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  1. Book ; Online ; E-Book: Infertility in women with polycystic ovary syndrome

    Palomba, Stefano

    pathogenesis and management

    2018  

    Author's details Stefano Palomba editor
    Keywords Medicine ; Endocrinology ; Reproductive medicine
    Subject code 612.6
    Language English
    Size 1 Online-Ressource (xiii, 337 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019621324
    ISBN 978-3-319-45534-1 ; 9783319455334 ; 3-319-45534-6 ; 3319455338
    DOI 10.1007/978-3-319-45534-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The progression of intensity and complexity of treatment as a cornerstone of the management of polycystic ovary syndrome-related infertility.

    Palomba, Stefano

    Fertility and sterility

    2023  Volume 121, Issue 2, Page(s) 252–253

    MeSH term(s) Female ; Humans ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/therapy ; Infertility, Female/diagnosis ; Infertility, Female/etiology ; Infertility, Female/therapy
    Language English
    Publishing date 2023-12-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2023.11.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Large randomized controlled trials in reproductive medicine: another battle won by biases and confounders?

    Palomba, Stefano

    Human reproduction (Oxford, England)

    2022  Volume 37, Issue 5, Page(s) 1097

    MeSH term(s) Acupuncture Therapy ; Bias ; Female ; Humans ; Insulin Resistance ; Metformin ; Polycystic Ovary Syndrome ; Randomized Controlled Trials as Topic ; Reproductive Medicine
    Chemical Substances Metformin (9100L32L2N)
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deac055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2892: Show issues Location:
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  4. Article ; Online: Is fertility reduced in ovulatory women with polycystic ovary syndrome? An opinion paper.

    Palomba, Stefano

    Human reproduction (Oxford, England)

    2021  Volume 36, Issue 9, Page(s) 2421–2428

    Abstract: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility; however, whether women with PCOS and spontaneous or drug-induced ovulatory cycles have the same reproductive potential as non-PCOS controls is a matter of debate. In ... ...

    Abstract Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility; however, whether women with PCOS and spontaneous or drug-induced ovulatory cycles have the same reproductive potential as non-PCOS controls is a matter of debate. In the present opinion paper, the author takes the opportunity to summarize the collective evidence supporting the hypothesis of reduced fertility potential in women with PCOS, regardless of ovulatory status, and speculate that reduced reproductive potential may be caused by altered oocytes, embryo and endometrial competence, and infertility-related co-morbidities as well as an increased risk of pregnancy complications.
    MeSH term(s) Endometrium ; Female ; Fertility ; Humans ; Infertility, Female/etiology ; Oocytes ; Polycystic Ovary Syndrome/complications ; Pregnancy
    Language English
    Publishing date 2021-07-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 632776-x
    ISSN 1460-2350 ; 0268-1161 ; 1477-741X
    ISSN (online) 1460-2350
    ISSN 0268-1161 ; 1477-741X
    DOI 10.1093/humrep/deab181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2892: Show issues Location:
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  5. Article: Editorial: PCOS: from infertility to pregnancy.

    Palomba, Stefano / Dewailly, Didier

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1220014

    MeSH term(s) Pregnancy ; Female ; Humans ; Polycystic Ovary Syndrome/complications ; Infertility, Female/etiology ; Infertility, Female/therapy
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1220014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Is the era of the endometrial scratching finished?

    Palomba, Stefano / Vitagliano, Amerigo

    Fertility and sterility

    2022  Volume 118, Issue 3, Page(s) 603

    MeSH term(s) Endometrium ; Female ; Humans ; Pregnancy ; Pregnancy Rate
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Letter
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 73: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Endometrial scratching: is it all over?

    Palomba, Stefano / Macklon, Nick

    Reproductive biomedicine online

    2022  Volume 44, Issue 4, Page(s) 583–585

    MeSH term(s) Embryo Implantation ; Endometrium ; Female ; Humans
    Language English
    Publishing date 2022-04-29
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2113823-0
    ISSN 1472-6491 ; 1472-6483
    ISSN (online) 1472-6491
    ISSN 1472-6483
    DOI 10.1016/j.rbmo.2022.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5792: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Efficacy and safety of follitropin delta for ovarian stimulation in vitro fertilization/ intracytoplasmic sperm injection cycles: a systematic review with meta-analysis.

    Palomba, Stefano / Caserta, Donatella / Levi-Setti, Paolo Emanuele / Busnelli, Andrea

    Journal of ovarian research

    2024  Volume 17, Issue 1, Page(s) 60

    Abstract: Background: Follitropin delta is a novel recombinant follicle stimulating hormone preparation uniquely expressed in a human fetal retinal cell line by recombinant DNA technology. To date, no systematic review was available about the safety and the ... ...

    Abstract Background: Follitropin delta is a novel recombinant follicle stimulating hormone preparation uniquely expressed in a human fetal retinal cell line by recombinant DNA technology. To date, no systematic review was available about the safety and the efficacy of the follitropin delta. The objective of this study was systematically reviewing the available literature and to provide updated evidence regarding the efficacy-safety profile of follitropin delta when compared to other gonadotropin formulations for ovarian stimulation in in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles.
    Methods: An extensive search was performed to identify phase 1, phase 2 and phase 3 RCTs in humans focused on follitropin delta use for ovarian stimulation in IVF/ICSI cycles. The risk of bias and the overall quality of the evidence was analyzed. All data were extracted and analyzed using the intention-to-treat principle and expressed per woman randomized.
    Results: A total of 7 RCTs (1 phase 1 RCT, 2 phase 2 RCTs and 4 phase 3 RCTs) were included in the qualitative analysis, whereas data of three phase 3 RCTs were meta-analyzed. All trials compared personalized recombinant follitropin delta treatment versus conventional recombinant follitropin alfa/beta administration in potentially normo-responder patients who receive ovarian stimulation in GnRH antagonist IVF/ICSI cycles. No difference between two regimens was detected for clinical pregnancy rate [odds ratio (OR) 1.06; 95% confidence intervals (CI): 0.90, 1.24; P = 0.49; I
    Conclusion: Personalized follitropin delta treatment is associated with a lower risk of OHSS compared to conventional follitropin alfa/beta administration in potentially normo-responder patients who receive ovarian stimulation in GnRH antagonist IVF/ICSI cycles. The absence of cumulative data does not allow definitive conclusions to be drawn regarding the comparison of the effectiveness of the two treatments.
    Protocol study registration: CRD42023470352 (available at http://www.crd.york.ac.uk/PROSPERO ).
    MeSH term(s) Pregnancy ; Female ; Humans ; Male ; Sperm Injections, Intracytoplasmic ; Semen ; Fertilization in Vitro/methods ; Ovulation Induction/methods ; Ovarian Hyperstimulation Syndrome/prevention & control ; Follicle Stimulating Hormone ; Gonadotropin-Releasing Hormone ; Recombinant Proteins ; Follicle Stimulating Hormone, Human
    Chemical Substances follitropin delta (076WHW89TW) ; Follicle Stimulating Hormone (9002-68-0) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Recombinant Proteins ; Follicle Stimulating Hormone, Human
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2455679-8
    ISSN 1757-2215 ; 1757-2215
    ISSN (online) 1757-2215
    ISSN 1757-2215
    DOI 10.1186/s13048-024-01372-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Integrated enhanced Raman scattering: a review.

    Eslami, Sahand / Palomba, Stefano

    Nano convergence

    2021  Volume 8, Issue 1, Page(s) 41

    Abstract: The demand for effective, real-time environmental monitoring and for customized point-of-care (PoC) health, requires the ability to detect low molecular concentrations, using portable, reliable and cost-effective devices. However, traditional techniques ... ...

    Abstract The demand for effective, real-time environmental monitoring and for customized point-of-care (PoC) health, requires the ability to detect low molecular concentrations, using portable, reliable and cost-effective devices. However, traditional techniques often require time consuming, highly technical and laborious sample preparations, as well as expensive, slow and bulky instrumentation that needs to be supervised by laboratory technicians. Consequently, fast, compact, self-sufficient, reusable and cost-effective lab-on-a-chip (LOC) devices, which can perform all the required tasks and can then upload the data to portable devices, would revolutionize any mobile sensing application by bringing the testing device to the field or to the patient. Integrated enhanced Raman scattering devices are the most promising platform to accomplish this vision and to become the basic architecture for future universal molecular sensors and hence an artificial optical nose. Here we are reviewing the latest theoretical and experimental work along this direction.
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2760386-6
    ISSN 2196-5404 ; 2196-5404
    ISSN (online) 2196-5404
    ISSN 2196-5404
    DOI 10.1186/s40580-021-00290-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature.

    Palomba, Stefano / Colombo, Carla / Busnelli, Andrea / Caserta, Donatella / Vitale, Giovanni

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1251866

    Abstract: Background: Published data on the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction are sparse and confusing.: Objective: To comprehensively review data available in the literature regarding the relationship between PCOS ... ...

    Abstract Background: Published data on the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction are sparse and confusing.
    Objective: To comprehensively review data available in the literature regarding the relationship between PCOS and the thyroid function, and its abnormalities.
    Methods: Nine main areas of interest were identified and analyzed according to the available evidence: 1) Evaluation of thyroid function for PCOS diagnosis; 2) Epidemiology data on thyroid function/disorders in patients with PCOS, and vice versa; 3) Experimental data supporting the relationship between thyroid function/disorders and PCOS; 4) Effects of thyroid function/disorders on PCOS features, and vice versa; 5) Effect of thyroid alterations on the cardiometabolic risk in women with PCOS; 6) Effect of thyroid abnormalities on reproductive outcomes in women with PCOS; 7) Relationship between thyroid function/abnormalities in patients with PCOS who are undergoing fertility treatment; 8) Effect of treatments for thyroid diseases on PCOS; and 9) Effect of treatments for PCOS on thyroid function. An extensive literature search for specific keywords was performed for articles published from 1970 to March 2023 using PubMed and Web of Science. Data were reported in a narrative fashion.
    Results: PCOS is a diagnosis of exclusion for which diagnosis is possible only after excluding disorders that mimic the PCOS phenotype, including thyroid dysfunctions. However, the tests and the cutoff values used for this are not specified. Many experimental and clinical data suggest a relationship between perturbations of the thyroid function and PCOS. Direct and unequivocal evidence on the effects of thyroid function/disorders on PCOS features are lacking. High thyroid-stimulating hormone levels and subclinical hypothyroidism may be associated with significant worsening of several intermediate endpoints of cardiometabolic risk in women with PCOS. Thyroid abnormalities may worsen reproductive outcomes, especially in patients undergoing fertility treatment. To date, there are no data demonstrating the efficacy of thyroid medications on fertility and cardiometabolic risk in women with PCOS. Lifestyle modification changes, metformin, and vitamin D seem to improve thyroid function in the general population.
    Conclusion: PCOS and thyroid disorders are closely related, and their coexistence may identify patients with a higher reproductive and metabolic risk. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
    MeSH term(s) Female ; Humans ; Pregnancy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/diagnosis ; Thyroid Diseases/complications ; Thyroid Diseases/epidemiology ; Hypothyroidism ; Thyroid Dysgenesis ; Antibodies ; Cardiovascular Diseases
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1251866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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