Article ; Online: The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).
Environmental health perspectives
2024 Volume 132, Issue 4, Page(s) 45001
Abstract: Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to : Objectives: We identify the flaws in the assumptions that the German BfR, as well as the ... ...
| Abstract | Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to Objectives: We identify the flaws in the assumptions that the German BfR, as well as the FDA, have used to justify maintaining the TDI for BPA at levels above what a vast amount of academic research shows to cause harm. We argue that regulatory agencies need to incorporate 21st century science into chemical hazard identifications using the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) nonguideline academic studies in a collaborative government-academic program model. Discussion: We strongly endorse EFSA's revised TDI for BPA and support the European Commission's (EC) apparent acceptance of this updated BPA risk assessment. We discuss challenges to current chemical risk assessment assumptions about EDCs that need to be addressed by regulatory agencies to, in our opinion, become truly protective of public health. Addressing these challenges will hopefully result in BPA, and eventually other structurally similar bisphenols (called regrettable substitutions) for which there are known adverse effects, being eliminated from all food-related and many other uses in the EU and elsewhere. https://doi.org/10.1289/EHP13812. |
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| MeSH term(s) | Humans ; Benzhydryl Compounds ; Food Safety ; No-Observed-Adverse-Effect Level ; Phenols ; Systematic Reviews as Topic | ||||||||||
| Chemical Substances | Benzhydryl Compounds ; bisphenol A (MLT3645I99) ; Phenols | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2024-04-09 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 195189-0 | ||||||||||
| ISSN | 1552-9924 ; 0091-6765 ; 1078-0475 | ||||||||||
| ISSN (online) | 1552-9924 | ||||||||||
| ISSN | 0091-6765 ; 1078-0475 | ||||||||||
| DOI | 10.1289/EHP13812 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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