Article ; Online: Diagnostic and prognostic role of HBME-1, galectin-3, and β-catenin in poorly differentiated and anaplastic thyroid carcinomas.
Applied immunohistochemistry & molecular morphology : AIMM
2013 Volume 21, Issue 3, Page(s) 237–241
Abstract: Aim: Thyroid cancer represents the first endocrine malignant neoplasm, accounting for 1% of human malignancy. The majority of which are well-differentiated cancer representing up to 90% of thyroid cancer and pursuing a favorable clinical course. The ... ...
| Abstract | Aim: Thyroid cancer represents the first endocrine malignant neoplasm, accounting for 1% of human malignancy. The majority of which are well-differentiated cancer representing up to 90% of thyroid cancer and pursuing a favorable clinical course. The groups of poorly differentiated thyroid cancer (PDC) and anaplastic thyroid cancer (ATC) have a poor outcome and need a strict clinical surveillance. Materials and methods: Thirty-four cases including 23 PDC/insular cancer and 9 ATC were examined for the expression of an immunohistochemical panel made up by HBME-1, galectin-3, and β-catenin and correlated either with histologic prognostic parameters or the overall surveillance. Results: HBME-1 and galectin-3 were expressed in 100% of the PDC/insular cases and in none of the ATC cases. The data for β-catenin pointed out an 80% expression (12/15) in the PDCs and only a focal and nonspecific positivity in the ATCs. A β-catenin-positive expression was found in all patients with a worse outcome/death and in the presence of vascular invasion and metastatic disease. All 3 PDC patients with β-catenin negativity are alive, whereas only 41% (5/12) are alive in the β-catenin-positive group. Conclusions: Our data set up the idea that PDC represents an intermediate step in the biological process of dedifferentiation of thyroid tumors toward ATC. This shift is underlined by the β-catenin expression, which seems to be related to a worse prognostic behavior. HBME-1 and galectin-3 show a similar pattern in PDC compared with well-differentiated carcinoma, whereas they are not expressed, as well as β-catenin, in anaplastic carcinomas. |
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| MeSH term(s) | Adult ; Aged ; Biomarkers, Tumor/genetics ; Carcinoma/diagnosis ; Carcinoma/genetics ; Carcinoma/pathology ; Cell Dedifferentiation ; Cell Differentiation ; Cell Transformation, Neoplastic ; Diagnosis, Differential ; Female ; Galectin 3/genetics ; Gene Expression ; Humans ; Male ; Middle Aged ; Prognosis ; Thyroid Carcinoma, Anaplastic ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; beta Catenin/genetics |
| Chemical Substances | Biomarkers, Tumor ; CTNNB1 protein, human ; Galectin 3 ; HBME-1 antigen ; beta Catenin |
| Language | English |
| Publishing date | 2013-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1473273-7 |
| ISSN | 1533-4058 ; 1062-3345 ; 1541-2016 |
| ISSN (online) | 1533-4058 |
| ISSN | 1062-3345 ; 1541-2016 |
| DOI | 10.1097/PAI.0b013e3182688d0f |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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