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Article: Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review.

Wang, Yu-Qi / Chen, Wen-Jin / Li, Wen-Yan / Pan, Xiu-Wu / Cui, Xin Gang

2022 Volume 12, Page(s) 995519

Abstract: Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine ... ...

Abstract	Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine whether tumor advancement is promoted or inhibited. Among them, infiltrated B lymphocytes are present in all stages of RCC, playing a major role in determining tumor formation and advancement, as an essential part in the tumor microenvironment (TME). Although the advent of targeted and immune therapies has remarkably improved the survival of patients with advanced RCC, few cases can achieve complete response due to drug resistance. In this review article, we intend to summary the recent studies that outline the interaction networks of B cells with other cells, discuss the role of B cells in RCC development and progression, and assess their impact on RCC immunotherapy.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.995519
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: "Zero ischemia" laparoscopic partial nephrectomy by high-power GreenLight laser enucleation for renal carcinoma: A single-center experience.

Zhang, Xiang-Min / Xu, Ji-Dong / Lv, Jian-Min / Pan, Xiu-Wu / Cao, Jian-Wei / Chu, Jian / Cui, Xin-Gang

World journal of clinical cases

2022 Volume 10, Issue 17, Page(s) 5646–5654

Abstract: Background: Laparoscopic partial nephrectomy has been widely used in renal cell carcinoma treatment. The efficacy of GreenLight laser on Laparoscopic partial nephrectomy is still unknown.: Aim: To present the first series of laparoscopic partial ... ...

Abstract	Background: Laparoscopic partial nephrectomy has been widely used in renal cell carcinoma treatment. The efficacy of GreenLight laser on Laparoscopic partial nephrectomy is still unknown. Aim: To present the first series of laparoscopic partial nephrectomy (LPN) by GreenLight laser enucleation without renal artery clamping. Due to the excellent coagulation and hemostatic properties of the laser, laser-assisted LPN (LLPN) makes it possible to perform a "zero ischemia" resection. Methods: Fifteen patients with T1a exogenous renal tumors who received high-power GreenLight laser non-ischemic LPN in our hospital were retrospectively analyzed. All clinical information, surgical and post-operative data, complications, pathological and functional outcomes were analyzed. Results: Surgery was successfully completed in all patients, and no open or radical nephrectomy was performed. The renal artery was not clamped, leading to no ischemic time. No blood transfusions were required, the average hemoglobin level ranged from 96.0 to 132.0 g/L and no postoperative complications occurred. The mean operation time was 104.3 ± 8.2 min. The postoperative removal of negative pressure drainage time ranged from 5.0 to 7.0 d, and the mean postoperative hospital stay was 6.5 ± 0.7 d. No serious complications occurred. Postoperative pathological results showed clear cell carcinoma in 12 patients, papillary renal cell carcinoma in 2 patients, and hamartoma in 1 patient. The mean creatinine level was 75.0 ± 0.8 μmol/L (range 61.0-90.4 μmol/L) at 1 mo after surgery, and there were no statistically significant differences compared with pre-operation ( Conclusion: GreenLight laser has extraordinary cutting and sealing advantages when used for small renal tumors (exogenous tumors of stage T1a) during LPN. However, use of this technique can lead to the generation of excessive smoke.
Language	English
Publishing date	2022-08-01
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v10.i17.5646
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Article ; Online: Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis.

Pan, Xiu-Wu / Xu, Da / Zhang, Hao / Zhou, Wang / Wang, Lin-Hui / Cui, Xin-Gang

Intensive care medicine

2020 Volume 46, Issue 6, Page(s) 1114–1116

MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/genetics ; Acute Kidney Injury/physiopathology ; Acute Kidney Injury/virology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/genetics ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Cytokine Release Syndrome/physiopathology ; Cytokine Release Syndrome/virology ; Ethnicity ; Gene Expression Profiling/methods ; Humans ; Kidney Tubules/pathology ; Kidney Tubules/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/genetics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Podocytes/pathology ; Podocytes/virology ; SARS-CoV-2 ; Sequence Analysis, RNA
Keywords	covid19
Language	English
Publishing date	2020-03-31
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-020-06026-1
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Zs.A 1089: Show issues

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Article ; Online: Glycolysis drives STING signaling to facilitate dendritic cell antitumor function.

Hu, Zhilin / Yu, Xiaoyan / Ding, Rui / Liu, Ben / Gu, Chuanjia / Pan, Xiu-Wu / Han, Qiaoqiao / Zhang, Yuerong / Wan, Jie / Cui, Xin-Gang / Sun, Jiayuan / Zou, Qiang

The Journal of clinical investigation

2023 Volume 133, Issue 7

Abstract: Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that ... ...

Abstract	Activation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity. Mechanistically, glycolysis augmented ATP production to boost STING activation and STING-dependent DC antitumor functions. Moreover, DC-intrinsic STING activation accelerated HIF-1α-mediated glycolysis and established a positive feedback loop. Importantly, glycolysis facilitated STING-dependent DC activity in tissue samples from patients with non-small cell lung cancer. Our results provide mechanistic insight into how the crosstalk of glycolytic metabolism and STING signaling enhances DC antitumor activity and can be harnessed to improve cancer therapies.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Signal Transduction ; Glycolysis ; Dendritic Cells
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI166031
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Ua VI Zs.184: Show issues

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Article ; Online: Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma.

Chen, Wen-Jin / Dong, Ke-Qin / Pan, Xiu-Wu / Gan, Si-Shun / Xu, Da / Chen, Jia-Xin / Chen, Wei-Jie / Li, Wen-Yan / Wang, Yu-Qi / Zhou, Wang / Rini, Brian / Cui, Xin-Gang

Cell death & disease

2023 Volume 14, Issue 1, Page(s) 30

Abstract: Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, transcriptomic and epigenetic alternations in ... ...

Abstract	Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, transcriptomic and epigenetic alternations in RCC progression have not been completely defined. In this study, single-cell RNA-sequencing (scRNA-seq) data were obtained from eight tissue samples of RCC patients, including two matched pairs of primary and metastatic sites (lymph nodes), along with Hi-C, transposable accessible chromatin by high-throughput (ATAC-seq) and RNA-sequencing (RNA-seq) between RCC (Caki-1) and human renal tubular epithelial cell line (HK-2). The identified target was verified in clinical tissue samples (microarray of 407 RCC patients, TMA-30 and TMA-2020), whose function was further validated by in vitro and in vivo experiments through knockdown or overexpression. We profiled transcriptomes of 30514 malignant cells, and 14762 non-malignant cells. Comprehensive multi-omics analysis revealed that malignant cells and TME played a key role in RCC. The expression programs of stromal cells and immune cells were consistent among the samples, whereas malignant cells expressed distinct programs associated with hypoxia, cell cycle, epithelial differentiation, and two different metastasis patterns. Comparison of the hierarchical structure showed that SERPINE2 was related to these NNMF expression programs, and at the same time targeted the switched compartment. SERPINE2 was highly expressed in RCC tissues and lowly expressed in para-tumor tissues or HK-2 cell line. SERPINE2 knockdown markedly suppressed RCC cell growth and invasion, while SERPINE2 overexpression dramatically promoted RCC cell metastasis both in vitro and in vivo. In addition, SERPINE2 could activate the epithelial-mesenchymal transition pathway. The above findings demonstrated that the role of distinct expression patterns of malignant cells and TME played a distinct role in RCC progression. SERPINE2 was identified as a potential therapeutic target for inhibiting metastasis in advanced RCC.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/metabolism ; Serpin E2/genetics ; Multiomics ; Single-Cell Gene Expression Analysis ; Cell Line, Tumor ; Kidney Neoplasms/metabolism ; Cell Proliferation/genetics ; RNA ; Gene Expression Regulation, Neoplastic ; Cell Movement ; Tumor Microenvironment/genetics
Chemical Substances	Serpin E2 ; RNA (63231-63-0) ; SERPINE2 protein, human
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-05566-w
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Article ; Online: Molecular subtyping and characterization of clear cell renal cell carcinoma by tumor differentiation trajectories.

Pan, Xiu-Wu / Chen, Wen-Jin / Xu, Da / Guan, Wen-Bin / Li, Lin / Chen, Jia-Xin / Chen, Wei-Jie / Dong, Ke-Qin / Ye, Jian-Qing / Gan, Si-Shun / Zhou, Wang / Cui, Xin-Gang

iScience

2023 Volume 26, Issue 12, Page(s) 108370

Abstract: Previous bulk RNA sequencing or whole genome sequencing on clear cell renal cell carcinoma (ccRCC) subtyping mainly focused on ccRCC cell origin or the complex tumor microenvironment (TME). Based on the single-cell RNA sequencing (scRNA-seq) data of 11 ... ...

Abstract	Previous bulk RNA sequencing or whole genome sequencing on clear cell renal cell carcinoma (ccRCC) subtyping mainly focused on ccRCC cell origin or the complex tumor microenvironment (TME). Based on the single-cell RNA sequencing (scRNA-seq) data of 11 primary ccRCC specimens, cancer stem-cell-like subsets could be differentiated into five trajectories, whereby we further classified ccRCC cells into three groups with diverse molecular features. These three ccRCC subgroups showed significantly different outcomes and potential targets to tyrosine kinase inhibitors (TKIs) or immune checkpoint inhibitors (ICIs). Tumor cells in three differentiation directions exhibited distinct interactions with other subsets in the ccRCC niches. The subtyping model was examined through immunohistochemistry staining in our ccRCC cohort and validated the same classification effect as the public patients. All these findings help gain a deeper understanding about the pathogenesis of ccRCC and provide useful clues for optimizing therapeutic schemes based on the molecular subtype analysis.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.108370
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Article ; Online: Acute kidney injury during the COVID-19 outbreak.

Pan, Xiu-Wu / Xu, Da / Chen, Wen-Jin / Chen, Jia-Xin / Ye, Jian-Qing / Zuo, Li / Cui, Xin-Gang

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2020 Volume 35, Issue 9, Page(s) 1635–1641

Keywords	covid19
Language	English
Publishing date	2020-09-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfaa218
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article: Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

Pan, Xiu-Wu / Xu, Da / Zhang, Hao / Zhou, Wang / Wang, Lin-Hui / Cui, Xin-Gang

Intensive Care Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #19482
Database	COVID19

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Article ; Online: Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak

Pan, Xiu-wu / Xu, Da / Zhang, Hao / Zhou, Wang / Wang, Lin-hui / Cui, Xin-gang

Intensive Care Medicine

a study based on single-cell transcriptome analysis

2020 Volume 46, Issue 6, Page(s) 1114–1116

Keywords	Critical Care and Intensive Care Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-020-06026-1
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 1089: Show issues

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Article ; Online: Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study.

Chen, Wen-Jin / Cao, Hao / Cao, Jian-Wei / Zuo, Li / Qu, Fa-Jun / Xu, Da / Zhang, Hao / Gong, Hai-Yi / Chen, Jia-Xin / Ye, Jian-Qing / Gan, Si-Shun / Zhou, Wang / Zhu, Da-Wei / Pan, Xiu-Wu / Cui, Xin-Gang

Cell death & disease

2022 Volume 13, Issue 1, Page(s) 50

Abstract: Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment paradigms for different subtypes. To reveal the ... ...

Abstract	Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment paradigms for different subtypes. To reveal the heterogeneity of tumor microenvironment (TME) in nccRCC, we performed 10x sing-cell genomics on tumor and normal tissues from patients with papillary renal cell carcinoma (pRCC), chromophobe RCC (chrRCC), collecting duct carcinoma (CDRCC) and sarcomatoid RCC (sarRCC). 15 tissue samples were finally included. 34561 cells were identified as 16 major cell clusters with 34 cell subtypes. Our study presented the sing-cell landscape for four types of nccRCC, and demonstrated that CD8+ T cells exhaustion, tumor-associated macrophages (TAMs) and sarcomatoid process were the pivotal factors in immunosuppression of nccRCC tissues and were closely correlated with poor prognosis. Abnormal metabolic patterns were present in both cancer cells and tumor-infiltrating stromal cells, such as fibroblasts and endothelial cells. Combined with CIBERSORTx tool, the expression data of bulk RNA-seq from TCGA were labeled with cell types of our sing-cell data. Calculation of the relative abundance of cell types revealed that greater proportion of exhausted CD8+ T cells, TAMs and sarRCC derived cells were correlated with poor prognosis in the cohort of 274 nccRCC patients. To the best of our knowledge, this is the first study that provides a more comprehensive sight about the heterogeneity and tumor biology of nccRCC, which may potentially facilitate the development of more effective therapies for nccRCC.
MeSH term(s)	Carcinoma, Renal Cell/metabolism ; Endothelial Cells/metabolism ; Genomics ; Humans ; Kidney Neoplasms/metabolism ; Tumor Microenvironment/genetics
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-04501-9
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