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  1. Article ; Online: Genomic and comparative analysis of the T cell receptor gamma locus in two

    Massari, Serafina / Giannico, Francesco / Paolillo, Nunzia Valentina / Pala, Angela / Jambrenghi, Anna Caputi / Antonacci, Rachele

    Frontiers in immunology

    2023  Volume 14, Page(s) 1264949

    Abstract: ... The ... ...

    Abstract The genus
    MeSH term(s) Horses/genetics ; Animals ; Amino Acid Sequence ; Genome ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Genomics ; Equidae/genetics
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2023-09-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1264949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Organization of the Pig T-Cell Receptor γ (TRG) Locus Provides Insights into the Evolutionary Patterns of the TRG Genes across Cetartiodactyla

    Linguiti, Giovanna / Giannico, Francesco / D’Addabbo, Pietro / Pala, Angela / Caputi Jambrenghi, Anna / Ciccarese, Salvatrice / Massari, Serafina / Antonacci, Rachele

    Genes. 2022 Jan. 19, v. 13, no. 2

    2022  

    Abstract: The domestic pig (Sus scrofa) is a species representative of the Suina, one of the four suborders within Cetartiodactyla. In this paper, we reported our analysis of the pig TRG locus in comparison with the loci of species representative of the Ruminantia, ...

    Abstract The domestic pig (Sus scrofa) is a species representative of the Suina, one of the four suborders within Cetartiodactyla. In this paper, we reported our analysis of the pig TRG locus in comparison with the loci of species representative of the Ruminantia, Tylopoda, and Cetacea suborders. The pig TRG genomic structure reiterates the peculiarity of the organization of Cetartiodactyla loci in TRGC “cassettes”, each containing the basic V-J-J-C unit. Eighteen genes arranged in four TRGC cassettes, form the pig TRG locus. All the functional TRG genes were expressed, and the TRGV genes preferentially rearrange with the TRGJ genes within their own cassette, which correlates the diversity of the γ-chain repertoire with the number of cassettes. Among them, the TRGC5, located at the 5′ end of the locus, is the only cassette that retains a marked homology with the corresponding TRGC cassettes of all the analyzed species. The preservation of the TRGC5 cassette for such a long evolutionary time presumes a highly specialized function of its genes, which could be essential for the survival of species. Therefore, the maintenance of this cassette in pigs confirms that it is the most evolutionarily ancient within Cetartiodactyla, and it has undergone a process of duplication to give rise to the other TRGC cassettes in the different artiodactyl species in a lineage-specific manner.
    Keywords Cetacea ; Sus scrofa ; T-lymphocytes ; genomics ; loci ; ruminants ; swine
    Language English
    Dates of publication 2022-0119
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020177
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: The Organization of the Pig T-Cell Receptor γ (TRG) Locus Provides Insights into the Evolutionary Patterns of the

    Linguiti, Giovanna / Giannico, Francesco / D'Addabbo, Pietro / Pala, Angela / Caputi Jambrenghi, Anna / Ciccarese, Salvatrice / Massari, Serafina / Antonacci, Rachele

    Genes

    2022  Volume 13, Issue 2

    Abstract: The domestic pig ( ...

    Abstract The domestic pig (
    MeSH term(s) Evolution, Molecular ; Genes, T-Cell Receptor gamma ; Genome/genetics ; Phylogeny ; Receptors, Antigen, T-Cell/genetics
    Chemical Substances Receptors, Antigen, T-Cell
    Language English
    Publishing date 2022-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The expansion of the TRB and TRG genes in domestic goats (Capra hircus) is characteristic of the ruminant species.

    Giannico, Francesco / Massari, Serafina / Caputi Jambrenghi, Anna / Soriano, Adriano / Pala, Angela / Linguiti, Giovanna / Ciccarese, Salvatrice / Antonacci, Rachele

    BMC genomics

    2020  Volume 21, Issue 1, Page(s) 623

    Abstract: Background: Goats (Capra hircus), one of the first domesticated species, are economically important for milk and meat production, and their broad geographical distribution reflects their successful adaptation to diverse environmental conditions. Despite ...

    Abstract Background: Goats (Capra hircus), one of the first domesticated species, are economically important for milk and meat production, and their broad geographical distribution reflects their successful adaptation to diverse environmental conditions. Despite the relevance of this species, the genetic research on the goat traits is limited compared to other domestic species. Thanks to the latest goat reference genomic sequence (ARS1), which is considered to be one of the most continuous assemblies in livestock, we deduced the genomic structure of the T cell receptor beta (TRB) and gamma (TRG) loci in this ruminant species.
    Results: Our analyses revealed that although the organization of the goat TRB locus is broadly similar to that of the other artiodactyl species, with three in-tandem D-J-C clusters located at the 3' end, a complex and extensive series of duplications have occurred in the V genes at the 5' end, leading to a marked expansion in the number of the TRBV genes. This phenomenon appears to be a feature of the ruminant lineage since similar gene expansions have also occurred in sheep and cattle. Likewise, the general organization of the goat TRG genes is typical of ruminant species studied so far, with two paralogous TRG loci, TRG1 and TRG2, located in two distinct and distant positions on the same chromosome as result of a split in the ancestral locus. Each TRG locus consists of reiterated V-J-J-C cassettes, with the goat TRG2 containing an additional cassette relative to the corresponding sheep and cattle loci.
    Conclusions: Taken together, these findings demonstrate that strong evolutionary pressures in the ruminant lineage have selected for the development of enlarged sets of TRB and TRG genes that contribute to a diverse T cell receptor repertoire. However, differences observed among the goat, sheep and cattle TRB and TRG genes indicate that distinct evolutionary histories, with independent expansions and/or contractions, have also affected each ruminant species.
    MeSH term(s) Animals ; Evolution, Molecular ; Gene Dosage ; Genes, T-Cell Receptor beta ; Genes, T-Cell Receptor gamma ; Goats/classification ; Goats/genetics ; Phylogeny
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Journal Article
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/s12864-020-07022-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The occurrence of three D-J-C clusters within the dromedary TRB locus highlights a shared evolution in Tylopoda, Ruminantia and Suina.

    Antonacci, Rachele / Bellini, Mariagrazia / Pala, Angela / Mineccia, Micaela / Hassanane, Mohamed S / Ciccarese, Salvatrice / Massari, Serafina

    Developmental and comparative immunology

    2017  Volume 76, Page(s) 105–119

    Abstract: The αβ T cells are important components of the adaptive immune system and can recognize a vast array of peptides presented by MHC molecules. The ability of these T cells to recognize the complex depends on the diversity of the αβ TR, which is generated ... ...

    Abstract The αβ T cells are important components of the adaptive immune system and can recognize a vast array of peptides presented by MHC molecules. The ability of these T cells to recognize the complex depends on the diversity of the αβ TR, which is generated by a recombination of specific Variable, Diversity and Joining genes for the β chain, and Variable and Joining genes for the α chain. In this study, we analysed the genomic structure and the gene content of the TRB locus in Camelus dromedarius, which is a species belonging to the Tylopoda suborder. The most noteworthy result is the presence of three in tandem TRBD-J-C clusters in the dromedary TRB locus, which is similar to clusters found in sheep, cattle and pigs and suggests a common duplication event occurred prior to the Tylopoda/Ruminantia/Suina divergence. Conversely, a significant contraction of the dromedary TRBV genes, which was previously found in the TRG and TRD loci, was observed with respect to the other artiodactyl species.
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752411-0
    ISSN 1879-0089 ; 0145-305X
    ISSN (online) 1879-0089
    ISSN 0145-305X
    DOI 10.1016/j.dci.2017.05.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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