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Article ; Online: LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy.

Wang, Qiushi / Yang, Jie / Pan, Rui / Zha, Zhengang

2024 Volume 229, Issue 3, Page(s) 152799

Abstract: We hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment; while for in ... ...

Abstract	We hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment; while for in vivo tests, OA model was established in mice using the destabilization of the medial meniscus (DMM) method. Cell viability and apoptosis were assessed with MTT and flow cytometry assays, respectively. Cartilage tissue was stained by Safranin-O/Fast Green Staining. The mRNA and protein levels were separately determined via quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. SNHG1 overexpression promoted the viability yet inhibited the apoptosis of chondrocytes injured by IL-1β. Moreover, the overexpression of SNHG1 promoted B-cell lymphoma-2 (Bcl-2) expression and activated phosphoinositol-3 kinase (PI3K)/protein kinase B (Akt) pathway but suppressed the process of autophagy, which led to down-regulation of light chain 3 (LC3)-II/I level and up-regulation of P62 level. However, rapamycin (RAPA, an autophagy activator) and LY294002 (a PI3K inhibitor) reversed the effects of SNHG1 overexpression on the viability and apoptosis of chondrocytes as well as on the proteins related to PI3K/Akt pathway and autophagy. In OA-modeled mice, SNHG1 overexpression prevented the loss of chondrocytes via the activation of PI3K/Akt pathway and the suppression of autophagy. SNHG1 overexpression might inhibit the apoptosis of chondrocytes by promoting PI3K/Akt pathway and inhibiting autophagy.
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	563292-4
ISSN	1878-3279 ; 0171-2985
ISSN (online)	1878-3279
ISSN	0171-2985
DOI	10.1016/j.imbio.2024.152799
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Article ; Online: A distributed parameter model of the Janus-Helmholtz transducer.

Liu, Wenzhao / Mo, Xiping / Chai, Yong / Wu, Tong / Pan, Rui

The Journal of the Acoustical Society of America

2024 Volume 155, Issue 1, Page(s) 681–694

Abstract: The Janus-Helmholtz (JH) transducer is a low-frequency, high-power, broadband underwater transducer type. Numerous studies have shown the effectiveness of the finite element method (FEM) in designing JH transducers and predicting their electroacoustic ... ...

Abstract	The Janus-Helmholtz (JH) transducer is a low-frequency, high-power, broadband underwater transducer type. Numerous studies have shown the effectiveness of the finite element method (FEM) in designing JH transducers and predicting their electroacoustic performance. However, a precise theoretical model for JH transducers has not yet been proposed, and the modal identification problem of JH transducers remains unsolved. In this paper, a distributed parameter model (DPM) of the JH transducer is proposed, which consists of the DPM of a Janus transducer and the DPM of a cylindrical liquid cavity under elastic wall conditions. By comparing the DPM with FEM, it is confirmed that the DPM can accurately calculate the resonant frequencies, admittance, amplitude, and phase of vibration velocity of the JH transducer. Additionally, a physical analogy is introduced to reveal the relationships between the transducer's resonances. Two JH transducers with different liquid cavities are fabricated and tested, and the results from the DPM, FEM, and experiments exhibit good agreement. The DPM can not only provide valuable theoretical support but also significantly reduce much time in designing JH transducers. Furthermore, it may inspire further advancements in adjusting the resonant frequencies or expanding the working bandwidth of JH transducers.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0024468
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Article ; Online: Label-free dual-mode sensing platform based on target-regulated CRISPR-Cas12a activity for ochratoxin A in

Xu, Huifeng / Pan, Rui / Huang, Weihua / Zhu, Xi

Analytical methods : advancing methods and applications

2023 Volume 15, Issue 35, Page(s) 4518–4523

Abstract: Many traditional Chinese herbs are susceptible to ochratoxin A (OTA), a potent mycotoxin, which causes serious effects on the quality of the herb and on people's health. The development of methods to detect OTA is extremely important. Most methods for ... ...

Abstract	Many traditional Chinese herbs are susceptible to ochratoxin A (OTA), a potent mycotoxin, which causes serious effects on the quality of the herb and on people's health. The development of methods to detect OTA is extremely important. Most methods for detecting OTA are based on a single-signal output mode, which might be easily influenced by complex environmental conditions. In this research, by taking advantage of the cleavage of DNA by target-induced CRISPR-Cas12a activity and the difference in electrostatic force of DNA to different charge electrochemiluminescent (ECL) and electrochemical (EC) probes, a biosensor is developed for the detection of OTA. First, the CRISPR-Cas12a system consists of a well-designed crRNA, its complementary strand (also as an aptamer for OTA), and Cas12a. Without the target, this CRISPR-Cas12a system is in the "activated stage", which digests hairpin DNA on the electrode, resulting in a weak ECL signal and strong current response. With the introduction of OTA bound with the aptamer, CRISPR-Cas12a activity is inhibited ("locked stage"). Thus, hairpin DNA remained intact on the electrode, resulting in recovery of the ECL signal and attenuation of the current intensity. As a result, this label-free dual-mode sensing platform realizes an assay for OTA in
MeSH term(s)	Humans ; CRISPR-Cas Systems/genetics ; Morinda ; Ochratoxins ; Mycotoxins ; Rubiaceae ; Oligonucleotides
Chemical Substances	ochratoxin A (1779SX6LUY) ; Ochratoxins ; Mycotoxins ; Oligonucleotides
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d3ay01025b
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Article ; Online: Detection of Interaction Effects in a Nonparametric Concurrent Regression Model.

Pan, Rui / Wang, Zhanfeng / Wu, Yaohua

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 9

Abstract: Many methods have been developed to study nonparametric function-on-function regression models. Nevertheless, there is a lack of model selection approach to the regression function as a functional function with functional covariate inputs. To study ... ...

Abstract	Many methods have been developed to study nonparametric function-on-function regression models. Nevertheless, there is a lack of model selection approach to the regression function as a functional function with functional covariate inputs. To study interaction effects among these functional covariates, in this article, we first construct a tensor product space of reproducing kernel Hilbert spaces and build an analysis of variance (ANOVA) decomposition of the tensor product space. We then use a model selection method with the L1 criterion to estimate the functional function with functional covariate inputs and detect interaction effects among the functional covariates. The proposed method is evaluated using simulations and stroke rehabilitation data.
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25091327
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Article: Arachidonate lipoxygenases 5 is a novel prognostic biomarker and correlates with high tumor immune infiltration in low-grade glioma.

Pan, Rui-Han / Zhang, Xin / Chen, Zu-Peng / Liu, Ya-Jun

Frontiers in genetics

2023 Volume 14, Page(s) 1027690

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1027690
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Article: Lactate metabolism in neurodegenerative diseases.

Yang, Chaoguang / Pan, Rui-Yuan / Guan, Fangxia / Yuan, Zengqiang

Neural regeneration research

2023 Volume 19, Issue 1, Page(s) 69–74

Abstract: Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular ... ...

Abstract	Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating transcription, cellular functions, and disease development. This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases, thus providing optimal perspectives for future research.
Language	English
Publishing date	2023-07-24
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.374142
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Article ; Online: Prefeeding interventions improve oral feeding in preterm infants.

Chen, Gaoyan / Li, Xiaogang / Pan, Rui

International journal of pediatric otorhinolaryngology

2022 Volume 162, Page(s) 111324

Abstract: Objective: To assess whether oral stimulation (OS), nonnutritive sucking (NNS) and combined tactile/kinesthetic (T/K) interventions can improve the effects of oral feeding in preterm infants.: Methods: A retrospective review was performed from 2014 ... ...

Abstract	Objective: To assess whether oral stimulation (OS), nonnutritive sucking (NNS) and combined tactile/kinesthetic (T/K) interventions can improve the effects of oral feeding in preterm infants. Methods: A retrospective review was performed from 2014 to 2016, in which one hundred thirty preterm infants were separated into two intervention groups (the OS + NNS group and the OS + NNS + T/K group) and one control group. Infants in the two intervention groups received 30 min of interventions a day. All interventions started 48 h after stopping nasal continuous positive airway pressure until participants reached complete oral feeding. Results: The transition times of the OS + NNS, OS + NNS + T/K, and control groups from the introduction of oral feeding to independent oral feeding were 9.03 ± 0.58, 7.20 ± 0.28, and 12.17 ± 0.64 days, respectively (P < 0.05). The infants' weights at full oral feeding in the OS + NNS, OS + NNS + T/K, and control groups were 1834.58 ± 47.96, 1999.17 ± 92.62, and 1725.87 ± 40.34 g, respectively (P = 0.007). Further post hoc analyses indicated that the weight gain at full oral feeding in the OS + NNS and OS + NNS + T/K groups were more significant than the control group (P = 0.012 and P = 0.036, respectively)Conclusion: OS + NNS and OS + NNS + T/K interventions could shorten the transition time from tube feeding to independent oral feeding; OS + NNS and OS + NNS + T/K interventions improved weight gain compared to the control group. Furthermore, the OS + NNS + T/K group was superior to the OS + NNS group regarding transition time and weight gain.
MeSH term(s)	Enteral Nutrition ; Humans ; Infant, Newborn ; Infant, Premature/physiology ; Sucking Behavior ; Weight Gain
Language	English
Publishing date	2022-09-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2022.111324
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Article ; Online: Event-Triggered Synchronization of Switched Nonlinear System Based on Sampled Measurements.

Zhou, Lei / Liu, Chang / Pan, Rui / Xiao, Xiaoqing

IEEE transactions on cybernetics

2022 Volume 52, Issue 5, Page(s) 3531–3538

Abstract: This article considers the event-triggered synchronization problem for continuous-time switched nonlinear systems. Based on the sampled data of system output and mode, a mode-dependent event-triggered condition is provided to determine the data ... ...

Abstract	This article considers the event-triggered synchronization problem for continuous-time switched nonlinear systems. Based on the sampled data of system output and mode, a mode-dependent event-triggered condition is provided to determine the data transmission. The synchronization error system with both delayed state and asynchronously switching signal are formulated by the input-delay method and switching signal merging techniques. Then, by the multiple Lyapunov-Krasovskii functional approach, a new sufficient synchronization condition is obtained, from which the synchronizing controller can be designed by solving a set of linear matrix inequalities (LMIs). Finally, the effectiveness of the proposed synchronization scheme is illustrated by one numerical example.
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2020.3009920
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Book ; Online: Effective Bilevel Optimization via Minimax Reformulation

Wang, Xiaoyu / Pan, Rui / Pi, Renjie / Zhang, Tong

2023

Abstract: Bilevel optimization has found successful applications in various machine learning problems, including hyper-parameter optimization, data cleaning, and meta-learning. However, its huge computational cost presents a significant challenge for its ... ...

Abstract	Bilevel optimization has found successful applications in various machine learning problems, including hyper-parameter optimization, data cleaning, and meta-learning. However, its huge computational cost presents a significant challenge for its utilization in large-scale problems. This challenge arises due to the nested structure of the bilevel formulation, where each hyper-gradient computation necessitates a costly inner optimization procedure. To address this issue, we propose a reformulation of bilevel optimization as a minimax problem, effectively decoupling the outer-inner dependency. Under mild conditions, we show these two problems are equivalent. Furthermore, we introduce a multi-stage gradient descent and ascent (GDA) algorithm to solve the resulting minimax problem with convergence guarantees. Extensive experimental results demonstrate that our method outperforms state-of-the-art bilevel methods while significantly reducing the computational cost. Comment: 25 pages
Keywords	Computer Science - Machine Learning ; Mathematics - Optimization and Control
Subject code	510
Publishing date	2023-05-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physicochemical properties and in vitro digestion behavior of emulsion gels stabilized by rice bran protein aggregates: Effects of heating time and induction methods.

Luo, Yongxue / Wang, Kexin / Pan, Rui / Li, Ting / Sun, Qingjie / Pu, Chuanfen / Tang, Wenting

Food research international (Ottawa, Ont.)

2023 Volume 170, Page(s) 112976

Abstract: To investigate the effects of heating time and induction methods on the physicochemical properties and in vitro digestion behavior of emulsion gels, rice bran protein aggregates (RBPAs) were formed by acid-heat induction (90 °C, pH 2.0) and the emulsion ... ...

Abstract	To investigate the effects of heating time and induction methods on the physicochemical properties and in vitro digestion behavior of emulsion gels, rice bran protein aggregates (RBPAs) were formed by acid-heat induction (90 °C, pH 2.0) and the emulsion gels were further prepared by adding GDL or/and laccase for single/double cross-linked induction. Heating time affected the aggregation and oil/water interfacial adsorption behavior of RBPAs. Suitable heating (1-6 h) was conducive to faster and more adsorption of aggregates at the oil/water interface. While excessive heating (7-10 h) resulted in protein precipitation, which inhibited the adsorption at the oil/water interface. The heating time at 2, 4, 5 and 6 h was thus chosen to prepare the subsequent emulsion gels. Compared with the single cross-linked emulsion gels, the double-cross-linked emulsion gels showed higher water holding capacity (WHC). After simulated gastrointestinal digestion, the single/double cross-linked emulsion gels all exhibited slow-release effect on free fatty acid (FFA). Moreover, the WHC and final FFA release rate of emulsion gels were closely related to the surface hydrophobicity, molecular flexibility, sulfhydryl, disulfide bond and interface behavior of RBPAs. Generally, these findings proved the potential of emulsion gels in designing fat alternatives, which could provide a novel technique for the fabrication of low-fat food.
MeSH term(s)	Emulsions ; Heating ; Oryza ; Protein Aggregates ; Fatty Acids, Nonesterified ; Gels ; Digestion
Chemical Substances	Emulsions ; Protein Aggregates ; Fatty Acids, Nonesterified ; Gels
Language	English
Publishing date	2023-05-18
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.112976
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