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  1. Article ; Online: Heterologous Covid-19 vaccines intervention effect on reactogenicity

    Wajeha Najeeb / Palvasha Waheed / Rehana Khadim

    Journal of the Pakistan Medical Association, Vol 74, Iss

    2023  Volume 1

    Abstract: To determine the change in the occurrence of short-term vaccine reactions on the use of heterologous Covid-19 booster, a single centre short-term study of two months duration was conducted. It was designed as an interventional study with registered ... ...

    Abstract To determine the change in the occurrence of short-term vaccine reactions on the use of heterologous Covid-19 booster, a single centre short-term study of two months duration was conducted. It was designed as an interventional study with registered clinical trial number # SLCTR/2022/008. It was conducted on medical students and faculty of a National university of medical sciences, Rawalpindi affiliated public sector medical college. A total of 348 individuals were administered with Ad5-nCoV vaccine and 101 with mRNA-1273 vaccine. They all had been previously vaccinated with two doses of BBIBP-CorV. BBIBP-CorV reactogenicity was considered a control group. Vaccine reactions, including pain and redness at the injection site, fever, no observed reactions at all, myalgia, feeling cold, dizziness, paraesthesia in the arm, light-headedness, had a significant change in their frequencies in comparison to homologous vaccine (BBIBP-CorV) reactogenicity. ---Continue
    Keywords Covid-19 vaccines ; Booster immunisation ; Adverse effects ; Medicine ; R
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Pakistan Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Response from M Maqsood, P Waheed, A Rashid, et al. (J Pak Med Assoc. 2023; 73

    Muntaha Maqsood / Palvasha Waheed / Amir Rashid / Asifa Majeed / Ahsan Mukhtar

    Journal of the Pakistan Medical Association, Vol 73, Iss

    978-982) Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics

    2023  Volume 11

    Abstract: Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources ... ...

    Abstract Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources and sample size. • Scarcity of literature regarding available and very limited publication available of the AKR1B1 gene. • Analysis not linked to demographic details, because samples used were de-identified in order to stick to the design of the study.2. The study only discussed the association of AR gene polymorphism rs752010122 and DR regardless of whether the polymorphism was familial or somatic. A family history of diabetic retinopathy (DR) increases its risk in patients with T2DM however it was not the scope of this study. Furthermore, as it was a single centre study with small sample size, including a patient population with diverse ethinicity was not possible. The discussion portion of the article highlights the scarce data available discussing the various AR gene polymorphisms in certain ethincities. However, a large collabrative multicentre study icluding a diverse patient popultaion spanning various demographic areas may be able to identify the association of AR gene polymorphism, ethinicity and DR. 3. The samples were de-identified prior to analysis by multiple blinded researchers. 4. It is acknowledged that the article does not specifically mention that patients with dyslipidaemia were excluded. However, patients with DR suspected secondary to other causes were excluded as mentioned in the “Patient and Methods” section. 5. It is acknowledged that the article does not include how the patients were screened for DR and T2DM, therefore this comment provides us the opportunity to provide those details. Patients were screened for DR by fundoscopy by expert ophthalmolgists at Armed Forces Institute of Ophthalmology. Clinical evaluation icluded BMI, blood pressure and other vital signs. Haematological work up included Fasting Blood Glucose, HbA1c, Fasting ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Pakistan Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Response from M Maqsood, P Waheed, A Rashid, et al. (J Pak Med Assoc. 2023; 73

    Muntaha Maqsood / Palvasha Waheed / Amir Rashid / Asifa Majeed / Ahsan Mukhtar

    Journal of the Pakistan Medical Association, Vol 73, Iss

    978-982) Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics

    2023  Volume 11

    Abstract: Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources ... ...

    Abstract Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources and sample size. • Scarcity of literature regarding available and very limited publication available of the AKR1B1 gene. • Analysis not linked to demographic details, because samples used were de-identified in order to stick to the design of the study.2. The study only discussed the association of AR gene polymorphism rs752010122 and DR regardless of whether the polymorphism was familial or somatic. A family history of diabetic retinopathy (DR) increases its risk in patients with T2DM however it was not the scope of this study. Furthermore, as it was a single centre study with small sample size, including a patient population with diverse ethinicity was not possible. The discussion portion of the article highlights the scarce data available discussing the various AR gene polymorphisms in certain ethincities. However, a large collabrative multicentre study icluding a diverse patient popultaion spanning various demographic areas may be able to identify the association of AR gene polymorphism, ethinicity and DR. 3. The samples were de-identified prior to analysis by multiple blinded researchers. 4. It is acknowledged that the article does not specifically mention that patients with dyslipidaemia were excluded. However, patients with DR suspected secondary to other causes were excluded as mentioned in the “Patient and Methods” section. 5. It is acknowledged that the article does not include how the patients were screened for DR and T2DM, therefore this comment provides us the opportunity to provide those details. Patients were screened for DR by fundoscopy by expert ophthalmolgists at Armed Forces Institute of Ophthalmology. Clinical evaluation icluded BMI, blood pressure and other vital signs. Haematological work up included Fasting Blood Glucose, HbA1c, Fasting ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Pakistan Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Response from M Maqsood, P Waheed, A Rashid, et al. (J Pak Med Assoc. 2023; 73

    Muntaha Maqsood / Palvasha Waheed / Amir Rashid / Asifa Majeed / Ahsan Mukhtar

    Journal of the Pakistan Medical Association, Vol 73, Iss

    978-982) Aldose reductase gene polymorphism rs752010122 and retinopathy in type 2 diabetics

    2023  Volume 11

    Abstract: Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources ... ...

    Abstract Madam, First of all, I would like to appreciate the reader for their insightful feedback as we can all learn when wisdom is shared. The readers concerns are addressed point by point as follows: 1. Limitations of study • Restriction of funding resources and sample size. • Scarcity of literature regarding available and very limited publication available of the AKR1B1 gene. • Analysis not linked to demographic details, because samples used were de-identified in order to stick to the design of the study.2. The study only discussed the association of AR gene polymorphism rs752010122 and DR regardless of whether the polymorphism was familial or somatic. A family history of diabetic retinopathy (DR) increases its risk in patients with T2DM however it was not the scope of this study. Furthermore, as it was a single centre study with small sample size, including a patient population with diverse ethinicity was not possible. The discussion portion of the article highlights the scarce data available discussing the various AR gene polymorphisms in certain ethincities. However, a large collabrative multicentre study icluding a diverse patient popultaion spanning various demographic areas may be able to identify the association of AR gene polymorphism, ethinicity and DR. 3. The samples were de-identified prior to analysis by multiple blinded researchers. 4. It is acknowledged that the article does not specifically mention that patients with dyslipidaemia were excluded. However, patients with DR suspected secondary to other causes were excluded as mentioned in the “Patient and Methods” section. 5. It is acknowledged that the article does not include how the patients were screened for DR and T2DM, therefore this comment provides us the opportunity to provide those details. Patients were screened for DR by fundoscopy by expert ophthalmolgists at Armed Forces Institute of Ophthalmology. Clinical evaluation icluded BMI, blood pressure and other vital signs. Haematological work up included Fasting Blood Glucose, HbA1c, Fasting ...
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Pakistan Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Identifying Risk Factors Associated with the Development of Diabetic Retinopathy in the Local Population

    Erum Tariq / Palvasha Waheed / Amir Rashid / Asifa Majeed

    Pakistan Armed Forces Medical Journal, Vol 72, Iss

    2022  Volume 6

    Abstract: Objective: To identify the risk factors for developing diabetic retinopathy. Study Design: Cross-sectional study. Place and Duration of Study: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pak Emirates Military ... ...

    Abstract Objective: To identify the risk factors for developing diabetic retinopathy. Study Design: Cross-sectional study. Place and Duration of Study: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pak Emirates Military Hospital (PEMH), Rawalpindi and Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi Pakistan,from Jun 2021 to May 2022. Methodology: A total of one hundred and fifty participants aged 25-70 years were included in the study. All participants were divided into three equal groups. Group-I was of age and gender-matched healthy individuals (n=50), Group-II was of people with diabetes without retinopathy (n=50), and Group-III was of diabetic patients having retinopathy (n=50). All the data of the participants were recorded on an especially designed proforma, and 5ml of venous blood was also drawn from the subjects to measure serum lipid levels. Results: Male gender was more common with 33(66%), 30(60%) and 33(66%) in Group-I, Group-II, and Group-III respectively.Most of the retinopathy cases had sedentary lifestyle 33(66%), poor dietary habits 34(68%), cardiovascular disease 38(76%),diabetic foot ulcers 44(88%) and increased levels of TAGS (p-value 0.001). Nephropathy and smoking showed no significant link with dr. Conclusion: It can be concluded that a sedentary lifestyle, poor dietary habits, cardiovascular disease, diabetic foot and increased TAGS may be risk factors for the development of diabetic retinopathy. These findings can help in the early identification and better prognosis of the disease in high-risk individuals.
    Keywords Diabetic Retinopathy ; Type 2 diabetes ; Risk factors ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

    Amena Arif / Palvasha Waheed / Robina Anees / Amir Rashid / Saleem Ahmed Khan

    Pakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1746-

    2021  Volume 1751

    Abstract: Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, ...

    Abstract Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.
    Keywords insulin resistance ; obesity ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Army Medical College Rawalpindi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: EXPRESSION ANALYSIS AND RELATIONSHIP OF PROTEIN KINASE CK2α WITH HISTOPATHOLOGICAL FEATURES IN HUMAN BREAST CANCER

    Fatima Qaiser / Abdul Khaliq Naveed / Sarah Sadiq / Palvasha Waheed / Iqbal Muhammad / Rubina Younis / Shoaib Naiyar Hashmi

    Khyber Medical University Journal, Vol 7, Iss 2, Pp 53-

    2015  Volume 59

    Abstract: Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical ... ...

    Abstract Objectives: The present study was designed to evaluate the role of CK2α; in prognosis of breast cancer patients diagnosed at the same stage of the disease, and to predict aggressiveness of the tumor. Methods: A retroprospective immunohistochemical analysis of CK2α was carried out in human breast cancer tissue specimens. All the cases included were diagnosed at stage II of disease. χ 2 tests and Regression analysis were carried out to determine the correlation between histopathological parameters and expression pattern of CK2α Results: There was a positive correlation between total as well as nuclear expression of CK2α with increasing Nottingham prognostic index (p<0.0001). CK2α was also found to be significantly associated with the lymph node metastasis (p<0.0001). Conclusion: Immunohistochemical expression of CK2α can be used as an indicator of poor prognosis of disease even if overall stage of the breast cancer is the same. CK2α can also serve to predict the aggressiveness of the breast cancer as well and can identify the sub set of patients at high risk of developing lymph node metastasis.
    Keywords Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2015-07-01T00:00:00Z
    Publisher Khyber Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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