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  1. Article ; Online: Polymeric Gel Scaffolds and Biomimetic Environments for Wound Healing.

    Alka / Verma, Abhishek / Mishra, Nidhi / Singh, Neelu / Singh, Priya / Nisha, Raquibun / Pal, Ravi Raj / Saraf, Shubhini A

    Current pharmaceutical design

    2024  Volume 29, Issue 40, Page(s) 3221–3239

    Abstract: Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed. Effective wound care becomes a bigger ... ...

    Abstract Infected wounds that do not heal are a worldwide problem that is worsening, with more people dying and more money being spent on care. For any disease to be managed effectively, its root cause must be addressed. Effective wound care becomes a bigger problem when various traditional wound healing methods and products may not only fail to promote good healing. Still, it may also hinder the healing process, causing wounds to stay open longer. Progress in tissue regeneration has led to developing three-dimensional scaffolds (3D) or constructs that can be leveraged to facilitate cell growth and regeneration while preventing infection and accelerating wound healing. Tissue regeneration uses natural and fabricated biomaterials that encourage the growth of tissues or organs. Even though the clinical need is urgent, the demand for polymer-based therapeutic techniques for skin tissue abnormalities has grown quickly. Hydrogel scaffolds have become one of the most imperative 3D cross-linked scaffolds for tissue regeneration because they can hold water perfectly and are porous, biocompatible, biodegradable, and biomimetic. For damaged organs or tissues to heal well, the porosity topography of the natural extracellular matrix (ECM) should be imitated. This review details the scaffolds that heal wounds and helps skin tissue to develop. After a brief overview of the bioactive and drug-loaded polymeric hydrogels, the discussion moves on to how the scaffolds are made and what they are made of. It highlights the present uses of
    MeSH term(s) Humans ; Tissue Scaffolds ; Biomimetics ; Wound Healing ; Polymers/pharmacology ; Hydrogels/pharmacology
    Chemical Substances Polymers ; Hydrogels
    Language English
    Publishing date 2024-04-19
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612829666230816100631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis.

    Pal, Ravi Raj / Rajpal, Vasundhara / Singh, Priya / Saraf, Shubhini A

    Pharmaceutics

    2021  Volume 13, Issue 6

    Abstract: Cancer causes a considerable amount of mortality in the world, while arthritis is an immunological dysregulation with multifactorial pathogenesis including genetic and environmental defects. Both conditions have inflammation as a part of their ... ...

    Abstract Cancer causes a considerable amount of mortality in the world, while arthritis is an immunological dysregulation with multifactorial pathogenesis including genetic and environmental defects. Both conditions have inflammation as a part of their pathogenesis. Resistance to anticancer and disease-modifying antirheumatic drugs (DMARDs) happens frequently through the generation of energy-dependent transporters, which lead to the expulsion of cellular drug contents. Thymoquinone (TQ) is a bioactive molecule with anticancer as well as anti-inflammatory activities via the downregulation of several chemokines and cytokines. Nevertheless, the pharmacological importance and therapeutic feasibility of thymoquinone are underutilized due to intrinsic pharmacokinetics, including short half-life, inadequate biological stability, poor aqueous solubility, and low bioavailability. Owing to these pharmacokinetic limitations of TQ, nanoformulations have gained remarkable attention in recent years. Therefore, this compilation intends to critically analyze recent advancements in rheumatoid arthritis and cancer delivery of TQ. This literature search revealed that nanocarriers exhibit potential results in achieving targetability, maximizing drug internalization, as well as enhancing the anti-inflammatory and anticancer efficacy of TQ. Additionally, TQ-NPs (thymoquinone nanoparticles) as a therapeutic payload modulated autophagy as well as enhanced the potential of other drugs when given in combination. Moreover, nanoformulations improved pharmacokinetics, drug deposition, using EPR (enhanced permeability and retention) and receptor-mediated delivery, and enhanced anti-inflammatory and anticancer properties. TQ's potential to reduce metal toxicity, its clinical trials and patents have also been discussed.
    Language English
    Publishing date 2021-05-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics13060775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis of flaxseed gum/melanin-based scaffold: A novel approach for nano-encapsulation of doxorubicin with enhanced anticancer activity.

    Kumar, Deepak / Pal, Ravi Raj / Das, Neeladri / Roy, Partha / Saraf, Shubhini A / Bayram, Sinan / Kundu, Patit P

    International journal of biological macromolecules

    2023  Volume 256, Issue Pt 2, Page(s) 127964

    Abstract: Doxorubicin is a powerful chemotherapy medicine that is frequently used to treat cancer, but because of its extremely destructive side effects on other healthy cells, its applications have been severely constrained. With the aim of using lower ... ...

    Abstract Doxorubicin is a powerful chemotherapy medicine that is frequently used to treat cancer, but because of its extremely destructive side effects on other healthy cells, its applications have been severely constrained. With the aim of using lower therapeutic doses of doxorubicin while maintaining the same anti-cancerous activity as those of higher doses, the present study designs nano-encapsulation of doxorubicin by acrylamide grafted melanin as core and acrylic acid grafted flax seed gum as shell (DOX@AAM-g-ML/AA-g-FSG-NPs) for studies in-vivo and in-vitro anticancer activity. For biological studies, the cytotoxicity of DOX@AAM-g-ML/AA-g-FSG-NPs was examined on a cancerous human cell line (HCT-15) and it was observed that DOX@AAM-g-ML/AA-g-FSG-NPs exhibited very high toxicity towards HCT-15. In-vivo investigation in colon cancer-inflicted rat model also showed that DOX@AAM-g-ML/AA-g-FSG-NPs showed better anticancer activity against cancerous cells as compared to free doxorubicin. The drug release behavior of DOX@GML-GFS-NPs was studied at several pH and maximum drug release (95 %) was recorded at pH -7.2, and kinetic data of drug release was follows the Higuchi (R
    MeSH term(s) Rats ; Humans ; Animals ; Flax ; Melanins ; Nanoparticles/therapeutic use ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Neoplasms/drug therapy ; Acrylamides ; Drug Carriers ; Drug Delivery Systems ; Acrylates
    Chemical Substances acrylic acid (J94PBK7X8S) ; Melanins ; Doxorubicin (80168379AG) ; Acrylamides ; Drug Carriers ; Acrylates
    Language English
    Publishing date 2023-11-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127964
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  4. Article ; Online: Transporter targeted-carnitine modified pectin-chitosan nanoparticles for inositol hexaphosphate delivery to the colon: An in silico and in vitro approach.

    Mishra, Nidhi / Sharma, Madhu / Mishra, Pooja / Nisha, Raquibun / Singh, Priya / Pal, Ravi Raj / Singh, Neelu / Singh, Samipta / Maurya, Priyanka / Pant, Suyash / Mishra, Prabhat Ranjan / Saraf, Shubhini A

    International journal of biological macromolecules

    2024  Volume 263, Issue Pt 2, Page(s) 130517

    Abstract: Orally targeted delivery systems have attracted ample interest in colorectal cancer management. In this investigation, we developed Inositol hexaphosphate (IHP) loaded Tripolyphosphate (Tr) crosslinked Pectin (Pe) Chitosan (Ch) nanoparticles (IHP@Tr*Pe- ... ...

    Abstract Orally targeted delivery systems have attracted ample interest in colorectal cancer management. In this investigation, we developed Inositol hexaphosphate (IHP) loaded Tripolyphosphate (Tr) crosslinked Pectin (Pe) Chitosan (Ch) nanoparticles (IHP@Tr*Pe-Ch-NPs) and modified them with l-Carnitine (CE) (CE-IHP@Tr*Pe-Ch-NPs) to improve uptake in colon cells. The formulated CE-IHP@Tr*Pe-Ch-NPs displayed a monodisperse distribution with 219.3 ± 5.5 nm diameter and 30.17 mV surface charge. Cell-line studies revealed that CE-IHP@Tr*Pe-Ch-NPs exhibited excellent biocompatibility in J774.2 and decreased cell viability in DLD-1, HT-29, and MCF7 cell lines. More cell internalization was seen in HT-29 and MCF7 due to overexpression of the OCTN2 and ATB
    MeSH term(s) Humans ; Phytic Acid ; Chitosan ; Pectins/pharmacology ; Carnitine ; MCF-7 Cells ; Nanoparticles ; Colon ; Drug Carriers
    Chemical Substances Phytic Acid (7IGF0S7R8I) ; Chitosan (9012-76-4) ; Pectins (89NA02M4RX) ; Carnitine (S7UI8SM58A) ; Drug Carriers
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130517
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  5. Article ; Online: QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer.

    Singh, Priya / Alka / Maurya, Priyanka / Nisha, Raquibun / Singh, Neelu / Parashar, Poonam / Mishra, Nidhi / Pal, Ravi Raj / Saraf, Shubhini A

    Journal of liposome research

    2022  Volume 33, Issue 2, Page(s) 154–169

    Abstract: Some breast cancers are caused by hormonal imbalances, such as estrogen and progesterone. These hormones play a function in directing the growth of cancer cells. The hormone receptors in hormone receptor-positive breast cancer lead breast cells to ... ...

    Abstract Some breast cancers are caused by hormonal imbalances, such as estrogen and progesterone. These hormones play a function in directing the growth of cancer cells. The hormone receptors in hormone receptor-positive breast cancer lead breast cells to proliferate out of control. Cancer therapy such as hormonal, targeted, radiation is still unsatisfactory because of these challenges namely multiple drug resistance (MDR), off-targeting, severe adverse effects. A novel aromatase inhibitor exemestane (Exe) exhibits promising therapy in breast cancer. This study aims to develop and optimize Exe-loaded lipid nanocapsules (LNCs) by using DSPC, PF68 and olive oil as lipid, surfactant and oil phase, respectively and to characterize the same. The prepared nanocapsules were investigated via
    MeSH term(s) Animals ; Nanocapsules ; Liposomes ; Androstadienes/pharmacology ; Androstadienes/therapeutic use ; Lipids ; Neoplasms/drug therapy
    Chemical Substances Nanocapsules ; exemestane (NY22HMQ4BX) ; Liposomes ; Androstadienes ; Lipids
    Language English
    Publishing date 2022-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 645173-1
    ISSN 1532-2394 ; 0898-2104
    ISSN (online) 1532-2394
    ISSN 0898-2104
    DOI 10.1080/08982104.2022.2108441
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  6. Article ; Online: Functionalized bosutinib liposomes for target specific delivery in management of estrogen-positive cancer.

    Singh, Priya / Singh, Neelu / Mishra, Nidhi / Nisha, Raquibun / Alka / Maurya, Priyanka / Pal, Ravi Raj / Singh, Samipta / Saraf, Shubhini A

    Colloids and surfaces. B, Biointerfaces

    2022  Volume 218, Page(s) 112763

    Abstract: This study was designed to create surface-functionalized bosutinib liposomes that could be used for the management of estrogen-positive cancers. The novelty of this work was the anti-cancer activity of bosutinib-loaded liposomes (Bos-LPs) in estrogen- ... ...

    Abstract This study was designed to create surface-functionalized bosutinib liposomes that could be used for the management of estrogen-positive cancers. The novelty of this work was the anti-cancer activity of bosutinib-loaded liposomes (Bos-LPs) in estrogen-positive cancer via estrogen response elements, responsible for the malignancy of cancer cells. Biotin effectively delivers active moiety to tumor tissues because it interacts with the biotin receptor and operates through the Sodium-dependent multivitamin transporters (SMVT) transporter. The prepared liposomes had a 257.73 ± 4.50 nm particle size, - 28.07 ± 5.81 mV zeta potential, 87.78 ± 1.16 % encapsulation efficiency and 85.56 ± 0.95 % drug release for 48 h. The surface architecture of biotin-modified bosutinib-loaded liposomes (b-Bos-LPs) was confirmed using scanning electron and transmission electron microscopies. In-vitro experiments revealed that b-Bos-LPs outperformed Bos and Bos-LPs in terms of significantly reduced cell viability in MCF-7 cells. According to biodistribution and pharmacokinetic studies, b-Bos-LPs have a higher Bos concentration in tumor tissues as compared to the other organs and also possess better pharmacokinetic activity, indicating that they can be used to treat carcinogen-induced estrogen-positive cancers. This is the first study to show that b-Bos-LPs can display activity against estrogen-positive cancer via biotin targeting. As evidenced by various parameters, b-Bos-LPs showed improved anticancer targeting, therapeutic safety and efficacy in carcinogen-induced estrogen-positive cancer. The receptor protein estrogen, which is primarily responsible for this cancer was downregulated by b-Bos-LPs in an immunoblotting assay. The results showed that biotinylated distearoylphosphatidylcholine (DSPC) augmented LPs loaded with Bosutinib can cause apoptosis in estrogen-positive breast cancer and be an effective way to treat estrogen-positive cancer.
    MeSH term(s) Aniline Compounds/therapeutic use ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Delivery Systems ; Estrogens/metabolism ; Female ; Humans ; Liposomes ; Nitriles/therapeutic use ; Particle Size ; Quinolines/therapeutic use
    Chemical Substances Aniline Compounds ; Estrogens ; Liposomes ; Nitriles ; Quinolines ; bosutinib (5018V4AEZ0)
    Language English
    Publishing date 2022-08-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2022.112763
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  7. Article ; Online: Downregulation of pro-inflammatory markers IL-6 and TNF-α in rheumatoid arthritis using nano-lipidic carriers of a quinone-based phenolic: an in vitro and in vivo study.

    Pal, Ravi Raj / Rajpal, Vasundhara / Singh, Neelu / Singh, Sukhveer / Mishra, Nidhi / Singh, Priya / Maurya, Priyanka / Alka / Saraf, Shubhini A

    Drug delivery and translational research

    2022  Volume 13, Issue 2, Page(s) 627–641

    Abstract: Rheumatoid arthritis (RA) is a joint ailment with multi-factorial immune-mediated degenerative pathogenesis, including genetic and environmental defects. Resistance to disease-modifying anti-rheumatic drugs (DMARDs) happens due to excessive drug efflux ... ...

    Abstract Rheumatoid arthritis (RA) is a joint ailment with multi-factorial immune-mediated degenerative pathogenesis, including genetic and environmental defects. Resistance to disease-modifying anti-rheumatic drugs (DMARDs) happens due to excessive drug efflux over time, rendering the concentration insufficient to elicit a response. Thymoquinone (TQ) is a quinone-based phenolic compound with antioxidant and anti-inflammatory activities that downregulate numerous pro-inflammatory cytokines. However, its pharmaceutical importance and therapeutic utility are underexplored due to intrinsic physicochemical characteristics such as inadequate biological stability, short half-life, low hydrophilicity, and less systemic availability. Tamanu oil-stabilised nanostructured lipid carriers (TQ-NLCs) were prepared and optimised using Box-Behnken design (BBD) with the size of 153.9 ± 0.52 nm and surface charge of -30.71 mV. The % entrapment efficiency and drug content were found to be 84.6 ± 0.50% and 14.75 ± 0.52%, respectively. Furthermore, the TQ-loaded NLCs (TQ-NLCs) assayed for skin permeation for transdermal delivery which significantly (p < 0.05) increased skin enhancement ratio 14.6 times compared to the aqueous solution of TQ. Tamanu oil displayed the synergistic anti-inflammatory potential with TQ in comparison to pure TQ, as evidenced against carrageenan (CRG)-induced paw oedema model and Freund's adjuvant-induced arthritic model. The arthritic and X-ray scores significantly (p < 0.05) reduced in TQ-NLCs and standard formulation-treated groups. Moreover, serum pro-inflammatory marker TNF-α and IL-6 levels were also significantly (p < 0.05) reduced in TQ-NLCs gel-treated group compared to the arthritic control group.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Antirheumatic Agents ; Arthritis, Rheumatoid/drug therapy ; Down-Regulation ; Drug Carriers/chemistry ; Interleukin-6 ; Quinones/therapeutic use ; Tumor Necrosis Factor-alpha/metabolism ; Animals
    Chemical Substances Anti-Inflammatory Agents ; Antirheumatic Agents ; Drug Carriers ; Interleukin-6 ; quinone (3T006GV98U) ; Quinones ; thymoquinone (O60IE26NUF) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-08-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-022-01221-7
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  8. Article: Functionalized bosutinib liposomes for target specific delivery in management of estrogen-positive cancer

    Singh, Priya / Singh, Neelu / Mishra, Nidhi / Nisha, Raquibun / Alka / Maurya, Priyanka / Pal, Ravi Raj / Singh, Samipta / Saraf, Shubhini A.

    Colloids and surfaces. 2022 Oct., v. 218

    2022  

    Abstract: This study was designed to create surface-functionalized bosutinib liposomes that could be used for the management of estrogen-positive cancers. The novelty of this work was the anti-cancer activity of bosutinib-loaded liposomes (Bos-LPs) in estrogen- ... ...

    Abstract This study was designed to create surface-functionalized bosutinib liposomes that could be used for the management of estrogen-positive cancers. The novelty of this work was the anti-cancer activity of bosutinib-loaded liposomes (Bos-LPs) in estrogen-positive cancer via estrogen response elements, responsible for the malignancy of cancer cells. Biotin effectively delivers active moiety to tumor tissues because it interacts with the biotin receptor and operates through the Sodium-dependent multivitamin transporters (SMVT) transporter. The prepared liposomes had a 257.73 ± 4.50 nm particle size, − 28.07 ± 5.81 mV zeta potential, 87.78 ± 1.16 % encapsulation efficiency and 85.56 ± 0.95 % drug release for 48 h. The surface architecture of biotin-modified bosutinib-loaded liposomes (b-Bos-LPs) was confirmed using scanning electron and transmission electron microscopies. In-vitro experiments revealed that b-Bos-LPs outperformed Bos and Bos-LPs in terms of significantly reduced cell viability in MCF-7 cells. According to biodistribution and pharmacokinetic studies, b-Bos-LPs have a higher Bos concentration in tumor tissues as compared to the other organs and also possess better pharmacokinetic activity, indicating that they can be used to treat carcinogen-induced estrogen-positive cancers. This is the first study to show that b-Bos-LPs can display activity against estrogen-positive cancer via biotin targeting. As evidenced by various parameters, b-Bos-LPs showed improved anticancer targeting, therapeutic safety and efficacy in carcinogen-induced estrogen-positive cancer. The receptor protein estrogen, which is primarily responsible for this cancer was downregulated by b-Bos-LPs in an immunoblotting assay. The results showed that biotinylated distearoylphosphatidylcholine (DSPC) augmented LPs loaded with Bosutinib can cause apoptosis in estrogen-positive breast cancer and be an effective way to treat estrogen-positive cancer.
    Keywords Bos ; antineoplastic activity ; apoptosis ; biotin ; breast neoplasms ; cell viability ; drugs ; encapsulation ; estrogens ; immunoblotting ; moieties ; particle size ; pharmacokinetics ; therapeutics ; zeta potential
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2022.112763
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  9. Article ; Online: Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and

    Pal, Ravi Raj / Parashar, Poonam / Singh, Indu / Saraf, Shubhini A

    Journal of microencapsulation

    2019  Volume 36, Issue 5, Page(s) 432–446

    Abstract: The present study was aimed at preparing and evaluating levocetirizine (LCZD) loaded emulgel containing tamanu oil and sericin for atopic dermatitis (AD) therapy. The emulgel envisaged topical delivery of LCZD utilising natural antioxidants for superior ... ...

    Abstract The present study was aimed at preparing and evaluating levocetirizine (LCZD) loaded emulgel containing tamanu oil and sericin for atopic dermatitis (AD) therapy. The emulgel envisaged topical delivery of LCZD utilising natural antioxidants for superior therapeutic outcomes when compared with other conventional therapy. Tamanu oil based microemulsion (ME) was optimised utilising Box-Behnken design (BBD). The OPT-ME displayed globule size 379.5 ± 2.33 nm, polydispersity index 0.284, drug loading 0.41 ± 0.01% w/w, entrapment efficiency 94.34 ± 2.11% w/w and drug release 86.24 ± 4.90% respectively over a period of 24 h. The optimised formulation (OPT-ME) was further incorporated into sericin gel to form emulgel (LSE).
    MeSH term(s) Animals ; Bombyx/chemistry ; Calophyllum/chemistry ; Cetirizine/administration & dosage ; Cetirizine/pharmacokinetics ; Cetirizine/therapeutic use ; Chlorocebus aethiops ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Dinitrochlorobenzene ; Drug Delivery Systems ; Drug Liberation ; Emulsions/chemistry ; Female ; Male ; Plant Oils/chemistry ; Rats, Wistar ; Sericins/chemistry ; Skin Absorption ; Vero Cells
    Chemical Substances Emulsions ; Plant Oils ; Sericins ; levocetirizine (6U5EA9RT2O) ; Dinitrochlorobenzene (GE3IBT7BMN) ; Cetirizine (YO7261ME24)
    Language English
    Publishing date 2019-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2019.1637474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Assessment of anti-arthritic activity of lipid matrix encased berberine in rheumatic animal model.

    Singh, Neelu / Pandey, Amit Kumar / Pal, Ravi Raj / Alka / Parashar, Poonam / Singh, Priya / Mishra, Nidhi / Kumar, Dinesh / Raj, Ritu / Singh, Sukhveer / Saraf, Shubhini A

    Journal of microencapsulation

    2023  Volume 40, Issue 4, Page(s) 263–278

    Abstract: The purpose of this study was to evaluate the drug delivery and therapeutic potential of berberine (Br) loaded nanoformulation in rheumatoid arthritis (RA)-induced animal model. The Br-loaded NLCs (nanostructured lipid carriers) were prepared employing ... ...

    Abstract The purpose of this study was to evaluate the drug delivery and therapeutic potential of berberine (Br) loaded nanoformulation in rheumatoid arthritis (RA)-induced animal model. The Br-loaded NLCs (nanostructured lipid carriers) were prepared employing melt-emulsification process, and optimised through Box-Behnken design. The prepared NLCs were assessed for in-vitro and in-vivo evaluations. The optimised NLCs exhibited a mean diameter of 180.2 ± 0.31 nm with 88.32 ± 2.43% entrapment efficiency. An enhanced anti-arthritic activity with reduced arthritic scores to 0.66 ± 0.51, reduction in ankle diameter to 5.80 ± 0.27 mm, decline in paw withdrawal timing, and improvements in walking behaviour were observed in the Br-NLCs treated group. The radiographic images revealed a reduction in bone and cartilage deformation. The Br-NLCs showed promising results in the management of RA disease, can be developed as an efficient delivery system at commercial levels, and may be explored for clinical application after suitable experiments in the future.
    MeSH term(s) Animals ; Drug Carriers/therapeutic use ; Berberine/pharmacology ; Berberine/therapeutic use ; Drug Delivery Systems ; Arthritis, Rheumatoid/drug therapy ; Nanostructures ; Models, Animal ; Lipids ; Particle Size
    Chemical Substances Drug Carriers ; Berberine (0I8Y3P32UF) ; Lipids
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2023.2194414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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