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Article ; Online: Protracted severe COVID-19 pneumonia following rituximab treatment: caution needed.

Daoussis, Dimitrios / Leonidou, Lydia / Kalogeropoulou, Christina / Paliogianni, Fotini / Tzouvelekis, Argyrios

2021 Volume 41, Issue 10, Page(s) 1839–1843

Abstract: The outcomes of COVID-19 in patients treated with biologic agents are a subject of intense investigation. Recent data indicated that patients under rituximab (RTX) may carry an increased risk of serious disease. We performed an electronic search in ... ...

Abstract	The outcomes of COVID-19 in patients treated with biologic agents are a subject of intense investigation. Recent data indicated that patients under rituximab (RTX) may carry an increased risk of serious disease. We performed an electronic search in Medline and Scopus using the keywords rituximab and COVID-19. We present a rare case of severe, protracted COVID-19 pneumonia in a patient with mixed connective tissue disease (MCTD) who was infected a few days following RTX treatment. In a relevant literature search, we identified 18 cases of patients with rheumatic diseases (6 RA, 8 ANCA vasculitis, 3 systemic sclerosis and 1 polymyositis) treated with RTX who experienced an atypical and/or prolonged course of COVID-19 pneumonia with no evidence of cytokine storm. Our case indicates that RTX may unfavorably affect outcomes following SARS-CoV-2 infection. B cell depletion may dampen the humoral response against the virus; we may hypothesize that B cell-depleted patients may be protected from cytokine storm but on the other hand may have difficulties in virus clearance leading to a protracted course. Taking into account that COVID-19 vaccines are available we may consider delaying RTX infusions at least in patients without life threatening disease, until vaccination is completed.
MeSH term(s)	Aged ; Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; COVID-19/diagnosis ; COVID-19/immunology ; Contraindications, Drug ; Fatal Outcome ; Female ; Humans ; Infusions, Intravenous ; Male ; Mixed Connective Tissue Disease/drug therapy ; Rituximab/administration & dosage ; Rituximab/adverse effects ; SARS-CoV-2
Chemical Substances	Antirheumatic Agents ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2021-08-19
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-021-04969-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1639: Show issues

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Article ; Online: A Molecular Lateral Flow Assay for SARS-CoV-2 Quantitative Detection.

Maglaras, Panagiotis / Lilis, Ioannis / Paliogianni, Fotini / Bravou, Vasiliki / Kalogianni, Despina P

Biosensors

2022 Volume 12, Issue 11

Abstract: Since the onset of the SARS-CoV-2 pandemic, several COVID-19 detection methods, both commercially available and in the lab, have been developed using different biomolecules as analytes and different detection and sampling methods with high analytical ... ...

Abstract	Since the onset of the SARS-CoV-2 pandemic, several COVID-19 detection methods, both commercially available and in the lab, have been developed using different biomolecules as analytes and different detection and sampling methods with high analytical performance. Developing novel COVID-19 detection assays is an exciting research field, as rapid accurate diagnosis is a valuable tool to control the current pandemic, and also because the acquired knowledge can be deployed for facing future infectious outbreaks. We here developed a novel gold-nanoparticle-based nucleic acid lateral flow assay for the rapid, visual, and quantitative detection of SARS-CoV-2. Our method was based on the use of a DNA internal standard (competitor) for quantification and involved RT-PCR, the hybridization of biotinylated PCR products to specific oligonucleotide probes, and detection with a dual lateral flow assay using gold nanoparticles conjugated to an anti-biotin antibody as reporters. The developed test allowed for rapid detection by the naked eye and the simultaneous quantification of SARS-CoV-2 in nasopharyngeal swabs with high specificity, detectability, and repeatability. This novel molecular strip test for COVID-19 detection represents a simple, cost-effective, and accurate rapid test that is very promising to be used as a future diagnostic tool.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Gold ; Metal Nanoparticles ; Pandemics ; Sensitivity and Specificity
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios12110926
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Article: Efficacy of Fosfomycin-Containing Regimens for Treatment of Bacteremia Due to Pan-Drug Resistant

Assimakopoulos, Stelios F / Karamouzos, Vassilis / Eleftheriotis, Gerasimos / Lagadinou, Maria / Bartzavali, Christina / Kolonitsiou, Fevronia / Paliogianni, Fotini / Fligou, Fotini / Marangos, Markos

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: Acinetobacter ... ...

Abstract	Acinetobacter baumannii
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12020286
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Article ; Online: Laboratory Surveillance of

Spiliopoulou, Anastasia / Giannopoulou, Ioanna / Assimakopoulos, Stelios F / Jelastopulu, Eleni / Bartzavali, Christina / Marangos, Markos / Paliogianni, Fotini / Kolonitsiou, Fevronia

Tropical medicine and infectious disease

2023 Volume 8, Issue 11

Abstract: Multidrug- ... ...

Abstract	Multidrug-resistant
Language	English
Publishing date	2023-11-19
Publishing country	Switzerland
Document type	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8110503
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Article ; Online: Acid-fast bacteria as causative agents of skin and soft tissue infections: case presentations and literature review.

Spiliopoulou, Anastasia / Kyriakou, Georgia / Georgiou, Sophia / Lekkou, Alexandra / Leonidou, Lydia / Militsopoulou, Maria / Papadogeorgaki, Eleni / Christofidou, Myrto / Kolonitsiou, Fevronia / Paliogianni, Fotini

Revista do Instituto de Medicina Tropical de Sao Paulo

2023 Volume 65, Page(s) e29

Abstract: Acid-fast bacteria can be implicated in skin and soft tissue infections. Diagnostic identification can be challenging or not feasible by routine laboratory techniques, especially if there is no access to the Matrix Assisted Laser Desorption Ionization ... ...

Abstract	Acid-fast bacteria can be implicated in skin and soft tissue infections. Diagnostic identification can be challenging or not feasible by routine laboratory techniques, especially if there is no access to the Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) technology. Here, we present two cases of skin and soft tissue infections caused by two different acid-fast bacteria, Nocardia brasiliensis and Mycobacterium marinum. They both grew on Löwenstein-Jensen medium, Sabouraud agar medium and blood agar medium. Both bacteria appeared acid-fast by Ziehl-Neelsen stain and Gram-positive by Gram stain. The identification was performed by MALDI-TOF MS and gene analysis. N. brasiliensis and nontuberculous mycobacterium M. marinum represent rare pathogens that cause severe skin and soft tissue infections. Failure to identify the causative agent and subsequent inappropriate or inadequate treatment may lead to severe complications or even disseminated disease, especially in immunocompromised individuals.
MeSH term(s)	Humans ; Agar ; Soft Tissue Infections/diagnosis ; Bacteria/chemistry ; Culture Media/chemistry ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Mycobacterium marinum
Chemical Substances	Agar (9002-18-0) ; Culture Media
Language	English
Publishing date	2023-04-14
Publishing country	Brazil
Document type	Review ; Journal Article
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202365029
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Zs.A 292: Show issues

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Article ; Online: Fungemia due to rare non-Candida yeasts between 2018 and 2021 in a Greek tertiary care university hospital.

Spiliopoulou, Anastasia / Lekkou, Alexandra / Vrioni, Georgia / Leonidou, Lydia / Cogliati, Massimo / Christofidou, Myrto / Marangos, Markos / Kolonitsiou, Fevronia / Paliogianni, Fotini

Journal de mycologie medicale

2023 Volume 33, Issue 3, Page(s) 101386

Abstract: Introduction: Non-Candida yeasts, although rare, are increasingly encountered and recognized as a growing threat.: Methods: Cases of bloodstream infections (BSIs) due to non-Candida yeasts (NCYs) during the last four years (2018-2021) are presented.!# ...

Abstract	Introduction: Non-Candida yeasts, although rare, are increasingly encountered and recognized as a growing threat. Methods: Cases of bloodstream infections (BSIs) due to non-Candida yeasts (NCYs) during the last four years (2018-2021) are presented. Results: During the study period, 16 cases caused by non-Candida yeasts out of 400 cases of yeast BSIs were recorded, corresponding to an incidence of 4%. Yeasts that were isolated included Cryptococcus spp (4 isolates-25%), Rhodotorula mucilaginosa (2 isolates-12.5%), Trichosporon asahii (7 isolates-43.75%) and Saccharomyces cerevisiae (3 isolates-18.75%). Predisposing factors involved mostly hematological malignancies, long term hospitalization or major surgical interventions. Most isolates, 15 out of 16 were susceptible to amphotericin B. Voriconazole was the most active azole in vitro. All isolates, except Saccharomyces spp., were resistant to echinocandins. Discussion: Early recognition of rare yeasts as causative agents of BSIs and prompt initiation of appropriate treatment based on current guidelines and expertise remain crucial in efficient patient management.
MeSH term(s)	Humans ; Fungemia/drug therapy ; Fungemia/epidemiology ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Greece ; Tertiary Healthcare ; Yeasts ; Sepsis ; Saccharomyces cerevisiae ; Hospitals ; Microbial Sensitivity Tests
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-04-04
Publishing country	France
Document type	Journal Article
ZDB-ID	1067006-3
ISSN	1773-0449 ; 1156-5233
ISSN (online)	1773-0449
ISSN	1156-5233
DOI	10.1016/j.mycmed.2023.101386
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Zs.A 3148: Show issues

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Article ; Online: Role of source control in critically ill candidemic patients: a multicenter retrospective study.

Marangos, Markos / Ioannou, Petros / Senn, Laurence / Spiliopoulou, Anastasia / Tzalis, Sotiris / Kolonitsiou, Fevronia / Valta, Maria / Kokkini, Sofia / Pagani, Jean-Luc / Stafylaki, Dimitra / Paliogianni, Fotini / Fligou, Fotini / Kofteridis, Diamantis P / Lamoth, Frédéric / Papadimitriou-Olivgeris, Matthaios

Infection

2024

Abstract: Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.: ...

Abstract	Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis. Methods: Multicenter retrospective study. Setting: This retrospective study was conducted in Intensive Care Units from three European university hospitals from 2015 to 2021. Adult patients with at least one positive blood culture for Candida spp. were included. Patients who did not require source control were excluded. Primary outcome was 14-day mortality. Results: A total of 409 episodes of candidemia were included. Most candidemias were catheter related (173; 41%), followed by unknown origin (170; 40%). Septic shock developed in 43% episodes. Overall, 14-day mortality rate was 29%. In Cox proportional hazards regression model, septic shock (P 0.001; HR 2.20, CI 1.38-3.50), SOFA score ≥ 10 points (P 0.008; HR 1.83, CI 1.18-2.86), and prior SARS-CoV-2 infection (P 0.003; HR 1.87, CI 1.23-2.85) were associated with 14-day mortality, while combined early appropriate antifungal treatment and source control (P < 0.001; HR 0.15, CI 0.08-0.28), and early source control without appropriate antifungal treatment (P < 0.001; HR 0.23, CI 0.12-0.47) were associated with better survival compared to those without neither early appropriate antifungal treatment nor source control. Conclusion: Early source control was associated with better outcome among candidemic critically ill patients.
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-024-02222-z
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article ; Online: Red Blood Cell Distribution Width: Another Prognostic Factor for COVID-19?

Lagadinou, Maria / Gkentzi, Despoina / Marangos, Markos N / Paliogianni, Fotini / Solomou, Elena E

Clinical hematology international

2021 Volume 3, Issue 2, Page(s) 69–71

Abstract: The coronavirus disease 2019 (COVID-19) is a pandemic with a high rate of hospitalization, admission to intensive care units, and mortality. Identifying patients at the highest risk for severe disease is important to facilitate early, aggressive ... ...

Abstract	The coronavirus disease 2019 (COVID-19) is a pandemic with a high rate of hospitalization, admission to intensive care units, and mortality. Identifying patients at the highest risk for severe disease is important to facilitate early, aggressive intervention. High red blood cell distribution width (RDW) values are associated with increased mortality in the general population in patients suffering from several conditions, including cardiovascular disease, sepsis, acute kidney injury, chronic obstructive pulmonary disease, and hepatitis B. Our study aimed to determine whether RDW levels in all COVID-19 confirmed cases admitted to the Patras University Hospital, Greece, was an independent prognostic factor of hospitalization and disease outcome.
Language	English
Publishing date	2021-04-10
Publishing country	France
Document type	Journal Article
ISSN	2590-0048
ISSN (online)	2590-0048
DOI	10.2991/chi.k.210404.001
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Article: Varicella-zoster virus aseptic meningitis: an atypical presentation in an immunocompetent male patient.

Platanaki, Christina / Leonidou, Leonidia / Siagkris, Dimitrios / Giannopoulou, Ιoanna / Paliogianni, Fotini / Velissaris, Dimitrios

Oxford medical case reports

2021 Volume 2021, Issue 6, Page(s) omab035

Abstract: Varicella-zoster virus (VZV) reactivation causes a relatively common disease in immunocompromised patients characterized by rash and radiating pain. Aseptic meningitis is a rare complication of VZV infection and commonly is associated with exanthem and ... ...

Abstract	Varicella-zoster virus (VZV) reactivation causes a relatively common disease in immunocompromised patients characterized by rash and radiating pain. Aseptic meningitis is a rare complication of VZV infection and commonly is associated with exanthem and neurological signs. We present an atypical case of VZV meningitis in a healthy 56-year-old male who was initially presented with persistent headache as the only symptom. Anti-VZV immunoglobulin G titer both in serum and in cerebrospinal fluid (CSF) and the polymerase chain reaction (PCR) CSF analysis revealed VZV infection. Our case highlights the importance of considering VZV aseptic meningitis in immunocompetent individuals even in the absence of the typical presentation of meningitis. Screening techniques such as CSF, PCR as well as anti-VZV antibodies in CSF show that VZV meningitis is a common cause of aseptic meningitis and allows the early recognition of CNS involvement in the VZV infection.
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omab035
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Article ; Online: Invasive Candida kefyr infection presenting as pyelonephritis in an ICU hospitalized COVID-19 patient: Case report and review of the literature.

Spiliopoulou, Anastasia / Kolonitsiou, Fevronia / Vrioni, Georgia / Tsoupra, Stamatia / Lekkou, Alexandra / Paliogianni, Fotini

Journal de mycologie medicale

2021 Volume 32, Issue 2, Page(s) 101236

Abstract: Candida kefyr (Kluyveromyces marxianus), an ascomycetous environmental yeast, occasionally isolated from dairy products, represents an uncommon but emerging pathogen in immunocompromised patients. Herein, we present a case of C. kefyr pyelonephritis in a ...

Abstract	Candida kefyr (Kluyveromyces marxianus), an ascomycetous environmental yeast, occasionally isolated from dairy products, represents an uncommon but emerging pathogen in immunocompromised patients. Herein, we present a case of C. kefyr pyelonephritis in a 41-year-old, previously immunocompetent, patient who was hospitalized in an COVID-19 ICU. Pyelonephritis was associated with caliectasis and obstruction due to possible fungus ball formation. Predisposing factors included ICU stay, use of broad spectrum antibiotics and steroids, central venous catheterization, mechanical ventilation and urologic manipulation. Susceptibility testing revealed high MIC values to amphotericin B. Infection was effectively controlled by prolonged administration of fluconazole without further surgical intervention. COVID-19 complicated with invasive candidiasis is an increasingly observed clinical situation that warrants high suspicion index and careful evaluation of laboratory data.
MeSH term(s)	Adult ; Antifungal Agents/therapeutic use ; COVID-19/complications ; Candida ; Candidiasis ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/drug therapy ; Fluconazole/therapeutic use ; Humans ; Intensive Care Units ; Kluyveromyces ; Pyelonephritis/diagnosis ; Pyelonephritis/drug therapy
Chemical Substances	Antifungal Agents ; Fluconazole (8VZV102JFY)
Language	English
Publishing date	2021-12-23
Publishing country	France
Document type	Case Reports ; Review
ZDB-ID	1067006-3
ISSN	1773-0449 ; 1156-5233
ISSN (online)	1773-0449
ISSN	1156-5233
DOI	10.1016/j.mycmed.2021.101236
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