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  1. Article ; Online: New fracture patterns distal epiphysis femur in youth: Update of current classification.

    Papotto, G / Milordo, G / Comitini, S / Salvo, G C / Palmeri, A / Costanzo, F / Longo, G F / Ganci, M

    Injury

    2024  , Page(s) 111534

    Abstract: Intro: Distal growth core fractures of the femur are the third most common fracture in patients older than 10 years. These fractures result from high-energy trauma and have a high risk of evolving into growth disorders. The classification most used to ... ...

    Abstract Intro: Distal growth core fractures of the femur are the third most common fracture in patients older than 10 years. These fractures result from high-energy trauma and have a high risk of evolving into growth disorders. The classification most used to describe these types of fractures is that described by Salter and Harris. Special clinical cases often occur in clinical practice that are not described in the classifications used. In our study, we analyzed and further focused on new fracture patterns related to pediatric epiphyseal detachments not easily described by the normal classifications currently used in the literature.
    Materials and methods: From January 2020 to December 2022, we treated 2 male clinical cases with epiphyseal detachments of the distal femur that could not be classified according to the Salter and Harris classification. age of the patients was 10 and 11 years, respectively; for both patients, the traumatic mechanism was a direct trauma to the right knee at high speed using an electric scooter; Serious clinical and radiographic follow-ups were performed at month 1, month 3, month 6, month 12, and month 24 from the date of surgery.
    Discussion: Distal femur fractures represent a challenge for the orthopedics because they have a high incidence of complications. In our experience, there has been an increase in this type of injury caused using recently developed electric vehicles, which can reach considerable speeds. The Salter Harris classification is among the most widely used for fractures involving the growth physis. This classification proved to be rather limiting in the present case, so we decided to classify the fracture as 'Salter Harris III equivalent'.
    Conclusions: The fracture examined is a very rare fracture of the distal femur and is not reflected in the classifications currently in use. The patient presented an excellent clinical and radiographic result after surgery with the presence of a shortening of the affected femur in relation to the contralateral one, which suggests that the growth deficit may continue and increase over time for which reason future studies until skeletal maturity will be necessary to quantify the damage to the growth physis.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2024.111534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer's disease.

    Tropea, Maria Rosaria / Gulisano, Walter / Vacanti, Valeria / Arancio, Ottavio / Puzzo, Daniela / Palmeri, Agostino

    Free radical biology & medicine

    2022  Volume 193, Issue Pt 2, Page(s) 657–668

    Abstract: The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in synaptic plasticity and memory processes, resulting in an increase of cAMP response element-binding (CREB) phosphorylation, and consequent synthesis of plasticity- ... ...

    Abstract The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in synaptic plasticity and memory processes, resulting in an increase of cAMP response element-binding (CREB) phosphorylation, and consequent synthesis of plasticity-related proteins. The NO/cGMP/CREB signaling is downregulated during aging and neurodegenerative disorders and is affected by Amyloid-β peptide (Aβ) and tau protein, whose increase and deposition is considered the key pathogenic event of Alzheimer's disease (AD). On the other hand, in physiological conditions, the crosstalk between the NO/cGMP/PKG/CREB pathway and Aβ ensures long-term potentiation and memory formation. This review summarizes the current knowledge on the interaction between the NO/cGMP/PKG/CREB pathway and Aβ in the healthy and diseased brain, offering a new perspective to shed light on AD pathophysiology. We will focus on the synaptic mechanisms underlying Aβ physiological interplay with cGMP pathway and how this balance is corrupted in AD, as high levels of Aβ interfere with NO production and cGMP molecular signaling leading to cognitive impairment. Finally, we will discuss results from preclinical and clinical studies proposing the increase of cGMP signaling as a therapeutic strategy in the treatment of AD.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Nitric Oxide ; Amyloid beta-Peptides/genetics ; Signal Transduction ; Cyclic GMP
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Amyloid beta-Peptides ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2022.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ketogenic Diet in Neonates with Drug-Resistant Epilepsy: Efficacy and Side Effects-A Single Center's Initial Experience.

    Falsaperla, Raffaele / Sortino, Vincenzo / Collotta, Ausilia Desiree / Privitera, Grete Francesca / Palmeri, Antonio / Mauceri, Laura / Ruggieri, Martino

    Neuropediatrics

    2023  Volume 54, Issue 5, Page(s) 315–321

    Abstract: Background: For patients with pharmacoresistant epilepsy, a therapeutic option is ketogenic diet. Currently, data on young infants are scarce, particularly during hospitalization in the neonatal intensive care unit (NICU).: Objective: The aim of the ... ...

    Abstract Background: For patients with pharmacoresistant epilepsy, a therapeutic option is ketogenic diet. Currently, data on young infants are scarce, particularly during hospitalization in the neonatal intensive care unit (NICU).
    Objective: The aim of the present study was to evaluate the short-term (3-month) efficacy and side effects of ketogenic diet in infants with "drugs-resistant" epilepsy treated during NICU stay.
    Methods: This retrospective study included infants aged under 2 months started on ketogenic diet during NICU hospitalization to treat drug-resistant epilepsy from April 2018 to November 2022.
    Results: Thirteen term-born infants were included, three (23.1%) of whom were excluded because they did not respond to the ketogenic diet. Finally, we included 10 infants. Six (60%) patients took three antiepileptics before starting the ketogenic diet, while four (40%) took more drugs. Diet had a good response in four (40%) patients. In four patients, the ketogenic diet was suspended because of the onset of serious side effects. The emetic levels of sodium, potassium, and chlorine, pH, and onset of diarrhea, constipation, and gastroesophageal reflux showed significant differences. Ketonuria was higher and blood pH lower in the group that took more than three drugs than in the group taking fewer than three drugs.
    Conclusion: The ketogenic diet is efficacious and safe in infants, but the early and aggressive management of adverse reactions is important to improve the safety and effectiveness of the ketogenic treatment.
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Diet, Ketogenic/adverse effects ; Retrospective Studies ; Drug Resistant Epilepsy/drug therapy ; Epilepsy ; Ketone Bodies ; Treatment Outcome
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2023-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-0043-1769505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Short Efficacy Evaluation of External Ventricular Drains Versus Ventriculosubgaleal Shunt in the Management of Neonatal Posthemorrhagic Hydrocephalus: A Retrospective Single-Center Cohort Study.

    Falsaperla, Raffaele / Lo Bianco, Manuela / Palmeri, Antonio / Betta, Pasqua / Altieri, Roberto / Barbagallo, Giuseppe Maria / Ruggieri, Martino

    Neurosurgery

    2023  Volume 93, Issue 3, Page(s) 622–627

    Abstract: Background: Different temporizing neurosurgical procedures are available for the management of posthemorrhagic hydrocephalus in preterm newborns.: Objective: To evaluate the short efficacy of the external ventricular drains (EVDs) and the ... ...

    Abstract Background: Different temporizing neurosurgical procedures are available for the management of posthemorrhagic hydrocephalus in preterm newborns.
    Objective: To evaluate the short efficacy of the external ventricular drains (EVDs) and the ventriculosubgaleal (VSG) shunt.
    Methods: This is a Strengthening the Reporting of Observational Studies in Epidemiology-conformed retrospective cohort study. The inclusion criteria were (1) gestational age <37 weeks, (2) birth weight <1500 g, (3) posthemorrhagic hydrocephalus because of intraventricular hemorrhage grade II/III, and (4) EVD or VSG shunt procedure before ventriculoperitoneal (VP)-definite shunt. Twenty-four newborns were collected from 2006 to 2022. The end points considered were infectious events, proteinorrachia, reintervention rate, and time to conversion to definite VP shunt.
    Results: Overall, 12/24 newborns underwent EVD, and the remnant had a VSG shunt. The results showed a statistically significant difference ( P = .02) concerning cerebrospinal fluid infections between the EVD group (50%) and VSG shunt 1 (8.33%). The reintervention rate of EVD was significantly higher (66.67%) compared with that of the VSG shunt group (8.33%). A statistically significant difference was stated between the 2 groups (t[13] = -8.250; P < .001) (mean difference ± standard error; 10.5 ± 1.273) in the mean number of days elapsed from the achievement of the ideal weight (2000 g) to the definitive VP drainage.
    Conclusion: The increased infectious risk and the higher reintervention rate in EVD were confirmed in this study. In addition, a significant delay in the time to -conversion from EVD to VP shunt was demonstrated. Despite these optimal results, the VSG shunt remains a low practiced intervention, probably because of the limited operator experience.
    MeSH term(s) Infant, Newborn ; Humans ; Infant ; Retrospective Studies ; Cohort Studies ; Treatment Outcome ; Ventriculoperitoneal Shunt/adverse effects ; Hydrocephalus/etiology ; Hydrocephalus/surgery ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/surgery ; Drainage/adverse effects ; Infant, Very Low Birth Weight
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/neu.0000000000002459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Shieh Score as a Risk Assessment Instrument for Reducing Hospital-Acquired Pressure Injuries: A Prospective Cohort Study.

    Shieh, David / Sevilla, Mia / Palmeri, Anthony / Ly, An H / Shi, Jiaxiao M / Berringer, Christine / Resurreccion, Juji

    Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society

    2023  Volume 50, Issue 5, Page(s) 375–380

    Abstract: Purpose: The purpose of this study was to evaluate the Shieh Score's effectiveness in decreasing the rate of hospital-acquired pressure injuries when combined with an early warning notification system and standard order set of preventative measures.: ... ...

    Abstract Purpose: The purpose of this study was to evaluate the Shieh Score's effectiveness in decreasing the rate of hospital-acquired pressure injuries when combined with an early warning notification system and standard order set of preventative measures.
    Design: This was a prospective cohort study.
    Subjects and setting: This target population was nonpregnant, adult, hospitalized patients on inpatient and observation status at a tertiary hospital (Kaiser Permanente, Baldwin Park, California) during the 2020 year of the COVID-19 pandemic.
    Methods: A new, risk assessment instrument, the Shieh Score, was developed in 2019 to predict hospitalized patients at high risk for pressure injuries. Data collection occurred between January 21, 2020, and December 31, 2020. When a hospital patient met the high-risk criteria for the Shieh Score, a provider-ordered pink-colored sheet of paper titled "Skin at Risk" was hung at the head of the bed and a standard order set of pressure injury preventative measures was implemented by nursing staff.
    Results: Implementation of the program (Shieh Score, early warning system, and standard order set for preventive interventions) resulted in a 38% reduction in the annual hospital-acquired pressure injury rate from a mean incidence rate of 1.03 to 0.64 hospital-acquired pressure injuries per 1000 patient-days measured for the year 2020.
    Conclusion: The Shieh Score is a pressure injury risk assessment instrument, which effectively identifies patients at high risk for hospital-acquired pressure injuries and decreases the hospital-acquired pressure injury rate when combined with an early warning notification system and standard order set.
    MeSH term(s) Adult ; Humans ; Pressure Ulcer/epidemiology ; Pressure Ulcer/prevention & control ; Pressure Ulcer/etiology ; Prospective Studies ; Pandemics ; Risk Assessment ; Hospitals
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1188388-1
    ISSN 1528-3976 ; 1071-5754
    ISSN (online) 1528-3976
    ISSN 1071-5754
    DOI 10.1097/WON.0000000000000997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The keystone of Alzheimer pathogenesis might be sought in Aβ physiology.

    Puzzo, D / Gulisano, W / Arancio, O / Palmeri, A

    Neuroscience

    2015  Volume 307, Page(s) 26–36

    Abstract: For several years Amyloid-beta peptide (Aβ) has been considered the main pathogenetic factor of Alzheimer's disease (AD). According to the so called Amyloid Cascade Hypothesis the increase of Aβ triggers a series of events leading to synaptic dysfunction ...

    Abstract For several years Amyloid-beta peptide (Aβ) has been considered the main pathogenetic factor of Alzheimer's disease (AD). According to the so called Amyloid Cascade Hypothesis the increase of Aβ triggers a series of events leading to synaptic dysfunction and memory loss as well as to the structural brain damage in the later stage of the disease. However, several evidences suggest that this hypothesis is not sufficient to explain AD pathogenesis, especially considering that most of the clinical trials aimed to decrease Aβ levels have been unsuccessful. Moreover, Aβ is physiologically produced in the healthy brain during neuronal activity and it is needed for synaptic plasticity and memory. Here we propose a model interpreting AD pathogenesis as an alteration of the negative feedback loop between Aβ and its physiological receptors, focusing on alpha7 nicotinic acetylcholine receptors (α7-nAchRs). According to this vision, when Aβ cannot exert its physiological function a negative feedback mechanism would induce a compensatory increase of its production leading to an abnormal accumulation that reduces α7-nAchR function, leading to synaptic dysfunction and memory loss. In this perspective, the indiscriminate Aβ removal might worsen neuronal homeostasis, causing a further impoverishment of learning and memory. Even if further studies are needed to better understand and validate these mechanisms, we believe that to deepen the role of Aβ in physiological conditions might represent the keystone to elucidate important aspects of AD pathogenesis.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Humans ; Signal Transduction/physiology
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
    Language English
    Publishing date 2015-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2015.08.039
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  7. Article ; Online: Persistence of elevated betaHCG after uterine curettage: unexpected diagnosis for a young woman.

    Palmeri, Agnese / D'Alessandro, Gloria / Costantini, Sergio

    American journal of obstetrics and gynecology

    2018  Volume 220, Issue 4, Page(s) 401–402

    MeSH term(s) Abortion, Spontaneous/blood ; Abortion, Spontaneous/diagnostic imaging ; Abortion, Spontaneous/surgery ; Adult ; Chorionic Gonadotropin, beta Subunit, Human/blood ; Diagnostic Errors ; Dilatation and Curettage ; Female ; Humans ; Magnetic Resonance Imaging ; Pregnancy ; Pregnancy, Cornual/diagnostic imaging ; Ultrasonography ; Uterus/abnormalities ; Uterus/diagnostic imaging
    Chemical Substances Chorionic Gonadotropin, beta Subunit, Human
    Language English
    Publishing date 2018-08-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2018.08.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding paediatric data standards challenges through academia-industry partnerships: A conect4children (c4c) qualitative study.

    Sen, Anando / Palmeri, Avril / Lee, Joanne / Hedley, Victoria / Thuet, Jacques / Lignon, Perrine / Cotonnec, Valerie / Leary, Rebecca / Nally, Sinéad / Straub, Volker

    The International journal of health planning and management

    2022  Volume 38, Issue 2, Page(s) 416–429

    Abstract: Introduction: The conect4children (c4c) consortium was setup to facilitate the development of new drugs and therapies for paediatric populations and address key challenges associated with paediatric clinical trials. Two of the major adopting principles ... ...

    Abstract Introduction: The conect4children (c4c) consortium was setup to facilitate the development of new drugs and therapies for paediatric populations and address key challenges associated with paediatric clinical trials. Two of the major adopting principles for c4c were academia-industry partnership and data harmonisation and interoperability through common eCRF definitions. To understand the challenges arising out of these principles, the c4c team at Newcastle University conducted semi-structured interviews with four c4c industry partners.
    Methods: Each partner was asked 10 questions about the data standards used in their company, management and maintenance of data dictionaries, how they dealt with paediatric-specific issues, major knowledge gaps and how academia could aid in bridging these gaps. Thematic analysis was performed to identify patterns in their answers.
    Results: All companies use the Clinical Data Interchange Standards Consortium (CDISC) standards but face problems when certain terminology is not included in CDISC (e.g., paediatric-specific terminologies). All companies were committed to interoperability and had strict policies about how additional terminology could be added to their dictionaries. Three of the four companies maintained a single dictionary but also had lighter versions for specific usage. The two major knowledge gaps identified from the interviews were handling of non-CDISC terminology and maintenance of normal lab ranges in dictionaries.
    Discussion: To address these gaps, c4c has been working on a four-point plan including the development of a cross-cutting paediatric dictionary and a paediatric user guide in collaboration with CDISC.
    MeSH term(s) Child ; Humans ; Qualitative Research ; Clinical Trials as Topic ; Drug Development ; Public-Private Sector Partnerships
    Language English
    Publishing date 2022-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 632786-2
    ISSN 1099-1751 ; 0749-6753
    ISSN (online) 1099-1751
    ISSN 0749-6753
    DOI 10.1002/hpm.3592
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  9. Article ; Online: Cystic Fibrosis and Oxidative Stress: The Role of CFTR.

    Moliteo, Evelina / Sciacca, Monica / Palmeri, Antonino / Papale, Maria / Manti, Sara / Parisi, Giuseppe Fabio / Leonardi, Salvatore

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 16

    Abstract: There is substantial evidence in the literature that patients with cystic fibrosis (CF) have higher oxidative stress than patients with other diseases or healthy subjects. This results in an increase in reactive oxygen species (ROS) and in a deficit of ... ...

    Abstract There is substantial evidence in the literature that patients with cystic fibrosis (CF) have higher oxidative stress than patients with other diseases or healthy subjects. This results in an increase in reactive oxygen species (ROS) and in a deficit of antioxidant molecules and plays a fundamental role in the progression of chronic lung damage. Although it is known that recurrent infection-inflammation cycles in CF patients generate a highly oxidative environment, numerous clinical and preclinical studies suggest that the airways of a patient with CF present an inherently abnormal proinflammatory milieu due to elevated oxidative stress and abnormal lipid metabolism even before they become infected. This could be directly related to cystic fibrosis transmembrane conductance regulator (CFTR) deficiency, which appears to produce a redox imbalance in epithelial cells and extracellular fluids. This review aims to summarize the main mechanism by which CFTR deficiency is intrinsically responsible for the proinflammatory environment that characterizes the lung of a patient with CF.
    MeSH term(s) Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Lung/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
    Chemical Substances CFTR protein, human ; Reactive Oxygen Species ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2022-08-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27165324
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  10. Article ; Online: Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy.

    Scuto, M / Modafferi, S / Rampulla, F / Zimbone, V / Tomasello, M / Spano', S / Ontario, M L / Palmeri, A / Trovato Salinaro, A / Siracusa, R / Di Paola, R / Cuzzocrea, S / Calabrese, E J / Wenzel, U / Calabrese, V

    Mechanisms of ageing and development

    2022  Volume 205, Page(s) 111686

    Abstract: Recent evidence demonstrates that Crocus sativus L. (saffron) counteracts oxidative stress, mitochondrial dysfunction and neuroinflammation, closely linked to initiation and progression of major brain pathologies. Interestingly, saffron constituents such ...

    Abstract Recent evidence demonstrates that Crocus sativus L. (saffron) counteracts oxidative stress, mitochondrial dysfunction and neuroinflammation, closely linked to initiation and progression of major brain pathologies. Interestingly, saffron constituents such as crocin, crocetin and safranal can exert antioxidant or toxic effects depending on their endogenous concentration. According to the hormesis principles, at low dose they act as antioxidants in a wide range of brain diseases by upregulating Nrf2 signaling pathway and the expression of vitagenes, such as NAD(P)H-quinone oxidoreductase (NQO1), glutathione transferase (GT), heme oxygenase-1 (HO-1), sirtuin-1 (Sirt1) and thioredoxin (Trx) system. Importantly, neuronal dysregulation of Nrf2 pathway can be a prominent cause of selective susceptibility, under neuroinflammatory conditions, due to the high vulnerability of brain cells to oxidative stress. Here we discuss natural inducers from saffron targeting Nrf2/vitagene pathway for development of new therapeutical strategies to suppress oxidative stress and neuroinflammation and consequently cognitive dysfunction. In this review we also focus on the hormetic effect of saffron active constituents, summarizing their neuroprotective and anti-neuroinflammatory properties, as well as pharmacological perspectives in brain disorders.
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Brain Diseases ; Crocus ; Humans ; NF-E2-Related Factor 2 ; Oxidation-Reduction ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use
    Chemical Substances Antioxidants ; NF-E2-Related Factor 2 ; Plant Extracts
    Language English
    Publishing date 2022-05-21
    Publishing country Ireland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2022.111686
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