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Article: [Prognostic comparison of active surveillance and adjuvant chemotherapy in the treatment of patients with stage Ⅰ ovarian immature teratoma after fertility-sparing surgery].

Zhang, X Y / Yang, J / Xiang, Y / Wu, M / Pan, L Y / Yang, J X

2023 Volume 58, Issue 11, Page(s) 838–845

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Pregnancy ; Humans ; Female ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Prognosis ; Watchful Waiting ; Neoplasm Staging ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery ; Chemotherapy, Adjuvant ; Teratoma/drug therapy ; Teratoma/surgery ; Retrospective Studies
Language	Chinese
Publishing date	2023-11-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604570-4
ISSN	0529-567X
ISSN	0529-567X
DOI	10.3760/cma.j.cn112141-20230801-00031
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Zs.A 1619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [Value of surgery combined chemotherapy and radiation therapy in locally advanced neuroendocrine carcinoma of the cervix: a single-center retrospective cohort study].

Song, X C / Zhang, H / Zhong, S / Tan, X J / Ma, S Q / Jin, Y / Pan, L Y / Wu, M / Cao, D Y / Yang, J X / Xiang, Y

Zhonghua fu chan ke za zhi

2024 Volume 59, Issue 3, Page(s) 200–209

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Treatment Outcome ; Retrospective Studies ; Cervix Uteri ; Chemoradiotherapy ; Neoadjuvant Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Neuroendocrine/surgery ; Neoplasm Staging
Language	Chinese
Publishing date	2024-03-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604570-4
ISSN	0529-567X
ISSN	0529-567X
DOI	10.3760/cma.j.cn112141-20230918-00106
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Zs.A 1619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: MiR-126 regulated myocardial autophagy on myocardial infarction.

Shi, C-C / Pan, L-Y / Peng, Z-Y / Li, J-G

European review for medical and pharmacological sciences

2020 Volume 24, Issue 12, Page(s) 6971–6979

Abstract: Objective: The aim of the study is to detect the effect of miR-126 in autophagy after acute myocardial infarction (AMI).: Materials and methods: First, the changes of miR-126 and autophagy in myocardial infarction tissue and normal heart tissue were ... ...

Abstract	Objective: The aim of the study is to detect the effect of miR-126 in autophagy after acute myocardial infarction (AMI). Materials and methods: First, the changes of miR-126 and autophagy in myocardial infarction tissue and normal heart tissue were compared by establishing the myocardial infarction rat model, so as to clarify the relationship between miR-126 and changes of myocardial infarction and autophagy. Second, the regulation of miR-126 on autophagy related protein Beclin-1 and the role in myocardial infarction were studied to clarify whether miR-126 regulates autophagy through Beclin-1 and participates in the occurrence and development of myocardial infarction. Finally, the relationship between plasma miR-126 was observed. Results: MiR-126 expression can regulate Beclin-1 expression and influence the cardiac function after AMI. The results are of great significance to reveal the new mechanism of myocardial infarction. Conclusions: The down-regulation of miR-126 will lead to the over-activation of myocardial autophagy induced by Beclin-1, which is an autophagy related protein. The plasm expression of miR-126 may be a clinical marker of autophagy after AMI.
MeSH term(s)	Animals ; Autophagy ; Cells, Cultured ; MicroRNAs/metabolism ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	MIRN126 microRNA, rat ; MicroRNAs
Language	English
Publishing date	2020-08-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202006_21689
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Zs.A 1887: Show issues

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Article ; Online: MicroRNA-323-3p inhibits oxidative stress and apoptosis after myocardial infarction by targeting TGF-β2/JNK pathway.

Shi, C-C / Pan, L-Y / Zhao, Y-Q / Li, Q / Li, J-G

European review for medical and pharmacological sciences

2020 Volume 24, Issue 12, Page(s) 6961–6970

Abstract: Objective: Myocardial infarction (MI), which causes irreversible damage and loss of cardiomyocytes, is the most important cause of death in the world. MicroRNA is an important regulator of physiological and pathological activities of cardiovascular ... ...

Abstract	Objective: Myocardial infarction (MI), which causes irreversible damage and loss of cardiomyocytes, is the most important cause of death in the world. MicroRNA is an important regulator of physiological and pathological activities of cardiovascular system. The aim of this research was to study the effect of microRNA-323-3p (miR-323-3p) on MI and its underlying mechanisms of action. Materials and methods: A rat model of MI was established to measure the expression of miR-323-3p, Bax, Bcl-2, SOD1, and SOD2 in ischemic myocardial tissue, and the cardiac function of rats were tested at seventh day after MI. H9c2 cells were divided into control group, miRNA negative control (NC) transfection group, miR-323-3p mimic (miR-323-3p min) transfection group, and then, treated with H2O2. Oxidative stress and apoptosis of H9c2 cells were observed by Western blot, Real Time-Polymerase Chain Reaction (RT-PCR), flow cytometry, SOD activity assay, TUNEL staining, DHR dye assay, etc. RESULTS: The level of miR-323-3p was decreased in ischemic myocardium, as well as H2O2-treated H9c2 cells. MiR-323-3p overexpression greatly decreased the level of Bax and increased the levels of SOD1, SOD2, and Bcl-2. After treated with miR-323-3p mimic, TUNEL positive cells were greatly reduced, and apoptosis rate of H9c2 cells was greatly decreased. Moreover, SOD levels significantly increased, while ROS production decreased after treatment of miR-323-3p. After intravenous injection of miR-323-3p agomir in rats with MI, the cardiac function of the rats was significantly improved. Western blot and Luciferase reporter gene experiments illustrated that miR-323-3p acts by targeting TGF-β2. Conclusions: MiR-323-3p was downregulated in ischemic myocardium and H2O2-treated H9c2 cells, and miR-323-3p overexpression reduced oxidative stress and apoptosis of cardiomyocytes. The protective function was achieved via regulation of TGF-β2/JNK pathway.
MeSH term(s)	Animals ; Apoptosis ; Cells, Cultured ; JNK Mitogen-Activated Protein Kinases/metabolism ; Male ; MicroRNAs/metabolism ; Myocardial Infarction/metabolism ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley ; Transforming Growth Factor beta2/metabolism
Chemical Substances	MIRN323 microRNA, rat ; MicroRNAs ; Transforming Growth Factor beta2 ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2020-08-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202006_21688
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Article: [Predictive value of net water uptake with respect to early neurological improvement after endovascular treatment in patients with acute anterior circulation large vessel occlusion stroke].

Liao, A Y / Wu, H / Cheng, X Q / Xiao, L L / Huang, K M / Lu, M X / Pan, L Y / Feiluola, Kasaer / Jiang, Y Y / Liu, Z H / Zhu, W S

Zhonghua nei ke za zhi

2023 Volume 62, Issue 10, Page(s) 1172–1177

Abstract: Objective: ...

Abstract	Objective:
Language	Chinese
Publishing date	2023-09-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
DOI	10.3760/cma.j.cn112138-20230129-00039
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Zs.A 1620: Show issues

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Article: [Value of postoperative radiotherapy and analysis of prognostic factors in early-stage neuroendocrine carcinoma of cervix].

Song, X C / Zhang, H / Zhong, S / Tan, X J / Ma, S Q / Jin, Y / Pan, L Y / Wu, M / Cao, D Y / Yang, J X / Xiang, Y

Zhonghua fu chan ke za zhi

2023 Volume 58, Issue 9, Page(s) 680–690

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Cervix Uteri/surgery ; Prognosis ; Retrospective Studies ; Uterine Cervical Neoplasms/radiotherapy ; Uterine Cervical Neoplasms/surgery ; Carcinoma, Neuroendocrine/radiotherapy ; Carcinoma, Neuroendocrine/surgery ; Recurrence
Language	Chinese
Publishing date	2023-05-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604570-4
ISSN	0529-567X
ISSN	0529-567X
DOI	10.3760/cma.j.cn112141-20230614-00263
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Zs.A 1619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association of non-alcoholic fatty liver disease with total testosterone in non-overweight/obese men with type 2 diabetes mellitus.

Yang, L J / Zhou, J Z / Zheng, Y F / Hu, X / He, Z Y / Du, L J / Gu, X / Huang, X Y / Li, J / Li, Y Q / Pan, L Y / Zhang, X X / Gu, X J

Journal of endocrinological investigation

2023 Volume 46, Issue 8, Page(s) 1565–1572

Abstract: Purpose: Non-alcoholic fatty liver disease (NAFLD) is considered as both a vital risk factor and a consequence of type 2 diabetes mellitus (T2DM). Low total testosterone (TT) is common in men with T2DM, contributing to increased risks of metabolic ... ...

Abstract	Purpose: Non-alcoholic fatty liver disease (NAFLD) is considered as both a vital risk factor and a consequence of type 2 diabetes mellitus (T2DM). Low total testosterone (TT) is common in men with T2DM, contributing to increased risks of metabolic diseases. This study aimed to investigate the association between TT levels and the prevalence of NAFLD in men with T2DM. Methods: In this cross-sectional study, 1005 men with T2DM were enrolled in National Metabolic Management Center (MMC) of First Affiliated Hospital of Wenzhou Medical University between January 2017 and August 2021. NAFLD was diagnosed using ultrasound as described by the Chinese Liver Disease Association. Overweight/obesity was defined as body mass index (BMI) ≥ 25 kg/m Results: Individuals without NAFLD had higher serum TT levels than those with NAFLD. After adjustments for potential confounding factors, the top tertile was significantly associated with lower prevalence of NAFLD compared with the bottom tertile of TT level [odds ratio (OR) 0.303, 95% confidence interval (CI) 0.281-0.713; P < 0.001]. The association between TT with NAFLD in individuals with normal weight (OR 0.175, 95% CI 0.098-0.315; P < 0.001) was stronger than in individuals with overweight/obesity (OR 0.509, 95% CI 0.267-0.971; P = 0.040). There was a significant interaction of TT with overweight/obesity (P for interaction = 0.018 for NAFLD). Conclusion: Higher serum TT was significantly associated with a lower prevalence of NAFLD in men with T2DM. We found that the relationship of TT and NAFLD was stronger in individuals with non-overweight/obesity.
MeSH term(s)	Male ; Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/diagnosis ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Testosterone ; Cross-Sectional Studies ; Obesity/complications ; Obesity/epidemiology ; Obesity/diagnosis ; Overweight/complications ; Overweight/epidemiology ; Body Mass Index
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-02-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-023-02006-6
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Zs.A 1480: Show issues

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Article ; Online: Mitochondrial quality control in cartilage damage and osteoarthritis: new insights and potential therapeutic targets.

Liu, D / Cai, Z-J / Yang, Y-T / Lu, W-H / Pan, L-Y / Xiao, W-F / Li, Y-S

Osteoarthritis and cartilage

2021 Volume 30, Issue 3, Page(s) 395–405

Abstract: Osteoarthritis (OA) is a multifactorial arthritic disease of weight-bearing joints concomitant with chronic and intolerable pain, loss of locomotion and impaired quality of life in the elderly population. Although the prevalence of OA increases with age, ...

Abstract	Osteoarthritis (OA) is a multifactorial arthritic disease of weight-bearing joints concomitant with chronic and intolerable pain, loss of locomotion and impaired quality of life in the elderly population. Although the prevalence of OA increases with age, its specific mechanisms have not been elucidated and effective therapeutic disease-modifying drugs have not been developed. As essential organelles in chondrocytes, mitochondria supply energy and play vital roles in cellular metabolism, proliferation and apoptosis. Mitochondrial quality control (MQC) is the key mechanism to coordinate various mitochondrial biofunctions, primarily through mitochondrial biogenesis, dynamics, autophagy and the newly discovered mitocytosis. An increasing number of studies have revealed that a loss of MQC homeostasis contributes to the cartilage damage during the occurrence and development of OA. Several master MQC-associated signaling pathways and regulators exert chondroprotective roles in OA, while cartilage damage-related molecular mechanisms have been partially identified. In this review, we summarized known mechanisms mediated by dysregulated MQC in the pathogenesis of OA and latent bioactive ingredients and drugs for the prevention and treatment of OA through the maintenance of MQC.
MeSH term(s)	Autophagy ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Chondrocytes/metabolism ; Down-Regulation ; Humans ; Mitochondria/metabolism ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Oxidative Stress/physiology ; Reactive Oxygen Species ; Up-Regulation
Chemical Substances	Reactive Oxygen Species
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2021.10.009
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Zs.A 3828: Show issues

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Article: [Analysis of intestinal microbial diversity in Leopoldamys edwardsi based on illumina sequencing technique].

Xuan, D D / Li, Y L / Zhang, G N / Ding, L W / Cao, P P / Jia, R J / Zheng, Y A / Zhou, X J / Pan, L Y / Hu, S K / Niu, L N

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2022 Volume 56, Issue 4, Page(s) 512–518

Abstract: To explore the composition and diversity of the intestinal microflora of Leopoldamys edwardsi in Hainan Island. In November 2019, DNA was extracted from fecal samples of 25 adult Leopoldamys edwardsi (14 males and 11 females) in Hainan Island at the ... ...

Abstract	To explore the composition and diversity of the intestinal microflora of Leopoldamys edwardsi in Hainan Island. In November 2019, DNA was extracted from fecal samples of 25 adult Leopoldamys edwardsi (14 males and 11 females) in Hainan Island at the Joint Laboratory of tropical infectious diseases of Hainan Medical College and Hong Kong University. Based on the IonS5TMXL sequencing platform, single-end sequencing (Single-End) was used to construct a small fragment library for single-end sequencing. Based on Reads shear filtration and OTUs clustering. The species annotation and abundance analysis of OTUs were carried out by using mothur method and SSUrRNA database, and further conducted α diversity and β diversity analysis. A total of 1481842 high quality sequences, belonging to 14 Phyla, 85 families and 186 Genera, were obtained from 25 intestinal excrement samples of Leopoldamys edwardsi. At the level of phyla classification, the main core biota of the Leopoldamys edwardsi contained Firmicutes (46.04%),Bacteroidetes (25.34%), Proteobacteria (17.09%), Tenericutes (7.38%) and Actinobacteria (1.67%), these five phyla account for 97.52% of all phyla. The ratio of
MeSH term(s)	Adult ; Animals ; Bacteria/genetics ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Intestines ; Male ; Murinae/genetics
Language	Chinese
Publishing date	2022-04-29
Publishing country	China
Document type	Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
DOI	10.3760/cma.j.cn112150-20210915-00892
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Zs.B 2487: Show issues

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Article: [Menstrual status as risk factors of endometriosis: a case-control study].

Pan, L Y

Zhonghua fu chan ke za zhi

1993 Volume 28, Issue 3, Page(s) 147–9, 188

Abstract: A case-control study, involving 203 cases of pelvic endometriosis and 406 randomly selected and age-matched community controls, was conducted. The results showed that women characterized by earlier menarche ( ... 7 days) ... ...

Abstract	A case-control study, involving 203 cases of pelvic endometriosis and 406 randomly selected and age-matched community controls, was conducted. The results showed that women characterized by earlier menarche (< or = 12 years) and longer period (> 7 days) were associated with an elevated risk. Longer cycle (> 35 days) seemed to have a protective effect. There are a tendency to increasing risk for endometriosis associated with primary dysmenorrhea and energetic physical activities during menstruation. The results indicate that intensive treatment of primary dysmenorrhea and avoidance of strenuous exercise during menstruation may prevent pelvic endometriosis.
MeSH term(s)	Adult ; Case-Control Studies ; China/epidemiology ; Dysmenorrhea ; Endometriosis/epidemiology ; Endometriosis/etiology ; Female ; Humans ; Menarche ; Menstruation ; Pelvic Neoplasms/epidemiology ; Pelvic Neoplasms/etiology ; Risk Factors
Language	Chinese
Publishing date	1993-03
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604570-4
ISSN	0529-567X
ISSN	0529-567X
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