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Article ; Online: Secure routing in the Internet of Things (IoT) with intrusion detection capability based on software-defined networking (SDN) and Machine Learning techniques.

Rui, Kunkun / Pan, Hongzhi / Shu, Sheng

2023 Volume 13, Issue 1, Page(s) 18003

Abstract: Routing and security are the two main prerequisites for ensuring the correct operation of wireless networks. The importance of these cases doubles in wide networks such as IoT. This paper presents an algorithm to improve Secure Routing in IoT called ... ...

Abstract	Routing and security are the two main prerequisites for ensuring the correct operation of wireless networks. The importance of these cases doubles in wide networks such as IoT. This paper presents an algorithm to improve Secure Routing in IoT called SRAIOT. This algorithm uses a hierarchical structure to determine the connections between network components and data transfer routing. In SRAIOT, the network structure is managed hierarchically and through SDN. For this purpose, the IoT network is first divided into a set of subnets using the SDN solution, communication control and authentication are managed using the controller nodes of each subnet. The communication between two objects (located in different subnets) will be possible if their identity is confirmed through the controller nodes related to them. On the other hand, in order to identify the sources of attacks and network security threats, the controller nodes in each subnet monitor the network traffic pattern using an ensemble learning model and identify possible attacks in their subnet. The performance of SRAIOT was tested in the simulation, and the results were compared with previous methods. The results of these tests show that SRAIOT improves network performance regarding routing and detecting attacks.
Language	English
Publishing date	2023-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44764-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An ultrasensitive aptasensor for exosomes detection based on biotin-streptavidin and MXenes.

Wang, Zhangmin / Zhang, Ze / Pan, Hongzhi / Chang, Dong

Analytical biochemistry

2023 Volume 676, Page(s) 115233

Abstract: Exosomes derived from lung cancer typically contain the genetic information of the donor cells. Therefore, exosomes contribute to early diagnosis, treatment effectiveness evaluation, and prognosis assessment of cancer. Based on the biotin-streptavidin ... ...

Abstract	Exosomes derived from lung cancer typically contain the genetic information of the donor cells. Therefore, exosomes contribute to early diagnosis, treatment effectiveness evaluation, and prognosis assessment of cancer. Based on the biotin-streptavidin system and MXenes nanomaterial, a dual-effect amplification method had been developed to construct an ultrasensitive colorimetric aptasensor for detecting exosomes. MXenes can enhance the loading of aptamer and biotin as the high specific surface area. Biotin-streptavidin system can increase the amount of horseradish peroxidase-linked (HRP-linked) streptavidin, considerably boosting the color signal of the aptasensor. The proposed colorimetric aptasensor exhibited excellent sensitivity, with a detection limit of 42 particles μL
MeSH term(s)	Streptavidin ; Biotin ; Exosomes ; Reproducibility of Results ; Aptamers, Nucleotide ; Biosensing Techniques/methods ; Limit of Detection
Chemical Substances	Streptavidin (9013-20-1) ; Biotin (6SO6U10H04) ; Aptamers, Nucleotide
Language	English
Publishing date	2023-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1110-1
ISSN	1096-0309 ; 0003-2697
ISSN (online)	1096-0309
ISSN	0003-2697
DOI	10.1016/j.ab.2023.115233
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Article ; Online: An ultrasensitive aptasensor for exosomes detection based on biotin-streptavidin and MXenes

Wang, Zhangmin / Zhang, Ze / Pan, Hongzhi / Chang, Dong

Analytical Biochemistry. 2023 Sept., v. 676 p.115233-

2023

Abstract	Exosomes derived from lung cancer typically contain the genetic information of the donor cells. Therefore, exosomes contribute to early diagnosis, treatment effectiveness evaluation, and prognosis assessment of cancer. Based on the biotin-streptavidin system and MXenes nanomaterial, a dual-effect amplification method had been developed to construct an ultrasensitive colorimetric aptasensor for detecting exosomes. MXenes can enhance the loading of aptamer and biotin as the high specific surface area. Biotin-streptavidin system can increase the amount of horseradish peroxidase-linked (HRP-linked) streptavidin, considerably boosting the color signal of the aptasensor. The proposed colorimetric aptasensor exhibited excellent sensitivity, with a detection limit of 42 particles μL⁻¹ and a linear range of 10² to 10⁷ particles μL⁻¹. The constructed aptasensor showed satisfactory reproducibility, stability, and selectivity, confirming the promising application of exosomes in clinical cancer detection.
Keywords	aptasensors ; biotin ; color ; colorimetry ; detection limit ; early diagnosis ; exosomes ; horseradish ; lung neoplasms ; nanomaterials ; oligonucleotides ; prognosis ; streptavidin ; surface area ; Colorimetric aptasensor ; Exosomes detection ; Lung cancer ; Dual-effect amplification method
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	1110-1
ISSN	1096-0309 ; 0003-2697
ISSN (online)	1096-0309
ISSN	0003-2697
DOI	10.1016/j.ab.2023.115233
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Article ; Online: Advances in the pharmacological effects and mechanisms of Nelumbo nucifera Gaertn. extract Nuciferine.

Ren, Xinshui / Chen, Hua / Wang, Haibo / Wang, Yue / Huang, Chuanjun / Pan, Hongzhi

Journal of ethnopharmacology

2024 , Page(s) 118262

Abstract: Ethnopharmacologic relevance: The leaves of Nelumbo nucifera Gaertn. are recorded in the earliest written documentation of traditional Chinese medicinal as "Ben Cao Gang Mu", a medicinal herb for blood clotting, dysentery and dizziness. Nuciferine, one ... ...

Abstract	Ethnopharmacologic relevance: The leaves of Nelumbo nucifera Gaertn. are recorded in the earliest written documentation of traditional Chinese medicinal as "Ben Cao Gang Mu", a medicinal herb for blood clotting, dysentery and dizziness. Nuciferine, one of N. nucifera Gaertn. leaf extracts, has been shown to possess several pharmacological properties, including but not limited to ameliorating hyperlipidemia, stimulating insulin secretion, inducing vasodilation, reducing blood pressure, and demonstrating anti-arrhythmic properties. Aim of the study: In light of the latest research findings on nuciferine, this article provides a comprehensive overview of its chemical properties, pharmacological activities, and the underlying regulatory mechanisms. It aims to serve as a dependable reference for further investigations into the pharmacological effects and mechanisms of nuciferine. Materials and methods: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the literature on extraction, separation, structural analysis and pharmacological activity of nuciferine published before November 2023. The key words are "extraction", "isolation", "purification" and "pharmacological action" and "nuciferine". Results: Nuciferine has been widely used in the treatment of ameliorating hyperlipidemia and lose weight, Nuciferine is a monomeric aporphine alkaloid extracted from the leaves of the plant Nymphaea caerulea and Nelumbo nucifera Gaertn. Nuciferine has pharmacological activities such as relaxing smooth muscles, improving hyperlipidemia, stimulating insulin secretion, vasodilation, inducing hypotension, antiarrhythmic effects, and antimicrobial and anti-HIV activities. These pharmacological properties lay a foundation for the treatment of tumors, inflammation, hyperglycemia, lipid-lowering and weight-loss , oxidative stress and other diseases with nuciferine. Conclusion: Nuciferine has been clinically used to treat hyperlipidemia and aid in weight loss due to its effects on lipid levels, insulin secretion, vasodilation, blood pressure reduction, anti-tumor properties, and immune enhancement. However, other potential benefits of nuciferine have not yet been fully explored in clinical practice. Future research should delve deeper into its molecular structure, toxicity, side effects, and clinical pharmacology to uncover its full range of effects and pave the way for its safe and expanded clinical use.
Language	English
Publishing date	2024-04-24
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118262
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Article ; Online: A sandwich electrochemical immunosensor based on MXene@dual MOFs for detection of tumor marker CA125.

Qu, Lingli / Wu, Mengdie / Zhao, Lu / Li, Jiang / Pan, Hongzhi

Mikrochimica acta

2023 Volume 190, Issue 4, Page(s) 147

Abstract: The detection signal of carbohydrate antigen 125 (CA125) can be quantitatively amplified via the dual metal-organic framework (MOF) sandwich strategy. We propose a versatile method for synthesizing uniform MXene and MIL-101(Fe)- ... ...

Abstract	The detection signal of carbohydrate antigen 125 (CA125) can be quantitatively amplified via the dual metal-organic framework (MOF) sandwich strategy. We propose a versatile method for synthesizing uniform MXene and MIL-101(Fe)-NH
MeSH term(s)	Biomarkers, Tumor ; Biosensing Techniques/methods ; Antibodies, Immobilized ; Immunoassay/methods ; Antibodies ; CA-125 Antigen ; Methylene Blue/chemistry
Chemical Substances	MIL-101 ; Biomarkers, Tumor ; MXene ; Antibodies, Immobilized ; Antibodies ; CA-125 Antigen ; Methylene Blue (T42P99266K)
Language	English
Publishing date	2023-03-22
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05719-w
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Article ; Online: Ratiometric electrochemical immunosensor for the detection of CA199 based on the ratios of NiCo@Fc-MWCNTs-LDH and 3D-rGOF@Ag/Au complexes.

Qi, Feifan / Wu, Mengdie / Liu, Simin / Mu, Wendi / Wu, Chunyan / Ren, Xinshui / Rui, Chuang / Wu, Fangfang / Chang, Dong / Pan, Hongzhi

Talanta

2024 Volume 272, Page(s) 125606

Abstract: Carbohydrate antigen 199 (CA199) is the most sensitive marker reported for pancreatic cancer, and it is a difficult task to develop a highly sensitive assay for CA199. During the experiment, a ratiometric electrochemical immunosensor for quantitative ... ...

Abstract	Carbohydrate antigen 199 (CA199) is the most sensitive marker reported for pancreatic cancer, and it is a difficult task to develop a highly sensitive assay for CA199. During the experiment, a ratiometric electrochemical immunosensor for quantitative analysis of CA199 was prepared for NiCo@Fc-MWCNTs-LDH as the electrode sensing surface and 3D-rGOF@Ag/Au as the label of Ab
MeSH term(s)	Humans ; Gold/chemistry ; Biosensing Techniques/methods ; Metal Nanoparticles/chemistry ; Electrochemical Techniques/methods ; Immunoassay/methods ; Biomarkers, Tumor ; Pancreatic Neoplasms/diagnosis ; Limit of Detection ; Graphite/chemistry
Chemical Substances	Gold (7440-57-5) ; Biomarkers, Tumor ; Graphite (7782-42-5)
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.125606
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Article ; Online: Ultrasensitive and label-free electrochemical immunosensor for the detection of the ovarian cancer biomarker CA125 based on CuCo-ONSs@AuNPs nanocomposites.

Mu, Wendi / Wu, Chunyan / Wu, Fangfang / Gao, Hongmin / Ren, Xinshui / Feng, Jing / Miao, Meng / Zhang, Hehua / Chang, Dong / Pan, Hongzhi

Journal of pharmaceutical and biomedical analysis

2024 Volume 243, Page(s) 116080

Abstract: Cancer antigen 125 (CA125) is pivotal as a tumor marker in early ovarian cancer prevention and diagnosis. In this work, we introduced an ultrasensitive label-free electrochemical immunosensor tailored for CA125 detection, leveraging nanogold- ... ...

Abstract	Cancer antigen 125 (CA125) is pivotal as a tumor marker in early ovarian cancer prevention and diagnosis. In this work, we introduced an ultrasensitive label-free electrochemical immunosensor tailored for CA125 detection, leveraging nanogold-functionalized copper-cobalt oxide nanosheets (CuCo-ONSs@AuNPs) as nanocomposites. For the inaugural application, copper-cobalt oxide nanosheets delivered the requisite DPV electrochemical response for the immunosensors. Their large specific surface area and commendable electrical conductivity amplify electron transfer and enable significant gold nanoparticle loading. Concurrently, AuNPs offer a plethora of active sites, facilitating easy immobilization of biomolecules via the bond between amino groups and AuNPs. We employed scanning electron microscopy, transmission electron microscopy, and x-ray photoelectron spectroscopy to characterize the nanomaterials' surface morphology and elemental composition. The electrochemical sensor response signals were ascertained using differential pulse voltammetry. Under optimal conditions, the immunosensor exhibited a linear detection range from 1×10
MeSH term(s)	Gold/chemistry ; Biosensing Techniques/methods ; Copper ; Limit of Detection ; Electrochemical Techniques/methods ; CA-125 Antigen ; Metal Nanoparticles/chemistry ; Immunoassay/methods ; Biomarkers, Tumor ; Nanocomposites/chemistry ; Neoplasms ; Cobalt ; Oxides
Chemical Substances	cobalt oxide (USK772NS56) ; Gold (7440-57-5) ; cuprous oxide (T8BEA5064F) ; Copper (789U1901C5) ; CA-125 Antigen ; Biomarkers, Tumor ; Cobalt (3G0H8C9362) ; Oxides
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.116080
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Article ; Online: Research advances of tissue-derived extracellular vesicles in cancers.

Li, Wei / Zhu, Jingyao / Li, Jiayuan / Jiang, Yiyun / Sun, Jiuai / Xu, Yan / Pan, Hongzhi / Zhou, Yan / Zhu, Jun

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 4, Page(s) 184

Abstract: Background: Extracellular vesicles (EVs) can mediate cell-to-cell communication and affect various physiological and pathological processes in both parent and recipient cells. Currently, extensive research has focused on the EVs derived from cell ... ...

Abstract	Background: Extracellular vesicles (EVs) can mediate cell-to-cell communication and affect various physiological and pathological processes in both parent and recipient cells. Currently, extensive research has focused on the EVs derived from cell cultures and various body fluids. However, insufficient attention has been paid to the EVs derived from tissues. Tissue EVs can reflect the microenvironment of the specific tissue and the cross-talk of communication among different cells, which can provide more accurate and comprehensive information for understanding the development and progression of diseases. Methods: We review the state-of-the-art technologies involved in the isolation and purification of tissue EVs. Then, the latest research progress of tissue EVs in the mechanism of tumor occurrence and development is presented. And finally, the application of tissue EVs in the clinical diagnosis and treatment of cancer is anticipated. Results: We evaluate the strengths and weaknesses of various tissue processing and EVs isolation methods, and subsequently analyze the significance of protein characterization in determining the purity of tissue EVs. Furthermore, we focus on outlining the importance of EVs derived from tumor and adipose tissues in tumorigenesis and development, as well as their potential applications in early tumor diagnosis, prognosis, and treatment. Conclusion: When isolating and characterizing tissue EVs, the most appropriate protocol needs to be specified based on the characteristics of different tissues. Tissue EVs are valuable in the diagnosis, prognosis, and treatment of tumors, and the potential risks associated with tissue EVs need to be considered as therapeutic agents.
MeSH term(s)	Humans ; Neoplasms ; Extracellular Vesicles ; Carcinogenesis ; Body Fluids ; Cell Communication ; Tumor Microenvironment
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-05596-z
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Article ; Online: A sandwich electrochemiluminescence immunoassay based on 1T-MoS

Qu, Lingli / Zhao, Wanyu / Liu, JiaYing / Wang, Junyi / Li, Jiang / Pan, Hongzhi

Talanta

2023 Volume 269, Page(s) 125412

Abstract: A "signal-on" electrochemiluminescence (ECL) immunosensor has been proposed for detecting carbohydrate antigen 153 (CA153) based on the dual MOFs sandwich strategy. The conductive and porous substrate consisting of 1T- ... ...

Abstract	A "signal-on" electrochemiluminescence (ECL) immunosensor has been proposed for detecting carbohydrate antigen 153 (CA153) based on the dual MOFs sandwich strategy. The conductive and porous substrate consisting of 1T-MoS
MeSH term(s)	Humans ; Molybdenum ; Immunoassay/methods ; Biosensing Techniques/methods ; Metal-Organic Frameworks/chemistry ; Biomarkers, Tumor ; Organometallic Compounds/chemistry ; Antibodies ; Luminescent Measurements/methods ; Electrochemical Techniques/methods ; Limit of Detection ; Metal Nanoparticles/chemistry
Chemical Substances	UiO-66 ; Molybdenum (81AH48963U) ; Metal-Organic Frameworks ; Biomarkers, Tumor ; Organometallic Compounds ; Antibodies
Language	English
Publishing date	2023-11-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.125412
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MXenes-Au NPs modified electrochemical biosensor for multiple exosome surface proteins analysis.

Wang, Zhangmin / Zhang, Ze / Zhang, Yingcong / Xu, Xin / Shen, Tong / Pan, Hongzhi / Chang, Dong

Talanta

2023 Volume 265, Page(s) 124848

Abstract: As a novel class of non-invasive biomarkers, exosome-carried proteins are essential in early detection and precise cancer diagnosis. In the study, we developed an electrochemical biosensor based on MXenes-Au NPs modification to assess the differential ... ...

Abstract	As a novel class of non-invasive biomarkers, exosome-carried proteins are essential in early detection and precise cancer diagnosis. In the study, we developed an electrochemical biosensor based on MXenes-Au NPs modification to assess the differential expression of EGFR, CEA, and EpCAM proteins of exosomes. This sensor has sensitively detected tumor biomarkers in the exosomes generated by various tumor cells (including A549, MCF-7, PC-3, and HeLa). Building a biosensor that can distinguish minute differences of proteins in various derived-from exosomes is crucial for addressing the issues with early and accurate cancer detection.
MeSH term(s)	Humans ; Membrane Proteins/metabolism ; Exosomes/chemistry ; Biosensing Techniques ; Biomarkers, Tumor/analysis ; HeLa Cells
Chemical Substances	Membrane Proteins ; Biomarkers, Tumor
Language	English
Publishing date	2023-06-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2023.124848
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