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  1. Article: A multifaceted evaluation of microgliosis and differential cellular dysregulation of mammalian target of rapamycin signaling in neuronopathic Gaucher disease.

    Zhang, Zhenting / Wang, Xiaohong / Lin, Yi / Pan, Dao

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 944883

    Abstract: Neuronopathic Gaucher disease (nGD) is an inherited neurodegenerative disease caused by mutations ... ...

    Abstract Neuronopathic Gaucher disease (nGD) is an inherited neurodegenerative disease caused by mutations in
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.944883
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  2. Article ; Online: Preparation of highly adsorptive biochar by sequential iron impregnation under refluxing and pyrolysis at low temperature for removal of tetracycline.

    Sun, Ahui / Bian, Siyao / Li, Linzhou / Guo, Zijing / Li, Wanjie / Li, Jihui / Xu, Shuying / Liu, Pan-Dao

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 348, Page(s) 123886

    Abstract: Iron-doping modification is a prevailing approach for improving adsorption capability of biochar with environmental friendliness, but usually requires high temperature and suffers from iron aggregation. Herein, a highly adsorptive biochar was ... ...

    Abstract Iron-doping modification is a prevailing approach for improving adsorption capability of biochar with environmental friendliness, but usually requires high temperature and suffers from iron aggregation. Herein, a highly adsorptive biochar was manufactured via sequential disperse impregnation of iron by refluxing and pyrolysis at low temperature for eliminating tetracycline (TC) from aqueous solution. Iron oxides and hydroxides were impregnated and stably dispersed on the carbon matrix as pyrolyzed at 200 °C, meanwhile abundant oxygen and nitrogen functional groups were generated on surface. The iron-doped biochar exhibited up to 891.37 mg/g adsorption capacity at pH 5, and could be recycled with high adsorption capability. The adsorption of TC should be mostly contributed to the hydrogen bonding of N/O functional groups and the hydrogen bonding/coordination of iron oxides/hydroxides. This would provide a valuable guide for dispersedly doping iron and conserving functional groups on biochar, and a super iron-doped biochar was prepared with superior recyclability.
    MeSH term(s) Temperature ; Iron ; Adsorption ; Pyrolysis ; Charcoal ; Tetracycline ; Anti-Bacterial Agents ; Water ; Hydroxides ; Water Pollutants, Chemical/analysis ; Kinetics
    Chemical Substances biochar ; Iron (E1UOL152H7) ; Charcoal (16291-96-6) ; Tetracycline (F8VB5M810T) ; Anti-Bacterial Agents ; Water (059QF0KO0R) ; Hydroxides ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123886
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
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  3. Article ; Online: Facile production of cellulose nanofibers from raw elephant grass by an aluminum chloride-enhanced acidic deep eutectic solvent

    Yuan, Jin-Chao / Huang, Rui / Jiang, Ling-Yan / Liu, Guo-Dao / Liu, Pan-Dao / Xu, Wen-Rong

    International Journal of Biological Macromolecules. 2023 Aug., v. 246 p.125687-

    2023  

    Abstract: To develop a greener and more efficient method for producing cellulose nanofibers (CNFs) from raw plants, an AlCl₃-enhanced ternary deep eutectic solvent, DES2 (consisting of choline chloride, citric acid, and AlCl₃·6H₂O in a molar ratio of 1:0.4:0.08), ... ...

    Abstract To develop a greener and more efficient method for producing cellulose nanofibers (CNFs) from raw plants, an AlCl₃-enhanced ternary deep eutectic solvent, DES2 (consisting of choline chloride, citric acid, and AlCl₃·6H₂O in a molar ratio of 1:0.4:0.08), was synthesized. Raw elephant grass (EG) was pretreated with DES2, followed by sodium chlorite (NaClO₂) bleaching and ultrasonic disruption to extract high-performance CNFs. The DES2 and NaClO₂ treatments effectively removed hemicellulose and lignin, achieving removal rates of 99.23 % and 99.62 %, respectively, while maintaining a cellulose content of 78.3 %. DES2 demonstrated easy recyclability and maintained excellent biomass pretreatment performance even after multiple cycles. Following a brief 30-min intermittent ultrasound treatment, the resulting CNFs demonstrated superior crystallinity, increased carboxyl content, and a narrower width distribution compared to CNFs obtained from AlCl₃-free DES1. Optimized conditions at 110 °C yielded CNFs with 85.3 % crystallinity, 0.64 mmol/g carboxyl content, 5.15 nm width distribution, and excellent dispersion in water for at least six months. Additionally, CNFs enhanced the tensile strength of chia seed mucilage (CM) composite films, showing a significant improvement to 26.6 MPa, representing a 231.3 % increase over the control film. This study offers a promising approach for efficiently producing CNFs from raw plants.
    Keywords Cenchrus purpureus ; Salvia hispanica ; aluminum ; biomass ; cellulose ; cellulose nanofibers ; chlorites ; choline chloride ; citric acid ; crystal structure ; hemicellulose ; lignin ; mucilages ; solvents ; tensile strength ; ultrasonic treatment ; ultrasonics ; Cellulose nanofibrils ; Deep eutectic solvent ; Elephant grass
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125687
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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  4. Article ; Online: Cell- and gene-based therapeutic approaches for neurological deficits in mucopolysaccharidoses.

    Pan, Dao

    Current pharmaceutical biotechnology

    2011  Volume 12, Issue 6, Page(s) 884–896

    Abstract: Mucopolysaccharidoses (MPS) are a group of lysosomal storage diseases that are resulted from abnormal accumulation of glycosaminoglycans. Among the progressive multi-organ abnormalities often associated with MPS diseases, the deterioration of central ... ...

    Abstract Mucopolysaccharidoses (MPS) are a group of lysosomal storage diseases that are resulted from abnormal accumulation of glycosaminoglycans. Among the progressive multi-organ abnormalities often associated with MPS diseases, the deterioration of central nervous system (CNS) is the most challenging manifestations to be tackled, due to the impermeability of the blood-brain-barrier (BBB). Evolved with recent development in stem cell biotechnology and gene therapy, several novel experimental approaches have been investigated in animal models. In this review, we will address different approaches attempting to bypass the BBB for neuropathic MPS treatment using cell- and gene-based therapies. Several neurological findings in CNS pathophysiology emerged with therapeutic investigation will also be discussed.
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Genetic Therapy/methods ; Glycosaminoglycans/metabolism ; Humans ; Mucopolysaccharidoses/genetics ; Mucopolysaccharidoses/metabolism ; Mucopolysaccharidoses/pathology ; Mucopolysaccharidoses/therapy ; Nervous System Diseases/genetics ; Nervous System Diseases/metabolism ; Nervous System Diseases/pathology ; Nervous System Diseases/therapy
    Chemical Substances Glycosaminoglycans
    Language English
    Publishing date 2011-01-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 1389-2010/11 $58.00+.00
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  5. Article ; Online: Successful treatment of persistent hiccups with myofascial trigger point dry needling: a case report.

    Sun, Wen-Qin / Pan, Dao-Bo / Huang, Qiang-Min

    Acupuncture in medicine : journal of the British Medical Acupuncture Society

    2020  Volume 39, Issue 1, Page(s) 72–74

    MeSH term(s) Dry Needling ; Hiccup/physiopathology ; Hiccup/therapy ; Humans ; Male ; Middle Aged ; Trigger Points/physiology
    Language English
    Publishing date 2020-06-12
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1360533-1
    ISSN 1759-9873 ; 0964-5284
    ISSN (online) 1759-9873
    ISSN 0964-5284
    DOI 10.1177/0964528420920296
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4628: Show issues Location:
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  6. Article ; Online: A comprehensive review on molecular mechanism of defective dry-cured ham with excessive pastiness, adhesiveness, and bitterness by proteomics insights.

    Zhou, Chang-Yu / Pan, Dao-Dong / Cao, Jin-Xuan / Zhou, Guang-Hong

    Comprehensive reviews in food science and food safety

    2021  Volume 20, Issue 4, Page(s) 3838–3857

    Abstract: Excessive bitterness, pastiness, and adhesiveness are the main organoleptic and textural defects of dry-cured ham, which often cause a lot of financial losses to manufacturers and seriously damage the quality of the product. These sensory and textural ... ...

    Abstract Excessive bitterness, pastiness, and adhesiveness are the main organoleptic and textural defects of dry-cured ham, which often cause a lot of financial losses to manufacturers and seriously damage the quality of the product. These sensory and textural defects are related to the protein degradation of dry-cured ham. Proteomics shows great potential to improve our understanding of the molecular mechanism of sensory and textural defects and identify biomarkers for monitoring their quality traits. This review presents some of the major achievements and considerations in organoleptic and textural defects of dry-cured ham by proteomics analysis in the recent decades and gives an overview about how to correct sensory and textural defects of dry-cured ham. Proteomics reveals that muscle proteins derived from myofibril and cytoskeleton and involved in metabolic enzymes and oxygen transport have been identified as potential biomarkers in defective dry-cured ham. Relatively high residual activities of cathepsin B and L are responsible for the excessive degradation of these protein biomarkers in defective dry-cured ham. Ultrasound-assisted mild thermal or high-pressure treatment shows a good correction for the organoleptic and textural defects of dry-cured ham by changing microstructure and conformation of muscle proteins by accelerating degradation of proteins and polypeptides into free amino acids.
    MeSH term(s) Adhesiveness ; Meat Products/analysis ; Muscle Proteins ; Pork Meat ; Proteomics
    Chemical Substances Muscle Proteins
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185829-9
    ISSN 1541-4337 ; 1541-4337
    ISSN (online) 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.12779
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  7. Article ; Online: Facile production of cellulose nanofibers from raw elephant grass by an aluminum chloride-enhanced acidic deep eutectic solvent.

    Yuan, Jin-Chao / Huang, Rui / Jiang, Ling-Yan / Liu, Guo-Dao / Liu, Pan-Dao / Xu, Wen-Rong

    International journal of biological macromolecules

    2023  Volume 246, Page(s) 125687

    Abstract: To develop a greener and more efficient method for producing cellulose nanofibers (CNFs) from raw plants, an ... ...

    Abstract To develop a greener and more efficient method for producing cellulose nanofibers (CNFs) from raw plants, an AlCl
    MeSH term(s) Cellulose ; Solvents ; Aluminum Chloride ; Deep Eutectic Solvents ; Nanofibers
    Chemical Substances Cellulose (9004-34-6) ; Solvents ; Aluminum Chloride (3CYT62D3GA) ; Deep Eutectic Solvents ; Salvia hispanica seed extract
    Language English
    Publishing date 2023-07-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.125687
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  8. Article: In situ (in vivo) gene transfer into murine bone marrow stem cells.

    Pan, Dao

    Methods in molecular biology (Clifton, N.J.)

    2009  Volume 506, Page(s) 159–169

    Abstract: Adult bone marrow stem cell is an ideal target for gene therapy of genetic diseases, selected malignant diseases, and AIDS. The in vivo approach of lentivirus vector (LV)-mediated stem cell gene transfer by intrafemoral (IF) injection can take full ... ...

    Abstract Adult bone marrow stem cell is an ideal target for gene therapy of genetic diseases, selected malignant diseases, and AIDS. The in vivo approach of lentivirus vector (LV)-mediated stem cell gene transfer by intrafemoral (IF) injection can take full advantage of any source of stem cells residing in the bone cavity. Such an approach may avoid several difficulties encountered by ex vivo hematopoietic stem cell (HSC) gene transfer. We have shown that both HSC and mesenchymal stem/progenitor cells (MSC) can be genetically modified successfully by a single "in situ" IF injection in their natural "niche" in mice without any preconditioning. This approach may provide a novel application for treatment of human diseases, and represent an interesting new tool to study adult stem cell plasticity and the nature of unperturbed hematopoiesis.
    MeSH term(s) Animals ; Gene Transfer Techniques ; Genetic Vectors ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Mice ; Vesiculovirus/genetics
    Language English
    Publishing date 2009
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1007/978-1-59745-409-4_12
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  9. Article: Rational Design of Gene Therapy Vectors.

    Pan, Dao / Büning, Hildegard / Ling, Chen

    Molecular therapy. Methods & clinical development

    2019  Volume 12, Page(s) 246–247

    Language English
    Publishing date 2019-02-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2019.01.009
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    Zs.A 7107: Show issues Location:
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  10. Article: A comprehensive review on molecular mechanism of defective dry‐cured ham with excessive pastiness, adhesiveness, and bitterness by proteomics insights

    Zhou, Chang‐Yu / Pan, Dao‐Dong / Cao, Jin‐Xuan / Zhou, Guang‐Hong

    Comprehensive reviews in food science and food safety. 2021 July, v. 20, no. 4

    2021  

    Abstract: Excessive bitterness, pastiness, and adhesiveness are the main organoleptic and textural defects of dry‐cured ham, which often cause a lot of financial losses to manufacturers and seriously damage the quality of the product. These sensory and textural ... ...

    Abstract Excessive bitterness, pastiness, and adhesiveness are the main organoleptic and textural defects of dry‐cured ham, which often cause a lot of financial losses to manufacturers and seriously damage the quality of the product. These sensory and textural defects are related to the protein degradation of dry‐cured ham. Proteomics shows great potential to improve our understanding of the molecular mechanism of sensory and textural defects and identify biomarkers for monitoring their quality traits. This review presents some of the major achievements and considerations in organoleptic and textural defects of dry‐cured ham by proteomics analysis in the recent decades and gives an overview about how to correct sensory and textural defects of dry‐cured ham. Proteomics reveals that muscle proteins derived from myofibril and cytoskeleton and involved in metabolic enzymes and oxygen transport have been identified as potential biomarkers in defective dry‐cured ham. Relatively high residual activities of cathepsin B and L are responsible for the excessive degradation of these protein biomarkers in defective dry‐cured ham. Ultrasound‐assisted mild thermal or high‐pressure treatment shows a good correction for the organoleptic and textural defects of dry‐cured ham by changing microstructure and conformation of muscle proteins by accelerating degradation of proteins and polypeptides into free amino acids.
    Keywords adhesion ; biomarkers ; bitterness ; cathepsin B ; cured meats ; cytoskeleton ; food safety ; ham ; high pressure treatment ; microstructure ; muscles ; oxygen ; polypeptides ; protein degradation ; proteomics ; ultrasonic treatment
    Language English
    Dates of publication 2021-07
    Size p. 3838-3857.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2185829-9
    ISSN 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.12779
    Database NAL-Catalogue (AGRICOLA)

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