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  1. AU="Palomar-Bonet, Miriam"
  2. AU="Rho, Seongheon"
  3. AU="Proux-Gillardeaux, Veronique"
  4. AU="Menon, Kartikeya M"
  5. AU="Pantell, Matthew" AU="Pantell, Matthew"
  6. AU="Maria Papadopoulou"
  7. AU="Wu, Jianrong"
  8. AU="Rodrigues, Daniel Sobreira"
  9. AU="Angello R. Retamal-Díaz"
  10. AU="Nicole C. Deziel"
  11. AU="Shajrawi, Abedalmajeed Methqal"
  12. AU=Aydin Seckin AU=Aydin Seckin
  13. AU="Narwal, Vikrant"
  14. AU="Minamoto, Toshinari"

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  1. Artikel ; Online: Blood total antioxidant status is associated with cortical glucose uptake and factors related to accelerated aging.

    Palomar-Bonet, Miriam / Atienza, Mercedes / Cantero, Jose L

    Brain structure & function

    2020  Band 225, Heft 2, Seite(n) 841–851

    Abstract: Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related ... ...

    Abstract Identifying cerebral vulnerability in late life is of paramount importance to prevent pathological trajectories of aging before the onset of symptoms. Considerable evidence suggests that impaired antioxidant mechanisms are a fingerprint of aging-related conditions, but there is a lack of human research linking total antioxidant capacity (TAC) measured in peripheral blood to in vivo brain changes and other factors featuring accelerated aging. To address this issue, we have assessed in cognitively normal elderly subjects (N = 100) correlations between serum TAC, using the oxygen radical absorbance capacity assay, surface-based cortical thickness, surface-based 18F-fluorodeoxyglucose positron emission tomography cortical uptake, and different factors associated with accelerated aging [i.e., serum homocysteine (HCY), self-reported memory problems, and self-reported patterns of physical activity]. While no relationship was observed between serum TAC and variations in cortical thickness, decreased TAC level was significantly associated with lower FDG uptake in temporal lobes bilaterally. Remarkably, decreased TAC level was linked to increased HCY concentrations, more subjective memory complaints, and lower frequency of physical activity. Overall, our results suggest that decreased serum TAC level may be helpful to detect vulnerable trajectories of aging.
    Mesh-Begriff(e) Aged ; Aging/blood ; Antioxidants/metabolism ; Brain/metabolism ; Female ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Homocysteine/blood ; Humans ; Male ; Middle Aged ; Oxygen Radical Absorbance Capacity ; Positron-Emission Tomography
    Chemische Substanzen Antioxidants ; Homocysteine (0LVT1QZ0BA) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2020-02-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-020-02039-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Associations of Salivary Total Antioxidant Capacity With Cortical Amyloid-Beta Burden, Cortical Glucose Uptake, and Cognitive Function in Normal Aging.

    Palomar-Bonet, Miriam / Atienza, Mercedes / Hernández-Ledesma, Blanca / Cantero, Jose L

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2021  Band 76, Heft 10, Seite(n) 1839–1845

    Abstract: Background: Determining susceptibility to Alzheimer's disease (AD) in asymptomatic individuals requires from noninvasive, simple, and inexpensive markers that can be easily obtained in primary care settings. While saliva meets all these requirements, ... ...

    Abstract Background: Determining susceptibility to Alzheimer's disease (AD) in asymptomatic individuals requires from noninvasive, simple, and inexpensive markers that can be easily obtained in primary care settings. While saliva meets all these requirements, there is a lack of evidence linking salivary constituents to in vivo AD pathology in aging.
    Methods: We examined the potential of salivary total antioxidant capacity (TAC) for identifying global cortical amyloid-beta (Aβ) burden, deficits in regional glucose uptake, and poorer cognition in 71 cognitively normal older adults. We further assessed whether salivary TAC-related cognitive performance was associated with higher Aβ load and lower cortical glucose consumption.
    Results: Linear regression analyses adjusted by age, sex, years of education, and ApoE4 status showed that salivary TAC was associated with slower processing speed and poorer sustained attention, as well as with higher Aβ load and lower glucose metabolism in cortical regions vulnerable to cognitive aging and AD. Results also revealed that lower scores in processing speed and sustained attention were associated with greater Aβ burden and lower regional glucose consumption, respectively.
    Conclusions: Together, these findings support the use of salivary TAC for preventive screening and detection of cerebral vulnerability to AD. Further research is needed to evaluate the utility of salivary TAC as a clinical marker.
    Mesh-Begriff(e) Aged ; Aging ; Alzheimer Disease ; Amyloid beta-Peptides/metabolism ; Antioxidants ; Brain/metabolism ; Cognition ; Cognitive Dysfunction ; Glucose ; Humans ; Positron-Emission Tomography
    Chemische Substanzen Amyloid beta-Peptides ; Antioxidants ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2021-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glab034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Decreased salivary lactoferrin levels are specific to Alzheimer's disease.

    González-Sánchez, Marta / Bartolome, Fernando / Antequera, Desiree / Puertas-Martín, Veronica / González, Pilar / Gómez-Grande, Adolfo / Llamas-Velasco, Sara / Herrero-San Martín, Alejandro / Pérez-Martínez, David / Villarejo-Galende, Alberto / Atienza, Mercedes / Palomar-Bonet, Miriam / Cantero, Jose Luis / Perry, George / Orive, Gorka / Ibañez, Borja / Bueno, Hector / Fuster, Valentin / Carro, Eva

    EBioMedicine

    2020  Band 57, Seite(n) 102834

    Abstract: Background: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial ... ...

    Abstract Background: Evidences of infectious pathogens in Alzheimer's disease (AD) brains may suggest a deteriorated innate immune system in AD pathophysiology. We previously demonstrated reduced salivary lactoferrin (Lf) levels, one of the major antimicrobial proteins, in AD patients.
    Methods: To assess the clinical utility of salivary Lf for AD diagnosis, we examine the relationship between salivary Lf and cerebral amyloid-β (Aβ) load using amyloid-Positron-Emission Tomography (PET) neuroimaging, in two different cross-sectional cohorts including patients with different neurodegenerative disorders.
    Findings: The diagnostic performance of salivary Lf in the cohort 1 had an area under the curve [AUC] of 0•95 (0•911-0•992) for the differentiation of the prodromal AD/AD group positive for amyloid-PET (PET
    Interpretation: Salivary Lf seems to have a very good diagnostic performance to detect AD. Our findings support the possible utility of salivary Lf as a new non-invasive and cost-effective AD biomarker.
    Funding: Instituto de Salud Carlos III (FIS15/00780, FIS18/00118), FEDER, Comunidad de Madrid (S2017/BMD-3700; NEUROMETAB-CM), and CIBERNED (PI2016/01) to E.C.; Spanish Ministry of Economy and Competitiveness (SAF2017-85310-R) to J.L.C., and (PSI2017-85311-P) to M.A.; International Centre on ageing CENIE-POCTEP (0348_CIE_6_E) to M.A.; Instituto de Salud Carlos III (PIE16/00021, PI17/01799), to H.B.
    Mesh-Begriff(e) Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Biomarkers/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Female ; Humans ; Immunity, Innate/genetics ; Lactoferrin/genetics ; Lactoferrin/metabolism ; Male ; Middle Aged ; Neuroimaging/methods ; Positron-Emission Tomography/methods ; Salivary Glands/metabolism ; Tomography, X-Ray Computed ; tau Proteins/genetics
    Chemische Substanzen Amyloid beta-Peptides ; Biomarkers ; tau Proteins ; Lactoferrin (EC 3.4.21.-)
    Sprache Englisch
    Erscheinungsdatum 2020-06-22
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.102834
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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