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  1. Article ; Online: Editorial: The pathogenesis and treatment of

    Xu, Yifei / Walduck, Anna K / Pan, Huafeng

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1219503

    MeSH term(s) Helicobacter pylori ; Stomach/pathology ; Gastric Mucosa/pathology
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1219503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: LINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma.

    Pan, Huafeng / Wei, Wei / Fu, Guanghou / Pan, Jiaren / Jin, Baiye

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Interleukin-6 ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Prognosis ; RNA, Long Noncoding
    Chemical Substances Interleukin-6 ; RNA, Long Noncoding
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: [Retracted] MicroRNA‑136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen‑activated protein kinase kinase 4.

    Zhu, Yudi / Shao, Siliang / Pan, Huafeng / Cheng, Zhongliang / Rui, Xin

    Molecular medicine reports

    2023  Volume 27, Issue 6

    Abstract: Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the cell migration and invasion assay data shown in Fig. 5C were strikingly similar to data appearing in different form in other ... ...

    Abstract Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the cell migration and invasion assay data shown in Fig. 5C were strikingly similar to data appearing in different form in other articles by different authors at different research institutes, some of which have been retracted. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published, prior to its submission to
    Language English
    Publishing date 2023-05-05
    Publishing country Greece
    Document type Retraction of Publication
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2023.13003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer.

    Gu, Tingting / Pan, Huafeng / Zhang, Fei / Wang, Li / Cheng, Zhongliang

    Cellular and molecular biology (Noisy-le-Grand, France)

    2022  Volume 68, Issue 10, Page(s) 161–166

    Abstract: The vital function of mounting long noncoding RNAs (lncRNAs) in prostate cancer (PCa) has been illustrated in increasing reports. However, the roles of many lncRNAs in PCa have not been deciphered. A total of 62 pairs of PCa and adjacent normal tissue ... ...

    Abstract The vital function of mounting long noncoding RNAs (lncRNAs) in prostate cancer (PCa) has been illustrated in increasing reports. However, the roles of many lncRNAs in PCa have not been deciphered. A total of 62 pairs of PCa and adjacent normal tissue samples were provided by PCa patients undergoing surgery. Extensive assays were conducted in this study to investigate the role of FOXP4 antisense RNA 1 (FOXP4-AS1) in PCa tumorigenesis. This study elucidated that FOXP4-AS1 expression was elevated in PCa tissue samples and cell lines. Loss-of-function experiments revealed that depleted FOXP4-AS1 inhibited PCa cell proliferation in vitro and retarded tumor growth in vivo. Mechanically, FOXP4-AS1 functioned as a competing endogenous RNA (ceRNA) of miR-3130-3p, releasing SP4 from the inhibitory effect of miR-3130-3p. Rescue assays validated that FOXP4-AS1 modulated PCa progression via SP4. Interestingly, SP4 is known as a transcription factor and was predicted to bind with the promoter region of FOXP4-AS1. This current research confirmed that SP4 activated the transcription activity of FOXP4-AS1 and thus positively regulated its expression. To conclude, we discovered that FOXP4-AS1, miR-3130-3p, and SP4 constitute a feedback loop and contribute to PCa tumorigenesis, providing a new valuable diagnosis and therapeutic strategy for PCa.
    MeSH term(s) Humans ; Male ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Feedback ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
    Chemical Substances Forkhead Transcription Factors ; FOXP4 protein, human ; MicroRNAs ; RNA, Long Noncoding ; SP4 protein, human
    Language English
    Publishing date 2022-09-30
    Publishing country France
    Document type Journal Article
    ZDB-ID 1161779-2
    ISSN 1165-158X ; 0145-5680
    ISSN (online) 1165-158X
    ISSN 0145-5680
    DOI 10.14715/cmb/2022.68.10.24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3812: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Integrated Analysis of the Role of Enolase 2 in Clear Cell Renal Cell Carcinoma.

    Pan, Jiaren / Jin, Yanyan / Xu, Xiaoming / Wei, Wei / Pan, Huafeng

    Disease markers

    2022  Volume 2022, Page(s) 6539203

    Abstract: Enolase 2 ( ...

    Abstract Enolase 2 (
    MeSH term(s) Humans ; Carcinoma, Renal Cell/genetics ; Phosphopyruvate Hydratase/genetics ; Axitinib ; Sunitinib ; Kidney Neoplasms/genetics ; Tumor Microenvironment
    Chemical Substances Phosphopyruvate Hydratase (EC 4.2.1.11) ; Axitinib (C9LVQ0YUXG) ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/6539203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  6. Article ; Online: Pancancer analysis of the prognostic and immunological role of FANCD2: a potential target for carcinogenesis and survival.

    Zhao, Zedan / Wang, Ruyu / Wang, Ruixue / Song, Jialing / Ma, Fengjun / Pan, Huafeng / Gao, Cuiyun / Wang, Deqiang / Chen, Xuemei / Fan, Xiangzhen

    BMC medical genomics

    2024  Volume 17, Issue 1, Page(s) 69

    Abstract: Recent evidence has shed light on the significant role of FANCD2 in cancer initiation, development, and progression. However, a comprehensive pan-cancer analysis of FANCD2 has been lacking. In this study, we have conducted a thorough investigation into ... ...

    Abstract Recent evidence has shed light on the significant role of FANCD2 in cancer initiation, development, and progression. However, a comprehensive pan-cancer analysis of FANCD2 has been lacking. In this study, we have conducted a thorough investigation into the expression profiles and prognostic significance of FANCD2, as well as its correlation with clinicopathological parameters and immune cell infiltration, using advanced bioinformatic techniques. The results demonstrate that FANCD2 is significantly upregulated in various common cancers and is associated with prognosis. Notably, higher expression levels of FANCD2 are linked to poor overall survival, as indicated by Cox regression and Kaplan-Meier analyses. Additionally, we have observed a decrease in the methylation of FANCD2 DNA in some cancers, and this decrease is inversely correlated with FANCD2 expression. Genetic alterations in FANCD2 predominantly manifest as mutations, which are associated with overall survival, disease-specific survival, disease-free survival, and progression-free survival in certain tumor types. Moreover, FANCD2 exhibits a strong correlation with infiltrating cell levels, immune checkpoint genes, tumor mutation burden (TMB), and microsatellite instability (MSI). Enrichment analysis further highlights the potential impact of FANCD2 on Fanconi anemia (FA) pathway and cell cycle regulation. Through this comprehensive pan-cancer analysis, we have gained a deeper understanding of the functions of FANCD2 in oncogenesis and metastasis across different types of cancer.
    MeSH term(s) Humans ; Fanconi Anemia ; Prognosis ; Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Cognition ; Fanconi Anemia Complementation Group D2 Protein/genetics
    Chemical Substances FANCD2 protein, human ; Fanconi Anemia Complementation Group D2 Protein
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411865-5
    ISSN 1755-8794 ; 1755-8794
    ISSN (online) 1755-8794
    ISSN 1755-8794
    DOI 10.1186/s12920-024-01836-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quality appraisal of clinical guidelines for Helicobacter pylori infection and systematic analysis of the level of evidence for recommendations.

    Ou, Jiayin / Li, Jiayu / Liu, Yang / Su, Xiaohong / Li, Wanchun / Zheng, Xiaojun / Zhang, Lang / Chen, Jing / Pan, Huafeng

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301006

    Abstract: Objectives: To systematically assess the quality of clinical practice guidelines (CPGs) for Helicobacter pylori (HP) infection and identify gaps that limit their development.: Study design and setting: CPGs for HP infection were systematically ... ...

    Abstract Objectives: To systematically assess the quality of clinical practice guidelines (CPGs) for Helicobacter pylori (HP) infection and identify gaps that limit their development.
    Study design and setting: CPGs for HP infection were systematically collected from PubMed, Embase, the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, and six online guideline repositories. Three researchers independently used the AGREE Ⅱ tool to evaluate the methodological quality of the eligible CPGs. In addition, the reporting and recommendation qualities were appraised by using the RIGHT and AGREE-REX tools, respectively. The distribution of the level of evidence and strength of recommendation among evidence-based CPGs was determined.
    Results: A total of 7,019 records were identified, and 24 CPGs met the eligibility criteria. Of the eligible CPGs, 19 were evidence-based and 5 were consensus-based. The mean overall rating score of AGREE II was 50.7% (SD = 17.2%). Among six domains, the highest mean score was for scope and purpose (74.4%, SD = 17.7%) and the lowest mean score was for applicability (24.3%, SD = 8.9). Only three of 24 CPGs were high-quality. The mean overall score of recommendation quality was 35.5% (SD = 12.2%), and the mean scores in each domain of AGREE-REX and RIGHT were all ≤ 60%, with values and preferences scoring the lowest (16.6%, SD = 11.9%). A total of 505 recommendations were identified. Strong recommendations accounted for 64.1%, and only 34.3% of strong recommendations were based on high-quality evidence.
    Conclusion: The overall quality of CPGs for HP infection is poor, and CPG developers tend to neglect some domains, resulting in a wide variability in the quality of the CPGs. Additionally, CPGs for HP infection lack sufficient high-quality evidence, and the grading of recommendation strength should be based on the quality of evidence. The CPGs for HP infection have much room for improvement and further researches are required to minimize the evidence gap.
    MeSH term(s) Humans ; Helicobacter pylori ; Helicobacter Infections ; Evidence-Based Practice ; Consensus
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Biological role of long non-coding RNA KCNQ1OT1 in cancer progression.

    Zhan, Kai / Pan, Huafeng / Zhou, Zhang / Tang, Wenqian / Ye, Zhining / Huang, Shaogang / Luo, Lei

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 169, Page(s) 115876

    Abstract: Long non-coding RNAs (lncRNAs) are a type of RNAs that are more than 200 nucleotides without protein-coding potential. In recent years, more and more attention has been paid to the role of lncRNAs in cancer pathogenesis. LncRNA KCNQ1 overlapping ... ...

    Abstract Long non-coding RNAs (lncRNAs) are a type of RNAs that are more than 200 nucleotides without protein-coding potential. In recent years, more and more attention has been paid to the role of lncRNAs in cancer pathogenesis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) is located on chromosome 11p15.5 with a total length of 91 kb and is highly expressed in various malignancies, which is closely related to tumor growth, lymph node metastasis, survival cycle and recurrence rate. In addition, KCNQ1OT1 is involved in the regulation of PI3K/AKT and Wnt/β-catenin signaling pathways. In this review, the mechanism and related progress of KCNQ1OT1 in different cancers were reviewed. It was found that KCNQ1OT1 can stabilize mRNA expression through sponging miRNA, which not only induced tumor cell proliferation, migration, invasion, drug resistance, epithelial-mesenchymal transition (EMT) and inhibited cell apoptosis in vitro, but also promoted tumor growth and metastasis in vivo. Therefore, as a new biomarker and therapeutic target, KCNQ1OT1 has broad prospects for the diagnosis and treatment of different cancers.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor
    Chemical Substances RNA, Long Noncoding ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; MicroRNAs
    Language English
    Publishing date 2023-11-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Retraction Note: Weipiling ameliorates gastric precancerous lesions in Atp4a

    Liu, Wei / Zhao, Zi-Ming / Liu, Yuan-Liang / Pan, Hua-Feng / Lin, Li-Zhu

    BMC complementary medicine and therapies

    2023  Volume 23, Issue 1, Page(s) 98

    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Retraction of Publication
    ISSN 2662-7671
    ISSN (online) 2662-7671
    DOI 10.1186/s12906-023-03941-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inflammatory microenvironment in gastric premalignant lesions: implication and application.

    Zhang, Shengxiong / Shen, Yang / Liu, Hao / Zhu, Di / Fang, Jiansong / Pan, Huafeng / Liu, Wei

    Frontiers in immunology

    2023  Volume 14, Page(s) 1297101

    Abstract: Gastric precancerous lesions (GPL) are a major health concern worldwide due to their potential to progress to gastric cancer (GC). Understanding the mechanism underlying the transformation from GPL to GC can provide a fresh insight for the early ... ...

    Abstract Gastric precancerous lesions (GPL) are a major health concern worldwide due to their potential to progress to gastric cancer (GC). Understanding the mechanism underlying the transformation from GPL to GC can provide a fresh insight for the early detection of GC. Although chronic inflammation is prevalent in the GPL, how the inflammatory microenvironment monitored the progression of GPL-to-GC are still elusive. Inflammation has been recognized as a key player in the progression of GPL. This review aims to provide an overview of the inflammatory microenvironment in GPL and its implications for disease progression and potential therapeutic applications. We discuss the involvement of inflammation in the progression of GPL, highlighting
    MeSH term(s) Humans ; Stomach Neoplasms ; Precancerous Conditions/pathology ; Inflammation ; Helicobacter pylori ; Antioxidants ; Tumor Microenvironment
    Chemical Substances Antioxidants
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1297101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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