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Article: [Correlations of Birth Defects With Birth Weight and Gestational Age].

Yu, Min / Pan, Xiao-Min / Yang, Jin / Liu, Fei / Zhou, Zhe-Ren

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2024 Volume 46, Issue 2, Page(s) 204–209

Abstract: Objective To analyze the incidence rate of birth defects in infants born at different gestational ages and birth weights,so as to provide a basis for improving the surveillance system and reducing the incidence of birth defects. Methods Data of all ... ...

Abstract	Objective To analyze the incidence rate of birth defects in infants born at different gestational ages and birth weights,so as to provide a basis for improving the surveillance system and reducing the incidence of birth defects. Methods Data of all perinatal infants born at and after 28 weeks of gestation and within 7 days after delivery in all the hospitals with the obstetrical department from October 1,2003 to September 30,2015 were collected. Results From 2003 to 2015,1 236 937 perinatal infants were monitored,including 10 619 with birth defects (incidence rate of 8.59‰).Among the infants with birth defects identified by the hospital surveillance system of birth defects in Xi'an during the study period,3 306,3 473,and 224 infants showed the birth weights less than 2 500 g,the gestational age within the range of [28,37] weeks,and the gestation age≥42 weeks,respectively.The low birth weight infants showed higher incidence rate of birth defects than the normal birth weight infants (
MeSH term(s)	Humans ; Congenital Abnormalities/epidemiology ; Infant, Newborn ; Birth Weight ; Female ; Gestational Age ; Pregnancy ; Incidence ; Infant, Low Birth Weight
Language	Chinese
Publishing date	2024-04-30
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.15436
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Article: [Multiple Correspondence of Abnormal Birth History with Genetic and Environmental Risk Factors].

Yu, Min / Ping, Zhi-Guang / Song, Hui / Pan, Xiao-Min / Hao, Yan

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2022 Volume 44, Issue 5, Page(s) 822–827

Abstract: Objective To investigate the multiple correspondence of genetic and environmental risk factors with abnormal birth history and provide a scientific basis for improving the birth defects surveillance system and reducing the incidence of birth defects. ... ...

Abstract	Objective To investigate the multiple correspondence of genetic and environmental risk factors with abnormal birth history and provide a scientific basis for improving the birth defects surveillance system and reducing the incidence of birth defects. Methods Data were collected from all the perinatal infants from 28-week-old fetuses to 7-day-old infants born in all the hospitals with obstetrical department in Xi'an from 2003 to 2015. Results A total of 1 236 937 perinatal infants were surveyed,including 10 619 with birth defects.The average incidence rate of birth defects was 0.86% (0.70%-1.15%).Multiple correspondence analysis showed that the women who had had 1 or 2 children with birth defects were associated with the history of spontaneous abortion,family history of birth defects,and history of exposure to toxic and harmful substances.The women who had had 3 or more children with birth defects showed stronger association with family history of birth defects.The birth defects in women with history of spontaneous abortion (257/10 619) was ranked in the order of congenital heart disease,polydactyly,neural tube defects,congenital hydrocephalus,cleft lip with cleft palate,and simple cleft lip.The birth defects in women who had given birth to children with birth defects (135/10 619) followed the order of cleft lip with cleft palate,anencephaly,hydrocephalus,neural tube defects,cleft lip,and talipes equinovarus. Conclusions Abnormal birth history is associated with family history of birth defects and history of exposure to environmental risk factors.Giving birth to three or more children with birth defects is highly correlated with the family history of birth defects.
MeSH term(s)	Child ; Pregnancy ; Female ; Humans ; Cleft Lip/epidemiology ; Cleft Lip/etiology ; Cleft Palate/complications ; Reproductive History ; Abortion, Spontaneous ; Neural Tube Defects/complications ; Neural Tube Defects/epidemiology ; Risk Factors
Language	Chinese
Publishing date	2022-10-26
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.14589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Engineered FGF19

Shi, Lu / Zhao, Tiantian / Huang, Lei / Pan, Xiaomin / Wu, Tianzhen / Feng, Xin / Chen, Taoli / Wu, Jiamin / Niu, Jianlou

BMC biotechnology

2023 Volume 23, Issue 1, Page(s) 43

Abstract: Background: The major safety concern of the clinical application of wild type FGF19 (FGF19: Results: We found that, similar to that of FGF19: Conclusions: Together, our findings raise hope that ... ...

Abstract	Background: The major safety concern of the clinical application of wild type FGF19 (FGF19 Results: We found that, similar to that of FGF19 Conclusions: Together, our findings raise hope that FGF19
MeSH term(s)	Animals ; Mice ; Bile Acids and Salts ; Cholestasis/drug therapy ; Cholestasis/pathology ; Cholestasis, Intrahepatic/drug therapy ; Cholestasis, Intrahepatic/genetics ; Cholestasis, Intrahepatic/pathology ; Disease Models, Animal ; Liver
Chemical Substances	Bile Acids and Salts ; fibroblast growth factor 15, mouse
Language	English
Publishing date	2023-10-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052746-9
ISSN	1472-6750 ; 1472-6750
ISSN (online)	1472-6750
ISSN	1472-6750
DOI	10.1186/s12896-023-00810-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Methanol-Enhanced Liquid Electrode Discharge Microplasma-Induced Vapor Generation of Hg, Cd, and Zn: The Possible Mechanism and Its Application

Pan, Xiaomin / Lin, Yao / Su, Yubin / Yang, Jiahui / He, Liangbo / Deng, Yurong / Hou, Xiandeng / Zheng, Chengbin

Analytical chemistry. 2021 June 02, v. 93, no. 23

2021

Abstract: Despite increased interest in microplasma-induced vapor generation (μPIVG) over the past several years, applications in real sample analyses remain limited due to their relatively low vapor generation efficiency and ambiguous mechanism. In this work, a ... ...

Abstract	Despite increased interest in microplasma-induced vapor generation (μPIVG) over the past several years, applications in real sample analyses remain limited due to their relatively low vapor generation efficiency and ambiguous mechanism. In this work, a novel method using methanol for significantly enhancing the liquid electrode discharge μPIVG efficiency was developed for the simultaneous and sensitive determination of Hg, Cd, and Zn by atomic fluorescence spectrometry (AFS). It is worth noting that the possible enhancement mechanism was investigated via the characterizations of volatile products by AFS, microplasma optical emission spectrometry, online gas chromatography, and gas chromatography–mass spectrometry, which involved the reductive species such as electrons, hydrogen radicals (·H), methyl radicals (·CH₃), and other intermediates in the argon plasma adding methanol. Under the optimized conditions, the limits of detection of 0.007, 0.05, and 0.5 μg L–¹ were obtained for Hg, Cd, and Zn, respectively, with relative standard deviations of 3.1, 3.7, and 5.2% for these elements, respectively. Vapor generation efficiencies of 90, 83, and 55% were achieved for Hg, Cd, and Zn, respectively, and improved 2.7-, 4.8-, and 7.9-fold, respectively, compared to those obtained in the absence of methanol. The accuracy and practicability of the proposed method were validated by the determination of Hg, Cd, and Zn in a certified reference material (CRM, Lobster hepatopancreas, TORT-3) and crayfish samples collected from three different provinces of China.
Keywords	analytical chemistry ; crayfish ; electrodes ; fluorescence emission spectroscopy ; gas chromatography-mass spectrometry ; hepatopancreas ; hydrogen ; liquids ; lobsters ; methanol ; reference standards ; vapors ; China
Language	English
Dates of publication	2021-0602
Size	p. 8257-8264.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c01091
Database	NAL-Catalogue (AGRICOLA)

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Article: FGF4 protects the liver from immune-mediated injury by activating CaMKK

Huang, Zhifeng / Pan, Tongtong / Xu, Liang / Shi, Lu / Ma, Xiong / Zhou, Liya / Wang, Luyao / Wang, Jiaojiao / Zhu, Guoqing / Chen, Dazhi / Song, Lingtao / Pan, Xiaomin / Wang, Xiaodong / Li, Xiaokun / Luo, Yongde / Chen, Yongping

Acta pharmaceutica Sinica. B

2023 Volume 14, Issue 4, Page(s) 1605–1623

Abstract: Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine; however, its role ...

Abstract	Immune-mediated liver injury (ILI) is a condition where an aberrant immune response due to various triggers causes the destruction of hepatocytes. Fibroblast growth factor 4 (FGF4) was recently identified as a hepatoprotective cytokine; however, its role in ILI remains unclear. In patients with autoimmune hepatitis (type of ILI) and mouse models of concanavalin A (ConA)- or S-100-induced ILI, we observed a biphasic pattern in hepatic FGF4 expression, characterized by an initial increase followed by a return to basal levels. Hepatic FGF4 deficiency activated the mitochondria-associated intrinsic apoptotic pathway, aggravating hepatocellular apoptosis. This led to intrahepatic immune hyper-reactivity, inflammation accentuation, and subsequent liver injury in both ILI models. Conversely, administration of recombinant FGF4 reduced hepatocellular apoptosis and rectified immune imbalance, thereby mitigating liver damage. The beneficial effects of FGF4 were mediated by hepatocellular FGF receptor 4, which activated the Ca
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2023.12.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fibroblast growth factor 21 ameliorates cholestatic liver injury via a hepatic FGFR4-JNK pathway.

Zhou, Chuanren / Pan, Xiaomin / Huang, Lei / Wu, Tianzhen / Zhao, Tiantian / Qi, Jie / Wu, Jiamin / Mukondiwa, Alan Vengai / Tang, Yuli / Luo, Yongde / Tu, Qi / Huang, Zhifeng / Niu, Jianlou

Biochimica et biophysica acta. Molecular basis of disease

2023 Volume 1870, Issue 1, Page(s) 166870

Abstract: Cholestasis is characterized by hepatic accumulation of cytotoxic bile acids (BAs), which often subsequently leads to liver injury, inflammation, fibrosis, and liver cirrhosis. Fibroblast growth factor 21 (FGF21) is a liver-secreted hormone with ... ...

Abstract	Cholestasis is characterized by hepatic accumulation of cytotoxic bile acids (BAs), which often subsequently leads to liver injury, inflammation, fibrosis, and liver cirrhosis. Fibroblast growth factor 21 (FGF21) is a liver-secreted hormone with pleiotropic effects on the homeostasis of glucose, lipid, and energy metabolism. However, whether hepatic FGF21 plays a role in cholestatic liver injury remains elusive. We found that serum and hepatic FGF21 levels were significantly increased in response to cholestatic liver injury. Hepatocyte-specific deletion of Fgf21 exacerbated hepatic accumulation of BAs, further accentuating liver injury. Consistently, administration of rFGF21 ameliorated cholestatic liver injury caused by α-naphthylisothiocyanate (ANIT) treatment and Mdr2 deficiency. Mechanically, FGF21 activated a hepatic FGFR4-JNK signaling pathway to decrease Cyp7a1 expression, thereby reducing hepatic BAs pool. Our study demonstrates that hepatic FGF21 functions as an adaptive stress-responsive signal to downregulate BA biosynthesis, thereby ameliorating cholestatic liver injury, and FGF21 analogs may represent a candidate therapy for cholestatic liver diseases.
MeSH term(s)	Humans ; MAP Kinase Signaling System ; Liver/metabolism ; Cholestasis/drug therapy ; Cholestasis/metabolism ; Hepatocytes/metabolism ; Receptor, Fibroblast Growth Factor, Type 4/genetics ; Receptor, Fibroblast Growth Factor, Type 4/metabolism
Chemical Substances	fibroblast growth factor 21 ; FGFR4 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 4 (EC 2.7.10.1)
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2023.166870
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Article ; Online: An ic-ELISA and immunochromatographic strip assay for the detection of 2,4-dichlorophenoxyacetic acid in bean sprouts and cabbage.

Pan, Xiaomin / Xu, Xinxin / Song, Shanshan / Xu, Liguang / Kuang, Hua / Wu, Xiaoling / Liu, Liqiang / Xu, Chuanlai

Journal of pharmaceutical and biomedical analysis

2021 Volume 209, Page(s) 114524

Abstract: The compound 2,4-dichlorophenoxyacetic acid (2,4-D) is a synthetic plant growth regulator, which is widely used in agricultural production. Consequently, it is necessary to establish a rapid and sensitive detection method to monitor its use and prevent ... ...

Abstract	The compound 2,4-dichlorophenoxyacetic acid (2,4-D) is a synthetic plant growth regulator, which is widely used in agricultural production. Consequently, it is necessary to establish a rapid and sensitive detection method to monitor its use and prevent the environmental and human health problems caused by overuse. In this study, a monoclonal antibody (mAb) 2D5 against 2,4-D was prepared, and based on it, an ic-ELISA and an immunochromatographic strip assay (ICA) were developed for rapid detection. The 50% inhibitory concentration (IC
MeSH term(s)	2,4-Dichlorophenoxyacetic Acid/analysis ; Antibodies, Monoclonal ; Brassica/chemistry ; Chromatography, Affinity ; Enzyme-Linked Immunosorbent Assay ; Immunoassay ; Limit of Detection ; Phaseolus/chemistry
Chemical Substances	Antibodies, Monoclonal ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262)
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2021.114524
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Article ; Online: Methanol-Enhanced Liquid Electrode Discharge Microplasma-Induced Vapor Generation of Hg, Cd, and Zn: The Possible Mechanism and Its Application.

Pan, Xiaomin / Lin, Yao / Su, Yubin / Yang, Jiahui / He, Liangbo / Deng, Yurong / Hou, Xiandeng / Zheng, Chengbin

Analytical chemistry

2021 Volume 93, Issue 23, Page(s) 8257–8264

Abstract	Despite increased interest in microplasma-induced vapor generation (μPIVG) over the past several years, applications in real sample analyses remain limited due to their relatively low vapor generation efficiency and ambiguous mechanism. In this work, a novel method using methanol for significantly enhancing the liquid electrode discharge μPIVG efficiency was developed for the simultaneous and sensitive determination of Hg, Cd, and Zn by atomic fluorescence spectrometry (AFS). It is worth noting that the possible enhancement mechanism was investigated
MeSH term(s)	Cadmium/analysis ; China ; Electrodes ; Gas Chromatography-Mass Spectrometry ; Humans ; Mercury/analysis ; Methanol ; Patient Discharge ; Zinc
Chemical Substances	Cadmium (00BH33GNGH) ; Mercury (FXS1BY2PGL) ; Zinc (J41CSQ7QDS) ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c01091
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Article ; Online: Prediction of radiation pressure force exerted on moving particles by the two-level skeletonization.

Pan, Xiao-Min / Gou, Ming-Jiang / Sheng, Xin-Qing

Optics express

2014 Volume 22, Issue 8, Page(s) 10032–10045

Abstract: A fast full-wave method for computing radiation pressure force (RPF) exerted by shaped light beams on moving particles is presented. The problem of evaluating RPF exerted on a moving particle by a single excitation beam is converted into that of ... ...

Abstract	A fast full-wave method for computing radiation pressure force (RPF) exerted by shaped light beams on moving particles is presented. The problem of evaluating RPF exerted on a moving particle by a single excitation beam is converted into that of computing RPF's exerted on a static particle by multiple beams. The discretization of different beams leads to distinct right hand sides (RHS's) for the matrix system. To avoid solving each RHS by the brute-force manner, the algorithm conducts low-rank decomposition on the excitation matrix consisting of all RHS's to figure out the so-called skeleton light beams by interpolative decomposition (ID). The peak memory requirement of the skeletonization is a bottle-neck if the particle is large. A two-level skeletonization scheme is proposed to solve this problem. Some numerical experiments on arbitrarily shaped homogeneous particles are performed to illustrate the performance and capability of the developed method.
Language	English
Publishing date	2014-04-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.22.010032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prediction of metallic nano-optical trapping forces by finite element-boundary integral method.

Pan, Xiao-Min / Xu, Kai-Jiang / Yang, Ming-Lin / Sheng, Xin-Qing

Optics express

2015 Volume 23, Issue 5, Page(s) 6130–6144

Abstract: The hybrid of finite element and boundary integral (FE-BI) method is employed to predict nano-optical trapping forces of arbitrarily shaped metallic nanostructures. A preconditioning strategy is proposed to improve the convergence of the iterative ... ...

Abstract	The hybrid of finite element and boundary integral (FE-BI) method is employed to predict nano-optical trapping forces of arbitrarily shaped metallic nanostructures. A preconditioning strategy is proposed to improve the convergence of the iterative solution. Skeletonization is employed to speed up the design and optimization where iteration has to be repeated for each beam configuration. The radiation pressure force (RPF) is computed by vector flux of the Maxwell's stress tensor. Numerical simulations are performed to validate the developed method in analyzing the plasmonic effects as well as the optical trapping forces. It is shown that the proposed method is capable of predicting the trapping forces of complex metallic nanostructures accurately and efficiently.
Language	English
Publishing date	2015-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.23.006130
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