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Article ; Online: Association of red cell distribution width/albumin ratio and in hospital mortality in patients with atrial fibrillation base on medical information mart for intensive care IV database.

Pan, Li-Ya / Song, Jing

2024 Volume 24, Issue 1, Page(s) 174

Abstract: Background: Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence ... ...

Abstract	Background: Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence regarding the association between RDW to albumin ratio (RAR) and in hospital mortality in patients with AF admitted to the Intensive Care Unit (ICU) currently was unclear. The purpose of this study was to explore the association between RAR and in hospital mortality in patients with AF in the ICU. Methods: This retrospective cohort study used data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database for the identification of patients with atrial fibrillation (AF). The primary endpoint investigated was in-hospital mortality. Multivariable-adjusted Cox regression analysis and forest plots were utilized to evaluate the correlation between the RAR and in-hospital mortality among patients with AF admitted to ICU. Additionally, receiver operating characteristic (ROC) curves were conducted to assess and compare the predictive efficacy of RDW and the RAR. Results: Our study included 4,584 patients with AF with a mean age of 75.1 ± 12.3 years, 57% of whom were male. The in-hospital mortality was 20.3%. The relationship between RAR and in-hospital mortality was linear. The Cox proportional hazard model, adjusted for potential confounders, found a high RAR independently associated with in hospital mortality. For each increase of 1 unit in RAR, there is a 12% rise in the in-hospital mortality rate (95% CI 1.06-1.19). The ROC curves revealed that the discriminatory ability of the RAR was better than that of RDW. The area under the ROC curves (AUCs) for RAR and RDW were 0.651 (95%CI: 0.631-0.671) and 0.599 (95% CI: 0.579-0.620). Conclusions: RAR is independently correlated with in hospital mortality and in AF. High level of RAR is associated with increased in-hospital mortality rates.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Erythrocyte Indices ; Atrial Fibrillation/diagnosis ; Hospital Mortality ; Retrospective Studies ; Critical Care ; Prognosis
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-024-03839-6
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Article ; Online: Emerging function of main RNA methylation modifications in the immune microenvironment of digestive system tumors.

Zeng, Yifan / Yu, Tao / Lou, Zhuoqi / Chen, Lin / Pan, Liya / Ruan, Bing

Pathology, research and practice

2024 Volume 256, Page(s) 155268

Abstract: Digestive system tumors have been reported in more than 25% of all cancer cases worldwide, bringing a huge burden on the healthcare system. RNA methylation modification-an important post-transcriptional modification-has become an active research area in ... ...

Abstract	Digestive system tumors have been reported in more than 25% of all cancer cases worldwide, bringing a huge burden on the healthcare system. RNA methylation modification-an important post-transcriptional modification-has become an active research area in gene regulation. It is a dynamic and reversible process involving several enzymes, such as methyltransferases, demethylases, and methylation reader proteins. This review provides insights into the role of three major methylation modifications, namely m6A, m5C, and m1A, in the development of digestive system tumors, specifically in the development of tumor immune microenvironment (TIME) of these malignancies. Abnormal methylation modification affects immunosuppression and antitumor immune response by regulating the recruitment of immune cells and the release of immune factors. Understanding the mechanisms by which RNA methylation regulates digestive system tumors will be helpful in exploring new therapeutic targets.
MeSH term(s)	Humans ; RNA Methylation ; Gastrointestinal Neoplasms ; Digestive System Neoplasms/genetics ; Methyltransferases ; Protein Processing, Post-Translational ; Tumor Microenvironment ; RNA
Chemical Substances	Methyltransferases (EC 2.1.1.-) ; RNA (63231-63-0)
Language	English
Publishing date	2024-03-20
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155268
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Ud III Zs.20: Show issues

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Article ; Online: Prognostic and immune predictive roles of a novel tricarboxylic acid cycle-based model in hepatocellular carcinoma.

Zeng, Yifan / Yu, Tao / Jiang, Shuwen / Wang, Jinzhi / Chen, Lin / Lou, Zhuoqi / Pan, Liya / Zhang, Yongtao / Ruan, Bing

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2333

Abstract: Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Since the tricarboxylic acid cycle is widely involved in tumor metabolic reprogramming and cuproptosis, investigating related genes may help to identify prognostic signature of ... ...

Abstract	Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer. Since the tricarboxylic acid cycle is widely involved in tumor metabolic reprogramming and cuproptosis, investigating related genes may help to identify prognostic signature of patients with HCC. Data on patients with HCC were sourced from public datasets, and were divided into train, test, and single-cell cohorts. A variety of machine learning algorithms were used to identify different molecular subtypes and determine the prognostic risk model. Our findings revealed that the risk score (TRscore), based on the genes OGDHL, CFHR4, and SPP1, showed excellent predictive performance in different datasets. Pathways related to cell cycle and immune inflammation were enriched in the high-risk group, whereas metabolism-related pathways were significantly enriched in the low-risk group. The high-risk group was associated with a greater number of mutations of detrimental biological behavior and higher levels of immune infiltration, immune checkpoint expression, and anti-cancer immunotherapy response. Low-risk patients demonstrated greater sensitivity to erlotinib and phenformin. SPP1 was mainly involved in the interaction among tumor-associated macrophages, T cells, and malignant cells via SPP1-CD44 and SPP1-(ITGA5 + ITGB1) ligand-receptor pairs. In summary, our study established a prognostic model, which may contribute to individualized treatment and clinical management of patients with HCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Prognosis ; Citric Acid Cycle/genetics ; Liver Neoplasms/genetics ; Algorithms ; Tumor Microenvironment
Language	English
Publishing date	2024-01-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52632-0
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Article ; Online: Relaxin-3 Ameliorates Diabetic Cardiomyopathy by Inhibiting Endoplasmic Reticulum Stress.

Pan, Li-Ya / Zhang, Xiao-Hui / Xia, Wu-Jie / Pan, Jia-Lin

publication RETRACTED

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 9380283

Abstract: Background: This study is aimed at investigating whether relaxin-3 exhibits protective effects against cardiomyopathy in diabetic rats by suppressing ERS.: Methods: Eighty male SD rats were randomly divided into two groups: controls (: Results: (1) ...

Abstract	Background: This study is aimed at investigating whether relaxin-3 exhibits protective effects against cardiomyopathy in diabetic rats by suppressing ERS. Methods: Eighty male SD rats were randomly divided into two groups: controls ( Results: (1) HE and Masson staining indicated that relaxin-3 could attenuate myocardial lesions and myocardial collagen volume fraction. (2) BNP, TnI, and myoglobin in the DM group at four and eight weeks were significantly higher than in the controls ( Conclusions: Exogenous relaxin-3 ameliorates diabetic cardiomyopathy by inhibiting ERS in diabetic rats.
MeSH term(s)	Animals ; Apoptosis ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/drug therapy ; Diabetic Cardiomyopathies/pathology ; Endoplasmic Reticulum Stress ; Eosine Yellowish-(YS)/pharmacology ; Eosine Yellowish-(YS)/therapeutic use ; Glucose ; Hematoxylin/pharmacology ; Hematoxylin/therapeutic use ; Interleukin-17/pharmacology ; Interleukin-17/therapeutic use ; Male ; Myoglobin/pharmacology ; Myoglobin/therapeutic use ; Natriuretic Peptide, Brain/pharmacology ; Natriuretic Peptide, Brain/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Relaxin/pharmacology ; Relaxin/therapeutic use ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Troponin/pharmacology ; Troponin/therapeutic use ; Tumor Necrosis Factor-alpha
Chemical Substances	Interleukin-17 ; Myoglobin ; Troponin ; Tumor Necrosis Factor-alpha ; Natriuretic Peptide, Brain (114471-18-0) ; Streptozocin (5W494URQ81) ; Relaxin (9002-69-1) ; Glucose (IY9XDZ35W2) ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/9380283
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Zs.A 6373: Show issues

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Article ; Online: Gut microbiota is associated with weight gain in children treated with atypical antipsychotic: A pilot longitudinal study.

Pan, Li-Ya / Zhou, Yuan-Yue / Zhang, Xue / Jiang, Hai-Yin

Psychiatry research

2022 Volume 316, Page(s) 114784

Abstract: We studied longitudinal changes in the microbiome with weight gain during atypical antipsychotics (APs) treatment. 43 inpatients naive to AP paediatric medication were included in the longitudinal microbiota study. The baseline composition of the gut ... ...

Abstract	We studied longitudinal changes in the microbiome with weight gain during atypical antipsychotics (APs) treatment. 43 inpatients naive to AP paediatric medication were included in the longitudinal microbiota study. The baseline composition of the gut microbiome in the case group was characterised by an increase in Parabacteroides and Eubacterium_hallii_group. During the follow-up, the relative abundances of Romboutsia and Klebsiella increased significantly after 3 months of AP treatment; however, no significant changes in these two gut bacteria were observed in the control group. The baseline composition of the gut microbiome contributed to the risk of AP-associated weight gain.
MeSH term(s)	Antipsychotic Agents/adverse effects ; Child ; Gastrointestinal Microbiome ; Humans ; Longitudinal Studies ; Pilot Projects ; Weight Gain
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2022-08-17
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2022.114784
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Zs.A 1541: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: A Rare Case of a Subcutaneous Abscess Caused by

Lv, Huoyang / Chen, Mengyuan / Ji, Youqi / Pan, Liya / Hong, Xin / Ge, Yumei

Infection and drug resistance

2023 Volume 16, Page(s) 263–268

Abstract: Background: Nocardia cyriacigeorgica: Methods: The clinical data of a patient with cutaneous nocardiosis caused by : Results: Magnetic resonance imaging (MRI) showed that there was a 26 mm × 73 mm abscess under the skin. The pus in the abscess was ...

Abstract	Background: Nocardia cyriacigeorgica Methods: The clinical data of a patient with cutaneous nocardiosis caused by Results: Magnetic resonance imaging (MRI) showed that there was a 26 mm × 73 mm abscess under the skin. The pus in the abscess was green. Gram staining showed positive branched rod-shaped and undivided hyphae. After culture, small wrinkle dry white small colonies were observed, and it was identified as Conclusion: We report the first case of a subcutaneous abscess caused by
Language	English
Publishing date	2023-01-13
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S395333
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Article ; Online: HCC prediction models in chronic hepatitis B patients receiving entecavir or tenofovir: a systematic review and meta-analysis.

Xu, Xiaolan / Jiang, Lushun / Zeng, Yifan / Pan, Liya / Lou, Zhuoqi / Ruan, Bing

Virology journal

2023 Volume 20, Issue 1, Page(s) 180

Abstract: Background: Our study aimed to compare the predictive performance of different hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B patients receiving entecavir or tenofovir, including discrimination, calibration, negative predictive ... ...

Abstract	Background: Our study aimed to compare the predictive performance of different hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B patients receiving entecavir or tenofovir, including discrimination, calibration, negative predictive value (NPV) in low-risk, and proportion of low-risk. Methods: We conducted a systematic literature research in PubMed, EMbase, the Cochrane Library, and Web of Science before January 13, 2022. The predictive performance was assessed by area under receiver operating characteristic curve (AUROC), calibration index, negative predictive value, and the proportion in low-risk. Subgroup and meta-regression analyses of discrimination and calibration were conducted. Sensitivity analysis was conducted to validate the stability of the results. Results: We identified ten prediction models in 23 studies. The pooled 3-, 5-, and 10-year AUROC varied from 0.72 to 0.84, 0.74 to 0.83, and 0.76 to 0.86, respectively. REAL-B, AASL-HCC, and HCC-RESCUE achieved the best discrimination. HCC-RESCUE, PAGE-B, and mPAGE-B overestimated HCC development, whereas mREACH-B, AASL-HCC, REAL-B, CAMD, CAGE-B, SAGE-B, and aMAP underestimated it. All models were able to identify people with a low risk of HCC accurately. HCC-RESCUE and aMAP recognized over half of the population as low-risk. Subgroup analysis and sensitivity analysis showed similar results. Conclusion: Considering the predictive performance of all four aspects, we suggest that HCC-RESCUE was the best model to utilize in clinical practice, especially in primary care and low-income areas. To confirm our findings, further validation studies with the above four components were required.
MeSH term(s)	Humans ; Tenofovir/therapeutic use ; Carcinoma, Hepatocellular/epidemiology ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/epidemiology ; Liver Neoplasms/epidemiology ; Antiviral Agents/therapeutic use
Chemical Substances	Tenofovir (99YXE507IL) ; entecavir (5968Y6H45M) ; Antiviral Agents
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-02145-5
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Article ; Online: Nocardia pseudobrasiliensis

Ji, Youqi / Chen, Mengyuan / Hong, Xin / Pan, Liya / Cheng, Dongqing / Ge, Yumei

The Journal of international medical research

2023 Volume 51, Issue 12, Page(s) 3000605231206959

Abstract: ... Nocardia ... ...

Abstract	Nocardia pseudobrasiliensis
MeSH term(s)	Humans ; Hydrarthrosis ; Nocardia Infections/complications ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Nocardia ; Arthritis
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231206959
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Zs.A 925: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: Extrauterine growth restriction in preterm infants: Postnatal growth pattern and physical development outcomes at age 3-6 years.

Lan, Siyuan / Fu, Huanhuan / Zhang, Rui / Zhong, Guimei / Pan, Liya / Bei, Fei / Hong, Li

Frontiers in pediatrics

2022 Volume 10, Page(s) 945422

Abstract: Objectives: To investigate the postnatal growth trajectories of preterm infants and evaluate the association between extrauterine growth restriction (EUGR) at discharge and adverse physical growth outcomes at age 3-6 years.: Methods: Premature ... ...

Abstract	Objectives: To investigate the postnatal growth trajectories of preterm infants and evaluate the association between extrauterine growth restriction (EUGR) at discharge and adverse physical growth outcomes at age 3-6 years. Methods: Premature infants admitted to Shanghai Children's Medical Center within 24 h after birth from 1 January 2016 to 31 December 2018 were enrolled. Neonatal complications, nutrition support, and anthropometric data were collected and analyzed to diagnose EUGR on different definitions at discharge. The weight and the height of each subject were collected by telephone investigation from 1 September 2021 to 31 November 2021 to access the incidences of overweight/obesity, short stature, and thinness at age 3-6 years. Results: A total of 527 preterm infants were included in the final sample. The overall mean weight and height Conclusion: The growth trajectories of the preterm newborns tended toward the normal direction. Longitudinal EUGR on the head circumference and cross-sectional EUGR on height at discharge were associated with adverse physical growth outcomes at age 3-6 years.
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.945422
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Article: Overabundance of Veillonella parvula promotes intestinal inflammation by activating macrophages via LPS-TLR4 pathway.

Zhan, Zhiyan / Liu, Wenxue / Pan, Liya / Bao, Yiwen / Yan, Zhilong / Hong, Li

Cell death discovery

2022 Volume 8, Issue 1, Page(s) 251

Abstract: Hirschsprung's disease-associated enterocolitis (HAEC) is the most common complication of Hirschsprung's disease (HSCR). The microbiome pattern of intestinal flora in HAEC patients was significantly abnormal compared to that in HSCR patients. The ... ...

Abstract	Hirschsprung's disease-associated enterocolitis (HAEC) is the most common complication of Hirschsprung's disease (HSCR). The microbiome pattern of intestinal flora in HAEC patients was significantly abnormal compared to that in HSCR patients. The overabundance of V. parvula was detected in the gut of HAEC patients. To elucidate the pathological mechanisms of the overabundance of V. parvula, we established and analyzed inflammatory models induced by LPS or single-bacterial strain transplantation in vivo. The transplantation of V. parvula induced inflammatory response in the colon of mice. Besides, we found that LPS from V. parvula can significantly impair the barrier function of colonic epithelial cells and then activate macrophages which impaired pacemaker function of interstitial cells of Cajal (ICCs). It was thus a vicious cycle, where the macrophage-related inflammation caused by V. parvula via LPS-TLR4 pathway damaged the intestinal motility, which further aggravated the intestinal flora dysbiosis and promoted the development of HAEC. Itaconic acid could break the vicious cycle by inhibiting the activation of macrophages. It could be a potential therapeutic strategy for HAEC patients with intestinal flora dysbiosis.
Language	English
Publishing date	2022-05-06
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-022-01015-3
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