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Article ; Online: Direct Constraints on the Ultralight Boson Mass from Searches of Continuous Gravitational Waves.

Palomba, C / D'Antonio, S / Astone, P / Frasca, S / Intini, G / La Rosa, I / Leaci, P / Mastrogiovanni, S / Miller, A L / Muciaccia, F / Piccinni, O J / Rei, L / Simula, F

Physical review letters

2019 Volume 123, Issue 17, Page(s) 171101

Abstract: Superradiance can trigger the formation of an ultralight boson cloud around a spinning black hole. Once formed, the boson cloud is expected to emit a nearly periodic, long-duration, gravitational-wave signal. For boson masses in the range (10^{-13}-10^{- ... ...

Abstract	Superradiance can trigger the formation of an ultralight boson cloud around a spinning black hole. Once formed, the boson cloud is expected to emit a nearly periodic, long-duration, gravitational-wave signal. For boson masses in the range (10^{-13}-10^{-11}) eV, and stellar mass black holes, such signals are potentially detectable by gravitational-wave detectors, like Advanced LIGO and Virgo. In this Letter, we present full band upper limits for a generic all-sky search for periodic gravitational waves in LIGO O2 data, and use them to derive-for the first time-direct constraints on the ultralight scalar boson field mass.
Language	English
Publishing date	2019-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.123.171101
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Article ; Online: Unattended Automated Office Blood Pressure Measurement and Cardiac Target Organ Damage, A Pilot Study.

Palomba, Claudia / Donadio, Simone / Canciello, Grazia / Losi, Maria Angela / Izzo, Raffaele / Manzi, Maria Virginia / De Pisapia, Federica / Mancusi, Costantino / De Luca, Nicola

High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

2019 Volume 26, Issue 5, Page(s) 383–389

Abstract: Introduction: The ESC-2018 guidelines suggest the use of Unattended automated office blood pressure (UAOBP) to avoid or at least reduce the white coat effect, even if do not support its use as preferred method.: Aim: To assess the pressure difference ...

Abstract	Introduction: The ESC-2018 guidelines suggest the use of Unattended automated office blood pressure (UAOBP) to avoid or at least reduce the white coat effect, even if do not support its use as preferred method. Aim: To assess the pressure difference between UAOBP and Attended office blood pressure (AOBP) and to evaluate their correlations with target organ damage in hypertensive patients. Methods: UAOBP and AOBP were taken in a cohort of 48 outpatients. The pressure difference between the 2 methods and their correlation with anthropometric and cardiac parameters were analyzed. Results: Unattended systolic and diastolic BP were lower than Attended systolic and diastolic BP (135 ± 17 mmHg vs 139 ± 21 mmHg and 79 ± 10 mmHg vs 82 ± 10 mmg). ΔDBP was significantly directly correlated with female sex (r = 0.347, p = 0.016) and it was lower in men compared to women (0.11 ± 8.9 mmHg vs 6.07 ± 7.42 mmHg, p = 0.016). Correlation coefficients for LVMi and RWT for attended and unattended BP were not statistically different (for LVMi r = 0.286 vs r = 0.381, p = 0.61, for RWT r = 0.413 vs r = 0.363, p = 0.78). The relationship between attended and unattended BP was described by the following equation: y = - 4.68 + 1.06x; where Y is the attended systolic BP and X is the unattended systolic BP; in accordance with this equation, an unattended systolic BP of 140 mmHg corresponds to an attended systolic BP of 143.7 mmHg. Conclusions:* UAOBP provides significantly lower values than AOBP. The difference in BP values between the two methods is much lower than the one obtained in most clinical studies.
MeSH term(s)	Aged ; Arterial Pressure ; Automation ; Blood Pressure Determination ; Echocardiography, Doppler, Color ; Female ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Diseases/physiopathology ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/physiopathology ; Male ; Middle Aged ; Office Visits ; Pilot Projects ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Reproducibility of Results ; Sex Factors ; White Coat Hypertension/diagnosis ; White Coat Hypertension/physiopathology
Language	English
Publishing date	2019-08-23
Publishing country	New Zealand
Document type	Comparative Study ; Journal Article
ZDB-ID	1236337-6
ISSN	1179-1985 ; 1120-9879
ISSN (online)	1179-1985
ISSN	1120-9879
DOI	10.1007/s40292-019-00337-1
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Article ; Online: Parenterally administered moderate sedation and paracervical block versus general anesthesia for hysteroscopic polypectomy: a pilot study comparing postoperative outcomes.

Centini, Gabriele / Calonaci, Andrea / Lazzeri, Lucia / Tosti, Claudia / Palomba, Caterina / Puzzutiello, Rosa / Luisi, Stefano / Petraglia, Felice / Zupi, Errico

Journal of minimally invasive gynecology

2015 Volume 22, Issue 2, Page(s) 193–198

Abstract: Study objective: To compare parenterally administered moderate sedation and paracervical block versus general anesthesia during day-case operative hysteroscopy for polypectomy in terms of patients' postoperative pain perception, operating time, and ... ...

Abstract	Study objective: To compare parenterally administered moderate sedation and paracervical block versus general anesthesia during day-case operative hysteroscopy for polypectomy in terms of patients' postoperative pain perception, operating time, and postoperative drug administration. Design: A pilot study (Canadian Task Force classification I). Setting: A university hospital. Patients: Women undergoing hysteroscopic polypectomy procedures (N = 56). Interventions: Hysteroscopic polypectomy with general anesthesia or moderate parenteral sedation and paracervical block. Measurements and main results: The patients were divided into 2 groups: 26 underwent general anesthesia (group 1), and 30 were submitted to moderate parenteral sedation and a paracervical block (group 2). General anesthesia was induced with the laryngeal mask airway with propofol (1% 1-2.5 mg/kg) and fentanyl (1-2 μg/kg) and maintained with an infusion of propofol (2% 3-5 mg/kg/h). After the procedure, patients in the general anesthesia group received postoperative analgesic medication with paracetamol (20 mg/kg) and ketorolac (0.6 mg/kg) or tramadol (2-3 mg/kg). The group receiving moderate parenterally sedation and a paracervical block received a paracervical block with mepivacaine (1% 10 mL) and lidocaine (2% 10 mL) and received fentanyl (1 μg/kg) and propofol (1% 1-3 mg/kg/h) maintaining spontaneous breathing. A blind observer recorded the operative time and the discomfort of patients using a 4-step scale (0-3). The postoperative pain assessment was performed 3 hours after the procedure with a self-administered validated tool, the Brief Pain Inventory. We found that women receiving moderate parenteral sedation and a paracervical block perceived significantly less pain in daily activity (p < .001), walking (p < .001), daily work (p < .001), relations with others (p = .007), sleep (p < .001), and pain contrasting enjoyment of life (p < .001). The total amount of time spent in the operating room in group 2 was significantly lower than in group 1 (p < .014). Conclusion: Moderate sedation plus a paracervical block for operative hysteroscopy is associated with reduced pain perception and a shorter operative time.
MeSH term(s)	Adult ; Analgesics/classification ; Analgesics/therapeutic use ; Anesthesia, General/adverse effects ; Anesthesia, General/methods ; Anesthesia, Intravenous/adverse effects ; Anesthesia, Intravenous/methods ; Anesthesia, Obstetrical/adverse effects ; Anesthesia, Obstetrical/methods ; Anesthetics/classification ; Anesthetics/therapeutic use ; Canada ; Conscious Sedation/adverse effects ; Conscious Sedation/methods ; Drug Administration Routes ; Female ; Humans ; Hysteroscopy/methods ; Middle Aged ; Monitoring, Intraoperative/methods ; Operative Time ; Pain Measurement ; Pain, Postoperative/diagnosis ; Pain, Postoperative/prevention & control ; Pilot Projects ; Polyps/surgery ; Treatment Outcome ; Uterine Diseases/surgery
Chemical Substances	Analgesics ; Anesthetics
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2186934-0
ISSN	1553-4669 ; 1553-4650
ISSN (online)	1553-4669
ISSN	1553-4650
DOI	10.1016/j.jmig.2014.09.008
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Article: Anti-CD20 treatments and the lymphocyte membrane: pathology for therapy.

Borisch, B / Semac, I / Soltermann, A / Palomba, C / Hoessli, D C

Verhandlungen der Deutschen Gesellschaft fur Pathologie

2001 Volume 85, Page(s) 161–166

Abstract: Therapeutic antibodies directed against the CD20 surface protein of B-lymphocytes are efficient means of controlling the growth and survival of malignant B-lymphocytes. The mechanisms of anti-CD20 antibody action remain in great part unexplained. However, ...

Abstract	Therapeutic antibodies directed against the CD20 surface protein of B-lymphocytes are efficient means of controlling the growth and survival of malignant B-lymphocytes. The mechanisms of anti-CD20 antibody action remain in great part unexplained. However, we show that incubation of CD20+ cells with therapeutic antibodies such as Rituximab results in the redistribution of the CD20 marker in plasma membrane rafts. Rafts are specialized membrane organizations of sphingolipids and cholesterol in the plasma membrane outer leaflet that serve as signalling platforms in lymphocytes and other cells, and allow transmembrane propagation of most receptor-mediated extracellular signals. This redistribution of CD20 to rafts is not acutely toxic to lymphoma cells, but leads to long-lasting perturbations of transmembrane signalling and contributes to the progressive elimination of B-lymphoma cells. The accumulation of CD20 in rafts causes downmodulation of raft-associated protein tyrosine kinases and modifies the spatial relationships between raft lipid and protein components. Such modifications of the raft structure and function are likely to cause relatively long-lasting perturbations of the lymphoma cell physiology and contribute to the elimination of the Rituximab-targeted cells.
MeSH term(s)	Amino Acid Sequence ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20/immunology ; Antineoplastic Agents/therapeutic use ; B-Lymphocytes/immunology ; Biomarkers, Tumor/analysis ; Cell Membrane/immunology ; Humans ; Lymphoma, B-Cell/drug therapy ; Membrane Microdomains/immunology ; Molecular Sequence Data ; Rituximab
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Antineoplastic Agents ; Biomarkers, Tumor ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2001
Publishing country	Germany
Document type	Journal Article
ISSN	0070-4113
ISSN	0070-4113
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Book ; Online: Towards a Model for Computing in European Astroparticle Physics

Berghöfer, T. / Agrafioti, I. / Allen, B. / Beckmann, V. / Chiarusi, T. / Delfino, M. / Hesping, S. / Chudoba, J. / Dell'Agnello, L. / Katsanevas, S. / Lamanna, G. / Lemrani, R. / Margiotta, A. / Maron, G. / Palomba, C. / Russo, G. / Wegner, P.

2015

Abstract: Current and future astroparticle physics experiments are operated or are being built to observe highly energetic particles, high energy electromagnetic radiation and gravitational waves originating from all kinds of cosmic sources. The data volumes taken ...

Abstract	Current and future astroparticle physics experiments are operated or are being built to observe highly energetic particles, high energy electromagnetic radiation and gravitational waves originating from all kinds of cosmic sources. The data volumes taken by the experiments are large and expected to grow significantly during the coming years. This is a result of advanced research possibilities and improved detector technology. To cope with the substantially increasing data volumes of astroparticle physics projects it is important to understand the future needs for computing resources in this field. Providing these resources constitutes a larger fraction of the overall running costs of future infrastructures. This document presents the results of a survey made by APPEC with the help of computing experts of major projects and future initiatives in astroparticle physics, representatives of current Tier-1 and Tier-2 LHC computing centers, as well as specifically astroparticle physics computing centers, e.g. the Albert Einstein Institute for gravitational waves analysis in Hanover. In summary, the overall CPU usage and short-term disk and long-term (tape) storage space currently available for astroparticle physics projects' computing services is of the order of one third of the central computing available for LHC data at the Tier-0 center at CERN. Till the end of the decade the requirements for computing resources are estimated to increase by a factor of 10. Furthermore, this document shall describe the diversity of astroparticle physics data handling and serve as a basis to estimate a distribution of computing and storage tasks among the major computing centers. (Abridged) Comment: 24 pages, APPEC (Astroparticle Physics European Consortium) white paper
Keywords	Astrophysics - Instrumentation and Methods for Astrophysics ; High Energy Physics - Experiment ; Physics - Computational Physics
Subject code	302
Publishing date	2015-12-03
Publishing country	us
Document type	Book ; Online
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Article: A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.

Carbone, E / Ruggiero, G / Terrazzano, G / Palomba, C / Manzo, C / Fontana, S / Spits, H / Kärre, K / Zappacosta, S

The Journal of experimental medicine

1997 Volume 185, Issue 12, Page(s) 2053–2060

Abstract: NK recognition is regulated by a delicate balance between positive signals initiating their effector functions, and inhibitory signals preventing them from proceeding to cytolysis. Knowledge of the molecules responsible for positive signaling in NK cells ...

Abstract	NK recognition is regulated by a delicate balance between positive signals initiating their effector functions, and inhibitory signals preventing them from proceeding to cytolysis. Knowledge of the molecules responsible for positive signaling in NK cells is currently limited. We demonstrate that IL-2-activated human NK cells can express CD40 ligand (CD40L) and that recognition of CD40 on target cells can provide an activation pathway for such human NK cells. CD40-transfected P815 cells were killed by NK cell lines expressing CD40L, clones and PBL-derived NK cells cultured for 18 h in the presence of IL-2, but not by CD40L-negative fresh NK cells. Cross-linking of CD40L on IL-2-activated NK cells induced redirected cytolysis of CD40-negative but Fc receptor-expressing P815 cells. The sensitivity of human TAP-deficient T2 cells could be blocked by anti-CD40 antibodies as well as by reconstitution of TAP/MHC class I expression, indicating that the CD40-dependent pathway for NK activation can be downregulated, at least in part, by MHC class I molecules on the target cells. NK cell recognition of CD40 may be important in immunoregulation as well as in immune responses against B cell malignancies.
MeSH term(s)	CD3 Complex/analysis ; CD40 Antigens/physiology ; CD40 Ligand ; CD56 Antigen/analysis ; Cytotoxicity, Immunologic ; Histocompatibility Antigens Class I/analysis ; Humans ; Interleukin-2/pharmacology ; Killer Cells, Natural/immunology ; Membrane Glycoproteins/physiology ; Tumor Cells, Cultured
Chemical Substances	CD3 Complex ; CD40 Antigens ; CD56 Antigen ; Histocompatibility Antigens Class I ; Interleukin-2 ; Membrane Glycoproteins ; CD40 Ligand (147205-72-9)
Language	English
Publishing date	1997-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.185.12.2053
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Article: Gravitational waves: search results, data analysis and parameter estimation: Amaldi 10 Parallel session C2.

Astone, Pia / Weinstein, Alan / Agathos, Michalis / Bejger, Michał / Christensen, Nelson / Dent, Thomas / Graff, Philip / Klimenko, Sergey / Mazzolo, Giulio / Nishizawa, Atsushi / Robinet, Florent / Schmidt, Patricia / Smith, Rory / Veitch, John / Wade, Madeline / Aoudia, Sofiane / Bose, Sukanta / Calderon Bustillo, Juan / Canizares, Priscilla /

Capano, Colin / Clark, James / Colla, Alberto / Cuoco, Elena / Da Silva Costa, Carlos / Dal Canton, Tito / Evangelista, Edgar / Goetz, Evan / Gupta, Anuradha / Hannam, Mark / Keitel, David / Lackey, Benjamin / Logue, Joshua / Mohapatra, Satyanarayan / Piergiovanni, Francesco / Privitera, Stephen / Prix, Reinhard / Pürrer, Michael / Re, Virginia / Serafinelli, Roberto / Wade, Leslie / Wen, Linqing / Wette, Karl / Whelan, John / Palomba, C / Prodi, G

General relativity and gravitation

2015 Volume 47, Issue 2, Page(s) 11

Abstract: The Amaldi 10 Parallel Session C2 on gravitational wave (GW) search results, data analysis and parameter estimation included three lively sessions of lectures by 13 presenters, and 34 posters. The talks and posters covered a huge range of material, ... ...

Abstract	The Amaldi 10 Parallel Session C2 on gravitational wave (GW) search results, data analysis and parameter estimation included three lively sessions of lectures by 13 presenters, and 34 posters. The talks and posters covered a huge range of material, including results and analysis techniques for ground-based GW detectors, targeting anticipated signals from different astrophysical sources: compact binary inspiral, merger and ringdown; GW bursts from intermediate mass binary black hole mergers, cosmic string cusps, core-collapse supernovae, and other unmodeled sources; continuous waves from spinning neutron stars; and a stochastic GW background. There was considerable emphasis on Bayesian techniques for estimating the parameters of coalescing compact binary systems from the gravitational waveforms extracted from the data from the advanced detector network. This included methods to distinguish deviations of the signals from what is expected in the context of General Relativity.
Language	English
Publishing date	2015-01-22
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2015524-4
ISSN	1572-9532 ; 0001-7701
ISSN (online)	1572-9532
ISSN	0001-7701
DOI	10.1007/s10714-014-1796-x
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Article: Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells.

Semac, Isabelle / Palomba, Carmen / Kulangara, Karina / Klages, Natacha / van Echten-Deckert, Gerhild / Borisch, Bettina / Hoessli, Daniel C

Cancer research

2003 Volume 63, Issue 2, Page(s) 534–540

Abstract: Incubation of Burkitt lymphoma-derived Raji cells at physiological temperature with submicromolar concentrations of humanized anti-CD20 antibody rituximab (RTX) redistributes CD20 to liquid-ordered, plasma membrane rafts. This accumulation of the CD20 ... ...

Abstract	Incubation of Burkitt lymphoma-derived Raji cells at physiological temperature with submicromolar concentrations of humanized anti-CD20 antibody rituximab (RTX) redistributes CD20 to liquid-ordered, plasma membrane rafts. This accumulation of the CD20 tetraspan protein in rafts does not change the existing lipid and phosphoprotein composition but makes sphingolipids and the Src regulator Cbp/PAG (Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomain) transmembrane phosphoprotein more resistant to n-octyl-beta-pyranoside, a detergent that dissociates sphingolipid clusters. On the contrary, sphingolipids and Cbp/PAG are not protected by the presence of CD20 against the disruptive effects of methyl-beta-cyclodextrin, a cyclic carbohydrate that removes membrane cholesterol. After accumulation of CD20, the activity of the raft-associated Lyn kinase is down-regulated without apparent alteration of its relationship to substrates. Moreover, in rafts of lymphoblastoid cells that express lower amounts of Cbp/PAG, RTX redistributes CD20 to rafts but does not modulate the raft-associated protein tyrosine kinase activity, suggesting that the presence of Cbp/PAG protein in rafts is necessary for RTX to exert its transmembrane "signaling effects." Lastly, redistribution of CD20 in rafts renders the glycosylphosphatidyl inositol (GPI)-linked CD55 C'-defense protein hypersensitive to glycosylphosphatidyl inositol-specific phospholipases. By redistributing CD20 to rafts, RTX modifies their stability and organization and modulates the associated signaling pathways and C' defense capacity.
MeSH term(s)	Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20/metabolism ; Antineoplastic Agents/pharmacology ; CD55 Antigens/metabolism ; Cyclodextrins/chemistry ; Glucosides/chemistry ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/metabolism ; Membrane Lipids/metabolism ; Membrane Microdomains/drug effects ; Membrane Microdomains/metabolism ; Membrane Proteins/metabolism ; Phospholipase D/metabolism ; Phosphoproteins/metabolism ; Rituximab ; Type C Phospholipases/metabolism ; beta-Cyclodextrins ; src-Family Kinases/metabolism
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Antineoplastic Agents ; CD55 Antigens ; Cyclodextrins ; Glucosides ; Membrane Lipids ; Membrane Proteins ; Phosphoproteins ; beta-Cyclodextrins ; methyl-beta-cyclodextrin ; octyl-beta-D-glucoside (29836-26-8) ; Rituximab (4F4X42SYQ6) ; lyn protein-tyrosine kinase (EC 2.7.10.2) ; src-Family Kinases (EC 2.7.10.2) ; Type C Phospholipases (EC 3.1.4.-) ; Phospholipase D (EC 3.1.4.4)
Language	English
Publishing date	2003-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
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Article: Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors.

Terrazzano, Giuseppe / Zanzi, Delia / Palomba, Carmen / Carbone, Ennio / Grimaldi, Serena / Pisanti, Simona / Fontana, Silvia / Zappacosta, Serafino / Ruggiero, Giuseppina

Journal of leukocyte biology

2002 Volume 72, Issue 2, Page(s) 305–311

Abstract: Natural killer (NK) cells are physiologically involved in the immune response against viruses, intracellular bacteria, and parasites as well as against malignant diseases. In addition to the cytotoxic activity, NK lymphocytes mediate a variety of ... ...

Abstract	Natural killer (NK) cells are physiologically involved in the immune response against viruses, intracellular bacteria, and parasites as well as against malignant diseases. In addition to the cytotoxic activity, NK lymphocytes mediate a variety of homeostatic effects by producing cytokines. This study focused on the differential role of CD40 and CD80 costimulatory molecules and major histocompatibility complex class I (MHC-I) antigens in the regulation of cytotoxicity and of interferon (IFN)-gamma secretion of resting and interleukin (IL)-2-activated human NK cells. CD40 and CD80 molecules were observed to play a specific role in the induction of cytotoxic function but not in IFN-gamma production of IL-2-activated NK effectors. In addition, a critical role of CD94-dependent MHC-I recognition for the regulation of IFN-gamma production and target lysis was demonstrated. These data provide a possible mechanism underlying functional interactions between NK lymphocytes and CD40/CD80-expressing cell targets, as represented by dendritic cells.
MeSH term(s)	ATP-Binding Cassette Sub-Family B Member 2 ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/physiology ; ATP-Binding Cassette, Sub-Family B, Member 3 ; Antigens, CD/immunology ; B7-1 Antigen/immunology ; CD40 Antigens/immunology ; Cytotoxicity, Immunologic/drug effects ; Histocompatibility Antigens Class I/immunology ; Humans ; Interferon-gamma/biosynthesis ; Interferon-gamma/genetics ; Interferon-gamma/secretion ; Interleukin-2/pharmacology ; Killer Cells, Lymphokine-Activated/drug effects ; Killer Cells, Lymphokine-Activated/metabolism ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Lectins, C-Type ; Lymphocyte Activation/drug effects ; Membrane Glycoproteins/immunology ; NK Cell Lectin-Like Receptor Subfamily D ; Recombinant Fusion Proteins/physiology ; Tumor Cells, Cultured/immunology
Chemical Substances	ATP-Binding Cassette Sub-Family B Member 2 ; ATP-Binding Cassette, Sub-Family B, Member 3 ; Antigens, CD ; B7-1 Antigen ; CD40 Antigens ; Histocompatibility Antigens Class I ; Interleukin-2 ; KLRD1 protein, human ; Lectins, C-Type ; Membrane Glycoproteins ; NK Cell Lectin-Like Receptor Subfamily D ; Recombinant Fusion Proteins ; TAP1 protein, human ; TAP2 protein, human (145892-13-3) ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2002-08
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
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Article ; Online: Frequency-Dependent Squeezed Vacuum Source for the Advanced Virgo Gravitational-Wave Detector.

Acernese, F / Agathos, M / Ain, A / Albanesi, S / Alléné, C / Allocca, A / Amato, A / Amra, C / Andia, M / Andrade, T / Andres, N / Andrés-Carcasona, M / Andrić, T / Ansoldi, S / Antier, S / Apostolatos, T / Appavuravther, E Z / Arène, M / Arnaud, N /

Assiduo, M / Melo, S Assis de Souza / Astone, P / Aubin, F / Babak, S / Badaracco, F / Bagnasco, S / Baird, J / Baka, T / Ballardin, G / Baltus, G / Banerjee, B / Barneo, P / Barone, F / Barsuglia, M / Barta, D / Basti, A / Bawaj, M / Bazzan, M / Beirnaert, F / Bejger, M / Benedetto, V / Berbel, M / Bernuzzi, S / Bersanetti, D / Bertolini, A / Bhardwaj, U / Bianchi, A / Bilicki, M / Bini, S / Bischi, M / Bitossi, M / Bizouard, M-A / Bobba, F / Boër, M / Bogaert, G / Boileau, G / Boldrini, M / Bonavena, L D / Bondarescu, R / Bondu, F / Bonnand, R / Boschi, V / Boudart, V / Bouffanais, Y / Bozzi, A / Bradaschia, C / Braglia, M / Branchesi, M / Breschi, M / Briant, T / Brillet, A / Brooks, J / Bruno, G / Bucci, F / Bulashenko, O / Bulik, T / Bulten, H J / Buscicchio, R / Buskulic, D / Buy, C / Cabras, G / Cabrita, R / Cagnoli, G / Calloni, E / Canepa, M / Santoro, G Caneva / Cannavacciuolo, M / Capocasa, E / Carapella, G / Carbognani, F / Carpinelli, M / Carullo, G / Diaz, J Casanueva / 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Vinet, J-Y / Viret, S / Virtuoso, A / Vocca, H / Walet, R C / Was, M / Yadav, N / Zadrożny, A / Zelenova, T / Zendri, J-P / Zhao, Y / Zerrad, M / Vahlbruch, H / Mehmet, M / Lück, H / Danzmann, K

Physical review letters

2023 Volume 131, Issue 4, Page(s) 41403

Abstract: In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. ... ...

Abstract	In this Letter, we present the design and performance of the frequency-dependent squeezed vacuum source that will be used for the broadband quantum noise reduction of the Advanced Virgo Plus gravitational-wave detector in the upcoming observation run. The frequency-dependent squeezed field is generated by a phase rotation of a frequency-independent squeezed state through a 285 m long, high-finesse, near-detuned optical resonator. With about 8.5 dB of generated squeezing, up to 5.6 dB of quantum noise suppression has been measured at high frequency while close to the filter cavity resonance frequency, the intracavity losses limit this value to about 2 dB. Frequency-dependent squeezing is produced with a rotation frequency stability of about 6 Hz rms, which is maintained over the long term. The achieved results fulfill the frequency dependent squeezed vacuum source requirements for Advanced Virgo Plus. With the current squeezing source, considering also the estimated squeezing degradation induced by the interferometer, we expect a reduction of the quantum shot noise and radiation pressure noise of up to 4.5 dB and 2 dB, respectively.
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.041403
Database	MEDical Literature Analysis and Retrieval System OnLINE

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