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Article ; Online: Optimized protocol for conditioned place avoidance learning in juvenile zebrafish.

Palumbo, Fabrizio / Serneels, Bram / Yaksi, Emre

STAR protocols

2021 Volume 2, Issue 2, Page(s) 100465

Abstract: Conditioned place avoidance assays are broadly used in mammals to study different cognitive aspects of operant learning. Here, we introduce a series of experimental designs for training juvenile zebrafish in short-term and long-term conditioned place ... ...

Abstract	Conditioned place avoidance assays are broadly used in mammals to study different cognitive aspects of operant learning. Here, we introduce a series of experimental designs for training juvenile zebrafish in short-term and long-term conditioned place avoidance assays. Our goal is to promote standardization of animal handling procedures and setup conditions to improve animal welfare and reproducibility while studying operant learning behaviors in juvenile zebrafish. For complete details on the use and execution of this protocol, please refer to Palumbo et al. (2020).
MeSH term(s)	Animals ; Avoidance Learning ; Behavior, Animal/physiology ; Conditioning, Operant/physiology ; Zebrafish/physiology
Language	English
Publishing date	2021-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2021.100465
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Article ; Online: The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors.

Palumbo, Fabrizio / Serneels, Bram / Pelgrims, Robbrecht / Yaksi, Emre

Cell reports

2020 Volume 32, Issue 8, Page(s) 108054

Abstract: Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a ... ...

Abstract	Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope with a changing environment. We show that juvenile zebrafish can perform conditioned place avoidance learning, with improving performance across development. Ablation of the dorsolateral habenula (dlHb), a brain region involved in associative learning and prediction of outcomes, leads to an unexpected improvement in performance and delayed memory extinction. Interestingly, the control animals exhibit rapid adaptation to a changing learning rule, whereas dlHb-ablated animals fail to adapt. Altogether, our results show that the dlHb plays a central role in switching animals' strategies while integrating new evidence with prior experience.
MeSH term(s)	Animals ; Behavior, Animal/physiology ; Habenula ; Zebrafish
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.108054
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Article ; Online: Urologists' knowledge base and practice patterns in Peyronie's disease. A national survey of members of the italian andrology society.

Paulis, Gianni / Pisano, Francesca / Palmieri, Alessandro / Cai, Tommaso / Palumbo, Fabrizio / Giammusso, Bruno

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

2021 Volume 93, Issue 3, Page(s) 348–355

Abstract: Peyronie's disease is a chronic inflammatory disease involving the formation of plaque in the tunica albuginea of the corpora cavernosa, resulting in penis deformity. It is often associated with penile pain, especially in younger patients, but it is not ... ...

Abstract	Peyronie's disease is a chronic inflammatory disease involving the formation of plaque in the tunica albuginea of the corpora cavernosa, resulting in penis deformity. It is often associated with penile pain, especially in younger patients, but it is not rare for pain to be absent; the disease is also associated with erectile dysfunction and a depressive state in a large percentage of cases. Objective: Aim of our study was to explore the basic knowledge base and diagnostic and therapeutic practice patterns in Peyronie's disease (PD) of a large number of physicians belonging to the Italian Andrology Society (SIA). Methods: Our survey is based on two questionnaires which were e-mailed to the members of the SIA. The first questionnaire explored diagnostic and therapeutic practice patterns of SIA physicians, while the second questionnaire focused on their knowledge of the disease, as well as their training and level of experience in the specific field. We then planned to compare our outcomes with similar PD surveys from other countries. Results: The first questionnaire was answered by 142 SIA physicians. The second questionnaire was answered by 83 SIA physicians. Most respondents (74.6%) chose penile ultrasonography as first-line diagnostic approach and 47.1% prefer to perform a color Doppler ultrasound after pharmaco-induced erection. Concerning the therapeutic practice patterns in active stage of the disease, most respondents (99.29%) prefer conservative medical therapy. Additionally, most respondents (64.78%), when failure of conservative treatment had been established, considered surgical treatment necessary, specifically corporoplasty, which may be associated with other techniques. Conclusions: The results of our survey show that, in comparison to their foreign counterparts, Italian SIA uro-andrologists have a more proactive diagnostic approach right from when patients first present. When PD is still in its active stage, SIA uro-andrologists mostly opt for medical therapy. In advanced disease or if conservative treatment fails, our survey indicates a greater preference for surgical treatment. Answers to the theoretical knowledge questions showed that SIA physicians have a good understanding of the disease's etiology, epidemiology, and clinical picture, and of the appropriate indications for treatment.
MeSH term(s)	Andrology ; Humans ; Italy/epidemiology ; Knowledge Bases ; Male ; Penile Induration/diagnosis ; Penile Induration/epidemiology ; Penile Induration/therapy ; Urologists
Language	English
Publishing date	2021-10-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1153526-x
ISSN	2282-4197 ; 1120-8538 ; 1124-3562
ISSN (online)	2282-4197
ISSN	1120-8538 ; 1124-3562
DOI	10.4081/aiua.2021.3.348
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Article ; Online: Longitudinal Impact of Social Restrictions on Sexual Health in the Italian Population.

Vedovo, Francesca / Capogrosso, Paolo / Di Blas, Lisa / Cai, Tommaso / Arcaniolo, Davide / Privitera, Salvatore / Palumbo, Fabrizio / Palmieri, Alessandro / Trombetta, Carlo

The journal of sexual medicine

2022 Volume 19, Issue 6, Page(s) 923–932

Abstract: Background: Several trials have reported on the impact of social restrictions due to SARS-CoV-2 (COVID-19) pandemic on sexual function and psycho-physical well-being. However, data showing modifications of these outcomes over time and at the end of lock- ...

Abstract	Background: Several trials have reported on the impact of social restrictions due to SARS-CoV-2 (COVID-19) pandemic on sexual function and psycho-physical well-being. However, data showing modifications of these outcomes over time and at the end of lock-down are scant. Aim: We investigated the longitudinal changes in sexual function during social restrictions for COVID-19 pandemic in Italy. Methods: A web-based survey was administered to Italian citizens of legal age via social networks. The Beck Depression Inventory Primary Care, the General Health Survey, Female Sexual Function Index, International Index of Erectile Function, UCLA Loneliness Scale-version 3 questionnaires were used to test mental, physical and sexual well-being. The questionnaires were administered at the beginning of the lockdown (T0), 15 days from the first assessment (T1) and 1 month after the end of the restrictions in 2020 (T2). Outcomes: Descriptive statistics and multiple regression analysis were applied to investigate changes in sexual function over and at the end of social restrictions. Results: Data were available for 2543 people (47.2% of men; 43.4% women; 9.4% undefined). Mean age was 48.3 ± 15.1 years for males and 43.9 ± 13.4 for females. Overall, 2.6% reported depressive symptoms according to Beck Depression Inventory Primary Care, 7.4% reported a high level of UCLA loneliness and 19.4% low levels of general mental health. Mild to severe erectile dysfunction was reported by 59.1% of men at T0, while 68.4% of women reported sexual dysfunction. Sexual function levels remain generally unchanged at further follow-up over the social restriction time period (T1), although those who were sexually active at baseline showed a decrease in sexual function scores. At T2, there was an overall improvement in sexual function scores with a rate of severe erectile dysfunction decreasing from 37.1% to 24.1% from T0 to T2 among males and a significant decrease of female sexual dysfunction from 68.4% to 51.2%. Clinical implications: Young individuals and those with good mental and physical health were more likely to improve sexual function at the end of social restrictions. Strengths & limitations: Valid and reliable questionnaires and longitudinal approach design represent strengths; a large but convenient sample and lack of pre-pandemic baseline data represent limits. Conclusion: Social restrictions due to COVID-19 pandemic led to an increase in sexual dysfunctions in both genders. However, these conditions appeared temporary since an overall improvement was observed at the end of lockdown and especially in younger individuals with higher psycho-physical well-being. Vedovo F, Capogrosso P, Di Blas L, et al. Longitudinal Impact of Social Restrictions on Sexual Health in the Italian Population. J Sex Med 2022;19:923-932.
MeSH term(s)	Adult ; COVID-19 ; Communicable Disease Control ; Erectile Dysfunction ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Sexual Health
Language	English
Publishing date	2022-05-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2022.03.607
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Article ; Online: Information processing in the vertebrate habenula.

Fore, Stephanie / Palumbo, Fabrizio / Pelgrims, Robbrecht / Yaksi, Emre

Seminars in cell & developmental biology

2017 Volume 78, Page(s) 130–139

Abstract: The habenula is a brain region that has gained increasing popularity over the recent years due to its role in processing value-related and experience-dependent information with a strong link to depression, addiction, sleep and social interactions. This ... ...

Abstract	The habenula is a brain region that has gained increasing popularity over the recent years due to its role in processing value-related and experience-dependent information with a strong link to depression, addiction, sleep and social interactions. This small diencephalic nucleus is proposed to act as a multimodal hub or a switchboard, where inputs from different brain regions converge. These diverse inputs to the habenula carry information about the sensory world and the animal's internal state, such as reward expectation or mood. However, it is not clear how these diverse habenular inputs interact with each other and how such interactions contribute to the function of habenular circuits in regulating behavioral responses in various tasks and contexts. In this review, we aim to discuss how information processing in habenular circuits, can contribute to specific behavioral programs that are attributed to the habenula.
MeSH term(s)	Animals ; Behavior, Addictive/physiopathology ; Emotions/physiology ; Habenula/physiology ; Humans ; Mental Disorders/physiopathology ; Mental Processes/physiology ; Sensation/physiology ; Zebrafish/physiology
Language	English
Publishing date	2017-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2017.08.019
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Article ; Online: Spectroscopic characterization of dipicolinic acid and its photoproducts as thymine photosensitizers.

Nardi, Giacomo / Lineros-Rosa, Mauricio / Palumbo, Fabrizio / Miranda, Miguel A / Lhiaubet-Vallet, Virginie

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2020 Volume 245, Page(s) 118898

Abstract: Dipicolinic acid (DPA), present in large amount in bacterial spores, has been proposed to act as an endogenous photosensitizer in spore photoproduct formation. The proposed mechanism involves a triplet-triplet energy transfer from DPA to thymine. However, ...

Abstract	Dipicolinic acid (DPA), present in large amount in bacterial spores, has been proposed to act as an endogenous photosensitizer in spore photoproduct formation. The proposed mechanism involves a triplet-triplet energy transfer from DPA to thymine. However, up to now, no spectroscopic studies have been performed to determine the interaction between the endogenous compound and the nucleobase, probably due to its photolability in aqueous solutions. Here, triplet excited state properties of DPA are reported together with its bimolecular quenching rate constant by thymidine, k
MeSH term(s)	Energy Transfer ; Photosensitizing Agents ; Picolinic Acids ; Thymine
Chemical Substances	Photosensitizing Agents ; Picolinic Acids ; Thymine (QR26YLT7LT) ; dipicolinic acid (UE81S5CQ0G)
Language	English
Publishing date	2020-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2020.118898
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Article ; Online: How the andrological sector suffered from the dramatic Covid 19 outbreak in Italy: supportive initiatives of the Italian Association of Andrology (SIA).

Rizzo, Michele / Liguori, Giovanni / Verze, Paolo / Palumbo, Fabrizio / Cai, Tommaso / Palmieri, Alessandro

International journal of impotence research

2020 Volume 32, Issue 5, Page(s) 547–548

MeSH term(s)	Andrology/methods ; Andrology/organization & administration ; Andrology/trends ; Betacoronavirus ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Elective Surgical Procedures/methods ; Humans ; Italy/epidemiology ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Remote Consultation/methods ; SARS-CoV-2 ; Urologic Diseases/epidemiology ; Urologic Diseases/therapy
Keywords	covid19
Language	English
Publishing date	2020-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-020-0288-7
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Article ; Online: Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability.

Kermen, Florence / Darnet, Lea / Wiest, Christoph / Palumbo, Fabrizio / Bechert, Jack / Uslu, Ozge / Yaksi, Emre

BMC biology

2020 Volume 18, Issue 1, Page(s) 66

Abstract: Background: Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and involve the activity of diverse ... ...

Abstract	Background: Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and involve the activity of diverse brain regions following stimulation of the olfactory bulb by specific odors. However, while the zebrafish olfactory circuitry is well understood, a comprehensive characterization linking odor-driven behaviors to specific odors is needed to better relate olfactory computations to animal responses. Results: Here, we used a medium-throughput setup to measure the swimming trajectories of 10 zebrafish in response to 17 ecologically relevant odors. By selecting appropriate locomotor metrics, we constructed ethograms systematically describing odor-induced changes in the swimming trajectory. We found that adult zebrafish reacted to most odorants using different behavioral programs and that a combination of a few relevant behavioral metrics enabled us to capture most of the variance in these innate odor responses. We observed that individual components of natural food and alarm odors do not elicit the full behavioral response. Finally, we show that zebrafish blood elicits prominent defensive behaviors similar to those evoked by skin extract and activates spatially overlapping olfactory bulb domains. Conclusion: Altogether, our results highlight a prominent intra- and inter-individual variability in zebrafish odor-driven behaviors and identify a small set of waterborne odors that elicit robust responses. Our behavioral setup and our results will be useful resources for future studies interested in characterizing innate olfactory behaviors in aquatic animals.
MeSH term(s)	Animals ; Female ; Male ; Odorants/analysis ; Olfactory Perception ; Swimming ; Zebrafish/physiology
Language	English
Publishing date	2020-06-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2133020-7
ISSN	1741-7007 ; 1741-7007
ISSN (online)	1741-7007
ISSN	1741-7007
DOI	10.1186/s12915-020-00801-8
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Article ; Online: Observation of scissors modes in solid state systems with a SQUID.

Hatada, Keisuke / Hayakawa, Kuniko / Palumbo, Fabrizio / Marcelli, Augusto

Journal of synchrotron radiation

2016 Volume 23, Issue 2, Page(s) 560–565

Abstract: The occurrence of scissors modes in crystals that have deformed ions in their unit cells was predicted some time ago. The theoretical value of their energy is rather uncertain, however, ranging between ten and a few tens of eV, with the corresponding ... ...

Abstract	The occurrence of scissors modes in crystals that have deformed ions in their unit cells was predicted some time ago. The theoretical value of their energy is rather uncertain, however, ranging between ten and a few tens of eV, with the corresponding widths of 10(-7) to 10(-6) eV. Their observation by resonance fluorescence experiments therefore requires a photon spectrometer covering a wide energy range with a very high resolving power. Here, a new experiment is proposed and discussed in which such difficulties are overcome by measuring with a superconducting quantum interference device (SQUID) the variation of the magnetic field associated with the excitation of scissors modes.
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577516001326
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Article: Loss of consciousness in a helicopter pilot as plausible first sign of insulinoma: a case report.

Pratò, Simone / Didonna, Vittoria / Garletti, Francesca / Marfia, Giovanni / Barbaresi, Adriano / Palumbo, Fabrizio / Garzia, Emanuele / Ciniglio Appiani, Giuseppe / Riboldi, Luciano / Vigna, Luisella

La Medicina del lavoro

2022 Volume 113, Issue 1, Page(s) e2022007

Abstract: A 50-year-old man who worked as a helicopter rescue pilot transiently lost consciousness while piloting a helicopter rescue. In the diagnostic process, all tests for the main possible differential diagnoses of loss of consciousness (cardiological and ... ...

Abstract	A 50-year-old man who worked as a helicopter rescue pilot transiently lost consciousness while piloting a helicopter rescue. In the diagnostic process, all tests for the main possible differential diagnoses of loss of consciousness (cardiological and neurological) were performed and yielded normal results. Blood chemistry tests revealed recurrent fasting hypoglycemia and Chromogranin A was at the upper limit of normal. Fine needle aspiration guided by endoscopic ultrasonography was used to diagnose insulinoma-type neuroendocrine tumor of the pancreas. According to the Italian policies, the occupational physician aims to maintain professional skills without neglecting flight safety. A careful analysis of the relationship between the characteristics of the state of health of the aviator and his specific work needs was carried out, and he was given the opportunity to continue working as a rescue pilot thanks to medical therapies associated with organizational interventions in the workplace.
MeSH term(s)	Aircraft ; Consciousness ; Humans ; Insulinoma/complications ; Insulinoma/diagnosis ; Insulinoma/pathology ; Male ; Middle Aged ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology ; Pilots ; Unconsciousness/complications
Language	English
Publishing date	2022-02-22
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	123678-7
ISSN	0025-7818
ISSN	0025-7818
DOI	10.23749/mdl.v113i1.12037
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