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  1. Article ; Online: Confirmation of survival prediction based on 2022 ESC/ERS pulmonary hypertension guidelines new haemodynamic thresholds.

    Galiè, Nazzareno / Palazzini, Massimiliano / Manes, Alessandra

    European heart journal

    2023  Volume 44, Issue 44, Page(s) 4692–4695

    MeSH term(s) Humans ; Hypertension, Pulmonary/physiopathology ; Diagnostic Imaging ; Hemodynamics ; United Kingdom
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
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  2. Article ; Online: Linee guida europee sull’ipertensione polmonare: cosa c’è di nuovo?

    Manes, Alessandra / Dardi, Fabio / Galiè, Nazzareno / Palazzini, Massimiliano

    Giornale italiano di cardiologia (2006)

    2023  Volume 24, Issue 3, Page(s) 161–165

    Title translation European guidelines on pulmonary hypertension: what's new?
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Practice Guidelines as Topic
    Language Italian
    Publishing date 2023-02-28
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3980.39616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The burden of comorbidities in pulmonary arterial hypertension.

    Lang, Irene M / Palazzini, Massimiliano

    European heart journal supplements : journal of the European Society of Cardiology

    2019  Volume 21, Issue Suppl K, Page(s) K21–K28

    Abstract: Patients with comorbidities are often excluded from clinical trials, limiting the evidence base for pulmonary arterial hypertension (PAH)-specific therapies. This review aims to discuss the effect of comorbidities on the diagnosis and management of PAH. ... ...

    Abstract Patients with comorbidities are often excluded from clinical trials, limiting the evidence base for pulmonary arterial hypertension (PAH)-specific therapies. This review aims to discuss the effect of comorbidities on the diagnosis and management of PAH. The comorbidities discussed in this review (systemic hypertension, obesity, sleep apnoea, clinical depression, obstructive airway disease, thyroid disease, diabetes, and ischaemic cardiovascular event) were chosen based on their prevalence in patients with idiopathic PAH in the REVEAL registry (Registry to EValuate Early and Long-term PAH disease management). Comorbidities can mask the symptoms of PAH, leading to delays in diagnosis and also difficulty evaluating disease progression and treatment effects. Due to the multifactorial pathophysiology of pulmonary hypertension (PH), the presence of comorbidities can lead to difficulties in distinguishing between Group 1 PH (PAH) and the other group classifications of PH. Many comorbidities contribute to the progression of PAH through increased pulmonary artery pressures and cardiac output, therefore treatment of the comorbidity may also reduce the severity of PAH. Similarly, the development of one comorbidity can be a risk factor for the development of other comorbidities. The management of comorbidities requires consideration of drug interactions, polypharmacy, adherence and evidence-based strategies. A multidisciplinary team should be involved in the management of patients with PAH and comorbidities, with appropriate referral to supportive services when necessary. The treatment goals and expectations of patients must be managed in the context of comorbidities.
    Language English
    Publishing date 2019-12-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suz205
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  4. Article: Progress in the treatment of acute pulmonary embolism and chronic thrombo-embolic pulmonary hypertension/disease.

    Palazzini, Massimiliano / Dardi, Fabio / Magnani, Ilenia / Guarino, Daniele / Galie', Nazzareno / Manes, Alessandra

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl B, Page(s) B90–B94

    Abstract: The combination of an initial clinical approach aimed at evaluating the early risk of mortality with subsequent diagnostic and therapeutic approaches articulated on the overall patient's profile is recommended in acute pulmonary embolism (PE). The ... ...

    Abstract The combination of an initial clinical approach aimed at evaluating the early risk of mortality with subsequent diagnostic and therapeutic approaches articulated on the overall patient's profile is recommended in acute pulmonary embolism (PE). The presence of pulmonary hypertension associated with the persistence of chronic vascular obstructions in the pulmonary arteries after one or more acute thrombo-embolic events identifies a condition defined as chronic thrombo-embolic pulmonary hypertension (CTEPH). The evolution of technology and knowledge in the field of imaging has allowed us to qualify the computed tomography angiography of the pulmonary arteries as the gold standard for the diagnostic confirmation of both acute PE and CTEPH. In both these conditions, the first therapeutic step is the immediate initiation of anticoagulant therapy. In acute high-risk PE, in addition to anticoagulant therapy, thrombolytic therapy is recommended; in the event of contraindications to thrombolysis, surgical embolectomy or percutaneous catheter-directed treatment represents viable treatment options. In CTEPH, the combination of data collected from cardiac catheterization, computed tomography angiography, and conventional angiography of pulmonary arteries allows a team of experts to identify candidates for pulmonary endarterectomy surgery. Inoperable patients should be considered for percutaneous balloon angioplasty of the pulmonary arteries which can improve patients' symptoms, quality of life, and prognosis.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad080
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  5. Article ; Online: Progressi nel trattamento delle malattie della circolazione polmonare.

    Galiè, Nazzareno / Dardi, Fabio / Manes, Alessandra / Palazzini, Massimiliano

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 10, Page(s) 781–792

    Abstract: Multiple progresses have been achieved in pulmonary vascular diseases in the last decades, including the areas of pulmonary hypertension and pulmonary thromboembolic disease. The increase in knowledge has been accomplished in pathophysiological, clinical ...

    Title translation Progress in the treatment of pulmonary vascular diseases.
    Abstract Multiple progresses have been achieved in pulmonary vascular diseases in the last decades, including the areas of pulmonary hypertension and pulmonary thromboembolic disease. The increase in knowledge has been accomplished in pathophysiological, clinical and treatment domains and has included as examples the discovery of gene mutations related to the hereditary forms of pulmonary arterial hypertension and the proposals of personalized treatment algorithms in patients with acute pulmonary embolism, chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension, validated in this specific area by more than 45 randomized controlled trials. The diagnostic processes have been refined, increasing the awareness that appropriate and precise diagnosis is essential for the optimal treatment strategy. The drugs approved for pulmonary arterial hypertension are recommended in this group and in specific patients with chronic thromboembolic pulmonary hypertension but are contraindicated in patients with pulmonary hypertension due to left heart and lung diseases. In pulmonary vascular diseases, the therapy cannot be considered as a simple prescription of medications and interventions but is a complex strategy which includes baseline patients' risk stratification, initial therapy, long-term follow-up and treatment adjustments when required. Today, computed tomography pulmonary artery angiography is the gold standard for diagnosis in both acute pulmonary embolism and chronic thromboembolic pulmonary hypertension. In this last condition, the combination with data derived from the right heart catheterization and the traditional pulmonary artery angiography, allows to a team of experts to decide if the patient is a candidate to surgical pulmonary endarterectomy or to percutaneous pulmonary artery balloon angioplasty which may improve symptoms, quality of life and prognosis.
    MeSH term(s) Angioplasty, Balloon ; Chronic Disease ; Endarterectomy ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Pulmonary Artery ; Pulmonary Embolism/therapy ; Quality of Life
    Language Italian
    Publishing date 2021-09-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3666.36509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Balloon pulmonary angioplasty after pulmonary thromboendarterectomy.

    Palazzini, Massimiliano / Saia, Francesco / Taglieri, Nevio / Guarino, Daniele / Rotunno, Mariangela / Galiѐ, Nazzareno / Dardi, Fabio

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 2, Page(s) 192–194

    Language English
    Publishing date 2022-03-20
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-pte-19
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  7. Article ; Online: Thrombolysis in high-risk patients with acute pulmonary embolism: underuse of a life-saving treatment in the real-world setting.

    Galié, Nazzareno / Manes, Alessandra / Dardi, Fabio / Palazzini, Massimiliano

    European heart journal

    2019  Volume 41, Issue 4, Page(s) 530–533

    MeSH term(s) Fibrinolytic Agents ; Germany ; Humans ; Pulmonary Embolism ; Thrombolytic Therapy ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2019-05-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz296
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Aiming at the appropriate target for the treatment of pulmonary hypertension due to left heart disease.

    Galiè, Nazzareno / Manes, Alessandra / Dardi, Fabio / Palazzini, Massimiliano

    European heart journal

    2018  Volume 39, Issue 15, Page(s) 1265–1268

    MeSH term(s) Double-Blind Method ; Heart Diseases ; Heart Valve Diseases ; Humans ; Hypertension, Pulmonary ; Sildenafil Citrate
    Chemical Substances Sildenafil Citrate (BW9B0ZE037)
    Language English
    Publishing date 2018-01-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehx751
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  9. Article ; Online: Extracorporeal cardiopulmonary support in acute high-risk pulmonary embolism: still waiting for solid evidence.

    Galiè, Nazzareno / Palazzini, Massimiliano / Manes, Alessandra

    European heart journal

    2018  Volume 39, Issue 47, Page(s) 4205–4207

    MeSH term(s) Embolectomy ; Extracorporeal Membrane Oxygenation ; Heart ; Humans ; Pulmonary Embolism/surgery
    Language English
    Publishing date 2018-10-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy507
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  10. Article: Long-term outcomes after pulmonary endarterectomy.

    Dardi, Fabio / Manes, Alessandra / Guarino, Daniele / Suarez, Sofia Martin / Loforte, Antonio / Rotunno, Mariangela / Pacini, Davide / Galiѐ, Nazzareno / Palazzini, Massimiliano

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 2, Page(s) 172–174

    Language English
    Publishing date 2022-03-20
    Publishing country China
    Document type Editorial
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-pte-179
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