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  1. Article ; Online: Response to the comment on "pattern of recurrence and survival after D2 right colectomy for cancer: is there place for a routine more extended lymphadenectomy?"

    Palmeri, Matteo / Peri, Andrea / Morelli, Luca

    Updates in surgery

    2022  

    Language English
    Publishing date 2022-11-23
    Publishing country Italy
    Document type Letter
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01423-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contrast Enhanced Ultrasound in Detecting Biliary Complications After ABO-Incompatible Liver Transplantation.

    Comandatore, Annalisa / Palmeri, Matteo / Fatucchi, Lorenzo Maria / Campatelli, Alessandro

    Progress in transplantation (Aliso Viejo, Calif.)

    2021  Volume 31, Issue 3, Page(s) 283–284

    MeSH term(s) Graft Rejection ; Graft Survival ; Humans ; Liver Transplantation ; Living Donors ; Ultrasonography
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2864264-8
    ISSN 2164-6708 ; 1526-9248
    ISSN (online) 2164-6708
    ISSN 1526-9248
    DOI 10.1177/15269248211024619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Minimally Invasive Surgery for the Treatment of Moderate to Critical Acute Pancreatitis: A Case-matched Comparison With the Traditional Open Approach Over 10 years.

    Morelli, Luca / Guadagni, Simone / Palmeri, Matteo / Bechini, Bianca / Gianardi, Desirée / Furbetta, Niccolò / Di Franco, Gregorio / Di Candio, Giulio

    Surgical laparoscopy, endoscopy & percutaneous techniques

    2023  Volume 33, Issue 2, Page(s) 191–197

    Abstract: Purpose: The purpose of this study is to compare short-term and midterm outcomes between patients with acute pancreatitis (AP) treated with minimally invasive surgery (MIS) and patients treated with open necrosectomy (ON).: Materials and methods: We ... ...

    Abstract Purpose: The purpose of this study is to compare short-term and midterm outcomes between patients with acute pancreatitis (AP) treated with minimally invasive surgery (MIS) and patients treated with open necrosectomy (ON).
    Materials and methods: We compared data of all patients who had undergone MIS for AP with a similar group of patients with ON patients between January 2012 and June 2021 using a case-matched methodology based on AP severity and patient characteristics. Inhospital and midterm follow-up variables, including quality-of-life assessment, were evaluated.
    Results: Starting from a whole series of 79 patients with moderate to critical AP admitted to our referral center, the final study sample consisted of 24 patients (12 MIS and 12 ON). Postoperative (18.7±10.9 vs. 30.3±21.7 d; P =0.05) and overall hospitalization (56.3±17.4 vs. 76.9±39.4 d; P =0.05) were lower in the MIS group. Moreover, the Short-Form 36 scores in the ON group were statistically significantly lower in role limitations because of emotional problems ( P =0.002) and health changes ( P =0.03) at 3 and 6 months and because of emotional problems ( P =0.05), emotional well-being ( P =0.02), and general health ( P =0.007) at 1 year.
    Conclusions: MIS for the surgical management of moderate to critical AP seems to be a good option, as it could provide more chances for a better midterm quality of life compared with ON. Further studies are needed to confirm our findings.
    MeSH term(s) Humans ; Treatment Outcome ; Quality of Life ; Acute Disease ; Pancreatitis/surgery ; Minimally Invasive Surgical Procedures/methods ; Retrospective Studies
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1475108-2
    ISSN 1534-4908 ; 1530-4515 ; 1051-7200
    ISSN (online) 1534-4908
    ISSN 1530-4515 ; 1051-7200
    DOI 10.1097/SLE.0000000000001157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New perspectives about the role of robot-assisted surgery for the treatment of endometriosis.

    Furbetta, Niccolò / Bianchini, Matteo / Palmeri, Matteo / Morelli, Luca

    Journal of robotic surgery

    2019  Volume 13, Issue 4, Page(s) 609–610

    MeSH term(s) Endometriosis/surgery ; Female ; Humans ; Laparoscopy ; Quality of Life ; Robotic Surgical Procedures ; Robotics
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-019-00947-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The use of da Vinci Xi and the increased surgeon's experience could change the perspective over the cost-benefit ratio of robot-assisted surgery.

    Gianardi, Desirée / Palmeri, Matteo / Morelli, Luca

    Updates in surgery

    2018  Volume 71, Issue 2, Page(s) 399–400

    MeSH term(s) Costs and Cost Analysis ; Humans ; Inpatients ; Laparoscopy ; Robotics ; Surgeons
    Language English
    Publishing date 2018-12-26
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-018-00617-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Robotic Hepatectomy plus Biliary Reconstruction for Bismuth Type III and Type IV Hilar Cholangiocarcinoma: State of the Art and Literature Review.

    Guadagni, Simone / Comandatore, Annalisa / Furbetta, Niccolò / Di Franco, Gregorio / Carpenito, Cristina / Bechini, Bianca / Vagelli, Filippo / Ramacciotti, Niccolò / Palmeri, Matteo / Di Candio, Giulio / Morelli, Luca

    Journal of personalized medicine

    2023  Volume 14, Issue 1

    Abstract: Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this ... ...

    Abstract Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this setting, the aim of this study is to evaluate the potential benefits of RAS in III-IV HC in terms of post-operative outcomes.
    Methods: We conducted a systematic review using the PRISMA checklist for article selection. We searched the PubMed database and included only studies with clinical data about the treatment of III-IV HC using RAS.
    Results: A total of 12 papers involving 50 patients were included. All cases were Bismuth IIIa (
    Conclusions: RAS for III-IV HC is safe and feasible, at least if performed by experienced surgeons on selected cases. The oncological outcomes appear acceptable, given the aggressiveness of this pathology, but further studies are needed to fully elucidate the exact role of robotics in this setting.
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Initial 50 consecutive full-robotic pancreatoduodenectomies without conversion by a single surgeon: a learning curve analysis from a tertiary referral high-volume center.

    Morelli, Luca / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Di Franco, Gregorio / Gianardi, Desirée / Cervelli, Rosa / Lorenzoni, Valentina / Comandatore, Annalisa / Carpenito, Cristina / Di Candio, Giulio / Cuschieri, Alfred

    Surgical endoscopy

    2023  Volume 37, Issue 5, Page(s) 3531–3539

    Abstract: Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic ... ...

    Abstract Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic experiences and do not take into account the previous surgical background in pancreatic surgery (PS) and in robotic-assisted surgery (RAS), the center's volume, as well as the platform used, we aimed to perform a surgical outcomes analysis with a particular view to these aspects.
    Methods: Intraoperative and perioperative outcomes of the first 50 consecutive R-PD performed with the da Vinci Xi by the same surgeon, within a tertiary referral high-volume center, between January 2018 and March 2022, were analyzed. The surgeon was previously experienced in both PS and RAS. Shewhart control chart and cumulative sum (CUSUM) analysis were used to evaluate the learning curve of R-PD.
    Results: All the operations were performed with a full-robotic technique, without any conversion to open surgery. Twenty of 50 patients (40%) had a BMI ≥ 25 kg/m
    Conclusions: An extensive prior experience in both PS and RAS, within a tertiary referral high-volume center with availability of the da Vinci Xi platform, can significantly flatten the learning curve and, therefore, enable safe performance of challenging operations, i.e., pancreatoduodenectomies with a minimally invasive approach, with very low risk of conversion to open surgery, even in the first 50 operations.
    MeSH term(s) Humans ; Learning Curve ; Pancreaticoduodenectomy ; Referral and Consultation ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Surgeons/education
    Language English
    Publishing date 2023-01-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09784-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy: Comparison between traditional open surgery and full-robotic approach with da Vinci Xi.

    Morelli, Luca / Di Franco, Gregorio / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Gianardi, Desirée / Carpenito, Cristina / Comandatore, Annalisa / Giovannetti, Elisa / Di Candio, Giulio / Cuschieri, Alfred

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2023  , Page(s) e2571

    Abstract: Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD.: Methods: Open ... ...

    Abstract Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD.
    Methods: Open and robotic PDs were performed in 353 and 50 cases, respectively, from January 2009 to March 2022. We compared the clinical outcomes and incidence of clinically relevant DGE between robotic PpPD (R-PpPD) and open PpPD after one-to-one case-control matching.
    Results: Each group consisted of 30 patients. Clinically relevant DGE was less common after R-PpPD (3/30 [10%] vs. 10/30 cases [33.3%], p = 0.028). The median length of hospital stay (LoS) was significantly lower in the R-PpPD group (10 vs. 15 days, p = 0.013).
    Conclusion: The reduced tissue trauma by the minimally invasive robotic approach is associated with a lower incidence of DGE, reducing the LoS and encouraging PpPD performed using the fully robotic approach.
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.2571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Immune landscape and oncobiota in HPV-Associated Colorectal Cancer: an explorative study.

    Ambrosio, Maria Raffaella / Niccolai, Elena / Petrelli, Federica / Di Gloria, Leandro / Bertacca, Gloria / Giusti, Andrea / Baldi, Simone / Cavazzana, Andrea / Palmeri, Matteo / Perotti, Bruno / Ramazzotti, Matteo / Arganini, Marco / Amedei, Amedeo

    Clinical and experimental medicine

    2023  Volume 23, Issue 8, Page(s) 5101–5112

    Abstract: Worldwide more than 550,000 new patients suffering from malignant tumors are associated with human papillomaviruses (HPV) infection. However, only a small portion of patients infected progress to cancer, suggesting that other factors other than HPV may ... ...

    Abstract Worldwide more than 550,000 new patients suffering from malignant tumors are associated with human papillomaviruses (HPV) infection. However, only a small portion of patients infected progress to cancer, suggesting that other factors other than HPV may play a role. Some studies have investigated HPV infection in colorectal cancer (CRC) with discordant results; moreover, the role of HPV in CRC development is still unknown. We investigated HPV infection in 50 CRC from different regions, excluding the anal one, by immunohistochemistry (IHC), real-time PCR and RNA-seq. For each patient, we studied the tumor microenvironment in neoplastic and matched non-neoplastic samples, and we compared the tumor-infiltrating immune cell phenotypes among HPV-positive and negative samples. Finally, we compared the CRC-associated microbiota in HPV-positive and negative neoplastic samples by 16S rRNA sequencing. HPV infection was identified in 20% of CRC from the right side (caecum, ascending and transverse colon) and in 40% from the left side (descending colon and rectum). In all HPV-positive CRCs we found no expression of p53 and RB, thus suggesting HPV involvement in tumorigenesis. As far as the tumor microenvironment is concerned, in HPV-related cancers we observed a neoplastic environment with a reduced immune surveillance but an enhanced cytotoxic response by lymphocytes. HPV-positive and -negative CRC showed a different microbiota with lack of species normally found in CRC in the HPV-positive ones. Our results support the carcinogenic significance of HPV in CRC, suggesting a role of HPV in modulating the tumor immune microenvironment.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; RNA, Ribosomal, 16S ; Tumor Microenvironment
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-08-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-023-01165-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comment on: 'Money for nothing'. The role of robotic-assisted laparoscopy for the treatment of endometriosis.

    Palmeri, Matteo / Di Franco, Gregorio / Furbetta, Niccolò / Morelli, Luca

    Journal of robotic surgery

    2018  Volume 13, Issue 3, Page(s) 529–530

    MeSH term(s) Endometriosis/surgery ; Female ; Humans ; Laparoscopy ; Robotic Surgical Procedures ; Treatment Outcome
    Language English
    Publishing date 2018-12-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-018-00908-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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