankar / Maiti, Prabal Kumar / Ghosh, Anirban / Jayaraman, Narayanaswamy

ACS omega

2023 Volume 8, Issue 23, Page(s) 20513–20523

Abstract: Hyperphosphorylated nucleotide (p)ppGpp, synthesized by Rel protein, regulates the stringent response pathway responsible for biofilm and persister cell growth in mycobacteria. The discovery of vitamin C as an inhibitor of Rel protein activities raises ... ...

Abstract	Hyperphosphorylated nucleotide (p)ppGpp, synthesized by Rel protein, regulates the stringent response pathway responsible for biofilm and persister cell growth in mycobacteria. The discovery of vitamin C as an inhibitor of Rel protein activities raises the prospect of tetrone lactones to prevent such pathways. The closely related isotetrone lactone derivatives are identified herein as inhibitors of the above processes in a mycobacterium. Synthesis and biochemical evaluations show that an isotetrone possessing phenyl substituent at
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00822
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: PinnerSage

Pal, Aditya / Eksombatchai, Chantat / Zhou, Yitong / Zhao, Bo / Rosenberg, Charles / Leskovec, Jure

Multi-Modal User Embedding Framework for Recommendations at Pinterest

2020

Abstract: Latent user representations are widely adopted in the tech industry for powering personalized recommender systems. Most prior work infers a single high dimensional embedding to represent a user, which is a good starting point but falls short in ... ...

Abstract	Latent user representations are widely adopted in the tech industry for powering personalized recommender systems. Most prior work infers a single high dimensional embedding to represent a user, which is a good starting point but falls short in delivering a full understanding of the user's interests. In this work, we introduce PinnerSage, an end-to-end recommender system that represents each user via multi-modal embeddings and leverages this rich representation of users to provides high quality personalized recommendations. PinnerSage achieves this by clustering users' actions into conceptually coherent clusters with the help of a hierarchical clustering method (Ward) and summarizes the clusters via representative pins (Medoids) for efficiency and interpretability. PinnerSage is deployed in production at Pinterest and we outline the several design decisions that makes it run seamlessly at a very large scale. We conduct several offline and online A/B experiments to show that our method significantly outperforms single embedding methods. Comment: 10 pages, 7 figures
Keywords	Computer Science - Machine Learning ; Computer Science - Information Retrieval ; Computer Science - Social and Information Networks ; Statistics - Machine Learning
Subject code	004
Publishing date	2020-07-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Your last searches

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED