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Article: Analysis of metabolic differences between Jiaosu fermented from dendrobium flowers and stems based on untargeted metabolomics.

Jiang, Lihong / Li, Xingjiang / Wang, Shuo / Pan, Du / Wu, Xuefeng / Guo, Fengxu / Mu, Dongdong / Jia, Fuhuai / Zhang, Min

Heliyon

2024 Volume 10, Issue 5, Page(s) e27061

Abstract: Dendrobium ... ...

Abstract	Dendrobium officinale
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27061
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A semi-analytical solution and AI-based reconstruction algorithms for magnetic particle tracking.

Huixuan Wu / Pan Du / Rohan Kokate / Jian-Xun Wang

PLoS ONE, Vol 16, Iss 7, p e

2021 Volume 0254051

Abstract: Magnetic particle tracking is a recently developed technology that can measure the translation and rotation of a particle in an opaque environment like a turbidity flow and fluidized-bed flow. The trajectory reconstruction usually relies on numerical ... ...

Abstract	Magnetic particle tracking is a recently developed technology that can measure the translation and rotation of a particle in an opaque environment like a turbidity flow and fluidized-bed flow. The trajectory reconstruction usually relies on numerical optimization or filtering, which involve artificial parameters or thresholds. Existing analytical reconstruction algorithms have certain limitations and usually depend on the gradient of the magnetic field, which is not easy to measure accurately in many applications. This paper discusses a new semi-analytical solution and the related reconstruction algorithm. The new method can be used for an arbitrary sensor arrangement. To reduce the measurement uncertainty in practical applications, deep neural network (DNN)-based models are developed to denoise the reconstructed trajectory. Compared to traditional approaches such as wavelet-based filtering, the DNN-based denoisers are more accurate in the position reconstruction. However, they often over-smooth the velocity signal, and a hybrid method that combines the wavelet and DNN model provides a more accurate velocity reconstruction. All the DNN-based and wavelet methods perform well in the orientation reconstruction.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metal-Free Phosphination and Continued Functionalization of Pyridine

Pan Du / Yuhao Yin / Dai Shi / Kexin Mao / Qianyuan Yu / Jiyang Zhao

Molecules, Vol 27, Iss 5694, p

A Theoretical Study

2022 Volume 5694

Abstract: This study investigates the mechanism of metal-free pyridine phosphination with P(OEt) 3 , PPh 3 , and PAr 2 CF 3 using density functional theory calculations. The results show that the reaction mechanism and rate-determining step vary depending on the ... ...

Abstract	This study investigates the mechanism of metal-free pyridine phosphination with P(OEt) 3 , PPh 3 , and PAr 2 CF 3 using density functional theory calculations. The results show that the reaction mechanism and rate-determining step vary depending on the phosphine and additive used. For example, phosphination of pyridine with P(OEt) 3 occurs in five stages, and ethyl abstraction is the rate-determining step. Meanwhile, 2-Ph-pyridine phosphination with PPh 3 is a four-step reaction with proton abstraction as the rate-limiting step. Energy decomposition analysis of the transition states reveals that steric hindrance in the phosphine molecule plays a key role in the site-selective formation of the phosphonium salt. The mechanism of 2-Ph-pyridine phosphination with PAr 2 CF 3 is similar to that with PPh 3 , and analyses of the effects of substituents show that electron-withdrawing groups decreased the nucleophilicity of the phosphine, whereas aryl electron-donating groups increased it. Finally, TfO − plays an important role in the C–H fluoroalkylation of pyridine, as it brings weak interactions.
Keywords	phosphination ; metal free ; C–H fluoroalkylation ; mechanism ; DFT ; Organic chemistry ; QD241-441
Subject code	290
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Heparin-based sericin hydrogel–encapsulated basic fibroblast growth factor for in vitro and in vivo skin repair

Pan Du / Ling Diao / Yichi Lu / Chenyang Liu / Jin Li / Yang Chen / Junfeng Chen / Guozhong Lv / Xue Chen

Heliyon, Vol 9, Iss 3, Pp e13554- (2023)

2023

Abstract: The treatment of full-thickness cutaneous wounds remains a significant challenge in clinical therapeutics. Exogenous growth factor (GF) has been applied in clinics to promote wound healing. However, the retention of GF on the wound bed after its direct ... ...

Abstract	The treatment of full-thickness cutaneous wounds remains a significant challenge in clinical therapeutics. Exogenous growth factor (GF) has been applied in clinics to promote wound healing. However, the retention of GF on the wound bed after its direct application to the wound surface is difficult. Moreover, growth factors (GFs) are always inactivated in the complex wound healing microenvironment due to various factors, which significantly decrease the therapeutic effect. Sericin hydrogel (S) can be used as an effective carrier for GFs owing to its low immunogenicity, good biocompatibility, and good healing-promoting ability. Here, we designed a heparin-based sericin hydrogel (HS) -encapsulated basic fibroblast growth factor (bFGF-HS) to facilitate wound healing and skin regeneration. The hydrogel exhibited a three-dimensional (3D) microporous structure, excellent biodegradability, good adhesiveness, and low cytotoxicity. In vitro release of bFGF from bFGF-HS coacervates revealed that bFGF-HS might control the release of bFGF within 25 days through heparin regulation. bFGF-HS significantly promoted vascularization and re-epithelialization and improved collagen deposition, ultimately accelerating wound healing in vivo in mice. bFGF-HS treated wounds were also found to have more hair follicles and milder inflammatory reactions. Overall, this study provides a new therapeutic approach for full-thickness skin defect wounds using bFGF-HS.
Keywords	Sericin hydrogel ; bFGF ; Wound healin ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vivo and in vitro studies of a propolis-enriched silk fibroin-gelatin composite nanofiber wound dressing

Pan Du / Xue Chen / Yang Chen / Jin Li / Yichi Lu / Xiaoxiao Li / Kai Hu / Junfeng Chen / Guozhong Lv

Heliyon, Vol 9, Iss 3, Pp e13506- (2023)

2023

Abstract: In this study, electrospun nanofibers (NFs) used in trauma dressings were prepared using silk fibroin (SF) and gelatin (GT) as materials and highly volatile formic acid as the solvent, with three different concentrations of propolis extracts (EP), which ... ...

Abstract	In this study, electrospun nanofibers (NFs) used in trauma dressings were prepared using silk fibroin (SF) and gelatin (GT) as materials and highly volatile formic acid as the solvent, with three different concentrations of propolis extracts (EP), which were loaded through a simple process. The resulting samples were characterized by surface morphology, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), contact angle meter, water absorption, degradation rate, and mechanical property tests. The incorporation of propolis improved its antibacterial properties against Escherichia coli, and Staphylococcus aureus, compared to those of the silk gelatin nanofiber material (SF/GT) alone. In vitro biocompatibility assays showed that SF/GT-1%EP had good cytocompatibility and hemocompatibility. In addition, it can also significantly promote the migration of L929 cells. SF/GT-1%EP was applied to a mouse model of full thickness skin defects, and it was found to significantly promote wound healing. These results indicate that the SF/GT-EP nanofiber material has good biocompatibility, migrating-promoting capability, antibacterial properties, and healing-promoting ability, providing a new idea for the treatment of full thickness skin defects.
Keywords	Silk ; Gelatin ; Propolis ; Electrospun ; Wound healing ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	571
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trajectories of soil microbial recovery in response to restoration strategies in one of the largest and oldest open-pit phosphate mine in Asia

Kai Yan / Ya-Huang Luo / Yun-Ju Li / Ling-Pan Du / Heng Gui / Si-Chong Chen

Ecotoxicology and Environmental Safety, Vol 262, Iss , Pp 115215- (2023)

2023

Abstract: Southwestern China has the largest geological phosphorus-rich mountain in the world, which is seriously degraded by mining activities. Understanding the trajectory of soil microbial recovery and identifying the driving factors behind such restoration, as ...

Abstract	Southwestern China has the largest geological phosphorus-rich mountain in the world, which is seriously degraded by mining activities. Understanding the trajectory of soil microbial recovery and identifying the driving factors behind such restoration, as well as conducting corresponding predictive simulations, can be instrumental in facilitating ecological rehabilitation. Here, high-throughput sequencing and machine learning-based approaches were employed to investigate restoration chronosequences under four restoration strategies (spontaneous re-vegetation with or without topsoil; artificial re-vegetation with or without the addition of topsoil) in one of the largest and oldest open-pit phosphate mines worldwide. Although soil phosphorus (P) is extremely high here (max = 68.3 mg/g), some phosphate solubilizing bacteria and mycorrhiza fungi remain as the predominant functional types. Soil stoichiometry ratios (C:P and N:P) closely relate to the bacterial variation, but soil P content contributes less to microbial dynamics. Meanwhile, as restoration age increases, denitrifying bacteria and mycorrhizal fungi significantly increased. Significantly, based on partial least squares path analysis, it was found that the restoration strategy is the primary factor that drives soil bacterial and fungal composition as well as functional types through both direct and indirect effects. These indirect effects arise from factors such as soil thickness, moisture, nutrient stoichiometry, pH, and plant composition. Moreover, its indirect effects constitute the main driving force towards microbial diversity and functional variation. Using a hierarchical Bayesian model, scenario analysis reveals that the recovery trajectories of soil microbes are contingent upon changes in restoration stage and treatment strategy; inappropriate plant allocation may impede the recovery of the soil microbial community. This study is helpful for understanding the dynamics of the restoration process in degraded phosphorus-rich ecosystems, and ...
Keywords	Dianchi basin ; Hierarchical bayesian model ; Microbial function ; Open-pit phosphate mine reclamation ; Restoration strategies ; Scenario analysis ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	550
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thermal Expansion Neutralization Enhancing the Cycling Stability of Ni-Rich LiNi

Du, Kai / Wu, Maokun / Hu, Xinhong / Wang, Wei-Hua / Pan, Du / Wang, Zhenbo / Yin, Yanfeng / Zhao, Huiling / Bai, Ying

ACS applied materials & interfaces

2023 Volume 15, Issue 28, Page(s) 33703–33711

Abstract: As promising cathode candidates with advantageous capacity and price superiority for lithium-ion batteries, Ni-rich materials are severely impeded in the practical application due to their poor microstructural stability induced by the intrinsic ... ...

Abstract	As promising cathode candidates with advantageous capacity and price superiority for lithium-ion batteries, Ni-rich materials are severely impeded in the practical application due to their poor microstructural stability induced by the intrinsic Li
Language	English
Publishing date	2023-07-09
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c06932
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Article ; Online: Mesenchymal stem cells pretreated with proinflammatory cytokines accelerate skin wound healing by promoting macrophages migration and M2 polarization

Chenyang Liu / Yichi Lu / Pan Du / Fengbo Yang / Peng Guo / Xiaoyu Tang / Ling Diao / Guozhong Lu

Regenerative Therapy, Vol 21, Iss , Pp 192-

2022 Volume 200

Abstract: Introduction: Numerous studies have shown that mesenchymal stem cells (MSCs) promote cutaneous wound healing via paracrine signaling. Our previous study found that the secretome of MSCs was significantly amplified by treatment with IFN-γ and TNF-α (IT). ... ...

Abstract	Introduction: Numerous studies have shown that mesenchymal stem cells (MSCs) promote cutaneous wound healing via paracrine signaling. Our previous study found that the secretome of MSCs was significantly amplified by treatment with IFN-γ and TNF-α (IT). It has been known that macrophages are involved in the initiation and termination of inflammation, secretion of growth factors, phagocytosis, cell proliferation and collagen deposition in wound, which is the key factor during wound healing. In the present study, we used a unique supernatant of MSCs from human umbilical cord-derived MSCs (UC-MSCs) pretreated with IT, designated S-IT MSCs, to explore whether S-IT MSCs have a better effect on improving wound healing by improving the biological function of macrophages than the control supernatant of MSCs (S-MSCs). Methods: In the present study, we used a unique supernatant of MSCs pretreated with IT subcutaneously injected into a mice total skin excision. We evaluated the effect of S-IT MSCs on wound healing and the quality of wound repair via promoting macrophages migration and M2 polarization in vivo. In addition, the effect of S-IT MSCs on macrophages migration, converting toward M2 phenotype and phagocytosis were also investigated in vitro. Results: Indeed, S-IT MSCs were found to be more potent in promoting macrophage migration, M2 polarization, phagocytosis, and promoting wound closure than S-MSCs during the wound repair. High levels of CCL2 and IL-6 were found in S-IT MSCs, which indicated that the optimization of macrophage function by S-IT MSCs may be achieved through their high expression of CCL2 and IL-6. Conclusions: Our results suggest that the beneficial paracrine effect of MSCs on wound healing can be amplified by pretreatment with IT, which may represent a new strategy for optimizing the therapeutic effect of MSCs on wound healing.
Keywords	Mesenchymal stem cell ; IFN-γ and TNF-α ; Macrophages ; Migration ; M2 polarization ; Wound healing ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hydrogenolysis of Lignin and C–O Linkages Containing Lignin-Related Compounds over an Amorphous CoRuP/SiO 2 Catalyst

Liang-Qiu Huang / Zhi-Jun Diao / Bo Chen / Qing-Pan Du / Kai-Yang Duan / Si-Jia Zhao

Catalysts, Vol 12, Iss 1328, p

2022 Volume 1328

Abstract: Efficient depolymerization of C–O linkages is essential for converting lignin into fuels and higher value-added chemicals. In this work, CoRuP/SiO 2 , an amorphous Ru-Co phosphide composite, was fabricated for the efficient hydrogenolysis of ether ... ...

Abstract	Efficient depolymerization of C–O linkages is essential for converting lignin into fuels and higher value-added chemicals. In this work, CoRuP/SiO 2 , an amorphous Ru-Co phosphide composite, was fabricated for the efficient hydrogenolysis of ether linkages. The 4– O –5 and α – O –4 linkages containing lignin-related compounds, such as diphenyl ether, benzyl phenyl ether, 3-methyl diphenyl ether, and dibenzyl ether, are selected as representatives of linkages in lignin. Under mild conditions, Ru-containing metallic phosphides have high-performance for the catalytic depolymerization of C–O linkages. Compared with other catalysts, CoRuP/SiO 2 shows an outstanding selectivity for benzene and excellent efficiency in depolymerizing diphenyl ethers, yielding only a small amount of by-products. Furthermore, the total acidity shows a linear relationship with the hydrogenolysis reactivity in cleaving aromatic ether bonds. The mechanisms for the catalytic hydrogenolysis of 4– O –5 and α – O –4 bonds over CoRuP/SiO 2 are proposed. Moreover, two-dimensional heteronuclear single quantum coherence nuclear magnetic resonance spectroscopic analysis demonstrates that CoRuP/SiO 2 could effectively depolymerize C–O bonds of lignin. These dominant hydrogenolysis products from lignin have excellent potential in the production of high value-added drugs or pharmaceutical intermediates. The hydrogenolysis of lignin can be a highly efficient alternative to the existing method of lignin utilization.
Keywords	hydrogenolysis ; C–O linkages ; metallic phosphides ; reaction pathway ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mesenchymal stromal cells pretreated with proinflammatory cytokines enhance skin wound healing via IL-6-dependent M2 polarization

Chenyang Liu / Yan Xu / Yichi Lu / Pan Du / Xiaoxiao Li / Chengchun Wang / Peng Guo / Ling Diao / Guozhong Lu

Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-

2022 Volume 17

Abstract: Abstract Background Numerous studies have shown that mesenchymal stromal cells (MSCs) promote cutaneous wound healing via paracrine signaling. Our previous study found that the secretome of MSCs was significantly amplified by treatment with IFN-γ and TNF- ...

Abstract	Abstract Background Numerous studies have shown that mesenchymal stromal cells (MSCs) promote cutaneous wound healing via paracrine signaling. Our previous study found that the secretome of MSCs was significantly amplified by treatment with IFN-γ and TNF-α (IT). It has been known that macrophages are involved in the initiation and termination of inflammation, secretion of growth factors, phagocytosis, cell proliferation, and collagen deposition in wound, which is the key factor during wound healing. In this study, we aim to test whether the supernatant of MSCs pretreated with IT (S-IT MSCs) possesses a more pronounced effect on improving wound healing and describe the interplay between S-IT MSCs and macrophages as well as the potential mechanism in skin wound healing. Methods In the present study, we used a unique supernatant of MSCs from human umbilical cord-derived MSCs (UC-MSCs) pretreated with IT, designated S-IT MSCs, subcutaneously injected into a mice total skin excision. We evaluated the effect of S-IT MSCs on the speed and quality of wound repair via IT MSCs-derived IL-6-dependent M2 polarization in vivo by hematoxylin–eosin staining (H&E), immunohistochemistry (IHC), immunofluorescence (IF), Masson’s trichrome staining, Sirius red staining, quantitative real-time PCR (qPCR). In addition, the effect of S-IT MSCs on the polarization of macrophages toward M2 phenotype and the potential mechanism of it were also investigated in vitro by flow cytometry (FCM), enzyme-linked immunosorbent assay (ELISA), tube formation assay, and western blot analysis. Results Compared with control supernatant (S-MSCs), our H&E and IF results showed that S-IT MSCs were more effectively in promoting macrophages convert to the M2 phenotype and enhancing phagocytosis of M2 macrophages. Meanwhile, the results of tube formation assay, IHC, Masson’s trichrome staining, Sirius red staining showed that the abilities of M2 phenotype to promote vascularization and collagen deposition were significantly enhanced by S-IT ...
Keywords	Mesenchymal stromal cells ; IFN-γ and TNF-α ; M2 macrophages ; IL-6-dependent signaling pathways ; Wound healing ; Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
Subject code	610
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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