LIVIVO - Search results -

Search results

Result 1 - 10 of total 22

Search options

Article: Cariprazine in Three Special Different Areas: A Real-World Experience.

Gesi, Camilla / Paletta, Silvia / Palazzo, Maria Carlotta / Dell'Osso, Bernardo / Mencacci, Claudio / Cerveri, Giancarlo

Neuropsychiatric disease and treatment

2021 Volume 17, Page(s) 3581–3588

Abstract: Cariprazine is an antipsychotic medication which received approval from the US Food and Drug Administration for the treatment of schizophrenia in September 2015. Cariprazine is a dopamine ... ...

Abstract	Cariprazine is an antipsychotic medication which received approval from the US Food and Drug Administration for the treatment of schizophrenia in September 2015. Cariprazine is a dopamine D
Language	English
Publishing date	2021-12-07
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S335332
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6068: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: How Did COVID-19 Affect Suicidality? Data from a Multicentric Study in Lombardy.

Gesi, Camilla / Grasso, Federico / Dragogna, Filippo / Vercesi, Marco / Paletta, Silvia / Politi, Pierluigi / Mencacci, Claudio / Cerveri, Giancarlo

Journal of clinical medicine

2021 Volume 10, Issue 11

Abstract: The aim of the study was to describe the characteristics of subjects accessing the emergency rooms for suicidal behavior during the first epidemic wave of COVID-19 in three Emergency Departments (EDs) in Lombardy (Italy). A retrospective chart review was ...

Abstract	The aim of the study was to describe the characteristics of subjects accessing the emergency rooms for suicidal behavior during the first epidemic wave of COVID-19 in three Emergency Departments (EDs) in Lombardy (Italy). A retrospective chart review was conducted for the period 8 March-3 June 2020, and during the same time frame in 2019. For all subjects accessing for suicidality, socio-demographic and clinical data were collected and compared between the two years. The proportion of subjects accessing for suicidality was significantly higher in 2020 than in 2019 (13.0 vs. 17.2%,
Language	English
Publishing date	2021-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10112410
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Switch From Paliperidone Long-Acting Injectable 1- to 3-Monthly: Clinical Pharmacokinetic Evaluation in Patients With Schizophrenia (Preliminary Data).

Mauri, Massimo Carlo / Franco, Gemma / Minutillo, Alessandro / Paletta, Silvia / Di Pace, Chiara / Reggiori, Alessandra / Baldelli, Sara / Cattaneo, Dario

Journal of clinical psychopharmacology

2021 Volume 42, Issue 1, Page(s) 23–30

Abstract: Purpose/background: The aim of the study was a preliminary evaluation of the maintenance of clinical efficacy and tolerability of paliperidone palmitate in patients with schizophrenia during the transition phase from 1-monthly paliperidone palmitate ... ...

Abstract	Purpose/background: The aim of the study was a preliminary evaluation of the maintenance of clinical efficacy and tolerability of paliperidone palmitate in patients with schizophrenia during the transition phase from 1-monthly paliperidone palmitate formulation (PP1M) to PP3M, with the evaluation of plasma levels of the drug. Methods/procedures: A prospective observational study was conducted for 13 months involving 22 outpatients, aged 18 to 66 years and clinically stabilized. Patients were affected by schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria. For each patient, clinical assessment, safety and tolerability, and drug plasma level determination were performed. Clinical efficacy was assessed by Brief Psychiatric Rating Scale, Positive and Negative Symptom Scale, and Hamilton Rating Scale for Depression. During the first 4 months of the study, once-monthly paliperidone palmitate was administered, and then during the following 9 months, the 3-monthly formulation was administered. Findings/results: The time course of the Brief Psychiatric Rating Scale total scores showed a statistically significant (P = 0.006) improvement from T0 to T8; Positive and Negative Symptom Scale scores showed a similar time course, with a statistically significant (P = 0.0016) reduction of the mean total score; Hamilton Rating Scale for Depression mean scores showed a statistically significant (P = 0.003) reduction with substantial maintenance of clinical stabilization of the patients. Only 1 patient dropped out after the first PP3M injection. Implications/conclusions: Our preliminary data currently confirm the maintenance of clinical stability shifting from PP1M to PP3M.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/blood ; Female ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Paliperidone Palmitate/administration & dosage ; Paliperidone Palmitate/blood ; Prospective Studies ; Psychiatric Status Rating Scales ; Schizophrenia/drug therapy ; Secondary Prevention ; Young Adult
Chemical Substances	Antipsychotic Agents ; Paliperidone Palmitate (R8P8USM8FR)
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001484
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1664: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Paliperidone LAI and Aripiprazole LAI Plasma Level Monitoring in the Prophylaxis of Bipolar Disorder Type I with Manic Predominance.

Mauri, Massimo Carlo / Reggiori, Alessandra / Minutillo, Alessandro / Franco, Gemma / Pace, Chiara Di / Paletta, Silvia / Cattaneo, Dario

Pharmacopsychiatry

2020 Volume 53, Issue 5, Page(s) 209–219

Abstract: Introduction: The objective of this study was the evaluation of utility of plasma level monitoring in the clinical stabilizing efficacy and tolerability of paliperidone palmitate (PP) vs. aripiprazole monohydrate (AM) in bipolar disorder I (BD I) with ... ...

Abstract	Introduction: The objective of this study was the evaluation of utility of plasma level monitoring in the clinical stabilizing efficacy and tolerability of paliperidone palmitate (PP) vs. aripiprazole monohydrate (AM) in bipolar disorder I (BD I) with manic predominance. Methods: Fifty-six outpatients of both sexes, age ranging from 18 to 65 years, affected by BD I with manic predominance, orally treated and stabilized after acute episode for at least 2 weeks with paliperidone or aripiprazole (n=31, paliperidone; n=25, aripiprazole) underwent a prospective observational study of switching to the corresponding long-acting injection (LAI) on the basis of clinical evaluation. The efficacy and tolerability of the 2 treatments were assessed by BPRS, PANSS, HAMD21, and MRS rating scales and a check list every month for 12 months. Drug plasma levels determinations (PLs) were performed at the same times. Results: A good clinical stability and tolerability of both drugs were reported. Lower mean PLs of PP showed a positive effect on depressive symptoms. AM PLs variability was associated with greater instability of manic symptoms whereas intermediate PLs seem to have more influence on depressive symptomatology. Discussion: PLs drug monitoring has been proven to be useful, and further investigations to identify optimal therapeutic ranges for LAI formulations are needed.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antimanic Agents/administration & dosage ; Antimanic Agents/adverse effects ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Aripiprazole/administration & dosage ; Aripiprazole/adverse effects ; Aripiprazole/therapeutic use ; Bipolar Disorder/prevention & control ; Bipolar Disorder/psychology ; Delayed-Action Preparations ; Depression/drug therapy ; Female ; Humans ; Injections ; Male ; Mania/prevention & control ; Mania/psychology ; Middle Aged ; Paliperidone Palmitate/administration & dosage ; Paliperidone Palmitate/adverse effects ; Paliperidone Palmitate/therapeutic use ; Prospective Studies ; Psychiatric Status Rating Scales ; Treatment Outcome ; Young Adult
Chemical Substances	Antimanic Agents ; Antipsychotic Agents ; Delayed-Action Preparations ; Aripiprazole (82VFR53I78) ; Paliperidone Palmitate (R8P8USM8FR)
Language	English
Publishing date	2020-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605670-2
ISSN	1439-0795 ; 0720-4280 ; 0176-3679
ISSN (online)	1439-0795
ISSN	0720-4280 ; 0176-3679
DOI	10.1055/a-1113-7862
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Correction to: Clinical Pharmacokinetics of Atypical Antipsychotics: An Update.

Mauri, Massimo Carlo / Paletta, Silvia / Di Pace, Chiara / Reggiori, Alessandra / Cirnigliaro, Giovanna / Valli, Isabel / Altamura, Alfredo Carlo

Clinical pharmacokinetics

2019 Volume 58, Issue 9, Page(s) 1219–1220

Abstract: The pharmacokinetics of CRP was tested in small short-term studies in both healthy volunteers and in subjects with schizophrenia, with similar results [242]. ...

Abstract	The pharmacokinetics of CRP was tested in small short-term studies in both healthy volunteers and in subjects with schizophrenia, with similar results [242].
Language	English
Publishing date	2019-06-18
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-019-00797-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1246: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Pharmacokinetics of antidepressants in patients with hepatic impairment.

Mauri, Massimo Carlo / Fiorentini, Alessio / Paletta, Silvia / Altamura, Alfredo Carlo

Clinical pharmacokinetics

2014 Volume 53, Issue 12, Page(s) 1069–1081

Abstract: Appropriate use of antidepressant in patients with hepatic impairment requires careful consideration of how the hepatic illness may affect pharmacokinetics. This review aims to analyze pharmacokinetic profile, plasma level variations so as the metabolism ...

Abstract	Appropriate use of antidepressant in patients with hepatic impairment requires careful consideration of how the hepatic illness may affect pharmacokinetics. This review aims to analyze pharmacokinetic profile, plasma level variations so as the metabolism of several antidepressants relating to their use in patients with an hepatic impairment. Due to the lack of data regarding hepatic impairment itself, the review is focused mainly on studies investigating pharmacokinetics in hepatic cirrhosis or alcohol-related conditions. More data on reduced hepatic metabolism can be extrapolated by drug studies conducted in elderly populations. Dose adjustment of antidepressants in these patients is important as most of these drugs are predominantly metabolized by the liver and many of them are associated with dose-dependent adverse reactions. As no surrogate parameter is available to predict hepatic metabolism of drugs, dose adjustment according to pharmacokinetic properties of the drugs is proposed. There is a need for a more balanced assessment of the benefits and risks associated with antidepressants use in patients with hepatic impairment, particularly considering pharmacokinetic profile of the drugs to ensure that patients, who would truly benefit from these agents, are not denied appropriate treatment. In conclusion, kinetic studies for centrally acting drugs including antidepressants with predominant hepatic metabolism should be carried out in patients with liver disease to allow precise dose recommendations for enhanced patient safety.
MeSH term(s)	Antidepressive Agents/pharmacokinetics ; Dose-Response Relationship, Drug ; Humans ; Liver Diseases/metabolism
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2014-09-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-014-0187-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1246: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Intraindividual and Interindividual Variability of Olanzapine Trough Concentrations in Patients Treated With the Long-Acting Injectable Formulation.

Baldelli, Sara / Mauri, Massimo C / Di Pace, Chiara / Paletta, Silvia / Reggiori, Alessandra / Rovera, Chiara / Clementi, Emilio / Cattaneo, Dario

Journal of clinical psychopharmacology

2018 Volume 38, Issue 4, Page(s) 365–369

Abstract: Background: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate ...

Abstract	Background: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate the intraindividual and interindividual variability of olanzapine concentrations with time in patients on maintenance therapy with the LAI formulation carried out in the routine clinical practice. Methods: To address this issue, we carried out a retrospective analysis of therapeutic drug monitoring of olanzapine concentrations in 21 schizophrenic patients on maintenance LAI olanzapine. Drug concentrations were correlated with LAI olanzapine doses, duration of treatment, and main clinical characteristics. Results: Fifty percent of the patients had olanzapine trough concentrations lower than 20 ng/mL. Only drug doses significantly correlated with olanzapine exposure. Mean interindividual and intraindividual coefficients of variations of olanzapine concentrations were 56% (range, 21%-97%) and 34% (range, 15%-69%), respectively. Conclusions: We have documented that, in a real-life setting, a large proportion of patients treated with olanzapine LAI had drug trough concentrations of less than 20 ng/mL; wide intraindividual and interindividual variability of olanzapine concentrations has been also observed. Our results could provide the rationale for the design of larger prospective, concentration-controlled clinical trials specifically designed with the goal to identify ad hoc therapeutic ranges of drug concentrations for olanzapine LAI.
MeSH term(s)	Adult ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/blood ; Antipsychotic Agents/pharmacokinetics ; Benzodiazepines/administration & dosage ; Benzodiazepines/blood ; Benzodiazepines/pharmacokinetics ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/pharmacokinetics ; Female ; Humans ; Injections ; Male ; Retrospective Studies
Chemical Substances	Antipsychotic Agents ; Delayed-Action Preparations ; Benzodiazepines (12794-10-4) ; olanzapine (N7U69T4SZR)
Language	English
Publishing date	2018-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000000913
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1664: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical Pharmacokinetics of Atypical Antipsychotics: An Update.

Mauri, Massimo Carlo / Paletta, Silvia / Di Pace, Chiara / Reggiori, Alessandra / Cirnigliaro, Giovanna / Valli, Isabel / Altamura, Alfredo Carlo

Clinical pharmacokinetics

2018 Volume 57, Issue 12, Page(s) 1493–1528

Abstract: Therapeutic drug monitoring studies have generally concentrated on controlling compliance and avoiding side effects by maintaining long-term exposure to minimally effective blood concentrations. The rationale for using therapeutic drug monitoring in ... ...

Abstract	Therapeutic drug monitoring studies have generally concentrated on controlling compliance and avoiding side effects by maintaining long-term exposure to minimally effective blood concentrations. The rationale for using therapeutic drug monitoring in relation to second-generation antipsychotics is still being discussed at least with regard to the real clinical utility, but there is evidence that it can improve efficacy, especially when patients do not respond or develop side effects using therapeutic doses. Furthermore, drug plasma concentration determinations can be of some utility in medico-legal problems. This review concentrates on the clinical pharmacokinetic data related to clozapine, risperidone, paliperidone, olanzapine, quetiapine, amisulpride, ziprasidone, aripiprazole, sertindole, asenapine, iloperidone, lurasidone, brexpiprazole and cariprazine and briefly considers the main aspects of their pharmacodynamics. Optimal plasma concentration ranges are proposed for clozapine, risperidone, paliperidone and olanzapine because the studies of quetiapine, amisulpride, asenapine, iloperidone and lurasidone provide only limited information and there is no direct evidence concerning ziprasidone, aripiprazole, sertindole, brexpiprazole and cariprazine: the few reported investigations need to be confirmed and extended.
MeSH term(s)	Animals ; Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/pharmacokinetics ; Dose-Response Relationship, Drug ; Drug Monitoring/methods ; Humans ; Medication Adherence
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2018-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-018-0664-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1246: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Aggressiveness and violence in psychiatric patients: a clinical or social paradigm?

Mauri, Massimo C / Cirnigliaro, Giovanna / Di Pace, Chiara / Paletta, Silvia / Reggiori, Alessandra / Altamura, Carlo A / Dell'Osso, Bernardo

CNS spectrums

2018 Volume 24, Issue 5, Page(s) 564–573

Abstract: Objective: Psychiatric disorders are often considered the leading cause of violence. This may be due to a stereotype created by media and general opinion.: Method: The Modified Overt Aggression Scale (MOAS) was used to evaluate the severity of ... ...

Abstract	Objective: Psychiatric disorders are often considered the leading cause of violence. This may be due to a stereotype created by media and general opinion. Method: The Modified Overt Aggression Scale (MOAS) was used to evaluate the severity of aggressive and violent behaviors in 400 patients who attended a post-acute psychiatric service in Milan from 2014 to 2016 and suffered from different psychiatric disorders. The psychopathological clinical picture was evaluated by Clinical Global Impression (CGI). The study also assessed the possible correlation between epidemiologic and sociodemographic factors, clinical variables, and aggression and violence. Results: Of the total number of subjects, 21.50% showed a MOAS score >0, 11.50% presented mild aggression (0-10 MOAS weighted score), 9% moderate aggression (11-20), and 1% severe aggression (MOAS >20). With respect to violent behaviors, 16% of patients showed a score >0 in one MOAS subscale other than verbal aggression according to violence definition. The severity of clinical picture seemed to be related to higher weighted MOAS score. Multivariate testing of different sociodemographic and clinical variables showed that violence was related to unemployment status, and significantly correlated to compulsory admission (TSO), suicide attempts (TS), and personality disorders, while the severity of clinical psychiatric picture seemed to play a secondary role. Conclusion: Results have shown that personality disorders and sociodemographic factors, including economic factors, seem to be major determinants of violence among patients diagnosed with mental disorders.
MeSH term(s)	Adolescent ; Adult ; Aggression ; Female ; Humans ; Italy ; Male ; Mental Disorders/diagnosis ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Middle Aged ; Prejudice ; Psychiatric Status Rating Scales/standards ; Social Stigma ; Socioeconomic Factors ; Violence/psychology ; Violence/statistics & numerical data
Language	English
Publishing date	2018-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2008418-3
ISSN	2165-6509 ; 1092-8529
ISSN (online)	2165-6509
ISSN	1092-8529
DOI	10.1017/S1092852918001438
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5171: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 340: Show issues

Order via subito

Details ▾

Article: [No title information]

Mauri, Massimo Carlo / Reggiori, Alessandra / Minutillo, Alessandro / Franco, Gemma / Pace, Chiara Di / Paletta, Silvia / Cattaneo, Dario

Pharmacopsychiatry

2020 Volume 53, Issue 05, Page(s) 209–219

Abstract	Introduction: The objective of this study was the evaluation of utility of plasma level monitoring in the clinical stabilizing efficacy and tolerability of paliperidone palmitate (PP) vs. aripiprazole monohydrate (AM) in bipolar disorder I (BD I) with manic predominance. Methods: Fifty-six outpatients of both sexes, age ranging from 18 to 65 years, affected by BD I with manic predominance, orally treated and stabilized after acute episode for at least 2 weeks with paliperidone or aripiprazole (n=31, paliperidone; n=25, aripiprazole) underwent a prospective observational study of switching to the corresponding long-acting injection (LAI) on the basis of clinical evaluation. The efficacy and tolerability of the 2 treatments were assessed by BPRS, PANSS, HAMD21, and MRS rating scales and a check list every month for 12 months. Drug plasma levels determinations (PLs) were performed at the same times. Results: A good clinical stability and tolerability of both drugs were reported. Lower mean PLs of PP showed a positive effect on depressive symptoms. AM PLs variability was associated with greater instability of manic symptoms whereas intermediate PLs seem to have more influence on depressive symptomatology. Discussion: PLs drug monitoring has been proven to be useful, and further investigations to identify optimal therapeutic ranges for LAI formulations are needed.
Keywords	bipolar disorder ; antipsychotics ; therapeutic drug monitoring
Language	English
Publishing date	2020-03-10
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605670-2
ISSN	1439-0795 ; 0176-3679 ; 0720-4280
ISSN (online)	1439-0795
ISSN	0176-3679 ; 0720-4280
DOI	10.1055/a-1113-7862
Database	Thieme publisher's database

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito