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Article: Clinical Significance of Molecular Alterations and Systemic Therapy for Meningiomas: Where Do We Stand?

Pellerino, Alessia / Bruno, Francesco / Palmiero, Rosa / Pronello, Edoardo / Bertero, Luca / Soffietti, Riccardo / Rudà, Roberta

Cancers

2022 Volume 14, Issue 9

Abstract: Meningiomas are common intracranial tumors that can be treated successfully in most cases with surgical resection and/or adjuvant radiotherapy. However, approximately 20% of patients show an aggressive clinical course with tumor recurrence or progressive ...

Abstract	Meningiomas are common intracranial tumors that can be treated successfully in most cases with surgical resection and/or adjuvant radiotherapy. However, approximately 20% of patients show an aggressive clinical course with tumor recurrence or progressive disease, resulting in significant morbidity and increased mortality. Despite several studies that have investigated different cytotoxic agents in aggressive meningiomas in the past several years, limited evidence of efficacy and clinical benefit has been reported thus far. Novel molecular alterations have been linked to a particular clinicopathological phenotype and have been correlated with grading, location, and prognosis of meningiomas. In this regard,
Language	English
Publishing date	2022-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14092256
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Article: Neratinib and Capecitabine for the Treatment of Leptomeningeal Metastases from HER2-Positive Breast Cancer: A Series in the Setting of a Compassionate Program.

Pellerino, Alessia / Soffietti, Riccardo / Bruno, Francesco / Manna, Roberta / Muscolino, Erminia / Botta, Pierangela / Palmiero, Rosa / Rudà, Roberta

Cancers

2022 Volume 14, Issue 5

Abstract: Background: Leptomeningeal metastasis is a neurological complication from HER2-positive breast cancer with a poor prognosis and limited treatment options. This study has evaluated the activity of neratinib in association with capecitabine in 10 patients ...

Abstract	Background: Leptomeningeal metastasis is a neurological complication from HER2-positive breast cancer with a poor prognosis and limited treatment options. This study has evaluated the activity of neratinib in association with capecitabine in 10 patients with LM from HER2-positive BC after the failure of multiple lines of treatment, including trastuzumab-based therapy, within a compassionate program, and a comparison was made with a historical control group of 10 patients. Methods: Patients aged ≥ 18 years with histological diagnosis of primary HER2-positive BC, either amplified or mutated, and newly-diagnosed LM were enrolled. Coexistence of BM that has or has not received radiotherapy, as well as prior chemotherapy, hormone therapy, or monoclonal HER2-targeting antibodies or antibody-drug conjugates, were allowed, with the exclusion of lapatinib. Results: Six-months OS was 60% with a median OS of 10 months (95% CI: 2.00-17.0). Three-month intracranial PFS was 60% with a median intracranial PFS of 4.0 months (95% CI: 2.00-6.0). The neurological benefit was observed in 70% of patients with a median duration of neurological response of 6.5 months. The best radiological response was stable disease in 60% of patients. Conclusions: This small series shows that the combination of neratinib and capecitabine is a safe treatment in LM from heavily pretreated HER2-positive BC with clinical efficacy in some patients and is worth investigating in a larger study.
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14051192
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Article: Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects.

Bruno, Francesco / Pellerino, Alessia / Palmiero, Rosa / Bertero, Luca / Mantovani, Cristina / Garbossa, Diego / Soffietti, Riccardo / Rudà, Roberta

Biomedicines

2022 Volume 10, Issue 3

Abstract: Glioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to ... ...

Abstract	Glioblastoma (GBM) is the most aggressive primary brain tumour. As GBM incidence is associated with age, elderly people represent a consistent subgroup of patients. Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. Age is a negative prognostic factor, which correlates with clinical frailty, poorer tolerability to surgery or adjuvant radio-chemotherapy, and higher occurrence of comorbidities and/or secondary complications. The aim of this paper is to review the clinical and molecular characteristics, current therapeutic options, and prognostic factors of elderly patients with GBM.
Language	English
Publishing date	2022-03-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10030644
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Article: Elderly Gliobastoma Patients: The Impact of Surgery and Adjuvant Treatments on Survival: A Single Institution Experience.

Bruno, Francesco / Pellerino, Alessia / Pronello, Edoardo / Palmiero, Rosa / Bertero, Luca / Mantovani, Cristina / Bianconi, Andrea / Melcarne, Antonio / Garbossa, Diego / Rudà, Roberta

Brain sciences

2022 Volume 12, Issue 5

Abstract: Introduction. Elderly glioblastoma (GBM) patients often show limited response to treatment and poor outcome. Here, we provide a case series of elderly GBM patients from our Institution, in whom we assessed the clinical characteristics, feasibility of ... ...

Abstract	Introduction. Elderly glioblastoma (GBM) patients often show limited response to treatment and poor outcome. Here, we provide a case series of elderly GBM patients from our Institution, in whom we assessed the clinical characteristics, feasibility of surgical resection, response to adjuvant treatments, and outcome, along with the impact of comorbidities and clinical status on survival. Patients and Methods. We included patients ≥ 65-year-old. We collected information about clinical and molecular features, extent of resection, adjuvant treatments, treatment-related complications, and outcome. Results. We included 135 patients. Median age was 71 years. In total, 127 patients (94.0%) had a Karnofsky Performance Status (KPS) ≥70 and 61/135 (45.2%) a Charlson Comorbidity Score (CCI) > 3. MGMTp methylation was found in 70/135 (51.9%). Subtotal resections (STRs), gross-total resections (GTRs), and biopsies were 102 (75.6%), 10 (7.4%) and 23 (17.0%), respectively. Median progression-free survival and overall survival (mOS) were 8.0 and 10.5 months for the whole cohort. Notably, GTR and radio-chemotherapy with temozolomide in patients with MGMTp methylation were associated with significantly longer mOS (32.8 and 44.8 months, respectively). In a multivariable analysis, risk of death was affected by STR vs. GTR (HR 2.8, p = 0.002), MGMTp methylation (HR 0.55, p = 0.007), and KPS at baseline ≥70 (HR 0.43, p = 0.031). Conversely, CCI and post-surgical complications were not significant. Conclusions. Elderly GBM patients often have a dismal prognosis. However, it is possible to identify a subgroup with favourable clinical and molecular features, who benefit from GTR and radio-chemotherapy with temozolomide. A comprehensive prognostic score is needed to guide treatment modality and predict the outcome.
Language	English
Publishing date	2022-05-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12050632
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Article: Richter's Syndrome of the Central Nervous System.

Pronello, Edoardo / Mo, Francesca / Gottardi, Daniela / Palmiero, Rosa / Bertero, Luca / Lanotte, Michele / Ferrio, Maria Federica / Rudà, Roberta / Soffietti, Riccardo

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 48, Issue 6, Page(s) 889–892

MeSH term(s)	Central Nervous System ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphoma, Large B-Cell, Diffuse
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2020.281
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Zs.A 1203: Show issues

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Article ; Online: Observational real-life study on regorafenib in recurrent glioblastoma: does dose reduction reduce toxicity while maintaining the efficacy?

Rudà, Roberta / Bruno, Francesco / Pellerino, Alessia / Pronello, Edoardo / Palmiero, Rosa / Bertero, Luca / Crasto, Stefania / Polo, Valentina / Vitaliani, Roberta / Trincia, Elena / Internò, Valeria / Porta, Camillo / Soffietti, Riccardo

Journal of neuro-oncology

2022 Volume 160, Issue 2, Page(s) 389–402

Abstract: Purpose: In the phase 2 REGOMA trial, regorafenib improved overall survival, as compared with lomustine, in glioblastoma (GBM) patients at first progression after chemoradiation. Recently, some real-life trials showed similar impact on survival but a ... ...

Abstract	Purpose: In the phase 2 REGOMA trial, regorafenib improved overall survival, as compared with lomustine, in glioblastoma (GBM) patients at first progression after chemoradiation. Recently, some real-life trials showed similar impact on survival but a higher rate of adverse events than in REGOMA, thus raising concerns over tolerability. The aim of this study was to assess the efficacy and tolerability of a lower intensity regorafenib regimen. Patients and methods: Regorafenib daily dose was gradually increased from 80 to 160 mg across the first 2 cycles. Progression-free survival (PFS) and overall survival (OS) were defined as time from regorafenib initiation and disease progression or death. Results: Sixty-six GBM patients were included. Median age was 60.0 years. Median PFS and OS following regorafenib were 2.7 and 7.1 months, respectively. Best RANO response to regorafenib were partial response (PR) in 10 (15.1%), stable disease in 17 (25.8%), and progressive disease in 39 (59.1%) patients. Forty-six (69.7%) patients presented adverse events of any grade, and 21 (31.8%) grade 3-4 toxicity. In a multivariable analysis, higher age and absence of MGMTp methylation were significantly associated with poorer disease control after regorafenib. Conclusions: Our study is the largest observational real-life study on the use of regorafenib. Our lower intensity regimen proved as effective as the standard 160 mg daily schedule (mPFS and mOS being 2.7 vs 2.0 months and 7.1 vs 7.4 months in our study vs REGOMA, respectively). Moreover, we observed a higher rate of PRs as compared with REGOMA (15.0% vs 3.0%).
Language	English
Publishing date	2022-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-022-04155-9
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Article: A study on two different CAD systems for mammography as an aid to radiological diagnosis in the search of microcalcification clusters.

Lauria, A / Palmiero, R / Forni, G / Fantacci, M E / Imbriaco, M / Sodano, A / Indovina, P L

European journal of radiology

2005 Volume 55, Issue 2, Page(s) 264–269

Abstract: Objective: The aim of the present study was to evaluate the efficacy of two different computer aided detection (CAD) systems for mammography in improving radiological diagnosis in the search of microcalcification clusters. The CAD systems used are: the ... ...

Abstract	Objective: The aim of the present study was to evaluate the efficacy of two different computer aided detection (CAD) systems for mammography in improving radiological diagnosis in the search of microcalcification clusters. The CAD systems used are: the SecondLooktrade mark (CADx Medical Systems, Canada) commercial system and the CALMA (computer assisted library in MAmmography) research CAD system. Three radiologists were asked to read mammographic images with and without the support of the CAD systems. Material and methods: Three radiologists with respectively 3, 5 and 7 years of practice in mammogram reading in an Italian public hospital analysed a dataset composed of 120 digitized mammograms of healthy subjects with no lesion (proven by a radiological follow up of at least 3 years) and 70 images of patients with malignant cluster of microcalcification (proven by histopathological examination) both with no CAD support as well as with the help of the SecondLooktrade mark system. After 3 months they were asked to observe the same digitized mammograms with the assistance of the CALMA system. The radiologists worked independently and were unaware of the final diagnosis. The values of the area A(z) under the ROC curve, diagnostic sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were evaluated with and without the support of the CAD systems. The reading time and qualitative evaluations of each radiologist were also reported. Results: With the support of the two CAD systems an improvement in A(z) area was obtained ranging from 0.01 to 0.04. Sensitivity increased from +8.6 to +15.7% and specificity decreased from 0.8 to 4.2%. Conclusion: In our study, not conditioned by the dataset, the CAD systems as second reader produced an increase in overall sensitivity of up to 15.7%, with a little decrease in specificity of up to 4.2%. Based on these results both CAD systems might be used in the current practise to improve the sensitivity values of conventional reading (radiologist alone). The results of this study show that no significant differences exist in term of A(z), sensitivity and specificity between CALMA and CADx.
MeSH term(s)	Breast Diseases/diagnostic imaging ; Calcinosis/diagnostic imaging ; Diagnosis, Computer-Assisted ; Female ; Humans ; Mammography/instrumentation ; Predictive Value of Tests ; ROC Curve ; Radiographic Image Interpretation, Computer-Assisted ; Sensitivity and Specificity ; Software
Language	English
Publishing date	2005-08
Publishing country	Ireland
Document type	Comparative Study ; Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2004.10.010
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Article ; Online: Trastuzumab-related cardiotoxicity in the herceptin adjuvant trial.

Montemurro, Filippo / Redana, Stefania / Valabrega, Giorgio / Martinello, Rossella / Aglietta, Massimo / Palmiero, Renato

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2008 Volume 26, Issue 12, Page(s) 2052–3; author reply 2053–4

MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cardiovascular Diseases/chemically induced ; Chemotherapy, Adjuvant ; Heart Failure/chemically induced ; Humans ; Middle Aged ; Trastuzumab
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2008-04-20
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2007.15.5044
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Article: Studio clinico, emodinamico indiretto ed aritmico di 40 casi di sindrome del click.

Speziali, B / Palmiero, R / Besso, E

Bollettino della Societa italiana di cardiologia

1981 Volume 26, Issue 12, Page(s) 2151–2161

Title translation	Clinical, indirect hemodynamic and arrhythmic study of 40 cases of the click syndrome.
MeSH term(s)	Adolescent ; Adult ; Aged ; Arrhythmias, Cardiac/etiology ; Child ; Echocardiography ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/diagnosis ; Phonocardiography
Language	Italian
Publishing date	1981
Publishing country	Italy
Document type	Journal Article
ZDB-ID	132283-7
ISSN	0037-878X
ISSN	0037-878X
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Article: Alterazioni elettrocardiografiche indotte dalla somministrazione di catecolamine in narcosi etranica. Ricerche cliniche sperimentali.

Balma, C / Belloni, G / Mazzone, G / Palmiero, R

Minerva anestesiologica

1977 Volume 43, Issue 5, Page(s) 291–296

Title translation	Electrocardiographic changes induced with administration of catecholamines in ethrane anesthesia. Experimental clinical studies.
MeSH term(s)	Adult ; Anesthesia, Inhalation ; Catecholamines/pharmacology ; Electrocardiography ; Enflurane/pharmacology ; Female ; Heart/drug effects ; Humans ; Male ; Methyl Ethers/pharmacology ; Middle Aged
Chemical Substances	Catecholamines ; Methyl Ethers ; Enflurane (91I69L5AY5)
Language	Italian
Publishing date	1977-03
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0375-9393 ; 0026-4717
ISSN (online)	1827-1596
ISSN	0375-9393 ; 0026-4717
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Zs.MO 192: Show issues

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